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OTAR3088
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PMC11534377
The histological examination of the IR treated tissue reveals disorganized proliferation of malignant lung cancer cells, characterized by hyperchromatic and polymorphic nuclei, an increased number of mitoses, and the presence of scattered intratumoral lymphocytes, indicative of an immune response to the radiation induced cellular damage.
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PMC9587298
6Effect of methylglyoxal (MGO) and elderberry extracts using cell-models: Dose-dependent effect of exposure to MGO, for 24 h and 48 h, on Caco-2 cell viability (a1) and HepG2 cell viability (a3) and cell morphology recorded after 48 h of exposure to MGO (a2 and a4, Caco-2 and HepG2 cells, respectively), photos captured using an ocular camera (ODC-89 camera, Kern & Sohn) coupled to a microscope (amplification 100x). (
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PMC11594806
Studies indicate that high CD73 expression correlates with poor prognosis in advanced colorectal, pancreatic, and non-small-cell lung cancers.
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PMC4695073
C. Average IC50 values of cisplatin.
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PMC11541409
Pimitespib inhibits HSP90 by competitively blocking HSP90 enzymatic activity and disrupts the formation of the correct conformation of nascent KIT protein.
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PMC9559528
Syphilis is a highly infectious sexually transmitted infection (STI) with a multitude of presentations.
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PMC11075223
Cimicifugamide enhanced myocardial contractility and relieved heart failure symptoms through activated β-ARs in the toad heart failure model.
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PMC10033453
Edge wells were loaded with media only to avoid edge effects.
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PMC8193813
At the St. Charles location, the UAS pilot was approximately 100m from the center point of the two stacks, easily allowing for line-of-sight operation.
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PMC9429973
A role of ICM in relapse mechanisms was suggested by CTLA-4/PD-1 expression on her T-cells and CD86 expression on AML blasts.
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PMC11483468
Telomeres are located at the ends of linear chromosomes in eukaryotic cells and consist of a series of simple tandem and repeated 5'-TTAGGG-3' nucleotide sequences and related proteins, which play a role in stabilizing chromosomes (1).
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PMC5874706
The investigation of drug formulations remains a key point in the use of bioactive molecules, especially for indenoindoles used as CK2 inhibitors.
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PMC8973085
Yellow solid [A] (86%); [B] (73%); mp: 165–168 °C (EtOH); IR (KBr, v, cm): 3465–3314 (NH2), 3280 (NH), 1721 (C=O), 1656 (C=O); H NMR (DMSO-d6): δ 2.51 (s, 3H, CH3), 3.66 (s, 3H, OCH3), 3.68 (s, 3H, OCH3), 7.03–7.79 (m, 14H, 12CH-Ar + NH2), 10.39 (bs, 1H, NH); C NMR (DMSO-d6): δ 23.21, 56.03, 56.70, 103.49, 113.75, 115.82, 115.95, 117.12, 120.16, 121.76, 121.81, 122.44, 127.76, 129.03, 131.10, 131.74, 141.16, 142.11, 150.43, 151.00, 153.31, 157.47, 158.17, 161.14, 164.93, 189.46; MS m/z (%): 541 [M] (90).
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PMC9164404
As shown in Fig. 3B, Abplatin were evenly distributed in the whole body at 3 h. Then, Abplatin began to accumulate at the tumor site at 6 h, indicating their excellent tumor-targeting ability.
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PMC11531735
The blood brain barrier restricts the delivery of systemically administered TKIs to brain metastatic sites, limiting their bioavailability within the brain.
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PMC11488203
The cells were cultured in αMEM (Sigma Chemie GmbH, Taufkirchen, Germany) supplemented with 10% of allogeneic human AB-serum (Pan Biotech GmbH, Aidenbach, Germany), 100U/ml penicillin, 100 µg/ml streptomycin and 2 mM L-glutamine (Sigma).
