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PMC10055960
Complex 6 showed an increased cytotoxicity when compared to the precursor ligand 2 in the A2780 and OVCAR-3 cell lines, but an overall lower activity when compared to cisplatin.
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PMC11116779
Since the side scatter indicates the internal complexity, i.e., the granularity of the cells, we studied the internalization of PS-NPs in A549 cells by TEM, confirming the internalization by target cells.
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PMC5600151
PPI dendrimers can be based on a 1,4-diaminobutane (DAB) core, but can also be synthesized from an ethylenediamine nucleus and other core molecules by a double Michael addition reaction.
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PMC11462673
Analysis of the GEO dataset GSE13159 unveiled a notably elevated mRNA expression of LDB1 in T-ALL patients compared to bone marrow samples from healthy donors (Fig. 1A).
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PMC10671321
Can asymmetric forms including ColQ1a p.E428HfsX58 be secreted?
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PMC9960565
= 4598.51, m/z found = 4597.5 [M+2H] C238H482N90O92Pt16.
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PMC11756937
In the current study, we included AP staining, viral genome and transgene detection, SA expression of stem cell markers and cytogenomics as direct measures of reprogramming success.
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PMC9429973
We also propose miR-9 as a predictive ABCB1-related biomarker that could be helpful in identifying ABCB1-resistant AML phenotype.
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PMC11711935
PubMed was searched for literature on fibroblast factors, hyperpigmentation, and hypopigmentation, and a comprehensive summary and analysis were performed.
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PMC11055510
The cells were then fixed for 15 min in 5 ml of 4 % paraformaldehyde, an appropriate amount of 1X GIMSA dye solution (Solarbio) was applied, and the cells were incubated for 10–30 min at room temperature.
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PMC6799808
Taken together, our findings reveal that GLPT is able to induce caspase-dependent apoptosis through both the mitochondrial and death receptor pathways.
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PMC11534035
In our study, treating A431 and CAL39 cells with the GPER1 agonist G1 induced rapid estrogen effects within the cells.
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PMC11747949
We also assessed changes of CAIX on 143B cells, a key enzyme for cancer cell survival in hypoxia (Pastorekova and Gillies 2019).
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PMC11794568
The most significant difference in CRIP1 expression was from T1-2 to T4 stage tissues. (
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PMC3995603
The dorsal skin and one ear of each mouse were removed and fixed in 10% (v/v) natural buffered formalin for 24 hr.
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PMC9429973
The Woman trial showed that the antifibrinolytic tranexamic acid (TXA) reduces PPH deaths.
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PMC9429973
C. Sol Reis, D. Duarte, I. Brito, P. Silva Coelho, L. Leite, R. Branca, S. Roncon, C. Pinho Vaz, A. Campos Bone Marrow Transplantation Service; Celular Therapy Service, Instituto Português de Oncologia do Porto IPO-Porto, Porto, Portugal Background: Graft-versus-host disease (GvHD) is a major complication of allogenic stem-cell transplantation.
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PMC10988808
Using Western blot (WB) analysis, we measured the expression levels of CCDC25 and found that its expression was notably lower in tumor tissues compared to the adjacent normal tissues (Fig. 1H, I).
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PMC11680982
Optimization of neratinib dosing for enhanced CDK4/6 inhibitor combined with endocrine therapy efficacy. (
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PMC11592008
Secondary antibodies: Goat anti-mouse IgG1 human ads-HRP (dilution 1:2000, 1070-05), rabbit anti-goat IgG(H+L)-HRP (dilution 1:2000, 6160-05), and goat anti-rabbit IgG-HRP (1:5000, 4030-05), all from SouthernBiotech, Birmingham, AL, USA).
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PMC11406030
These peptides show potential to be safe treatment options, either alone or in combination with other therapies, for ovarian cancer.
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PMC11088135
Silencing of lncRNA NUTM2A-AS1 enhanced the levels of miR-376a-3p, leading to reduced cell proliferation and increased apoptosis in glioma cells.
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PMC11348300
However, assessing oxygen at the cellular level, where PpIX is situated, presents a significant challenge.
