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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Emerging evidences proved combination of new treatment modalities is significant better than traditional therapy.
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PMC6835428
These data suggest that the effect of FR targeting was minimal, and tumor accumulation was most likely driven by passive targeting.
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PMC9424261
HERPUD1 is a recognized UPR target, a component and regulator of ERAD , and E3 ubiquitin ligase HRD1 , ubiquitin , SEL1L, OS-9 and Derlin-1 interact to degrade a variety of proteins.
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PMC10747160
The 96-well plate was returned to the 37 °C humidified incubator at 4.5% CO2 in order to allow the HEK-293 cells to adhere and recover for 8–12 h. While cells recovered, Griffithsin proteins were resuspended in sterile commercial Phosphate-buffered Saline (PBS) (ThermoFisher Cat # 14190-136, Waltham, MA, USA) to create a stock solution.
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PMC9429973
Despite the high percentage of pt with high cytogenetic risk and differences in drug access in this cohort, outcomes analyzed with the use of VEN in the real-world setting in Argentina suggest an effectiveness comparable to that reported in pivotal clinical trials and no unexpected adverse events.
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PMC11711127
This also indicates that the defective clonal deletion of T cells is not due to the impaired presentation of the endogenous superantigens by macrophages solely because of the strict tissue distribution of the superantigens.
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PMC11746948
Tumor cells are susceptible to ferroptosis within the bloodstream, indicating that the hematogenous spread of tumors depends on GPX4.
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PMC11684297
The typical flower structure enhances the surface area hugely because each petal of the flower, being a part of the nanoparticle, provides additional surface .
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PMC8557138
Challenges in developing appropriate vascular 3D model systems Albeit, diseases related to aberrant vasculature are broadly classified into excessive and insufficient angiogenesis, paracrine interactions, and the key mediators to modulate pathological angiogenesis are highly heterogeneous and thus specific to diseases.
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PMC11731161
C NCI-H929 cells treated with DMSO or 500 nM SEL, with 200ug/ml CHX added to both groups.
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PMC9429973
43% (14/32) were heavily pre-treated (>3 lines).
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PMC9429973
In the multivariate analysis UHR myeloma was the strongest independent predictor for OS (p<0.001; HR: 0.42), supervening the prognostic value of R-ISS (R-ISS1 vs. R-ISS2 HR=0.58, R-ISS2 vs. R-ISS3 HR: 0.75).
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PMC10024132
Retroviral transductions of γ9δ2 T cells with blinatumomab- or GFP-encoding DNA were carried out in parallel.
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PMC9429973
The day-100 cumulative incidence of grade 2-4 acute GVHD was significantly lower in the PT-Cy group (23% vs. 45%, p=0.014, Figure A).
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PMC10443665
The specificity of the primers was verified by Blast analysis at NCBI.
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PMC11529598
C. Photographs of colonies formed by miR-3154 sponge transfected cells and control cells were captured under microscope.
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PMC8913139
ROCK1 vector restored the downregulation of ROCK1 induced by miR-448 mimics (Figure 5(a)).
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PMC8873393
Coverslips were counterstained and mounted on slides using mounting medium with DAPI (Vector Laboratories, Inc. Peterborough, UK).
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PMC11674441
Advances in genetic analysis technology using next generation sequencing and artificial intelligence have made it possible to predict HLA class I-restricted neoantigens, and the development of vaccine therapies targeting neoantigens has progressed rapidly, with their safety and efficacy demonstrated in clinical trials .
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PMC9429973
We generated genetic knockout lines of DUSP1 or DUSP6, which inhibited CLL cell expansion, to confirm the inhibitor’s specificity.
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PMC11507371
The non-tumourigenic HaCaT cells exhibited a steady and significantly elevated Nrf2 nuclear translocation after plasma treatment, suggesting a robust antioxidant reaction and supporting the observed increase in antioxidant capacity.
