Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11377827
CaCl2/HBS/DNA precipitate was prepared by mixing 438 µl of H2O with 2 M CaCl2 and DNA in one tube and then adding it dropwise to 500 µl of 2xHBS (0.27 M NaCl, 1.5 mM Na2HPO4·7H2O, 0.055 M HEPES, pH 7).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918
The generation of a tumor antigen-specific T-cell response requires the maturation of dendritic cells and the presentation of tumor antigens to T-cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gener...
PMC3274243
Slides were viewed and photomicrographs taken with a Motic DM-BA300 digital photomicroscope system.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "viewed", "and", "photomicrographs", "taken", "with", "a",...
PMC7582629
Raman microscopy allows for imaging the distribution of chemotherapeutic drugs in cells, opening avenues as a non-invasive and label-free technique to investigate pharmacokinetics at the highest possible resolution in living cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808
Evidence has shown that G. lucidum exerts a variety of biological activities, including anti-inflammatory, antioxidant, antiglycemic, antiulcer, anticancer, and immunostimulatory effects.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912
The molecular mechanism(s) responsible for the differential susceptibility of HIV-1 and HIV-2/SIV to GSK232 require further investigation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molecular", "mechanism(s", ")", ...
PMC10729469
D Representative images showing amyloid plaque (pan-Aβ) and Thioflavin-S staining in different brain regions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Representative", "images", "showing", "amyloid", ...
PMC11736898
Neither inhibitor had a significant effect on expression of FZD7 in normal or keloid keratinocytes in the absence of vitamin D, but the combination of vitamin D plus ketoconazole significantly reduced FZD7 in keloid keratinocytes compared with vitamin D treatment alone (Figure 7f).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393
Cells were washed once with PBS then stained with DAPI (Fisher Scientific, # 15757405, 1:1000) in PBS for 10 mins.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973
We were able to identify causative variants in 94% of the 69 patients, including atypical disease-causing genetic findings such as intronic and CNV mutations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6617630
MYC protein has been considered “undruggable” and the main approach has been directed at interfering with MYC:MAX dimerization .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYC", "prote...
PMC11477621
H NMR (600 MHz, CDCl3) δ 6.97 (dd, J = 4.1, 1.7 Hz, 1H), 6.84 (t, J = 2.1 Hz, 1H), 6.10 (dd, J = 4.1, 2.4 Hz, 1H), 4.25 (t, J = 7.5 Hz, 2H), 2.81 (q, J = 7.4 Hz, 2H), 2.15 (t, J = 7.5 Hz, 2H), 1.69 (p, J = 7.4 Hz, 2H), 1.61 (p, J = 7.4 Hz, 2H), 1.36–1.26 (overlap, 4H), 1.16 (t, J = 7.4 Hz, 3H).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241
The analysis was performed with the Azure CieloTM 3 Real-Time PCR System software (version 1.0.0.300.).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "was", "performed", ...
PMC10988555
Lipophilicity/hydrophilicity is among the most important physicochemical properties in biomedical applications, as it considerably influences its cytotoxicity/bioactivity, general toxicity, cell membrane/tissue permeability, availability to interact with drug targets, biodistribution, and excretion, as well as drug formulation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427
In the analysis cohort, plasma samples were collected from 176 participants, including 33 healthy subjects and 143 newly diagnosed MM patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC7757104
Total cellular RNA was isolated from the cells using TRIzol reagent (Invitrogen; Thermo Fisher Scientific, Inc.) according to the manufacturer's protocol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11612794
Similarly, interphase Mis12C localization at kinetochores via CENP-C may be important for timely KMN network assembly for the subsequent mitosis in cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar...
