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OTAR3088
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BioData-CellLine_annotated

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PMC11549062
In addition, we further found that PTP1B modulated PDGFR‐β signaling via Rab5‐mediated endocytosis.
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PMC11748618
Variants in high linkage disequilibrium (LD) in the region overlap three coding genes CHD1L, PRKAB2, and FMO5, but this region had not been previously implicated in HIV host genomic studies with European populations.
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PMC9429973
Results: The patient exhibited a rapid and complete response to ibuprofen with normalization of full blood counts.
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PMC9844987
Promoter shape entropy for promoters split by variability quartiles, displayed as densities (left) and in a box-and-whisker plot (right). (
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PMC9429973
Methods: Dutch hematologists who treated CML pts in the asciminib EAP were asked to provide clinical data of consenting pts.
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PMC11286266
Data analysis was performed using FlowJo V10, and median reporter analysis was conducted using Prism 10 (GraphPad).
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PMC11574271
Scale bar 1 µm) Experiments in B–H were repeated three times (n = 3).
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PMC11519567
Scale bars, 5 μm.
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PMC11335267
These observations are in agreement with studies showing that energy expenditure is directly correlated with the amount of muscle mass, and that decreased muscle mass is associated with lower energy expenditure and increased visceral fat accumulation [77–79].
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PMC10965315
MTT assay was performed on both A2780 and NIH/3T3 cells to determine cell viability.
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PMC11634794
LAMP1 exerts anti-tumor effects by suppressing the proliferation, migration, and invasion of renal cancer cells.
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PMC9000591
The SM extract was then fractionated to retrieve hexane (SH, 5.4 g), ethyl acetate (SE, 4.84 g), butanol (SB, 13.6 g), and water (SW, 13.6 g) extracts via liquid–liquid phase extractions.
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PMC11742290
However, EGF treatment which can stimulate cell growth, proliferation, and differentiation, complicated this study because both the EGFR and WNT/β-catenin pathways would be activated in these cells.
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PMC9351137
The colors of bars are referred to Fig. 1B.
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PMC11569208
Interference of signal transduction following IFN-β binding could potentially explain our observed decreases in downstream antiviral effectors such as MX2 and IFITM1 (Fig. 3E).
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PMC11194678
The 647 signal was bleached using a 647-nm laser beam with a Leica TCS SP8 confocal microscope.
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PMC9516447
To prepare tumor tissues for protein level analysis, tumor tissues were homogenized in cold RIPA buffer (50mM Tris-HCl, 150mM NaCl, 1% NP-40, 0.5% sodium deoxycholate, and 0.1% SDS) supplemented with Protease and Phosphatase inhibitor cocktail (ThermoFisher Scientific, Waltham, MA, Cat#78440).
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PMC4005030
Also PCA treatments at 2% and 4% significantly lowered plasminogen activator inhibitor-1 activity and fibrinogen level; increased plasma activity of antithrombin-III and protein C; decreased triglyceride content in plasma, heart, and liver; elevated glutathione level and the retention of glutathione peroxidase and catalase activities in heart and kidney.
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PMC11543853
Identification of enterovirus particles in tomograms of infected cells enabled the calculation of the multiplicity of infection.
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PMC11750161
Plasmid DNA and transfection reagent were mixed with Opti-MEM and incubated for 20 min at room temperature.
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PMC11473750
MRC5 and WI-38 normal human fibroblasts were grown in alpha-minimum essential media (MEM) (Life Technologies) supplemented with 10% heat-inactivated FCS.
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PMC11190238
Lastly, the formation of EMT-TF centric enhancer-promoter interactions, via loop extrusion model, within the TADs is required for activation of EMT gene transcription.
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PMC11469524
As only active ERK is able to enter the nucleus but not MEK it is unlikely that the cause of the upregulation is a prolonged retention of ERK together with active MEK in the cytosolic scaffold.
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PMC11394227
After 24 h of adherence culture, the culture medium was replaced with fresh medium or medium containing 20 μg/mL BFA (Beyotime), and the total protein was collected after 8 h of further incubation for Western blot analysis.
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PMC11629192
In the context of B-cell depletion therapies, both anti-NMDAR encephalitis and MS share a therapeutic approach involving the use of agents like RTX.
