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OTAR3088
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BioData-CellLine_annotated

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PMC11682224
Data are expressed as mean ± standard deviation; N = 6; **P < 0.01.
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PMC9878562
From the motility measures, we computed the continuous arrest coefficient (46), that is the proportion of time during which a cell does not move.
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PMC11543853
The raw data dataset and the complete analysis of the RT-qPCR data, using the standard Livak method, is provided in supplemental information.
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PMC11468365
Additionally, the zero-interaction potency model combines the benefits of the Loewe and Bliss models.
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PMC11655536
cDNA was then synthesized from 1 μg of total RNA with oligo(dT) primers using the HiScript II Q RT SuperMix (Vazyme, Nanjing, China).
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PMC10926885
Co‐immunoprecipitation assay was used to verify the direct interaction between proteins.
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PMC11477621
The residue was pulped with dichloromethane and ethyl acetate (1:1) and filtered to give 11 as a brown solid (12 mg, 32%).
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PMC9429973
Mechanisms of chemoresistance are still poorly understood, but drug export from cytosol plays a crucial role.
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PMC8740518
ROC analyses were performed for all selected differential metabolites using all samples.
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PMC11266100
The scientific data confirm the ability to long-term transfect the 4T1 mouse mammary tumor cell line with a luciferase-expressing plasmid; however, only when applying viral transfection methodology (Tao et al., 2008; Baklaushev et al., 2015; Baklaushev et al., 2017).
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PMC11699178
The cells were annotated by combining known cell lineage-specific marker genes with manual annotations using the CellMarker online tool in conjunction with the "Singel R" package .
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PMC11334037
P < 0.01; P < 0.001.
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PMC9429973
Understanding the metabolic reprogramming occurring in cancer, notably in CLL, may provide insights to support the development of novel therapies.
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PMC11474209
Furthermore, factors like the asymmetrical distribution of dNTPs in mitochondria promote higher levels of dGTP, may contribute to reduced fidelity during mtDNA replication, and increase the rate of spontaneous mutagenesis in the mitochondrial genome.
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PMC11721587
Expression of Fu∆Sufu failed to rescue the fu null mutant phenotypes (Fig. 1J).
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PMC11637284
Note that the efficiency of the RNAi was monitored in cell lines that in addition to expressing the mutant TAC60 variants also expressed an in situ tagged endogenous allele of TAC60 carrying a C-terminal myc-tag (insets in left panels of Fig 4B and 4C).
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PMC3813807
In order to further investigate the effect of miR-373 on the regulation of TNFAIP1 expression in the AGS cells, AGS cells grown on a 6 cm plate were co-transfected with miR-373 mimics and TNFAIP1 expression vector pCMV-TNFAIP1, pCMV-TNFAIP1-3′UTR and pCMV-TNFAIP1-3′UTRMT, respectively.
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PMC10965315
Harmaline has been proposed to have numerous therapeutic uses, such as relief from psoriasis, immunosuppression, antipruritic effects, analgesia, reduction of inflammation, protection from radiation, and anticancer activities (Nasehi et al., 2016).
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PMC9398137
Symbols indicate sensitivity to S63845: ++ highly sensitive, + sensitive, - resistant.
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PMC10919056
The survival rate ranges from 20% to 95% for patients in the early, middle, and advanced stages, while for patients with metastatic ccRCC, the survival rate is only between 0% and 10% (8, 9).
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PMC11597291
Clearly, the binding affinity and biocompatibility of GO family nanomaterials can be significantly enhanced by PEG polymers’ modification, reducing the tendency to aggregation, enhancing cytocompatibility effects, and regulating hemocompatibility .
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PMC10158546
Lentiviral-transduced ReN cell lines overexpress PrP and differentiate into neurons and astrocytes. (
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PMC11441402
Adherent cells were dissociated from T75 flasks by incubation in TrypLE® Express trypsin (Gibco™, Life Technologies, USA).
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PMC9621239
These findings aid in improving our knowledge of the pathogenesis of HBV-related HCC.
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PMC10798140
The results of the apoptosis/necrosis assay are shown in Fig. 4.
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PMC7185206
786–0 renal cancer cell line sPD-L1 production varied predictably with incubation time, cell concentration, and inhibitor concentration (Supplemental Figure 4a-b).
