Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9872547
The expression of E6, E7, P53, and Rb genes was measured in HeLa cells.
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PMC9429973
This process should be studied in more detail to determine its potential as a therapeutic target for AML treatment.
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PMC5839394
We examined whether AgNPs-EPS-induced cell death occurs via apoptosis, autophagy, or both.
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PMC11721064
Immunofluorescence staining revealed a significantly higher abundance of CK12 + cells in LN-KS-induced KPCs compared to LN-SH and KSFM groups (all p < 0.001) (Fig. 4B,C).
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PMC11377827
The representative immunoblot is shown in Fig. EV5K.
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PMC10723784
A synergistic effect was observed when cannabinoids at sublethal doses were combined with carboplatin in both carcinoma cells.
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PMC9429973
Median EFS1 did not statistically differ between pts with low LN TL % vs those with normal-high values (10 vs 13.6 m respectively, p: 0.41).
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PMC11718109
Scale bar, 10 μm.
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PMC11623887
Erythroid progenitor cells (EPCs) are the main target that are permissive to the virus and support the infection.
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PMC6160470
Upon observing that crown ethers inhibit P-gp activity, we decided to study their mechanism of action.
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PMC11409031
Contrary to the study of inflammation, M2 macrophages possess the ability to suppress inflammation and stimulate tumor growth within the tumor associated macrophages.
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PMC9841531
This changes the basic energy supply from mitochondrial oxidative phosphorylation (as in normoxic cells) to glycolytic metabolism.
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PMC11700340
Cytotoxicity study The cervical cancer cells grown in a 96-well microtiter plate were treated with linagliptin and vincristine.
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PMC9429973
Results: To date, 17 pts have been enrolled (Table).
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PMC9429973
Risk-adapted allo-HSCT was performed at the discretion of the treating haematologist.
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PMC11411004
Brifely, pLC-pHC plasmid was transfected into CHO-S cells (Life Technologies, A11557-01).
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PMC8409415
Conjugation with anti‐CD70 mAb led to the successful delivery of MMAF into OvCA cells, where it induced mitotic arrest via the inhibition of tubulin polymerization.
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PMC11731161
This may partially explain why LMB are more toxic than other inhibitors.
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PMC10728535
Darker color and bigger circles represents higher degree.
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PMC11401350
CAR T cells are considered an individualized cell therapy product because it demands harvesting of the patient’s T cells, which are then modified and expanded ex vivo to be re-infused as a living drug.
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PMC9430052
As of data cute-off February 22, 2022, with a median of 90 (range 29-92) days of follow-up, 3 pts with r/r DLBCL had received one GC012F infusion at dose levels 3.7*10 CAR- T/kg and 2-3*10 CAR- T/kg and completed at least 28 days of follow-up.
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PMC9429973
The remaining 6 pts (2 CM, 3 ISM, 1 ASM) received vaccination (5 mRNA and 1 viral vector vaccine) without any prophylaxis and/or caution.
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PMC11779605
The increased processes involving cytoskeletal organization in the tumor compared to ascites cells are consistent with increased capacity of the cells to attach, invade, and migrate.
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PMC11736898
All work involving human subjects was performed in accordance with the principles of the Declaration of Helsinki and with University of Cincinnati (UC) Institutional Review Board (IRB) and WCG IRB (Puyallup, WA) approval.
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PMC11705862
The thickness of the Z-stack varies between 19.8 and 39.6 μm Depletion of SNAP-25 or Syntaxin1 induces neurodegeneration, and neuronal death respectively suggesting SNARE protein involvement in the pathology of neurodegenerative diseases.
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PMC11543935
Dewhirst et al. showed that the thermal necrosis process has an exponential correlation between temperature and the exposure time with 43 °C as a breakpoint.
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PMC11700340
Human Hsp90 Binding Site with Linagliptin Human Hsp90 Binding Site with Geldanamycin.
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PMC6889484
Normalized p24 CA amounts were used to transduce 4 × 10 293T cells in a 96-well plate, and luciferase activity was measured 48 h post-transduction using a 96-well luminometer (LUMIstar Galaxy, BMG LABTECH, Cary, NC, USA).