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PMC11599565
Microscopic inspection of SKOV3 cells reveals a naturally occurring, distinctive cell type with a morphology resembling that of bipolar and multipolar neurons.
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PMC11754784
The yellow dots indicate the CEM cells pre-stained with Mitochondrial Red and the gray dots indicate erythrocytes.
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PMC9429973
Seventy one per cent of our population had lymphopenia and polynucleosis was found in 45.7% of cases.
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PMC11604015
However, CAR-T cells' short persistence (4 weeks) was sufficient for most patients to achieve CR in both studies .
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PMC10253973
Frei et al. described polypyridyl complexes such as Ru(dip)2(bdt) (64) (where dip= 4,7-diphenyl-1,10-phenanthroline; bdt=1,2-Benzenedithiolate) and [Ru(dqpCO2Me)(ptpy)] (65) (where dqpCO2Me, 4-Methylcarboxy-2,6-Di(Quinolin-8-yl)Pyridine; ptpy, 4′-Phenyl-2,2′:6′,2″-Terpyridine) (Figure 25).
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PMC11635519
After 6 h of incubation, 20 μL of cell medium was transferred to a black flat-bottomed 96-well plate.
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PMC11397654
In the final step, the addition of dimethyl(3 chlorocycloprop-1-ene-1,2-diyl)di-L-prolinate led to the target compounds 7a,b and 8a,b in 55–75% yield.
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PMC11661024
The data are provided as the mean + SD of triplicate experiments (n = 3, *** p < 0.001; **p < 0.01; *p < 0.5).
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PMC9985266
sh-DNMT1-1 had the best influence on DNMT1 inhibition (Additional file 1: Fig. S8A, B).
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PMC10938336
The molecular docking results provide valuable insights into the interactions between selected active compounds and two key hub proteins, PARP1 and CASP3, shedding light on their potential therapeutic effects in the context of cancer (Table 4).
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PMC9429973
Results: In cohort C, 38 pts (median age 63.5 y [range 32–82]; 63% male) received teclistamab (median prior LOT 6 [range 3–14]) at the data cutoff date of Sep 7, 2021.
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PMC8557138
Multicellular organoids developed by 3D fabrication of heterogeneous population of cells derived from stem cells or iPSCs (ECs, pericytes, and smooth muscle cells) derived from the same individual would possibly integrate better with the host vasculature and re-vascularize the damaged tissue.
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PMC11767725
Conversely, microbial dysbiosis exacerbates cytokine production.
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PMC11435360
Fold changes in gene expression were compared to the no-hypoxia condition and were calculated using the ∆∆Ct method.
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PMC11763126
Luciferase-expressing 786-O cells ( cells in 0.2 ml PBS) were injected via the tail vein.
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PMC11775197
Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the majority of patients are found to be in advanced stages, which is a burden to human health all over the world.
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PMC11781181
After rinsing three times with buffer solution, the intracellular ROS concentration was checked using Fluorescence Microplate Reader (Thermo Fisher Scientific).
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PMC11773391
The promotion of MGMT transcription after TMZ action may be a mechanism of acquired drug resistance in melanoma cells.
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PMC9429973
Summary/Conclusion: The use of a desensitisation protocol comprising the combination of plasma exchange, high dose immunoglobulin and pre transplant immunosuppression constitutes an effective desensitisation strategy for DSA and abrogates the risk of graft failure in multiply transfused paediatric patients undergoing haploidentical HCT for red cell disorders, enabling HCT where no alternative donor exists.
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PMC9268620
The structural integrity of organelles such as the mitochondria, on the other hand, remained preserved and unaffected during the process of apoptosis (Figure 10).
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PMC5311252
miRNAs were extracted from 50 000 cells in biological triplicates from each cell line (A549, U1810, NCI-H1703, SK-MES1 and 833KE) and type (parental cells (PC), GFP-control cells (CC) and hsa-mir-372-transduced cells (MC)) using mirVana miRNA isolation kit with phenol (Thermo Fisher Scientific, AM1560).
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PMC10988555
This band is tentatively assigned as a metal-to-ligand dCo to π*Cp charge transitions (MLCT).
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PMC11711347
Infrared Characterization IR spectroscopy of the Ni(II)ProDtc complex provides insights into the complex’s properties.
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PMC11116779
SOD is considered a crucial player in scavenging most of the superoxide produced by respiration (35, 36).