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PMC11574029
Our findings emphasize the critical role of NOTCH3 in the progression of BLCA and propose NOTCH3 as a potential therapeutic target for BLCA.
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PMC8357004
They may play this role by inhibition of the activity of DNMTs and HDACs.
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PMC9100622
Then, we ran bedGraphToBigWig to convert the file to a binary format (BigWig).
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PMC11422497
Upon querying the circBase database, has_circRNA_103870 (circBase ID: hsa_circ_0072805) was identified to be located on chromosome 5:69206201–69,206,389.
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PMC11285179
Each symbol represents data from a replicate.
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PMC10758402
786-0 were cultured overnight to reach in a confluency next day.
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PMC8777939
Cell invasion was examined using Matrigel-coated transwell plates.
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PMC11476222
This mixture was also analyzed using LC-MS.
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PMC6379402
In this study, our iCells are based on the widely available tissue expression data.
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PMC11782508
Unbound proteins were removed by washing the column with 2-bed volumes of the equilibration buffer.
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PMC8806312
MTNR1B (melatonin receptor 1B) is the membrane receptor of melatonin.
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PMC9429973
These observations suggest that a sustained high level of guanosine caused by forodesine treatment lead to continuous activation of TLR7 signaling, resulting in cytokine production from APCs.
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PMC10747139
RM175 was the first Ru(II) complex reported to have potential for anticancer activity.
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PMC11782508
The antimicrobial potential of purified azurin was assessed qualitatively against Gram-negative bacteria (E. coli and K. pneumoniae) and Gram-positive bacteria (S. aureus and B. subtilis) using well diffusion assay (Fig. 6).
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PMC9429973
Excessive activation or insufficient control of C5 is believed to play a role in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optical spectrum disorder (NMOSD).
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PMC9960565
Cultures were conducted at 37°C, in a humidified atmosphere of 5% CO2, in 96-well plates (seeding density = 1 × 10 cells/well), using adequate culture media complemented with fetal bovine serum (FBS) 10% (v/v) and antibiotic-antimycotic (AA, 100x solution) 1% (v/v).
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PMC10587429
hCD68+ human macrophages were only shown in tumors from huNSG-SGM3 mice.
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PMC11244823
While these three fragments are all thought to be secreted to the cell culture supernatant during transient expression in transfected cell cultures, the original molecule (gD1_402) will remain predominantly cell-associated, anchored through its transmembrane domain and cytoplasmic tail (see S3 Fig).
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PMC11574029
BLCA cells were co-transfected with the reporter plasmid and either NOTCH3 overexpression plasmid or NOTCH3 small interfering RNAs.
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PMC7039683
All the cell lines used in this study were tested for mycoplasma contamination and authenticated by genetic profiling using polymorphic short tandem repeats.
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PMC11126803
Data are presented as mean ± SD.
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PMC11746948
APT2 (encoded by LYPLA2), a known protein acyltransferase (PAT) involved in depalmitoylation, was identified as an interacting partner of GPX4 (Fig. 5a).
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PMC10810426
This supports the observation that APOBEC3G deaminates cytoplasmic reverse transcripts and that cytoplasmic nucleic acid sensors respond to MLV RNA/DNA hybrids and reverse transcribed DNA .
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PMC11545737
Of note, GBP2 ablation was sufficient to prevent pyroptosis triggered by E. coli OMVs but not that triggered by Salmonella OMVs .
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PMC2193049
The eluate was dialysed for 24 h at 4°C against 20 mM Tris–HCl (pH 7.6) and concentrated to 4 mg/ml.
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PMC7841067
Animal procedures were carried out according to a protocol approved by the Institutional Animal Care and Use Committee at Huaihe Hospital of Henan University.
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PMC11748335
Oncogenes are reported to be enriched in BGRDs .
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PMC9429973
Image: Summary/Conclusion: Taken together, we established a multiplex protocol for in vivo therapy trials that allows simultaneous testing of up to 5 PDX samples in competitive in vivo trials.
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PMC11021472
Both shRNAs induced a clear knockdown of the circZDHHC11 transcript levels without affecting the levels of lncZDHHC11 and pcZDHHC11 transcripts (Supplemental Fig. 4 A,B).