PMC11765988
The first mechanism involves exposure of the organs—mainly the lungs and skin—to the antigen, which is captured and bound to the HLA II molecules of APCs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267
Decreased motor performance of Alx3-ko mice relative to wild type animals as assessed by the rotarod test (n = 8 wild type and 7 Alx3-deficient mice).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467800
However, in K562 5%‐K562‐IR 95% group, the motility of K562 cells remained low and did not exhibit an increase over time (3 dpi‐7%; 5 dpi‐9%) (Figure 2B, Supplementary file Table S4).
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10705095
ROS arise during essential cellular processes such as mitochondrial respiration, inflammation, and immune responses .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROS", "arise", "during", "essential", "cellular", "pro...
PMC5810978
~10 MNC cells/well) with 1 mL medium with or without chemicals and immediately inoculated with 100 μL GIII.2 BoNoV filtrate (approx.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "~10", ...
PMC11283030
ACLY is transcriptionally regulated by sterol regulatory element-binding proteins 1c (SREBP1c) and peroxisome proliferator-activated receptor γ (PPARγ) , and ACLY protein is activated by AKT/mTORC1 signaling pathway .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The CD38 binding arm consists of bi-paratopic Fabs that strongly bind to CD38 in two different epitopes on tumor cells and do not functionally compete with daratumumab.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519
We hypothesize that these peptides interact with GLP-1R in a manner distinct from GLP-1, potentially providing unique opportunities for modulating receptor activity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11488203
Western blots were performed with 20 µg protein/lane of untreated control exosomes (control) and corresponding taxol-loaded exosomes (taxol) from different individual MSC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973
Within group-1 and group-2, six patients in PLASMA (18.2%) and 10 in CONTROL (28.6%) died.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "gr...
PMC11670954
These cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM)/F12 (C11330500BT, Gibco) supplemented with 10% FBS (F8318-500 ml, Sigma) and 50 U/mL penicillin‒streptomycin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874
EL.4 lymphoma cells were transfected with the plasmid pAc-neo-Ova to generate the cell line E.G7-Ova.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "EL.4", "lymphoma", "cells", "were", "transfected", ...
PMC9352806
With the MS/MS spectrum, lipid identification was achieved through a spectral match using LipidBlast library.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "MS/MS", "spectrum", ",", "lipid", ...
PMC8316344
A Endogenous TRIB2 protein expression level in Bel-7404 and SK-Hep1 cells, as measured by IB.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Endogenous", "TRIB2", "protein", "exp...
PMC11545737
N. meningitidis and non-pathogenic Neisseria spp.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "N.", "meningitidis", "and", "non-pathogenic", "Neisseria", "spp", "." ] } ]
PMC9784246
Our research also provides computational evidence that these flavan-3-ol derivatives may target PDK3 and HDAC6 in the suppression of lung malignancy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", ...
PMC11471176
The solution was stirred extensively and thereafter dispensed 50 μL of the resultant mixture into each of the designated wells of a 96-well microtiter plate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9479186
But most of the death are due to lack of effective antitumor therapy (19).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "most", "of", "the", "death", "are", "due"...
PMC11599565
Furthermore, we are not addressing the anatomical origin of ovarian carcinomas but rather the type of cell from which this tumor evolves.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further...
PMC11779605
A machine learning study of RNA expression profiles found prognostic significance of elevated FGF7 mRNA with worse ovarian cancer patient survival probability (28); however, to date, there are no reports of FGF7 protein prognostic significance in patients with cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704
Hydrogels can carry a variety of bioactive substances to promote wound repair, and PC capsules can precisely regulate inflammation and cell apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydroge...
PMC10565698
D. Tumor volume changes of nude mice in shNC and sh-circ groups were recorded every 7 days.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D.", "Tumor", "volume", "changes", "of", "n...
PMC11775197
In addition, PPARγ plays a pivotal role in combating oxidative stress.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "PPARγ", "plays", "a", "pivotal", "role", "in", "com...
PMC9429973
There was a lower rate of adverse outcomes in patients in the highest HbF range compared to patients in the lowest HbF range in 30 out of the 40 comparisons (10 were statistically significant, 13 were not significant, and 7 were not reported).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Pts recruitment, dosing regimen, response monitoring, and toxicity control were performed according to the MAP treatment plan.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "recruitment", ",", ...