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PMC10938377
The reported IC50 values are based on the means from two independent experiments, each comprising four tests per concentration level.
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PMC7987994
The degradation rate of Mg-based biomaterials in medium was observed to be lower in the presence of FBS and the degradation rate of Zn-based biomaterials was higher in pure FBS than in medium with 10% FBS.
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PMC3995603
The maximum dermatitis score was recorded following the fourth week of D. farinae extract application in all groups.
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PMC11698348
In postnatal skin (PN5.5-PN10.5); Elf5 is expressed in the epidermis (basal and suprabasal, arrowheads), developing hair bulge and proliferative and differentiating keratinocytes of the developing hair bulb (arrows).
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PMC8557138
The co-culturing of mesenchymal progenitor cells and neural organoids generated complex vascularized neural organoids.
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PMC8633974
The specificities of tat- and control-targeting gRNAs were predicted using Broad Institute GPP sgRNA Designer and CRISPR-OFF webserver v1.1 (https://rth.dk/resources/crispr/crisproff/).
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PMC11575040
In addition, lncRNAs serve as decoys to titrate cancer-related miRNAs and regulate the aforementioned cellular activities .
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PMC11078693
The stained cells can be stored for up to 3 weeks.
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PMC9712534
After that, cells were treated with etoposide at concentrations indicated in the figure legend.
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PMC9250505
Elevated levels of BADS99 phosphorylation exhibited a negative correlation with decreased Olaparib sensitivity in EOC cells.
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PMC10761571
Furthermore, there is a close association between these two apoptotic pathways so that the protein Bid, which is activated by caspase 8 can be transferred to the mitochondria leading to the release of cytochrome c from the mitochondrial membrane through the activity of the proapoptotic proteins such as the BAX and BAK, while the anti-apoptotic proteins such as the Bcl-2, are usually inhibited.
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PMC9780037
This modification has been related to increased cyt c peroxidase activity, which is associated with its efflux into the cytoplasm and subsequent apoptosis triggering.
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PMC9429973
Results: The study cohort consisted of 300 MCL patients (59% male; 69% white); most (64%) patients were covered by Medicare, 34% had commercial insurance.
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PMC11748335
Despite all cell lines showing a preference for the enrichment of H3K9me3 long LOCKs within common PMDs, a notable distinction was observed for tumors.
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PMC11724582
A549 cells were cultured in F12K medium (Cat.
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PMC10522430
Furthermore, a range of peaks spanning from 3970.97 cm to 1884.09 cm showcased various functional groups, including alcohol (O-H stretching), amine (N-H stretching), carboxylic acid (O-H stretching), alkane (C-H stretching), alkyne (C=C stretching), and allene (C=C=C stretching).
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PMC10993311
This is a prospective cohort study involving 75 pregnant women from the “Araraquara Cohort Study”, Araraquara city, São Paulo, Brazil.
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PMC10297204
A skin incision was made directly above the tumor, and the sciatic nerve was identified (Figure 1B).
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PMC11597291
Shi et al. reported the functionalization of rGO with PEG(5 kDa) for the effective conjugation of the TRC105 anti-CD105 antibody.
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PMC11787651
For correlation heatmap, Pearson r was used for distance measure.
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PMC10988555
Therefore, the production of ROS was investigated through the exposure of the A2780 cell line to IC50 concentrations of complexes 2–4 (Figure 13).
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PMC8750422
Many studies conducted so far in lung adenocarcinoma have mostly examined the biological function of iNOS, and few studies have been conducted on eNOS.
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PMC11748618
When we compared the dosage of likely causal variants to imputed CHD1L expression, controlling for sex and PC1, we saw that protective HIV spVL associated variant alleles were significantly correlated with increased CHD1L expression (p ≤ 2.22 × 10, df = 11, F = 10.09) (Fig. 5).
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PMC10604092
The rats were randomly assigned to control or SLC transplantation groups, pair-matched on the basis of body weight.