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PMC11453018
The ATP assay data are represented as mean ± SEM; p<0.05, by two-way ANOVA.
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PMC10578720
Additionally, it was found that the expression of IL-10 and inhibitory cell surface molecules of monocytes in patients with chronic HBV was significantly higher than in healthy individuals.
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PMC11731161
D The Venn diagram illustrates the overlap between the XPO1 interacting proteins identified by IP-MS and the prediction results obtained from UbiBrowser.
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PMC9429973
No pt had Gr ≥3 CRS or discontinued treatment due to CRS.
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PMC11534035
The cell proliferation in A431 cells treated with G1 showed a dose dependent reduction at the tested concentrations.
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PMC11419566
P. cocos contains polysaccharides, triterpenoids, sterols, and other chemical components.
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PMC11655536
Tumor cells enhance the utilization of glucose, glutamine, and other substances to produce a large amount of lactic acid and H, and MM is no exception .
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PMC11746948
These inhibitors, along with LOC1886 which also binds covalently to C66, induce a conformational alteration in GPX4, leading to its degradation via a mechanism that remains to be elucidated.
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PMC11194678
It was observed that the translation factor poly(A) tail-binding protein C1 (PABPC1) (Passmore and Coller, 2022) and large ribosomal subunit protein L7a (RPL7a) (Hemmerich et al., 1993) were well colocalized with endogenous STAU1 puncta in both HepG2 and COS7 cells (Fig. 3, G and H), indicating that STAU1 condensate promote translation of its target mRNAs by recruiting and enriching multiple components of the translation machinery.
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PMC11489175
ML323 is a USP1 inhibitor that showed interesting antiproliferative activity on ovarian cancer cells by blocking S-phase cell-cycle 121.
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PMC11381192
CCK‐8 assay was conducted to assess the cell viability after stable transfection.
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PMC11401350
This could be explained by fact that the CD4 receptor is upregulated upon TCR stimulation and therefore anti-CD4 CAR binding to the CD4 T cells is more efficient, inducing their elimination more effiently.
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PMC11754432
Punch biopsies (6 mm) were taken, fixed in 4% PFA and paraffin embedded.
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PMC11541241
Previous research showed that nitrogen limitation was proposed to be a decisive signal to promote the expression of pathogen virulence genes (López‐Berges et al., 2010a, 2010b).
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PMC6799808
While it is probable that G. lucidum extracts may impact each of these individual signaling molecules depending on the cell types and/or experimental conditions, it seems more conceivable that G. lucidum extracts may target certain major targets directly, subsequently influencing the abovementioned targets indirectly.
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PMC11705862
To further study the cellular localization of IRIS-1 and 2 in the human brain, we focused on three major cell populations: microglia, astrocytes, and neurons.
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PMC11488203
Eventually, MSC can also fuse with cancer cells in vitro and in vivo by the formation of new cancer hybrid cells displaying increased tumor plasticity associated with completely new tumorigenic and metastatic properties .
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PMC11746942
The primary antibodies used included anti-phospho-STAT3 (Tyr705) (Cell Signaling Technology, 9145), anti-STAT3 (Cell Signaling Technology, 12640), anti-Ki67 (Beyotime, AF1738), anti-Keratin 16 (Santa Cruz Biotechnology, sc-53255), anti-Keratin 17 (Cell Signaling Technology, 12509), and anti-CD130 (Thermo Fisher Scientific, PA5-28932).
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PMC9429973
Myeloid-cell intrinsic circadian clock components control inflammatory cytokine production (Gibbs et al. 2012; Curtis et al. 2015; Bellet et al. 2013), and metabolic inputs influence lethality in response to LPS (Wang et al. 2016; Weis et al. 2017; Traba et al. 2017), but the relative contributions of these inputs to daily changes in sepsis susceptibility are not known.
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PMC7802142
The total protein concentration was determined by BCA protein assay (Pierce, USA).
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PMC6160470
of three individual experiments performed in quadruplicates) on indicated cell lines, along with the calculated ALOGP values for each structure. (
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PMC9429973
When necessary, the genetic diagnosis of hemoglobinopathies was performed by t-NGS.