PMC9581083
H. cordata essential oil inhibits activities of cyclooxygenase-2, an important inflammatory regulator (Shingnaisui et al., 2018), while H. cordata aqueous extracts reduce influenza symptoms and LPS-induced lung injury.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698
N. Changes in TCF12 protein following transfection of miR-NC, miR-211-5p, miR-211-5p + oe-NC, or miR-211-5p + oe-circ in HCCLM3 and BEL-7407 cells. *:
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11243198
GANT61 was one of first compounds shown to directly inhibit GLI1/2-mediated transcription and was subsequently shown to bind directly to GLI1 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GANT61", "was", "...
PMC11787355
Single-cell data were aligned with cellranger (7.0.0) and handled with Seurat (5.0.3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-cell", "data", "were", "aligned", "with", "cell...
PMC11697189
We detected the expression level of HSPA7 in several common ccRCC cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "detected", "the", "expression", "level", "of", "HSPA7", "in", "...
PMC11453018
I RT-qPCR analysis of EWS::FLI1, its target genes, senescence-related genes, and cell cycle genes in the xenografts from experiment “F”.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6133382
Alexa Fluor 488 conjugated anti-human IgG, anti-rabbit IgG, and anti-mouse IgG polyclonal antibodies were obtained from Invitrogen (Invitrogen, Thermo Fisher, Carlsbad, CA, US).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390
The reason for the strong PAR by rs570516915 is its large effect size.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reason", "for", "the", "strong", "PAR", "by", "rs570516915", "...
PMC11774747
The therapy has an orphan drug status in Europe.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "therapy", "has", "an", "orphan", "drug", "status", "in", "Europe", "." ] } ]
PMC11617590
Cells were cultured for 24 h at 37°C in an incubator supplied with 5% CO2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "for", "24...
PMC11144200
The means ± standard deviation (SD) were used to display all the data.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "means", "±", "standard", "deviation", "(", "SD", ...
PMC9429973
Methods: The clinical data of patients with DLBCL or other B-cell lymphomas who had received ≥3 lines of prior therapies and received glofitamab salvage therapy in a compassionate use program in Nov. 2020 - Dec. 2021 were retrospectively analyzed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175
Specificity for K11 chains is reported for Cezanne, while ovarian tumor deubiquitinase (OTUD2) specifically acts on K11, K27, and K33 chains 40-42.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066
Mean ± SD; each dot represents a single replication fork; n = 2, one-way ANOVA and post hoc Dunnett test.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", ...
PMC11696659
Fig. 3 Distribution of telomere lengths in patients with lung cancer (N = 106) and controls (N = 453).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", ...
PMC11541241
The B. cinerea genome contains a single orthologue of FKBP12, and BcFKBP12 could mediate rapamycin sensitivity in B. cinerea, indicating that BcFKBP12 ensures FKBP12 typical functions conserved in other species (Meléndez et al., 2009).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028
Kaplan-Meier analysis suggested patients with high NAT10 expression had worse OS (p < 0.001, log-rank test) and lung metastasis-free survival (LMFS) (p < 0.001, log-rank test) (Figure 1P).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699178
The commercial FGFR1 silencing lentivirus (sc-39840-V) was purchased from Santa Cruz Biotechnology (Shanghai) and titrated to 10 TU/mL. After 72 h of infection, the medium was replaced with a medium containing 4 μg/mL puromycin, and the cells were cultured for at least 14 days.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Antonio e Biagio e Cesare Arrigo, Alessandria; Oncology and Hematology, Presidio ospedaliero “A. Tortora”, Pagani; Hematology, Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l Oncologia, Parma; Hematology, Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l Oncologia, Genova; Hematology, AOU Ospedali Riuniti, Ancona; Chair of Hematology, Università degli Studi di Milano e Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milano; Oncology and Hematology, AO.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320834
We prepared topotecan- and olaparib-loaded liposomes (TLL and OLL) composed of EPCs and cholesterol for preliminary evaluation in a 2D model of patient-derived ovarian cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11769516
In turn, in another study by Jonsson et al. conducted on the same rat model, they analyzed the lowest toxic concentration of MON given by LOAEL of 3 mg/kg body weight.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030
About 2.0 × 10 cells were suspended in 200 μl serum-free medium and seeded into the upper chamber coated or uncoated with Matrigel (BD Biosciences, USA), and 500 μl complete culture media was added into the lower chamber.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018
Fig. 3P300/CBP inhibition and EWS::FLI1 knockdown yield comparable transcriptional changes in ES.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3P300/CBP", "inhibition", "and", "EWS::FLI1", "knockdown", "yield", "comparabl...