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PMC10565698
EMT refers to the reduction in tight and adherent junctions between epithelial cells in response to several factors and the acquisition of the ability to infiltrate and migrate .
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PMC11576293
The FDA endorsed the use of a combination of dabrafenib (a BRAF inhibitor) and trametinib (a MEK inhibitor) for treating metastatic melanoma with BRAF mutations (Wahid et al., 2018).
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PMC11697703
Data are represented as mean ± SEM.
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PMC11291490
In the immunized groups (prM-E DNA vaccine group, prM-E-dusCD40L DNA vaccine group, and inactivated TMUV vaccine group), the ducks did not show significant clinical signs.
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PMC8751435
The difference among several means was analyzed by using one‐way Analysis of Variance (LSD or Dannet's T3) in SPSS 20.0 software.
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PMC9429973
Thus, early diagnosis and rapid initiation of a triplet Brotezomib based regimen for this high-risk group is essential and improves renal outcomes in RI pts.
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PMC11703992
J The percentage of apoptotic cells in Blank-PMA and DDIT4-OE-PMA induced Jurkat cells, evaluated by flow cytometry analysis with Annexin V-FITC/PI staining (n = 3) CD4+ Memory T cells were individually extracted from single-cell samples for cell cycle analysis (Fig. S7B).
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PMC9429973
A. Nagler, M. Labopin, S. Mielke, J. Passweg, D. Blaise, T. Gedde-Dahl, J. J. Cornelissen, U. Salmenniemi, I. Yakoub-Agha, P. Reményi, G. Socié, G. Van Gorkom, H. Labussière-Wallet, X.-J. Huang, M. Thérèse Rubio, J. L Byrne, C. Craddock, L. Griskevicius, F. Ciceri, M. Mohty Hematology Division, Sheba Medical Center, Ramat-Gan, Israel; EBMT ALWP office, Hôpital Saint-Antoine, Paris, France; Hematology, Karolinska University Hospital; Department of Cell Therapy and Allogenic Stem Cell Transplantation (CAST), Department of Laboratory Medicine (LabMED), Karolinska University Hospital and Institutet, Karolinska Comprehensive Cancer Center, Stockholm, Sweden; Programme de Transplantation & Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Paoli Calmettes, Marseille, France; Hematology Dept.,
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PMC11467800
The present study provides significant insights into the cellular dynamics displayed by a TKI‐resistant, phenotypically plastic CML cell line, using a zebrafish (Danio rerio) xenograft model.
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PMC7039683
Fortunately, single-nucleotide editing tools are improving rapidly (Zafra et al., 2018; Anzalone et al., 2019).
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PMC11656657
By contrast, the proportion of naïve CAR.GD2 T-cells significantly decreased from 52.4% ± 15.4% at day 0 to 7.9% ± 7.0% at day 5 (p = 0.004), with a significant enrichment of T Central Memory (TCM) and T Effector Memory (TEM) cells (Fig. 3G).
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PMC11473750
RNA-seq data, expressed in reads per million (RPM) for each gene, for 498 clinically annotated primary neuroblastoma samples (SEQC neuroblastoma cohort) were obtained from the gene expression omnibus (GEO) with the accession GSE62564.
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PMC11741906
In addition, resistance-related miRNAs target genes involved in protein synthesis in the mTOR pathway, and proteins that regulate cell cycle such as CCND1/3.
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PMC6468656
In particular, AURKA expression is driven by β-catenin transcription in VHL-null ccRCC.
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PMC11401350
In AITL the malignant cells are CD4 + Tfh like cells.
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PMC11607321
b Distribution of cancer cell line correlations (Pearson’s r) between an independent drug response dataset (CTD2) and the MOSA reconstructed dataset, grouped by whether the cancer cell line had prior availability of drug response in the datasets for the model training (orange, n = 571) versus cell lines without drug response data (light blue, n = 239).
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PMC10578720
On the other hand, DCA has also been found to induce regulatory T cells and suppress the differentiation of Th17 cells.
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PMC11676670
HGSOC is also characterized by the expression of epithelial phenotype markers such as MUC16 (CA125), MSLN, PAX8, and KRT7 .