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PMC10968586
A similar S phase cell cycle arrest was also observed for 800 μM HT, and induction of apoptosis also took place after 24 h incubation of HT-29 cells with 600 μM and 800 μM HT .
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PMC11126803
Activation of LncRNA-SERB/ESR2/ZEB1 signaling axis will directly lead to promoting VM formation in the tumor, and ultimately enhance the invasiveness and distant metastasis of RCC.
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PMC11767725
Biofilms are known to foster a chronic inflammatory environment by promoting the persistence of pathogenic C. acnes strains, making their disruption a key target for acne therapy.
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PMC11634027
We also note that as motifs that our molecular studies indicate should be crucial for PCP, i.e. interaction with Dachs and Sple, are embedded within a region that is also crucial for regulation of Ds membrane levels, we could not fully separate potential PCP activities downstream of Ds from regulation of PCP via Fat.
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PMC10698968
Scale bar = 100 µm.
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PMC11653168
To compare differences between the treatment and control groups, statistical significance was assessed using one-way ANOVA followed by Tukey's multiple comparisons test.
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PMC8524093
In addition, C57BL/6 μMT mice were unable to control CHIKV infection (Hawman et al., 2016).
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PMC11247842
The number of bulls and cows submitted by each study participant ranged from 134 to 55,547 individuals by trait and breed group (see Additional file 1: Table S2).
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PMC11754094
We also confirmed that POLQ overexpression conversely increased large-deletion frequencies in POLQ KO cell line (Extended Data Fig. 5b).
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PMC10178190
After 24 h, cells were treated with 5 μM RJY13 and incubated for an additional 24 h, following collection of cells by trypsinization.
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PMC11741906
Our findings suggest that hsa-miR-133b, hsa-miR-512-5p, hsa-miR-200b-3p, and hsa-miR-451a are good candidates for future studies aimed to establishing functional links and exploring therapeutic interventions to overcome cisplatin resistance.
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PMC11496728
The results indicated that the mRNA transcription level of the abovementioned three monoclonal cells was about 10 times lower than that in CHO-WT cells, which further confirmed that Apaf1 was successfully knocked out in CHO cells.
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PMC11655498
EBV miR-BHRF1-3 targets the 3′UTR region of BZLF1 gene and attenuates Zta expression (Fachko et al., 2022).
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PMC9429973
Data on subsequent treatment and survival are being collected in the ancillary study GIMEMA LAL2217.
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PMC11585565
Our study provides valuable insights into the interplay between genetic variations, molecular stability, and functional consequences in the context of CNNM4-related disorders, highlighting the importance of CNNM4-mediated Mg²⁺ transport in Jalili syndrome.
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PMC11621493
Experimental procedures were approved by the Ethics committee of the University of Graz, and the Austrian Federal Ministry of Education, Science and Research (protocol number 2023-0.288.364) and were conducted in accordance with the council of Europe Convention (ETS 123).
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PMC10882807
Cell Counting kit-8 (CCK-8) and colony formation assays were performed to detect cell proliferation.
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PMC11657744
Time-dependent deciliation upon serum stimulation.
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PMC11126803
and screened out candidates that may affect their downstream ERβ/ESR2.
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PMC11754291
Human cells were procured from healthy skin samples removed during surgical procedures.
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PMC11301242
The WGS data of 30 samples harboring circular amplicons was used to analyzing chromothripsis events.
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PMC11638255
Neutrophil RNA was extracted in TRI Reagent (Invitrogen, USA; #AM9738) according to manufacturer’s instructions.
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PMC11656657
In particular, data are shown at Day 0 (scattered bar histogram), referring to CAR + T cell percentage before co-culture with tumor cells, and at Day + 5 (white bars), Day + 10 (light grey bars), Day + 15 (dark grey bars) and Day + 20 (black bars) after tumor addiction.
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PMC9429973
Of patients with ≥10% SVR at week 24, 4/6 with low PC and 9/13 with higher PC were on all daily dosing regimens.
