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OTAR3088
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PMC5673060
The colour intensity of the node represents the significance of enrichment (ranging from moderate to high) and grey depicts no proteins. (
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PMC11634794
Subgroup analysis of ccRCC patients revealed that those with low LAMP1 expression had poorer overall survival in Stage T3&4, T3, M1, G3&4, Stage III&IV, and Stage IV ( Figures 3D–I , P< 0.05).
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PMC8708099
Our previous studies have confirmed that osthole possesses anti-inflammatory properties in peripheral blood mononuclear cells (PBMCs) isolated from children with allergy, autism spectrum disorder (ASD), and adults with allergy and asthma .
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PMC11599565
Rat brain cell cultures grown in 2D Neuropan induction medium allow the growth and differentiation of giant cells that develop into multipolar neuron-like cells.
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PMC10812665
Glutarate is a biomarker of another inborn error of metabolism called glutaric aciduria type I (Figure S12), linked to neurological disabilities .
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PMC4816271
HuK666-transduced PBMCs displayed comparable levels of cytotoxicity and cytokine release in response to Lan1 cells irrespective of prior culture with CID.
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PMC9429973
These effects were associated with activation of the cGAS-STING pathway (TBK1 phosphorylation) in cHL cells.
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PMC11469524
These so far undescribed network links include the strong negative crosstalk from p38 to RAF/MEK/ERK, which has been previously described in endothelial cells or EGFR-activated epithelial cells .
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PMC11348300
The variance in total mouse counts, sometimes falling below 10, can be attributed to instances where tumors did not develop.
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PMC11521786
Mice immunized as described were challenged intravenously with 50,000 3LL-R3 cells.
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PMC9429973
At DL1, ORR and complete response (CR) rate were both 75%.
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PMC2118063
GC of −/− mice exhibited comparable staining of the B cell population but were usually less well organized.
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PMC9917080
A similar effect was exerted on cells by the 24-h SeSo nanocomplex (Figure 10A, blue columns), but the increase in gene expression was less pronounced, compared to So.
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PMC11171319
Epstein–Barr virus (EBV), Kaposi sarcoma human virus (KSHV), human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), human T-lymphotropic virus-1 (HTLV-1), and the most recently discovered Merkel cell polyomavirus (MCPyV) belong to the group 1 carcinogens for humans, namely human oncoviruses .
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PMC10914904
MVP function has been linked to the TNFα-mediated maturation of monocytes into dendritic cells (DCs).
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PMC11714165
In this study, we propose to develop a bone‐targeted nanocarrier to deliver the NBD peptide to simultaneously inhibit osteoclastogenesis and osteosarcoma cell proliferation.
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PMC10747139
All the complexes could interact with BSA, with complex 37 being the one with the highest value with respect to its binding constant.
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PMC4443654
However, it was unclear whether other features show unusual patterns in TAD boundary regions, and whether the constellation of features involved changes between cell types.
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PMC11790599
Confocal microphotographs showing that TSL (6.32 μΜ, 24 h) induced macropinosomes of SK-BR-3 and ZR-75-1 cells with or without cholesterol inhibitor mβCD treatment (1 mM, 24 h) (63×).
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PMC10530622
In fact, intestinal secretion is an alternative to oxalate excretion in ESKD or other disease phenotypes characterized by high levels of bioavailable oxalate .
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PMC11764090
Under cold stress, the chloroplast structure is severely damaged due to excessive reactive oxygen species (ROS) accumulation (Figure 1).
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PMC9479186
No. 639506) was used to synthesize cDNA.
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PMC11001582
A selection cassette (FRT-PGK-gb2-neo-FRT, Gene Bridges) was inserted in the pMC-eGFP, pMC-(GR)400 and pMC-(PR)400 in the NheI site.
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PMC11257203
After fixing the samples with methanol/glacial acetic acid (3:1), the slides were prepared, stained with Giemsa solution (1.5%), and assessed randomly with an optical microscope (Micros Austria daffodil MCX100, Vienna, Austria).
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PMC9429973
The main determinants of HRQoL identified were psychological and social factors.