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PMC10988555
This quantification was executed with a Biorad microplate reader Model 680 (Bio-Rad, Hercules, CA, USA).
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PMC11650848
These results indicate that G/G individuals performed more poorly than CC/CG individuals in the placebo group, but this effect was not seen in the supplemented group.
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PMC6461034
Peptide and protein identifications are filtered at a false discovery rate of 1% using a decoy database strategy.
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PMC10530622
Additionally, nedosiran, which is administered via monthly subcutaneous injections, has demonstrated sustained and long-term reduction in urinary oxalate levels for patients with PH1 and PH2, bringing them closer to the normal range.
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PMC8992508
On this basis, both selective BCRP inhibitors and dual P-gp/BCRP ones are needed to define sound SARs and to discover new leads for the development of new molecules.
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PMC11012313
Our data indicate that LMP2A increases ATP generation in multiple Burkitt lymphoma cell lines that were dependent on HIF-1α.
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PMC11585587
The rate of change in MMP and the relative expression levels of proteins were reflected by GraphPad Prism 9.0 software plots histograms (B, D, F, H).
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PMC6600253
Cancer cells have been demonstrated to be forced to undergo senescence by natural compounds, with similar effects to those obtained by genetic and epigenetic manipulations, anticancer drugs, and irradiation.
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PMC11740907
To get biologically active conformation, the built POM was subjected to energy optimization using the Tripos force field with Gasteiger Hückel atomic charges.36 The co-crystal structures of Cyclin-Dependent Kinase 2 (CDK2), Protein Kinase B alpha (PKB-α), and Epidermal Growth Factor Receptor (EGFR) were retrieved from the RCSB Protein Data Bank using the corresponding PDB entries: 2FVD,37 4GV1,38 and 1XKK,39 respectively).
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PMC9429973
Pts received DVd in the approved schedule with 8 cycles (21 d/cycle) of BTZ (1.3 mg/m, SC) on Days 1, 4, 8, and 11 and DEX (20 mg, PO or IV) on days 1, 2, 4, 5, 8, 9, 11, and 12 + DARA (16 mg/kg, IV) given weekly for cycles 1-3, Q3W for cycles 4-8, and Q4W thereafter.
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PMC11699042
WGS data was aligned to the hg19 reference genome using the PanCancer alignment workflow for the whole genome from the Roddy Alignment Algorithms.
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PMC11218145
We did not use surrogate IVIS parameters, because the BLI values are reduced in case of peritoneal bleeding.
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PMC9621239
Significant sites, including x111, x119, x123 and x134, with higher mutation frequencies, located within the transactivation domain and strongly conserved region simultaneously are displayed in the volcano plot. (
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PMC11525028
Dual-luciferase reporter assays of ASNS promoter activity of ATF4-OE in NAT10-KO 143B (left) and HOS (right) cells (n = 3). (
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PMC11742231
In summary, the ablation study conducted on the effect of multi-channel attention demonstrated that including multi-channel attention improves the final representation of the model and leads to better performance on the task.
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PMC11737091
Additionally, the tumors were weighed and photographed.
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PMC11200978
Application of a repeat freeze to −20 °C resulted in 24 h survival of 1.6% (±0.1), but again the surviving cells were able to recover in vitro to 22.1% (±1.9) by day 7.
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PMC10344560
Delayed PD catheter removal was independently associated with mortality in fungal peritonitis patients.
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PMC11476837
The differences were considered to be statistically significant when the p value was <0.05.
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PMC9429973
Results: Of the 273 patients diagnosed with ALL, only 197 (72%) were able to get admitted for treatment at our institute.
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PMC10006224
They also showed a smaller increase in STAG1 occupancy at their anchors and, consequently, a larger loss in total cohesin (Supplementary Fig. 6e).
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PMC10965680
Within the realm of selection signal detection methods, CLR stands out for its ability to evaluate selection signals through comparisons between the likelihood of observing genetic data under a selection model and that under a neutral model (Chen et al., 2021).
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PMC9812014
A patent publication reports several indole alkaloid-based compounds having significant anti-RSV activities.
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PMC10158546
Images were taken with a phase contrast microscope 3 days following puromycin treatment. (
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PMC11678841
As expected, the majority of fungal cells exhibited the germ tube form (Figure 2).