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PMC9429973
This report focuses on overall and health-related quality of life.
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PMC8973085
Yellow solid [A] (87%); [B] (71%); mp: 230–232 °C (EtOH); IR (KBr, v, cm): 3403 (NH), 2226 (CN), 1649 (C=O); H NMR (DMSO-d6): δ 2.26 (s, 3H, CH3), 2.58 (s, 3H, CH3), 4.39 (s, 2H, CH2), 7.02–7.46 (m, 8H, CH-Ar), 10.52 (bs, 1H, NH); C NMR (DMSO-d6: δ 17.30, 21.10, 21.80, 114,60, 115.80, 117.20, 124.30, 127.60, 128.10, 131.20, 132.70, 135.10, 154.80, 162.70, 163.20, 164.20, 169.30, 171.30; MS m/z (%): 416 [M] (5); Anal.
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PMC9351137
2Localization of SRCAP and p400/Tip60 chromatin remodeling subunits (CRS) to the centrosomes, spindle, and midbody in HeLa cells.
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PMC11438317
After treatment with PV for 5 min, LP-DACS was immunoprecipitated and the presence of the putative substrates detected by Western Blot.
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PMC10587429
Establishing the humanized NSG-SGM3 mouse model utilizing CD34+ HSCs from fresh cord blood. (
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PMC10759659
Heat-based antigen retrieval was performed using citrate or EDTA-containing buffer.
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PMC11033180
Pregnant Sprague-Dawley rats were purchased on gestational day 15 (G15) (Janvier Labs, Le Genest Saint-Isle, France).
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PMC11615218
Moreover, the CD4/CD8 ratio generally decreases during the CAR T cell manufacturing period due to the higher expansion rate of CD8 T cells compared with that of CD4 T cells .
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PMC11033180
Western blot analysis for Sema5A showed a band at 140 kDa in brain and gut-derived samples, consistent with the reported molecular weight in various tissues and cell lines.
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PMC9250505
The brown triangle points to the end of the treatment.
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PMC9684669
The color represents the IC50 of each compound, as the scale bar showed. (
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PMC9503685
After incubation, the co-culture was washed 2–3 times with 0.5 mL PBS to remove planktonic bacteria and incubated for 30 min with 0.5% Triton-X in DMEM to disintegrate epithelial cells and biofilm.
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PMC11351758
Permanent MPT (p-MPT) may have been depicted in the NARP cells after testing with high glucose as the TMRM and calcein levels depleted after just 220 s in the time-lapse recordings (Figure 6D, panels I and II).
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PMC9622879
We construct general mathematical formulas of the DERs and load for each home and for the entire community.
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PMC5916734
It can be assumed that expression of auxiliary enzymes was not equally efficient in all stably transfected cells.
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PMC11395280
CCL198-83 was added for five minutes to the blocked cells, and the cells were stimulated with either CCL19 or CCL21.
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PMC11489351
This indicates that the observed loss of Notch1 was not due to inhibition of macropinocytosis but was instead driven by the lowered pHi with EIPA treatment.
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PMC11547972
Overall, evidence is provided that low-dosed amygdalin and SFN, when applied simultaneously, exert synergistic effects on RCC cell growth in vitro.
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PMC8623816
The dsRNAs extracted from R. solani AG-1 IA strain D122 were purified and used as templates for complementary DNAs (cDNAs) cloning.
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PMC11706491
Our selection of mutants included cdr1Δ and cdr2Δ, implicated in the mitotic G2 cell size control checkpoint signaling , alongside a strain carrying 5 copies of the wee1 gene (5xwee1), inducing a G2/M transition delay .
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PMC10033453
Four phase and red fluorescence images per well were taken every 3 h for a total time of 72 h. Images were analyzed in IncuCyte software for red object area.
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PMC11721295
Individual tumors were manually circled, and their areas measured.