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PMC11351758
Oxidation levels also have a direct link to many disease types, including metabolic disorders and neuronal dysfunction, as well as cardiomyopathy.
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PMC11754784
Nbs, also known as single-domain antibodies, are antibody fragments (variable region of heavy chain of heavy-chain-only antibody, VHH) with many good features like small size (2–4 nm in diameter, about 15 kDa), compact structure, high stability, superior water solubility, easy cloning and the capability of binding to difficult-to-access antigens.
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PMC11459296
Humanized immunodeficient mice serve as critical models for investigating the functional interplay between transplanted human cells and a pre-reconstituted human immune system.
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PMC11672142
The synthesis of DefNEtTrp (6) was accomplished through a four-step synthetic route (see Scheme 1) adapting a literature protocol.
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PMC6771295
Cells were transfected with siRNA against SIRT1, SIRT3, SIRT5, non-targeting siRNA, and GFP-LC3 plasmid (Addgene, # 24920) using Lipofectamine 2000 reagent (Thermo Fisher Scientific) for 24 h. After that, 10 μM rotenone, 10 μM etoposide, and 50 μM resveratrol were used to treat the cells for 24 h. Cells were collected and analyzed using BD FACSVerse™ Flow Cytometer (BD Biosciences).
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PMC10419319
In addition, a network pharmacology analysis revealed the potential targets and pathways associated with isoalantolactone-regulated glycolysis for OC treatment.
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PMC10777969
This effect was not seen for FCP26 (Figure 5C).
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PMC10713411
We utilized the estimate R-package to assess the immune and stromal scores.
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PMC11621493
Mutagenesis was performed using the Q5 site-directed mutagenesis kit (E0552S, New England Biolabs, Frankfurt am Main, Germany) according to the manufacturer’s instructions using the following primers: forward: 5′-CAGTGGCATCgcgGGCTCTACAT-3′; reverse: 5′-AAGTAGGTCACACAGTCC-3′. This mutation exchanges the active site serine residue of mPLA2G4D with an alanine (S370A).
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PMC11406030
In an orthotopic xenograft mouse model of OC, we saw a 35% tumor reduction in response to intravenous injections of 2 mg/kg LMTK3BP given three times a week for 3 weeks.
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PMC11536589
GSEA analysis showed the enrichment of ferroptosis and fatty acid metabolism in the AsPC1 cells treated with 1 µM MRTX1133 for 48 h. (D) The effects of DFO and Fer-1 on cell viability after MRTX1133 treatment were assessed by CCK8 assay.
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PMC11224020
However, whether chemokine receptor expression responds to the physical stimuli encountered by migrating immune cells is unclear.
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PMC11770130
For result processing, Protein Discoverer (Version 2.4, ThermoFisher Scientific) and the UniProt Human Protein Database (75,004 entries) were applied.
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PMC8873393
P values are calculated by student’s t-Test, n.s P = 0.382, *P = 0.013, **P = 0.005, **P = 4.66e.
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PMC11075223
It was usually applied to relieve the symptoms of endocrine disorders, hypertension, osteoporosis, hyperlipemia, and depression [59–61].
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PMC10048572
Sequential cancer cell transplants have made it possible to track further clonal evolution.
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PMC9429973
Capture panel was aimed to detect most common and relevant aberrations known in MM such as coding regions of 37 genes involved in MM progression and drug resistance, canonical IGH and IGK to capture IGH rearrangements and regions to cover traditional translocations.
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PMC9429973
During progression one patient gained a MECOM rearrangement and two patients other chromosomal aberrations present in the AML state.
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PMC10850553
U-937 cell line, an established human cell line of histiocytic lymphoma origin, was purchased from ATCC (#CRL-1593.2) and cultured using a DMEM supplied with 10% FBS (lot: 42F2102K, #10270-106, Thermo Fisher Scientific).
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PMC10998613
Representative epifluorescence images of COS7 cells expressing CXCR4 fused to AcGFP1 (Top Left image) and mCherry (Bottom Left image) at the C terminal and their schematic cartoons (Right). (
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PMC11697065
Cells were cultured at 36.5°C in a humidified 6 % CO2 atmosphere in a shaking incubator at 140 rpm.