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PMC11188874
A total of 1 mL MHC-I elution buffer was added to the pelleted resin and incubated for 5 minutes at 37°C.
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PMC11307990
Cell Counting Kit-8 was purchased from Glpbio (USA).
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PMC4360730
A selected subset of ontology terms is commonly referred to as a slim.
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PMC11457557
The impact of these small risk variants is uncertain on the development and progression of DKD, as it could be induced by the cumulative or synergistic impact of many variations with small risks.
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PMC10165258
The color of each square represents the averaged viability in the corresponding concentration range.
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PMC8592717
A part of the glucuronide conjugates of PAL and PCA excreted into the bile might be converted again to PAL and PCA and reabsorbed in the intestine (Figure 2) .
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PMC10818573
Five pairs of primers were designed, #1, #2, #3, #4, and #5, and 1 μL of B95-8 cell template DNA (50 ng/μL) was added to each group for PCR amplification; ddH2O was used as a blank control.
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PMC11751675
Grosheimol contains two exo-olefins while cynaropicrin contains four exo-olefins as shown in Fig. 3.
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PMC8633974
TatDE LNPs colocalized with Rab5 (Figure 6a) and Rab7 (Figure 6b) but not Lamp1 (Figure 6c).
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PMC10840195
Many researches shows that Wnt integrates with other signalling pathways to promote the occurrence and development of EMT.
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PMC8469018
A sample volume of 10 µL was injected onto the column.
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PMC7868205
The unassigned peaks could be correlated to the existence of phytoconstituents41–44 (Figure 2).
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PMC11597291
The released PCT was almost 90% at 48 h for the nCGO-PEG(10 kDa) particles, while the low MW nCGO-PEG(2 kDa) had a release near 60%.
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PMC11730311
Schild plot of hαCGRP8-37A36S and (d) Schild plot of hαCGRP8-37A36S, N25K-C20DA-γGlu.
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PMC9429973
The slides were digitally scanned and the number of positive cells was counted in five areas with the highest density of CD8(+) cells, a well validated antineoplastic population.
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PMC9429973
All DLs were reached (DL0=1, DL1=1, DL2=4, DL3=7, DL4=2), with no dose-limiting toxicities.
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PMC11787651
This exemplary showcase makes the argument that it would be a great improvement to the current mass spectrometric approaches for histone PTM analysis.
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PMC11576293
For C21H21N2O2S (M + H) 365.13183; found 365.13191.
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PMC11401358
Thus, (GAGSGA)2 and GAGVGAGY were dissolved in 5 mM phosphoric acid buffer solution (named (GAGSGA)2-8 h and GAGVGAGY-8 h) to shake for 8 h, and the controls were (GAGSGA)2 and GAGVGAGY dissolved in deionized water (named (GAGSGA)2-0 h and GAGVGAGY-0 h) under quiescent conditions.
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PMC7171147
ES2 scrambled or receptor knockdown cells were cultured in COL11A1-coated plates for 72 h. The mRNA expression was normalized to RPL32.
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PMC7057940
By contrast, the presence of the translocation t(1;16)(q21;p13) was not detected in the samples of patient 2.
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PMC11462673
The cell cycle was analyzed using Beckman Gallios™ flow cytometry (Beckman, Krefeld, Germany).
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PMC11576293
2H, Ar-H, J = 2.1 and 8.9 Hz), 6.98 (d., 1H, Ar-H, J = 8.4 Hz), 3.99(2 overlap singlets, 6H, 2 OCH3), 3.28 (apparent q., 2H, SCH2CH2CH3, J = 7.2 Hz), 1.91 (m., 2H, SCH2CH2CH3), 1.35 (t., 3H, SCH2CH2CH3, J = 7.2 Hz); C NMR (75 MHz, CDCl3) δ (ppm) = 172.5, 164.3, 163.2, 151.7, 149.3, 137, 135.5, 129.4, 129.1, 128.5, 120.4, 110.9, 110, 106.9, 56, 33.1, 22.9, 13.7; HRMS (ESI+) calcd.
