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PMC10988808
E Xenograft tumor tissues were stained by IHC using ki-67 antibodies.
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PMC11155445
This enhancement was due to the presence of electron-withdrawing inductive effect of an electronegative chlorine atom.
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PMC11665555
Elevated OVOL1 expression has been recognized in ovarian, breast, lung, and gastric cancers compared with their benign counterparts (52).
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PMC10850553
First, to narrow candidates to facilitate the migration of neutrophils into the site of rupture, which crucially contribute to the rupture of IAs, the two independent comprehensive gene expression data sets previously (GEO accession: GSE161044; Fig. 1A, No. 1, n = 3 in each group) and newly obtained from the rat model of ruptured and rupture-prone IA lesions (Fig. 1A, No. 2, n = 5 in each group) were analyzed.
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PMC11610461
It was also found that the expression of AMPK mRNA was significantly up-regulated in metformin-treated A498 cells compared to the control group, as well as the expression of mTOR mRNA was significantly down-regulated in metformin-treated A498 cells, both in a dose-dependent manner (Figs. 5H, 5I).
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PMC11705067
The data showed that cg02239377, cg06674932 and cg26061355 of FDX1 and cg08065721 of DLAT were the most methylated sites (Fig. 5E, 5F).
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PMC11724582
Owing to the lack of sequencing data on almonertinib resistance, we selected the GSE193258 dataset as the analysis object, screened the genes differentially expressed between the osimertinib-sensitive (acute group) and osimertinib-resistant (DTP group) groups, and then performed GO and KEGG enrichment analyses.
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PMC11674834
This is consistent with previous results following benzidine treatment .
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PMC10222971
It is also worth noting that an improvement of the activity could be observed for 2-O-alkyl lawsones with increase of side chain reaching the optimal value for derivative 10 (with 5 carbon atoms) and a loss of the activity with an increment in chain length.
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PMC11519583
c MPs, transfected with the respective siRNAs, followed by induction of adipogenic differentiation, were visualized using Oil Red O staining.
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PMC11733919
In the case of etoposide-induced senescence, the levels of a cell cycle inhibitor p21 served as a better biomarker of senescence than SA-β-gal activity compared with doxorubicin-mediated senescence in A431 cells (Figure 1b).
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PMC9429973
CD19-directed ThisCART (ThisCART19A) cells are readily produced with a single lentiviral vector, encoding both a CD19-targeting CAR and an anti-CD3 single chain antibody with the KDEL peptide fused to its C-termini (Figure 1).
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PMC11701801
In addition, several groups have reported attempts to search for synthetic lethal paralog pairs genome-wide from about 400 to 1,030 paralog pairs using the Cas9 or Cas12a CRISPR knockout system (46–49).
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PMC10652261
According to the data obtained by in vitro experiments, 1-(4-fluorophenyl)-3-(thiophen-3-yl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-2-pyrazoline (2f) and 1-(3-bromophenyl)-3-(thiophen-3-yl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-2-pyrazoline (2h) have proved to be potential antileukemic agents with remarkable cytotoxicity against HL-60 and K562 cells by activation of caspase 3, thereby inducing apoptosis.
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PMC8526701
A Nude mice were injected s.c.
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PMC6650823
Pettersen et al. report the discovery and optimization of a series of novel inhibitors of 5-lipooxygenase-activating protein, which stimulates the production of leukotrienes, important mediators in the pathogenesis and progression of atherosclerosis .
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PMC7961460
As a control, MCF-7 were nucleofected for 48 h with 30 nmol of siRNA against c10orf118 or scrambled siRNA, plated on coverslips, fixed and stained with antibodies against c10orf118 and Golgin-97.
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PMC11742290
LGR5 enhances chemo-resistance through the WNT/β-catenin signaling pathway in cervical cancer.
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PMC11574271
The remaining tumor-bearing mice from J82-RON cells and animals from J82-NC cells served as the control group.
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PMC8073654
This research group further performed elution-extrusion CCC using the n-hexane‒ethyl acetate‒methanol‒water (1:1:1:1, v/v) system for ethanol extraction from this plant, thereby producing milligram-amounts of four phenylbutenoids, (E)-4-(3′,4′-dimethoxyphenyl)but-1,2-diol (23); (E)-4-(3′,4′-dimethoxyphenyl)propenal (24); 2; and 3, which were more than 90% pure, and of a mixture of 4 and 11 .