PMC9844987
To systematically test how predictive TF binding sites are of the variability of active promoters, we made use of binding sites predicted from motif scanning for 746 TFs (Fornes et al., 2020).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014
In this study, berberine attenuated the cytopathic effect (CPE) of IAV in infected MDCK cells and lowered viral protein neuraminidase (NA) activity with an IC50 of 0.025 g/L. Berberine significantly reduced mortality, increased mean survival time, and decreased viral titers in IAV-infected mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801
By contrast, the absence of SMARCB1 promotes KREMEN2 expression through the collaborative action of CBP and p300, leading to the inhibition of KREMEN1 via homodimerization.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467
After adding the enzyme, the samples were incubated at 42 °C for 2 h, followed by 15 min at 70 °C to inactivate the enzyme.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654
Points are scaled by the absolute mean difference in signal over the boundary relative to the mean of peripheral bins.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Points", "are", "scaled", ...
PMC11697065
B: PCA analysis of cell pools from RNA-Seq and TMT proteomics.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ":", "PCA", "analysis", "of", "cell", "pools", "from", "RNA-Seq", "and...
PMC11687167
PCSK9 expression in different cells is affected by JAK/STAT-related cytokines or kinases The PI3K/Akt signaling pathway is an intracellular signaling pathway involved in many biological processes, including cell metabolism, growth, survival, proliferation, and apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808
The 3D structure of TLR4 bound efficiently with SCU with the interacting amino acids being T232, E154, N156, D181, L180, H179 and L155.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983
Twenty-four hours after the treatment, cells were irradiated at 0, 2, 4, 6, 8, and 10 Gy using a Co-60 Nordion GammaCamber 4000A irradiator at a 1 Gy/min dose rate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094712
Previously, we selected the optimal conditions for the expression of recombinant human SELENOM, in the open frame of which selenocysteine (Sec) was replaced by cysteine (Cys).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553
The images of immunofluorescent staining of IA lesions for tPA (green), Plasminogen (red), and merged images with nuclear staining by DAPI (blue) are shown.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597
p < 0.05; , p < 0.01; , p < 0.001; , p < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ";", ",", "p", ...
PMC9504875
After two days, the supernatants were incubated with HEK-Blue IFN-α/β cells (InvivoGen, San Diego, CA, USA) overnight.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11721277
Then Na2S2O3∙5H2O (386 mg, 1.555 mmol) was added to the reaction mixture and the resulting mixture was stirred for 15 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10125312
In clinical applications, intravenous administration of nanoparticles is the standard route of administration, and it involves a systemic biodistribution of the nanoparticle load and uptake by off-target cell types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014
Figure 7 presents the molecular docking for EA, 2, and 3 in the human glutathione S-transferase P1-1 and caspase-3 pocket.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973
Median study follow-up was 12.5 mo; median age was 64 yrs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "study", "follow-up", "was", "12.5", "mo", ";", "median", "age", ...