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PMC10656496
Treated experimental wells were normalized to untreated wells for a given cell line.
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PMC8973725
The χ test was used to analyze the differences in the expression pattern of RNA between the ccRCC and normal renal tissue groups and the relationship between ZNF677 expression and clinicopathological variables.
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PMC11672142
The EDS detector was a DRY SD30 (JEOL Ltd.).
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PMC10170482
Such models do not account for the additional mechanical cue that arises from 3D culturing itself: pressure of neighboring cells.
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PMC8632470
The materials used were HEK293 cell line (ATCC CRL-1573™), a collection of the Cell and Molecular Biology Laboratory, Faculty of Pharmacy, Universitas Padjadjaran.
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PMC11335267
E-J) Blood glucose levels observed during glucose tolerance tests performed after an overnight fast (E-G) or during insulin tolerance tests performed after a 4-hour fast (H-J) (n = 6 per group).
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PMC9739791
One of the first Pt(IV) prodrugs conjugated with photoactive ligand pyropheophorbide a (PPA), was reported by Wang et al. (Figure 4).
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PMC9111184
Atherosclerosis is the major cause of myocardial infarctions and ischemic strokes.
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PMC11473750
In our studies, immunofluorescence staining showed that RNF121 co-localized preferentially with the GM130 protein in the cis-Golgi network, but minimally with Golgin97 of the trans-Golgi or with protein disulfide isomerase (PDI) of the endoplasmic reticulum (Fig. 2a and Supplementary Fig. S2a), indicating that RNF121WT protein was located on the Golgi complex in neuroblastoma cells.
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PMC11678448
The bacteria were verified through a 16S rRNA PCR.
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PMC11088135
Mechanistic studies have shown that lncRNAs act as sponges for competing endogenous RNAs (ceRNAs), regulating the function of microRNAs (miRNAs), thus forming a complex regulatory network involved in tumour development .
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PMC9429973
Efficacy endpoints include change in lactate dehydrogenase (LDH), transfusion avoidance and hemoglobin stabilization (both assessed in 24-week intervals), and breakthrough hemolysis (BTH).
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PMC11777207
Antibodies that block only PD-L1:CD80 cis interactions are intended to bolster PD-L1:PD-1 signaling while limiting activation of T cells.
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PMC11098378
Recombinant GST-IpaH4 for in vitro experiments was expressed and purified as previously described for other IpaH proteins .
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PMC10900886
We did not observe VP1 cells in cells inoculated with heat-inactivated virus (Fig. S2).
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PMC11748335
We observe that in cancer cell lines, including those from esophageal and breast cancer, long LOCKs shift from short-PMDs to intermediate-PMDs and long-PMDs.
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PMC11773391
Furthermore, the results of MTT assays showed a significant increase in IC50 value in the MGMT OE group compared with that of the control and vector groups (Figure 4C).
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PMC11089031
G The OE of ZNF692 promoted the migration of Caki-1 cells.
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PMC11401350
Bone marrow (BM) was isolated from the tibia of C57BL/6 mice.
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PMC9429973
Except from the analysis of gene expression, we performed TCR repertoire analysis using VDJtools, an open-source Java/Groovy-based framework that can analyze immune repertoire sequencing (RepSeq) data and allows applying a diverse set of post-analysis strategies.
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PMC11740207
Research on the HE in human EpibCs, encompassing the processes of SD and AD, remains active.
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PMC11767725
In contrast, rosacea exhibited a weaker association with MetS, with an odds ratio (OR) of 1.56 (95% CI: 0.96–2.52).
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PMC9429973
The statistical difference between groups was performed using log-rank test.
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PMC6684588
P ≤ 0.001 vs. vehicle-injected muscle by unpaired t-test.
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PMC11473843
Here we revealed two FAK interactors, extracellular-signal-regulated kinase 5 (ERK5) and cyclin-dependent kinase 5 (CDK5), as key players underlying FAK-mediated maintenance of KRAS mutant NSCLC.
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PMC11725127
In addition to the CETSA results, the drug affinity-responsive target stability assay showed that GA could prevent the pronase-mediated digestion of USP2 in a dose-dependent manner (Supporting Information Fig. S4).
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