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PMC11055510
Wound healing experiments analyzed the effect of circMAN1A2 interaction with miR-135a-3p on the migration rate of SKOV3 cells. *
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PMC11472639
However, it is important to note that the assay used in our study was designed for PBMCs, and the investigation of whole blood was exploratory.
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PMC6468656
The results revealed the association of high ghrelin expression with cancer and cellular movement (ranked top 1, Figure 1B,C).
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PMC7192625
We then considered DNA methylation data for the GM06690 cell line.
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PMC11519583
Data in bar graphs are expressed as mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001, n.s.
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PMC11670407
Transfected 143B cells were treated with cisplatin (10 μM) for 24 h. j-q Western blot results and semiquantitative analysis of the band density for 143B or U2OS cells transfected with shRNA-OTULIN lentivirus or an OTULIN overexpression plasmid.
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PMC11746948
Compared to WT mice, APT2 heterozygous or homozygous knockout mice exhibited a marked increase in tumor numbers in both colorectal and small intestinal regions (Fig. 7b, c and Supplementary Fig. 10c, d), suggesting that APT2 knockout significantly exacerbated CRC development in the AOM/DSS-induced model.
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PMC8526701
P < 0.05; **P < 0.01; ***P < 0.001.
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PMC11711345
Given the highly divergent results obtained with our in silico analysis versus the in vitro data found in the literature on the level of antiproliferative activity of those compounds in the same HCCLs, an overall evaluation of the studies performed thus far is needed.
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PMC11706776
Specifically, in 7 of the 18 biopsies, areas with high SK1 levels were detected (Fig. 1D).
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PMC11544122
GPCRs are known to segregate into distinct functional pools at the plasma membrane, including CXCR4, which may co-segregate with SNX9 and/or other relevant proteins.
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PMC11392912
The graph represents the densitometric value of Clo-miR-14 PCR product of Clo-miR-14 treated and HC rat synovium, run in 1.5% agarose gel normalized with U6 loading control which depicts the level of Clo-niR-14 in rat synovium. (
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PMC11767817
The experiments included the following groups: cells treated with compound 2a only at concentrations of 4 μM, 6 μM, and 8 μM; cells treated with MK-2206 alone at concentrations of 1 μM and 5 μM; and cells treated with all compound concentrations in combination with both concentrations of the inhibitor.
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PMC9919300
Globally, the estimated prevalence of NAFLD is 25.2%, whereas high-risk group patients, such as diabetic and obese, are 50% more prone to developing NAFLD .
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PMC11577421
This difference is likely attributed to an efficient scavenger receptor-mediated uptake of NP_BSA–, resulting from the more anionic and partly denatured form of BSA– (see Figure 1D).
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PMC10976516
Mice were preimmunized against AdE3 and only the loaded A549 cells induced complete tumor regression.
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PMC11762280
A Photos of keratinocyte-specific Mlkl cKO mice (Krt14-Mlkl) and control mice (Krt14-Mlkl) at 48 h after exposure or non-exposure to 430 mJ/cm UVB irradiation (n = 5).
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PMC9386809
The anticancerous activity of the synthesized compound 4g against the A-172 cell line was assessed via the MTT assay and compared with control Dulbecco’s modified Eagle medium (DMEM).
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PMC11655498
By leveraging a combination of techniques, we can gain a deeper understanding of the complex interactions between EBV and its host, thereby guiding the development of novel therapeutic strategies.
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PMC11352746
This is a viability stain using membrane permeability, DNA binding, and red fluorescence to detect live cells .
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PMC3019555
In contrast, HIF-1α mRNA remained bound to microtubules after TX treatment (Fig. 3 D), which is consistent with our results in Fig. 3 C, where HIF-1α MBs remained associated with TX-induced microtubule bundles.
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PMC11047729
Moreover, telomestatin suppresses the activity of the telomerase in BCR-ABL-positive leukemic cell lines in a reproducible manner .
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PMC11535726
China • Yunnan Province, Lushui City, Sanhe Village, Gaoligong Mountain, saprobic on decaying wood in a freshwater stream, 5 May 2021, Rong-ju Xu, XS17 (HKAS 136930, holotype), ex-type living culture, KUNCC 10431; ibid. •
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PMC11477621
Most of the synthetic compounds exhibited significant HDAC inhibitory effects and potent anti-proliferation against cancer cells.