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PMC11734514
Although mRNA expression of IL-6 and VEGF in cells treated with C. aerizusa extract showed downregulation at both 12 hours and 24 hours, the analysis contradicted previous limitations on the inflammation inhibition of marine compounds (Figure 4C and D).
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PMC11352311
The STRING database facilitates the analysis of protein interaction relationships.
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PMC9429973
The study is ongoing.
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PMC11092382
Based on these findings, it can be inferred that while the precise relationship between sophocarpine and the p38MAPK signaling pathway remains unclear in other disease contexts, it is evident that this pathway plays a crucial role in mediating the biological effects of sophocarpine.
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PMC11696576
In other cancers where cPLA2α has prognostic significance e.g., lung cancer, acute myeloid leukemia and glioblastoma, synthetic cPLA2α inhibitors have been shown to suppress cancer cell or tumor growth and in preclinical models of ovarian and cervical cancers were effective sensitization agents for radiation or chemotherapy.
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PMC11628904
Quantification of C. albicans colonisation from B. N = 29 larvae for each condition. (
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PMC9221284
Another example is the anti-apoptotic isoform Bcl-xL which is strongly expressed in a large number of tumors to ensure high cell survival .
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PMC9429973
Median OS of the entire cohort was 68 months (95% CI 42-94) with 54% of patients being alive at 5 years.
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PMC11756514
The MGL-expressing cells, on the other hand, did not bind any of the S. aureus strains examined.
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PMC10723784
Cannabinoids induced selective and significant cytotoxicity in ovarian cisplatin‐sensitive and ‐resistant carcinoma cells.
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PMC9429973
There are limited data evaluating the risk of clinical coagulopathy (thrombosis and bleeding) and the optimal antithrombotic interventions in these patients are unknown.
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PMC11474209
It is also ideal for downsizing, distant, and multi-analyte detection.
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PMC11704135
To perform the assay, a specific volume (0.1 mL) of each sample was combined with 3.9 mL of the DPPH solution.
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PMC10818573
The nfo probe is introduced during amplification to bind to the test strip for the rapid visualization of the results.
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PMC11607764
Especially in the midst of the COVID-19 pandemic, cancer patients have a higher risk of COVID-19, severe events, complications, or delayed diagnosis.
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PMC9429973
Results: To date, 56 of 125 pts had their ASAb measured following 3 vaccine dose administered between October 2021 and January 2022: 28 WM pts (including 6/9 WM pts on the BTKi pause sub-study), 24 FL pts and 4 HC.
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PMC5839394
Nuclei were pelleted by centrifugation at 1000 g for 20 minutes; mitochondria from the post-nuclear supernatants were recovered by centrifugation at 8500 g for 30 minutes; lysosome by centrifugation at 20000 g for 30 minutes and membranes by centrifugation at 105000 g for 90 minutes.
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PMC11802929
Single, live, CD8, dextramer-positive T cells were sorted into FACS buffer (PBS, 2%FBS, 2 mM EDTA, and 10 mM HEPES) using a BD FACSAriaII cell sorter.
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PMC11786767
After washing 3 times with PBS, the coverslip with stained cells was placed on acrylamide solution (with the cell-attached side facing down) at 37°C for 2 h for gelation.
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PMC9429973
Most pts had adverse ELN cytomolecular risk on presentation (43% in IC, 50% in LIT without VEN, and 55% in LIT with VEN).
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PMC8193813
The response time was 4s longer than compared to CO2 measured by a portable gas analyzer (LI-820, LI-COR Biosciences, Lincoln, NE, USA).
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PMC11531744
We believed that our research constructed a reliable prognostic signature and hoped that this signature would be applied in clinical practice in the future.
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PMC11277157
The functional analysis and network view was based on STRING protein–protein interaction (PPI) platform.
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PMC9429973
Known high-risk clinical features including advanced stage, elevated LDH, >1 extranodal site, and IPI 3 are also associated with early PD.
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PMC11694346
The resulting probe BT-NH shows a maximum emission wavelength at 630 nm and a large Stokes shift (≈200 nm), enhancing detection accuracy.