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PMC11377827
The beads were washed three times in 1% Triton in 1xPBS and once in 1xPBS, resuspended in 100 µl of 1xPBS with 5 µl of DUB catalytic activity-based probe Biotin-ANP-Ub-PA (1 µM final concentration) and incubated at 37 °C for 5 min.
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PMC11674891
FNDC4 is a secreted protein known for its role as a crucial anti-inflammatory factor .
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PMC11200978
Flow Cytometry analysis was conducted on a minimum of three experimental repeats with an intraexperimental replicate of 3 (N ≥ 3; n ≥ 9).
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PMC9592219
In summary, the reduction of miR-22-5p level in HCC cells may be the reason for the high TOP2A expression.
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PMC9429973
Median leukemia-free survival of responding patient was not different between the two groups (9 months), indicating that VEN-AZA can be efficient as a salvage treatment for selected R/R AML patients.
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PMC10237474
Antibody-based therapeutics and recombinant protein reagents are often produced in mammalian expression systems, which provide human-like post-translational modifications.
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PMC11489175
A recent review of patents of USP7 inhibitors highlights the molecular heterogeneity of the main scaffolds of these inhibitors that have been described also in natural products 88.
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PMC11672142
complexation by DefNEtTrp was initially studied by reacting the ligand with Fe(III) dicitrate (Fe(Citrate)2), which is a labile Fe(III) complex.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973
Durie-Salmon).
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PMC11770746
Platinum drugs (cisplatin or oxaliplatin) or taxanes (paclitaxel or docetaxel) are associated with increased risk of CIPN, which can appear in the form of acute and/or chronic peripheral neuropathy.
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PMC11127909
Scale bar = 20 μm, N = 5.
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PMC9429973
With a mean follow-up of 10.1 years for cases and 9.7 years for controls, 27 patients died (13 SVT+ and 14 SVT-).
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PMC6771295
One-way analysis of variance (ANOVA) and Tukey's multiple comparisons post-test were used for the analysis of the data.
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PMC9429973
Results: Concordance between transcriptomic and genomic profiles was used to allocate samples to one of 15 established molecular driver subgroups (Figure A).
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PMC11731614
The GFP signal was not only detected in the cell body of the primary DRG cultures from EV-reporter mice but also along the neurites, further providing evidence that KDEVs are trafficked along the neurites.
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PMC11487720
Internucleosomal DNA fragmentation was not detected in the UV/cold shock-treated cells during incubation at 22 °C (Fig. S2I).
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PMC11803918
Two hours later, Brefeldin A (BFA) was added to the culture system at a concentration of 10 μg/mL for another 6 h. The intracellular level of IFN-γ was determined by flow cytometry.
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PMC11788920
Similar patterns were observed for protein level suppression in case of RNP2 and RNP3 (0.53 ± 0.04-fold and 0.40 ± 0.07-fold, respectively).
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PMC7081114
Data were analyzed by ANOVA or t-test.
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PMC11122631
To verify the absolute configuration of C-4, the computer-generated ECD data (Figure S1) of two isomers (4R,12S-1 and 4S,12S-1) were used for comparison with the experimental data.
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PMC11727145
The results revealed notable differences in keratinocyte adhesion and proliferation between burn wound exudates collected at the early stages and late stages of acute patient treatment, providing new information on a possible therapeutic window to apply cell therapies on burn patients.
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PMC11655536
In addition, genes responsible for lysosomal generation were activated.
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PMC6102174
Two species, namely Artemisia capillaris (Yinchenhao) and Artemisia scoparia (Binhao), are documented in Chinese Pharmacopoeia as the authentic resources of Yin-Chen.
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PMC11026382
The red line indicates a best-fit double gaussian, gray bars are the data.
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PMC11633763
Based on these results, it could be concluded that USP22 regulates β‐catenin in osteosarcoma cells.
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PMC10926885
NDE1 showed the strongest association with the following 10 genes: CTB‐193M12.5 (R = 0.75), CKAP2L (R = 0.61), NCAPG2 (R = 0.58), CENPI (R = 0.57), NCENP (R = 0.57), ARHGAP11A (R = 0.56), CLSPN CENPI (R = 0.56), DTL (R = 0.56), and FANCI (R = 0.56) (Figure 8B).
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