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PMC10823017
BYL719 combined with ICA-1 reduced the level of association between PKC-ι and Akt1.
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PMC10530622
Bashir and co-workers (2019) demonstrated that obese mice had enhanced gut passive paracellular permeability, which was associated with reduction in mRNA and protein levels of occludin, zonula occludens-1, claudins-1 and -3, resulting in a significantly increased of oxalate absorption.
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PMC11753435
On the day of transfection, each well was transfected with Lipofectamine 3000 (Thermo Fisher Scientific, L3000001) and 100 ng of plasmid DNA at a ratio of TOPFlash (Addgene, 12456)/FOPFlash (Addgene, 12457):Renilla (Addgene, #87121):uAbs = 1:0.1:3.
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PMC10729469
As expected, due to the presence of amyloid-β deposits in the AD mouse model, TCRAβ reactive Tregs were observed in untreated APP/PS1 mice at higher levels than found in non-transgenic mice. (
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PMC10547921
This difference has important implications for the structures of the two adducts, which as a result, will affect their relative alkylation efficiencies.
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PMC11774251
The major sources of IL-17 in psoriatic patients are TH17 cells, γδ T cells and ILC3 (group 3 innate lymphoid cells) in lesional skin.29,30 IL-17 interacts with IL17RA in keratinocytes, stimulating the production of inflammatory chemokines, cytokines, and antimicrobial peptides, including CXCL2, CXCL5, CXCL8, and IL-1β.31 Local inflammation increases as a result of these pro-inflammatory mediators.32 In our study, RNA-seq analysis confirmed that Tan-I exhibits anti-psoriasis effects by modulating IL-17 and various inflammatory pathways, including cytokine-cytokine receptor interaction, JAK-STAT, and TNF signaling, highlighting its therapeutic potential for psoriasis.
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PMC10142392
These structures have unique physical and chemical properties that make them attractive for use in drug delivery systems .
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PMC11281366
The bead-associated virus was then lysed with lysis buffer and quantified via p24 ELISA (XpressBio) following the manufacturer’s instructions.
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PMC11723947
e Volcano plot showing results of differential gene expression analyses between Treg that had been co-injected with WT or HP1α KO naive CD4 T cells.
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PMC11803149
ns, not significant, **p < 0.01. (
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PMC11763111
The donor CAR-T/PCDH-T cells were mixed and cultured with onefold allogeneic NK cells and fourfold CCRF-CEM-Luc-GFP cells for 48 h. F Representative flow plots showing the percentage of CAR-T cells and tumor cells in the well plate at the two time points of day 0 and day 2.
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PMC9964635
IR: ν (cm): 3272, 1640, 1516, 1445, 1388, 1081, 694.
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PMC9429973
Human induced pluripotent stem (iPS) cells are a promising prospect for future cell therapy in a wide range of diseases like congenital neutropenia for which there are currently no cures or effective therapies.
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PMC11742864
Currently, PPARγ agonists were investigated in Phase I/II clinical trials for their anti-tumor effects.
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PMC11290772
The fluorescence intensity was quantified and shown in Figure 4B, while the measurement of the fluorescence area is displayed in Figure 4C.
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PMC11730320
F qPCR results confirming that unrelated controls have copy number 2 at the deletion locus, whereas the parents have copy number 1 and the proband has copy number 0.
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PMC9429973
Summary/Conclusion: Our results show for the first time in a preclinical mouse model of MDS that iron excess driven by ineffective erythropoiesis has pathological implication in transfusion-independent MDS.
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PMC9844987
In contrast, when we compared promoter expression between these same groups of genes we observed no association with drug-targets or GWAS-associated genes.
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PMC11674891
This study aimed to investigate the function and underlying mechanisms of GRPR in LUAD metastasis.
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PMC11478724
This up-regulation can be introduced it as biomarker to predict the effectiveness of treatment with PMX.
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PMC11271800
Patients with active GIST with plasma PD-L1 concentrations above a critical value tend to have a worse prognosis, and plasma PD-L1 has the potential to serve as a prognostic biomarker for GIST patients.
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PMC8358176
Finally, FTIR spectroscopy verified the accuracy of CNT functionalization.