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PMC11754432
HDF/TERT164 (Evercyte) were cultured in Advanced DMEM/F12 (Gibco™) containing 10% foetal bovine serum (Capricorn Scientific, Ebsdorfergrund, Germany), 100 µg/ml G418 (InvivoGen, Toulouse, France) and 100 µg/ml ascorbic acid (Sigma-Aldrich) termed HDF media.
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PMC11095939
To further confirm the specificity of Mecp2 on the regulation of quiescence exit, we performed rescue experiments using AAV-mediated Mecp2 OE in Mecp2-cKO livers (Figure 2I and J).
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PMC11361748
This suggests that these 7 genes are associated with the response of skin to repeated inflammatory stress.
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PMC10873328
The binary FR models were as follows:[12pt] $$ it( ) & = 4.680 - 0.002}\;}\;}\;} \\ it( ) & = 4.138 - 0.003}\;}\;}\;} + 0.021*}\;}\;}\;}1 \\ it( ) & = 4.879 - 0.003}\;}\;}\;} - 0.006 \\ & }\;}\;}\;}12 + 0.022*}\;}\;}\;}1 \\ it( ) & = 4.699 - 0.005}\;}\;}\;} - 0.007}\;}\;}\;}12 + 0.022 \\ & *}\;}\;}\;}1 + 0.022*}\;}\;}\;}2 \\ $$1=4.680-0.002*expressionlevelofTGFBIlogitP2=4.138-0.003*expressionlevelofTGFBI+0.021∗expressionlevelofGPC1logitP3=4.879-0.003*expressionlevelofTGFBI-0.006*expressionlevelofAKAP12+0.022∗expressionlevelofGPC1logitP4=4.699-0.005*expressionlevelofTGFBI-0.007*expressionlevelofAKAP12+0.022∗expressionlevelofGPC1+0.022∗expressionlevelofTGM2 The AUCs of the predicted probability 1, 2, 3 and 4 were 0.645, 0.826, 0.875 and 0.893, respectively (Supplementary Table 2).
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PMC9429973
Results: X+X- genotype of XbaI (rs693) polymorphism was the most common among patients (48.5%) and controls (44%).
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PMC11721295
We also assessed expression changes for genes that change during lung cancer progression, including Cxcl1, Tgfa, and Tgfb1.
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PMC11545737
These pathogens deserve special attention because of the increasing antimicrobial resistance of S. flexneri and N. gonorrhoeae, the high prevalence of S. enterica and H. pylori, and the life-threatening diseases caused by N. meningitidis and Y. pestis.
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PMC9429973
V. Cuminetti, J. Konieczny, A. Bernal, A. Villatoro, H. Taman, M. Ristic, N. Villaplana-Lopera, R. H. Paulssen, G. Giovinazzo, A. Vik, P. Garcia, L. Arranz IMB, Stem Cells Ageing and Cancer; Genomics Support Center Tromsø, UiT The Arctic University of Norway, Tromsø, Norway; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; Pluripotent Cell Technology Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Department of Hematology, University Hospital of North Norway, Tromsø, Norway Background: Unlike healthy haematopoietic stem cells (HSC), leukaemia stem cells (LSC) have high oxidative phosphorylation and hence targeting the tricarboxylic acid (TCA) cycle seems a promising therapeutic strategy in acute myeloid leukemia (AML) treatment.
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PMC9429973
In addition, the TEMRA cell population were normalized.
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PMC11806106
Generation of a concentration-response curve for DAMGO (Fig. 3A) resulted in converging curves for the FRET- and BRET-based sensors (Fig. 3B).
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PMC7348793
Unexpectedly, in the process, we discovered a 108 bp sequence that was tandemly repeated up to five times in the control region.
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PMC9429973
In both human and murine AML, CD4 T cells were identified as the main source of IL21.
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PMC6114978
Loss of expression of the Hippo kinases was identified in clinical sarcoma samples demonstrating activated TAZ and YAP at a relatively high level, ranging from 19% (LATS1) to 47% (MST1).