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PMC11281366
These results suggest that other viral proteins, such as Tat, Rev, the Env glycoproteins or the products of the Gag and Gag-pol precursors, might potentially be involved.
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PMC9243326
Some researchers have explored the potential of C. chinensis in medicine.
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PMC11544771
Our in vitro finding provides a basis for further in vivo studies in animal NSCLC models.
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PMC11564322
The mean values ± SD with *, **, and *** are statistically different from the control group at p < 0.05, p < 0.01, and p < 0.001, respectively.
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PMC6450504
After the acclimatization period of 7 days, the animals were inoculated subcutaneously near the right flank with two million A2780-ADR cells in 100 µL of sterile PBS pH 7.4.
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PMC11423992
The rationale behind TFAB002s is to mitigate cytokine release while maintaining its efficacy compared with other CD20/CD3 bsAb .
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PMC10578720
The hyperacetylation of CS and PDHC can severely impact their enzymatic activities, contributing to the impaired TCA cycle.
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PMC11628904
Increased dye fluorescence post‐burn indicates localised tissue damage.
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PMC10490530
We observed that the binding of NF-κB to PIK3CA promoter in doxorubicin-treated p53-NLuc overexpressed A2780 cell line was lower than wild-type p53 expressing A2780 cell line (Figure 4h).
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PMC9917080
Pre-incubation with SeNPs and SeSo resulted in an increase in the expression of the DIO2 and SELENON genes in both cancer cells and cortical astrocytes, which improved the viability of cortical astrocytes.
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PMC6835762
In addition, the MTX nanoparticles showed 7 times higher toxicity to Saos-2 cells than MTX in 2D and 3D cell experiments (Scheme 1) .
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PMC9429973
Results: None of the participants developed thrombosis/VITT.
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PMC10545062
Animal care and use were in strict compliance with the Guide for the Care and Use of Laboratory Animals in a facility accredited by AAALAC and adhered to ARRIVE guidelines (Supplemental Digital Content, Figure 1, http://links.lww.com/TA/D127).
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PMC11047729
In our opinion, vitamins are the most promising substances in targeting telomerase in leukemia cells, as they have been studied both in vitro and in clinical studies with good results.
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PMC11670407
Specifically, OTULIN was markedly elevated following chemotherapy, particularly in response to cisplatin treatment, but not to doxorubicin or methotrexate.
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PMC11264242
FYN mRNA expression in soft tissue sarcoma samples from the TCGA database.
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PMC11790599
It may interact with a regulatory component in the NRF2 pathway, or perhaps modulate receptor tyrosine kinase signaling specifically activated in these cell types.
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PMC11237030
The hygromycin B concentration was determined using batch culture by choosing the concentration that was 0.1 mg/ml above the one showing complete cell death (data not shown).
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PMC8633974
Pink colocalization between the blue nucleus and red nucleic acid in a single plane confirmed that the CRISPR payload was delivered to the nucleus by the LNPs.
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PMC11694625
CDK inhibitors have advanced to the third generation, including palbociclib, ribociclib, and abemaciclib.
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PMC11736898
This study investigated the effects of CYP24A1 inhibition on proliferation, migration and gene expression in normal and keloid-derived keratinocytes.
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PMC11474209
This is due to favorable environmental conditions and the characteristics of the water bodies involved.
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PMC11594588
In 1994, the unequivocal identification of the malondialdehyde-derived deoxyguanosine (M1-dG) adduct was reported by Chaudhary et al. in human liver.
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PMC9429973
Patients in all Arms will have response assessments, safety assessments, and ophthalmic exams performed by an eye care specialist Q3W regardless of dosing schedule.
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PMC11543935
B: Temperature curve measured in the center of a hydrogel with a fiber optic temperature sensor during treatment with the IGEA GeneDrive at E = 1000 V/cm with 25 cycles of 8 pulses.
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PMC11277157
Highlighted are set genes that meet the threshold for FDR and FC.
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PMC8164677
The drug wipes out the sensitive cells but leaves the resistant ones.