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PMC6934009
Ethical approval was obtained from the local ethics committee, and written informed consent was obtained from all patients (approval number: 201917).
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PMC9275501
Through the reasonable design of the connecting group, the physiological environment such as pH value, enzyme, temperature, and magnetic sensitivity is obtained, so as to realize the effective release of drugs in tumor targeting sites.
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PMC8494202
The clinical and molecular characteristics of the 40 glioma patients and their corresponding follow-up characteristics were collected (Table S4).
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PMC11040965
These results suggest that CD28 stimulation specifically increases levels of the catalytic subunits PI3Kα, PI3Kβ and PI3Kδ (for all, P = 0.0156) and activates the PI3K/AKT pathway, as indicated by the level of phospho-AKT that was significantly lower with CD28 blockade (P = 0.0156).Fig.
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PMC10577955
A voucher specimen (6-05-2019) was kept in the herbarium of the Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt, with a deposition number (TC-00107).
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PMC11352746
These instruments have revolutionized our ability to quickly and accurately acquire large standardized datasets when studying complex cellular phenomena in real-time.
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PMC11701801
To further investigate transcriptional regulation at the KREMEN2 gene locus, we used published ChIP-seq data (GSE117735; ref.
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PMC9261184
Two of the six engine exhausts were continuously monitored at any one time, so an emission model was developed to estimate total emissions across the voyage.
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PMC11461833
On the basis of the above results, we will continue our studies by verifying whether the expression of STXBP5 affects the lifespan and ageing phenotype of HGPS mice or cells from HGPS patients, with a particular focus on whether the knockout or knockdown of STXBP5 delays the ageing and increases the lifespan of HGPS patients.
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PMC9895440
The inclusion of costimulatory domains, e.g. derived from CD28 or 4-1BB, is required for optimal CAR T cell persistence, cytokine production, and tumor rejection in vivo.
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PMC9429973
M. E. Mingot Castellano, C. A. Bradbury, C. Rosso Fernández, I. Thomas, M. T. Alvarez-Román, M. Canaro, I. S. Caparrós Miranda, M. Cappechi, M. Carpenedo, G. Evans, J. T. González-Lopéz, J. R. González-Porras, I. Jarque Ramos, M. L. Lozano-Almela, M. F. Lopez Fernandez, G. Lowe, H. Lyall, C. Pascual Izquierdo, S. Pavord, R. Rayment, P. Roberts, P. Rosique Cortina, B. Sánchez-González, C. Santoro, K. Talks, D. Valcarcel-Ferreiras, F. Zaja Hematology, Hospital Universitario Virgen del Rocio, Sevilla, Spain; Bristol Haematology and Oncology Centre, University of Bristol, Bristol, United Kingdom; Clinical Trials Unit Hospital Universitario Virgen del Rocío, Sevilla, Spain; Centre for Trials Research, Cardiff University, Cardiff, United Kingdom; Hematology Department, Hospital Universitario La Paz, Madrid; Hematology Department, Hospital Son Espases, Mallorca; Hematology Department, Hospital Universitario Virgen de la Victoria, Málaga, Spain; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and University of Milan, Milan; U.O Ematologia e Trapianto ASST Ospedale San Gerardo di Monza, Monza, Italy; East Kent Hospitals University NHS Foundation Trust, Kent, United Kingdom; Hematology Department, Hospital Universitario de Burgos, Burgos; Hematology Department, Hospital Universitario de Salamanca, Salamanca; Hematology Department, Hospital Universitario La Fe, Valencia; Hematology Department, Hospital Universitario Morales Meseguer, Murcia; Hematology Department, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain; University Hospitals Birmingham, Birmingham; Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom; Hematology Department, Hospital Universitario Gregorio Marañon, Madrid, Spain; Hematology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford; University Hospital of Wales, Cardiff; Torbay and South Devon NHS Foundation Trust, Devon, United Kingdom; Hematology Department, Hospital Virgen de la Arrixaca, Murcia; Hematology Department, Hospital del Mar, Barcelona, Spain; Sapienza University, Roma, Italy; Newcastle Haemophilia Comprehensive Care Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom; Hematology Department, Hospital Val de hebrom, Barcelona, Spain; Università degli Studi di Trieste/University of Trieste, Trieste, Italy Background: High dose glucocorticoids are recommended as initial treatment for adults with Immune primary thrombocytopenia (ITP).