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PMC4005030
The protectivity correlated with their capacity to bind transition metals and DPPH radical-scavenging ability.
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PMC10174970
The functions were grouped into highly (r>0.60), moderately (r=0.30–0.60), and poorly (r<0.30) consistent functions of each cell line, and the highly, moderately, and poorly consistent cell lines of each function were also collected.
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PMC11701801
These in vivo observations support the results obtained from the cell line models and indicate that a CBP/p300 inhibitor suppresses the growth of SMARCA4/SMARCA2-deficient and SS18–SSX fusion xenograft tumors.
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PMC8922418
The CCR5 targeted cells showed resistance to R5-tropic HIV-1 infection and selective advantage over unedited cells without off-target effects or cell proliferation deficiency.
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PMC11783017
Strong red fluorescence signals for CD86 were detected in both the Cis/Mn@Lipo-IL11+NH and Cis/Mn/NH@PGP groups while either undetectable or weakly expression in the PBS, Lipo-IL11, Mn@Lipo-IL11, and Cis/Mn@Lipo-IL11 groups was observed.
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PMC11407042
It was shown that co-culturing of the A549 cells with the ΔfleR mutant significantly increased absorbance at 490 nm compared to the co-culturing of the A549 cells with the wild-type strain PAO1 and complemented expression of fleR in the ΔfleR mutant restored the absorbance to the wild-type level, suggesting the higher cytotoxicity of ΔfleR. The absorbance of the negative and positive control groups represents the background without bacterial treatment and the maximum LDH release treated by 10x lysis solution, respectively.
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PMC10203589
In addition, in juvenile nasopharyngeal angiofibroma (JNA) (184, 185), FGF18 expression in endothelial cells of JNA was positively correlated with its expression in stromal cells (186), as verified by qPCR by gene expression analysis.
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PMC9429973
To improve our understanding of molecular dynamics in CK-AML, we established an integrated single cell multi-omics approach that combines the analysis of SVs and nucleosome occupancy (NO) profiling (scNOVA) with concurrent immunophenotypic and transcriptomic profiling (CITE-seq).
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PMC3203927
The rationale behind their choice was based on the fact that, in a 3D microenvironment cells are surrounded by homotypic neighbors forming a loosely bound disorganized aggregate.
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PMC10237474
Most targets of antibody drugs have extracellular domains which are often glycosylated.
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PMC11185260
Some animals also received total 3 injections of cisplatin (2mg/kg, weekly for 3 weeks) and/or 3 fractions of radiation (5Gy, weekly for 3 weeks). (
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PMC9429973
Majority of patients (88%) were SCT recipients within 6 month or having active malignancies at time of HBO therapy.
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PMC11013014
2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(2-hydroxyethyl)acetamide (23).
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PMC11757131
Protein expression levels were determined based on previous studies (17); methods included sample preparation, protein electrophoresis, transfer, blocking, and antibody incubation.
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PMC11569208
To confirm this at the protein level, lysates were probed for ACP2 protein by immunoblotting which also confirmed knockdown of ACP2 (Fig. 2C). Fig. 2ACP2 knockdown increases VSV∆51 infectivity and oncolysis. (
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PMC10454535
Across three MM cell lines, RES derivatives showed the greatest cytotoxic effects on RPMI 8226 cells, followed by their effects on NCI-H929 cells, and lastly on U266 cells, which showed the least cytotoxicity.
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PMC11286266
A similar mechanism, involving BiP and shared by other unfolded protein response (UPR) transducers, has been previously proposed (Bertolotti et al., 2000) and is included here as a complement to ATF6α-specific regulation by CRT.
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PMC11496491
The bubble chart analysis of most significant in terms of molecular function.
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PMC9429973
Aims: We aimed to examine the predictive value of monocytosis in primary care by relating monocyte count to subsequent 3-year incidence of hematological malignancy.
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PMC5963610
Each group represents mean±SD of lung weight/animals.
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