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PMC11521786
In this context, the results previously obtained with the autologous mErbB3 suggested the ability to circumvent tolerance and the therapeutic potential of a vaccine candidate that included the extracellular domain of the human ErbB3 (HER3) in patients.
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PMC11186948
Western blot of H3K27 acetylated (H3ac) protein (17 kDa) in three HD and #249 LCLs normalized on H3 (17 kDa), as represented in the quantification on the right (HD in grey, #249 in red). (
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PMC11786767
The lowest ratio of biotin-DHPE was identified as the relative lipid level in the chromosome interior.
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PMC9429973
In some experiments we also nucleofected HSPCs using the nuclease form of Cas9 with a gRNA targeting TET2.
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PMC11763111
To avoid primed peripheral blood mononuclear cells (PBMCs) rejecting CCRF-CEM cells because of an HLA mismatch, which could impact tumor growth, the B2M gene was knocked out in the CCRF-CEM cell line.
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PMC11753949
This enzyme is known to act as a “genetically-encoded latrunculin”: it ribosylates monomeric actin and prevents its incorporation into filaments.
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PMC11552389
Red arrows enote autophagosomes.
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PMC11095939
Increasing evidence indicates that quiescence is not a passive non-proliferating state but is rather an active metabolic state maintained by certain transcriptional programs (Roche et al., 2017; Yao, 2014).
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PMC11295144
After deconvolution, the background was eliminated using the Costes Optimized method (Coastes et al., 2004).
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PMC11774747
This dual targeting is particularly beneficial for sustained and targeted therapeutic responses.
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PMC11708541
3-Aminopyridine-2(1H)-one was reacted with several isothiocyanates to get thioureide derivatives.
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PMC6268318
Antiviral activity of a methanolic extract was reported against Herpes simplex 1 and Herpes simplex 2 .
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PMC11462673
Despite the potential therapeutic strategy of MYB inhibition emerging for various leukemias, including T-ALL, the exact mechanisms of its transcriptional regulation remain unclear.
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PMC3888431
Cufflinks shows the best performance with respect to the u80-metric with a value of 3,474.
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PMC3765139
One fraction stained positive for CD105 (88%) and another one for CD271 (45%).
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PMC10253973
Liu et al. performed molecular docking of two enantiomeric analogs of E52 (81a) and (81b) (Figure 35) to three different protein kinases: GSK3-β, CDK2/cyclin A and PIM1, as a potential cancer-oriented drug.
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PMC9635307
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a type I transmembrane glycoprotein and a member of the CEA family.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Carcinoembryonic",...
PMC11453018
The Z-axis represents the synergy score, with positive values indicating synergy and negative values indicating antagonism.
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PMC3035438
TSA (Wako) was added in the medium at each passage at 2.5 ng/ml when indicated.
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PMC11143482
Cancer models both in vitro and in vivo, allow us to perform investigations on patients that would be challenging due to economic, moral, and welfare issues.
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PMC3931643
We searched the Basso Lymphoma dataset for patterns of 4EBP1 expression.
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PMC9429973
Patients continued SOC CIT per discretion of treating physician.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "continued", "SOC", "CIT", "per", "discretion", "of", "treating", "physician", "." ] } ]
PMC9884169
The results showed that the expressions of FSP1 and SLC7A11 in 5637 cells were significantly downregulated after knockdown, thus suggesting that the cells underwent ferroptosis (Figure 2(b)).
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PMC11462673
The mixtures were subsequently subjected to overnight rotation at 4 °C.
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PMC11539788
The average number of invaded cells in five random fields was determined using ImageJ software.
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PMC10729469
2Characterization of TCRAβ-Treg immunosuppressive function.
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PMC11496491
qRT-PCR was used to verify the significantly expressed genes-HLA-DRB1, HLA-DRB5, CXCL5 and IGFL1.
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PMC9681981
The mean expression of etx gene showed significant differences in all experimental groups (P<0.05).
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PMC11730000
Next, electrophoresis was run at 25 V and 0.3 A for 20 min.
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PMC11387401
Gray depicts assays that were not executed for the corresponding protein. (
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PMC9429973
In addition, we evaluated the antineoplastic effect of the nanoparticle in a CXCR4 AML disseminated mouse model.
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PMC11726183
SAR studies showed that the prohibition of cancer cell lines became more effective using electron-withdrawing groups.