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PMC11568601
While, in human BMSCs, which served as normal control cells, TGT at concentrations ranging from 20 to 140 mg·mL did not significantly suppress the proliferation of BMSCs, indicating no toxicity in normal cells (Fig. 1A).
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PMC11306019
Moreover, the origin and configuration of VDMs, rather than the total VDM concentration, play a pivotal role in the combined antagonistic effects against BTZ in gallotannins.
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PMC11055510
The results of clone formation experiments showed that the number of clones in the si-IL1RAP group was significantly lower than that in the si-nc group.
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PMC10470467
Hence, we also evaluated the predictive performance of the signature in terms of clinical response to 5 commonly used chemotherapeutic agents for ES.
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PMC9429973
The most represented age group = 21-30 years: HR =1.94, p=.000 (s).
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PMC9429973
The patients in Stage III-IV were 73%.
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PMC9429973
In the avapritinib cohort, 136 (77%) patients from both trials were dosed at ≤200mg and 40 (23%) patients, all from EXPLORER, were dosed at ≥300mg.
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PMC10988808
Next, serum-free medium was added to the six-well plate and cultured in an incubator for 48 h. Take pictures and assess the closing rate.
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PMC11696576
We next measured the effect of cPLA2α inhibition on levels of intracellular reactive oxygen species (iROS) by flow cytometric analysis of ROS-red staining showing AVX420 treatment induced a dose-dependent increase in iROS in Jurkat E6.1 and CCRF-CEM cells (Fig. 6f).
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PMC11765879
The size and number of colonies in each well were evaluated every two days using a Leica SP8 UV/Visible inverted microscope (Leica Microsystems) with a 10× objective lens.
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PMC10758402
Quantification of IFN-β secretion 24 hpi by enzyme-linked immunosorbent assay (ELISA) followed a similar trend as shown in ( Figure 4B ).
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PMC10840195
The total protein concentration was determined by the RC-DC™ Protein Assay kit (Bio-Rad Laboratories, Inc.).
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PMC9388315
Next, centrifuged (10 min 12,000g at 4°C), the supernatant was collected and protein concentration was assayed by the bicinchoninic acid (BCA) method (BCA, Thermo Scientific pierce, USA).
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PMC11489351
B, representative confocal images of MCF10A cells expressing the Notch1 activity reporter and treated for 24 h with EIPA to lower pHi or NH4Cl to raise pHi (see Methods for details).
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PMC7642379
Here we present a genomic, transcriptomic and metabolic gene analysis of six of the most widely used HEK293 cell lines.
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PMC11802929
e Heatmap showing average value of peptide and TCR physicochemical properties for each phenotype.
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PMC9918897
This tumor-cell suspension was injected into the left-thigh muscles of tumor-free mice (10⁷ cells/0.1 mL, intramuscular), according to the protocol, which normally results in 100% tumor development.
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PMC11661040
The tumors of the nude mice in the two groups were isolated and photographed. (
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PMC7642379
Notably, a lower cholesterol biosynthesis in suspension cell lines compared to the original HEK293 strain was indeed predicted using IPA (Supplementary Fig. S7).
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PMC9917080
Suppression of DIO2 led to an increase in ROS, a serious impairment of mitochondrial respiration, significant fragmentation of mitochondria, and a decrease in cell viability .
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PMC11747467
We further silenced and overexpressed ERBB2 in luminal and basal cells.
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PMC11604015
Among 17 enrolled patients, only nine received infusion finally; the overall response rate was 44% (four of nine patients).
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PMC11342785
A, schematic of cytoskeletal circuit designs that inducibly connect TPPP to IDR-droplet hubs, mimicking the discrete and localized targeting of native TPPP to Golgi outposts in oligodendrocytes.
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PMC11551844
After 24 h, samples were centrifuged and washed with distilled water to remove excess of FITC and re-centrifuged.
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PMC11742290
Several studies have shown that LGR5 expression is increased following the development of chemotherapy resistance.
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PMC9429973
Methods: b-thalasssemic mice (Hbb) were treated with IMR-261 at 37.5 or 50 mg/kg BID for 4 weeks.
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PMC11772449
In addition, we preliminarily explored the effects of p38γ and PFD on Sora resistance in HCC cells.
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