PMC11770199
The flow cytometry results demonstrated that although the cell numbers did not show a clear change, the activity of NK cells and macrophages was increased in tumor, indicating that NK cells and macrophages enhanced the therapeutic effect of MSCs-p14.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
S. Duarte, A. Roque, D. Mota, J. Carda, C. Geraldes Clinical Hematology Department, University Hospital Center of Coimbra; Faculty of Medicine, University of Coimbra, Coimbra, Portugal Background: Multiple myeloma (MM) is an incurable disease and most patients (pts) will relapse during their lifetime.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965315
The cells were tested for viability using the MTT assay (#CAS No. 298‐93‐1) after 24 and 48 h of incubation at 37°C according to standard procedure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Methods: Two studies are in progress: (1) GBT021601-011: a phase 1, randomized, double-blind, placebo-controlled, parallel-group study of single ascending doses (SADs) and multiple ascending doses (MADs) of GBT021601 in healthy volunteers aged 18 to 55 years; and (2) GBT021601-012: a phase 1, single-arm, intrapatient, single-dose and MAD study in patients with SCD (homozygous HbS) aged 18 to 60 years.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610
The proliferation, migration and differentiation of KC is a precise regulation, problems in any links may lead to skin barrier dysfunction, causing various cutaneous diseases including AD and psoriasis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626
Treatment of RPMI-8226 cells with compound A increased the hydrolysis of Suc-LLVY-AMC and LLVY-R110 by >1.5-fold compared with vehicle-treated controls (Fig. 2A).
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC9429973
Image: Summary/Conclusion: In this cohort of neonatally screened patients with SCD, the SCD-related mortality and morbidity is still impressive with 1% mortality, 7 severe infections, and 2 patients with a CVA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350
CD8-LVs carry at their surface the measles virus fusion protein (F) and the receptor binding H protein fused to a DARPin, specific for mouse CD8.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266
Lower panel: Calibration curve derived from known quantities of purified rCRT, fitted to a linear function.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", "panel", ":", "Calibration", "...
PMC11277157
In our experiments, EIF2AK2 was already overexpressed (four-fold) by the siRNA of the RULC, which is likely to mediate the observed antiviral-like response.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734
The most productive cultures were selected by ELISA among the clonal cultures that retained viability upon suspension cultivation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "productive", "cultures", ...
PMC11607638
The mammalian peptide cholecystokinin (CCK) was also able to be activate the mosquito sulfakinin receptor (SKR) dose dependently, but probably less efficiently than the mosquito peptide SK2 (Figure 6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808
Richert et al reported that activation of TLR4 prevents the occurrence of OS metastasis according to the GSE33382 dataset, indicating the negative role of TLR4 on OS progression,23 whereas Wang et al found that knockdown of TLR4 expression inhibits migration and invasion of MG63 and Saos-2 OS cells, suggesting the positive role of TLR4 on OS oncogenesis.24 In line with the findings of this study, our data showed that TLR4 overexpression promotes OS growth in vivo and in vitro (Figures 5 and 6), thus TLR4 is an appealing target for OS therapy, but additional studies need to be carried out to fully elucidate the advantages and side effects of anti-TLR4-based strategies in OS therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11363012
Although this could not be quantified accurately due to the scarcity of the authentic standard, we could definitively determine that this alkaloid colocalized with catharanthine (6) (Figure S11), providing further support for the observation that alkaloids accumulate in specialized cell types in roots analogous to leaves.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8751435
Chemical constituents such as betaine, trehalose, nicotinic acid, adenosine, and cordycepin had the cytotoxic effect toward cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemical", "constituent...
PMC11704834
The migratory ability of cells was quantified with the use of a Boyden chamber cell migration assay as previously described (8).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "migra...
PMC9693627
After electrophoresis, either in-gel respiratory complex activities were measured, or Western blot analysis was performed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "electrophoresis", ",", "either", "in-gel...
PMC11795610
The effect of myricetin on the TRPV4 expression during the differentiation. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "myricetin", "on", "the", "TRPV4", "expression", "during",...