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PMC11281366
Abs from the sera of viremic individuals were purified using protein G Dynabeads (Life Technologies, ThermoFisher Scientific, #10003D), according to the manufacturer’s instructions.
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PMC11363012
The mechanism by which the pattern of metabolite accumulation observed in the scMS data set is established remains to be determined.
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PMC10965680
The tissue samples were preserved in 75% ethanol prior to being transferred to the laboratory.
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PMC11767582
for C17H17BrN3O3 [M+H]: 390.0448, found: 390.0438.
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PMC11629461
Although CHO‐K1 cells expressed endogenous DUOXA2 (G3H0S2), endogenous DUOX2 seemed rather low or undetectible; UVA irradiation had no effect on basal calcium in CHO‐K1 cells (Figure 6).
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PMC11706776
Antibody binding was visualized with a fluorescence system or an enhanced chemiluminescence system (SuperSignal West Dura Extended Duration Substrate, ThermoSientific, Illkirch, France).
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PMC10588957
AMPK regulates energy levels, enhances metabolic checkpoints and inhibits cell growth, possibly by inhibiting tumour metabolism.
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PMC3203927
Before cell seeding, both the 3D scaffolds and 2D substrates were coated with poly-ornithine and laminin to rule out any differences that may be caused by the polymer material itself.
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PMC9429973
The ORR was defined as the combination of complete response (CR), CR with incomplete hematologic recovery (CRi), and morphologic leukemia-free state (MLFS).
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PMC10976516
While some research groups recognized the potential of chiefly T lymphocytes and secondarily myeloid cells, proof-of-concept studies were not pursued by therapeutic refinement and a progression toward clinical trials.
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PMC11632064
Thus, we hypothesized that the antiproliferative effects of several RSK inhibitors might be caused by off-target inhibition of other protein kinases, such as PLK1, a master regulator of cell division and candidate for targeted therapy with increased expression in melanoma (Strebhardt et al, 2000; Kneisel et al, 2002; Chiappa et al, 2022).
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PMC11218145
Fig. 6NOD-SCID female mice were injected i.p.
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PMC11023271
LPA is also produced by resident tissues and cells and its level often elevated in pathological conditions [18–20].
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PMC10631132
Upon defrosting, cells were cultured with mTeSR Plus (StemCell Technologies, Vancouver, Canada) on Cultrex basement membrane extract (R&D Systems, Minneapolis, USA) coated 6-well plates and incubated at 37 °C and supplied with 5% CO2.
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PMC11621493
Principal component analysis of RNA sequencing data from all four groups revealed a clear segregation along PC1, primarily attributed to cytokine treatment, and a moderate separation along PC2, influenced by the genotypes (supplemental Fig. S9F).
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PMC11377827
Clonal HeLa HRE-GFP cells were transduced with Streptococcus pyrogenes Cas9 (pHRSIN-FLAG-NLS-Cas9-NLS-pGK-Hygro) and selected for Cas9 expression using hygromycin.
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PMC10092581
In addition, Au(I) and Ag(I) complexes bearing the [Se(IPr)] ligand were, on average, slightly more effective than auranofin against tested cancer cell lines whereas complexes with the [Se(IMes)] ligand showed an in vitro antitumor potency comparable to that of the reference gold(I) complex.
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PMC11638764
These academic efforts provided an excellent starting point for Cleave Bioscience to develop CB-5038, the first-in-class ATP-competitive inhibitor of p97, which disrupts the UPS and endoplasmic reticulum-associated degradation (ERAD) pathways (Zhou, 2015) .
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PMC11344246
Finally, despite not showing a significant effect via siRNA knockdown, we utilised the TRIP13 inhibitor, DCZ0415, against our MOC cell lines.
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PMC9429973
Cell lines experiments were triplicated.
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PMC11412721
Tumor-free survival of Trp53 Eμ-Myc and Trp53 Eμ-Myc mice, classified according to sex (n = cohort size). (
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PMC7602170
In a multicenter clinical study, only 10% of imatinib-treated patients had a 10-year progression-free survival, and interestingly GIST patients with KIT exon 11 mutations suggest a better outcome beyond 10 years .
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PMC11676674
Additionally, the methanolic extract of C. ladanifer showed IC50 values of 164.91, >500, and >500 µg/mL in A375, SCC-15, and HaCaT cells, respectively .
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PMC7612475
These data are in keeping with the requirement for an intact HR pathway to facilitate the repair and restart of stalled replication forks (28).
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