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PMC11679033
Consistent with the previous literature, CBD and CIT at their respective LOAEL doses did not independently impact cell viability (Figure 2), which aligns with findings that cannabinoids often exhibit non-toxic or minimal toxicity effects at lower concentrations .
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PMC8973725
Thus, the PI3K/AKT signaling pathway may play a role in ZNF677-promoted 786–0 cell EMT.
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PMC11739670
Further important interactions are also made by residues in the MHCIα3 domain outside of this flexible loop at residues E198, E229, L230, V231, E232, and K243.
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PMC9429973
Secondly, we studied if the outcomes of CMML have improved.
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PMC11682224
The isolated extracellular vesicles were characterized.
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PMC11201245
If this value is exceeded, tumor cells are detected.
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PMC11194678
Several autophagic factors have been found to undergo LLPS and transition to control autophagic degradation of protein aggregates (Zhang, 2022).
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PMC9024365
pCMV-HA-mIFITM3 was a gift from Howard Hang & Jacob Yount (Addgene plasmid # 58389; http://n2t.net/addgene:58389; RRID: Addgene_58389).
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PMC6181431
We also examined the growth of these various A704 sublines in a clonogenic assay under rapamycin treatment for 30 days (Fig 2D and 2E).
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PMC8270637
We used SMMC-7721 and Bel-7404 HCC cell lines which express PD-L1 ( Figure S3 ).
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PMC11367146
The filtered compounds were submitted to the Swiss Target Prediction server (http://www.swisstargetprediction.ch/) to identify the possible targets.
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PMC11568601
The 143B cells were seeded into 6-well plates (3 × 10 cells/well) containing reduced serum medium (Gibco, USA) without antibiotics, and transfected with reaction mixture following the protocol of Lipofectamine™ 3000 reagent (Thermo Fisher Scientific, USA).
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PMC11243198
GANT61 was the first small molecule identified to directly suppress GLI-mediated activity; however, its development as a potential anti-cancer agent has been hindered by its modest activity and aqueous chemical instability.
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PMC11046454
The recognition domain was incorporated with switchable, programmable, and TME-responsive (via adenosine triphosphate [ATP] expression) aptamers. (
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PMC11095939
Representative liver morphology and liver index of Mecp2-cKO mice without (Mecp2 cKO/AAV-EV) or with (Mecp2 cKO/AAV-Mecp2) the rescue of Mecp2 at 7 d post-PHx.
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PMC10114490
Moreover, the percentage of Ki67-positive cells was not higher in PD iHDF-T, excluding a progressive decline in the requirement of exogenous growth factors to proliferate, a typical feature of cellular transformation.
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PMC9429973
Interestingly, pts with hMDS had lower rates of high-risk mutations (38% vs. 51%, p=0.009) with less RUNX1 (p=0.079) and ASXL1 (p=0.010) mutations while the frequency of TP53 and RAS pathway mutations were comparable.
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PMC9429973
None of the patients had PD in the TN cohort.
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PMC8345486
Taking into consideration the unique physicochemical properties of metallacarboranes as modifiers of adenine nucleosides, the metalla bis(dicarbollide)-modified adenosine and 2′-deoxyadenosine derivatives studied herein that were found to exert antitumor activity may be promising candidates as drugs for cancer therapy .
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PMC10142392
Another advantage of PCL is its compatibility with a wide range of drugs, allowing for the homogeneous distribution of lipophilic drugs in the support matrix due to its hydrophobic nature .
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PMC11371747
In humans, this will limit its metabolism and lead to a larger fraction of unmetabolized folic acid in the circulation of patients receiving high doses of folic acid (>1 mg per day) (Maruvada et al., 2020).
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PMC4659567
H NMR spectra recorded on 10% MeOD-d 4/D2O solutions of the mixture of 8 with GSH did not contain any signals in the naza and p-cymene region and only the signals of the used biomolecules were detected.
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PMC9429973
Macrophage reprogramming was assessed by microscopy, FACS-immunophenotyping, ELISA, (phospho)-proteomic and metabolomic assessment.
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