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PMC11711345
Other significant correlations were not achieved (p > 0.33), but HSPA5 and the electrochemical transporter SLCO2B1 were pointed out as selective targets, respectively, to cuminol and concomitantly this compound and cuminic acid.
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PMC9429973
Z. Güven, M. Keklik, A. Ünal Department of Hematology, Erciyes University Medicine Faculty, Kayseri, Turkey Background: The COVID-19 vaccine is the most essential tool for altering the pandemic’s trajectory.
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PMC11473750
Hemizygous RNF121 knockout mice were then crossed with hemizygous TH-MYCN transgenic mice over 4 generations to an estimated congenicity of 93.75%.
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PMC11746948
Sample sizes: (a, b) n = 8; (c, d) n = 6; (e–j) n = 6 individual mice.
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PMC9046263
Of differentially expressed HERVs, HML-6 is overexpressed in a subset of highly invasive glioblastoma cell lines and patient-derived neurospheres.
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PMC11676674
In order to identify and score total cells, binucleated cells, mononucleated cells, multinucleated cells, and micronuclei, an optimized analysis template, defining new features and masks, was developed and created in IDEAS, based on previous literature .
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PMC11350568
Therefore, the synergistic internalization of TfR1 and clathrin enhances the rapid endocytic action of AptG-1.
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PMC10823017
This may be due to a concerted effect of reduced activation of Akt1 (Ser473) and ERK1/2 and a result of PKC-ι knockdown.
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PMC11594074
The membranes were treated with the primary antibodies, ß-actin, PARP, caspase-3, and BCL-XL.
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PMC11703896
While molecular docking and RMSF analyses offer valuable initial insights into rapamycin-receptor interactions, these findings are predictive and do not fully replicate the complexities of in vivo environments.
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PMC11678448
We identified the key pathways and genes associated with the response of PBLs to this infection, thereby determining the consistency of our research results at both the genetic and protein levels.
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PMC11704135
6FT-IR spectra of pyrimidine sulfonothioate derivatives (10–12).
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PMC6461034
CRC0254 was slightly more responsive than CRC0177 for both inhibitors.
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PMC9848491
In the internal validation cohort, the AUCs of 1, 3, and 5-years survival were 0.679, 0.719, and 0.7 ( Figure 5C ).
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PMC11036064
The primary GBM's raw single-cell RNA transcriptomes were made available through the GSE182109 dataset (Abdelfattah et al., 2022).
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PMC10530622
By effectively managing oxalate production, these treatments have the potential to improve long-term outcomes and enhance the quality of life for individuals living with PH.
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PMC8662250
We consider this point extremely interesting since the emerging importance of the intestine in viral replication, especially for SARS‐CoV‐2 variants (Du et al., 2020), the role exerted by intestinal mucosa in the immune response to viral attack mediated by SP in this site.
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PMC11578343
HMEC strains are as indicated.
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PMC11737091
Both survival analysis and Cox analyses were carried out with the R packages survival (v.3.3-1) and survminer (v.0.4.9).
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PMC11389534
In this section, we will explore the regulation of UFMylation in innate immunity, focusing on three key aspects: antiviral responses, inflammatory pathways and mucosal immunity (Figure 2).
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PMC11155445
A new methodology was developed by Pokotylo et al. for the synthesis of 2H-1,3,5-oxadiazine-2,4(3H)-diimines derivatives (30a–g) by dehydrosulfurization of acyl thiourea (29a–g) with dicyclohexyl carbodiimide.
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PMC8316344
The membranes were incubated with HRP-conjugated secondary antibodies (7076 and 7054, 1:2000, CST) and visualized using Clarity Western ECL substrate (1705060, Bio-Rad, Hercules, CA, USA).
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PMC7305184
In analysis single cells were separated from debris and clusters and the percentage of PI permeabilized cells was obtained from PI fluorescence intensity histogram by gating permeabilized cells from non-permeabilized.
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PMC9429973
Image: Summary/Conclusion: Low dose combination chemotherapy with VEN in a population of heavily pretreated R/R ALL was well-tolerated and resulted in a response rate of 63%.
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PMC11787355
Created in BioRender.
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PMC11473750
Scoring of RNF121 and c-Myc FISH was done on an Olympus BX51 fluorescence microscope.
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PMC11093197
S‐phase kinase‐associated protein 2 (Skp2) facilitates the degradation of p27 via ubiquitination.
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PMC8009078
Hence, to reduce the chemical space, the threshold glide score, ADV binding energy and Prime-MMGBSA binding free energy were considered to be − 7.21, − 7.90 and − 44.48 kcal/mol, respectively.
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PMC6617630
We sought to determine the effect of BETi on the PD-L1 and CD47 expression in DHL/THL cells.
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PMC9221284
As the electrophoretic profile of c-Myc proteins in tumors from lymph nodes from λc-MYC (A/a) mice was no longer similar to that which was described for the BL60 line, with c-Myc2 but also c-MycS, and c-MycS1 (apparent molecular weight of 64, 55, and 45 kDa respectively, Figure 2A), we then analyzed the c-MYC transcripts in these tumors.
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PMC7917457
Average tumor growth curves for all treatment groups are shown. (
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PMC11739484
In the case of MMP7, MMP11, and MMP14, the ROC curve analysis demonstrated their robust diagnostic potential in distinguishing SKCM patients from normal individuals.
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PMC9504875
NSs of Dabie bandavirus (belonging to the same family as RVFV; formerly named ‘severe fever with thrombocytopenia syndrome virus’) also antagonizes IFN production .
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PMC6379402
Furthermore, 50.8% of our newly identified genes have a potential clinical relevance as biomarkers of cancer, which is supported by significant associations with patient survival.
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PMC11792740
Types include tumor cell vaccines, protein/peptide vaccines, DNA/RNA vaccines, and viral vector vaccines.-Can induce a specific and robust immune response.- Potential for long-lasting immunity.- Minimal toxicity compared to conventional therapies.
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PMC11507371
For positive controls, cells were either treated with 20 μg/mL Poly(I:C) (Invivogen, Toulouse, France) to study the translocation of NF-κB and IκBα or with 15 μg/mL hydrogen peroxide (Merck Schuchardt OHG, Hohenbrunn, Germany) to analyse the translocation of Nrf2 and Keap1.
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PMC8494202
jar software was employed to analyze the cell signaling pathways associated with CKAP2L.
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PMC11087301
One of the major diversity contributors is acquirement of mesenchymal characteristics within carcinoma tissues.
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PMC11451940
The A2780 cells were seeded in 24-well cell culture plates at a density of 5 × 10 cells per well and allowed to cultivate for 24 hours.
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PMC6600253
The other example is the bioactive constituent in green tea, (-)-epigallocatechin-3-gallate (EGCG), which was shown to downregulate the expression of both hTERT mRNA and protein, leading to cell cycle arrest in both G2/M and S phases, and promoting DNA damage responses and apoptosis in cancer cell lines .
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PMC11291490
Intriguingly, despite CD40L typically being expressed by T cells, this study also uncovered the proliferation of T cells by qRT-PCR, including both CD4 and CD8 T cells (Fig. 1f).
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PMC9429973
Image: Summary/Conclusion: In the ALPINE trial, patients with RR CLL/SLL who received zanubrutinib monotherapy reported improvements in key HRQoL endpoints compared with patients who received ibrutinib monotherapy.
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PMC11438317
PBLs were purified by centrifugation at 700 g for 30 min on cushions of Ficoll-Hypaque (GE Healthcare, Little Chalfont, UK) from healthy donor buffy coats obtained from the regional blood bank with approval of its ethics committee.
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PMC8753818
:> 0.05, **:> 0.01, ***:> 0.001, ****:> 0.0001) Numerous approaches and strategies have been used for large scale and cost-effective production of biopharmaceuticals in CHO cell line to increase the production of high-quality therapeutics.
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PMC11291697
A Array-CGH (180 K and 1 M platforms) profile showing the de novo 2q22.3 microdeletion removing exons 5 and 6 of GTDC1.
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PMC8382973
OTU cluster analysis was performed according to the Galaxy online platform process.
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PMC11721587
To investigate the biophysical properties of Fu condensates, we applied various chemicals to dissolve Fu in the P100 fraction derived from Hh-treated Cl8 cells.
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