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PMC10114490
Wild-type (wt) human dermal fibroblasts (HDF) were purchased from ATCC® (CRL-2429).
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PMC11332076
In their study, insulin was administered by daily intraperitoneal injections or eye drops for four days.
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PMC6450504
The lower release from liposomes at pH 7.4 suggests that the bPEI-coated liposomes are not ‘leaky,’ meaning that they retain their therapeutic cargo while in the circulation.
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PMC10955424
Jacob Gopas: Writing – review & editing, Resources, Project administration, Conceptualization.
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PMC11489175
The USP family includes 58 members and is the largest one.
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PMC10996034
A Q value of <0.05 was considered to indicate significant enrichment.
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PMC11529598
p < 0.05.
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PMC11545737
The inflammation caused by these bacteria is associated with periodontitis and epithelial disruption is the first step of the pathology .
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PMC9429973
Summary/Conclusion: The JAK1/JAK2 inhibitor Ruxolitinib decreases functional and proliferative capacities of NK cells from healthy donor, inhibiting their GvL effect in vitro.
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PMC9429973
Pts with IR-MDS were 63% male and similar in number by score and median age at diagnosis compared with the total study population: 3.5 (n=268, 73 y), 4.0 (n=270, 75 y) and 4.5 (n=223, 75 y).
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PMC10969097
The clone formation assay showed that the number of clones in the combined treatment group was significantly lower than that in the group treated with oxaliplatin alone, indicating greater inhibition of cell proliferation in the group receiving the combined treatment compared to the oxaliplatin-alone group.
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PMC11116779
Fluorescent intensity correlates with β-gal levels present in the sample.
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PMC11626627
This will contribute to a more comprehensive understanding of the role of ERβ and TWIST1 in ccRCC.
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PMC9429973
Though the primary endpoint--PFS has not been reached in all treatment groups, dual MT improves response most and is quite tolerable.
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PMC11531735
HER receptors comprise extracellular ligand-binding, transmembrane, and intracellular tyrosine kinase domains.
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PMC11453295
Disclosure: C.A. Ufondu: None.
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PMC10243817
We found a significant reduction in COL1A1, COL4A1, COL4A2, and COL5A1 gene mRNA expression in epithelial cells from patients with CRSwNP as compared with epithelial cells from controls, with a more profound reduction in eosinophilic CRSwNP than in noneosinophilic CRSwNP (Figure 8, A–D).
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PMC9429973
Preliminary data using the NIK selective inhibitor ‘CW15337’ shows CLL cell migration to be inhibited with an IC50 of <1μM. Summary/Conclusion: CLL patient plasma contains high levels of TLR9 ligand (unmethylated DNA), which may promote CLL cell trafficking and BTKi resistance in select subgroups.
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PMC10747139
A comprehensive survey of the anti-COVID-19 options available using metal complexes has been recently reported by Gopal et al. (2023) .
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PMC11772449
After all the nude mice were sacrificed, the transplanted tumor tissue was separated and weighed and photographed.
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PMC10812665
Samples were shipped on dry ice for analysis by Metabolon (Research Triangle Park, NC, USA).
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PMC5810978
From microscopic analysis, an optimal concentration (highest non-toxic concentration) was determined qualitatively.
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PMC9368503
These limitations can be overcome by the establishment of matched PDX-derived cell lines which retain many of the genomic features of the PDX tumours, are easier to grow and manipulate in culture, and are amenable to high-throughput screens .
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PMC11461833
Through bioinformatics analysis, we found that STXBP5 affects ageing-related signalling pathways such as the mitogen-activated protein kinase (MAPK) pathway, the hippo pathway and the interleukin 17 (IL17) signalling pathway in progerin-expressing cells.
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PMC11682525
hHFSCs were isolated from human hair follicles, characterized, and subjected to hypoxia for up to 72 hours.
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PMC11320084
In PTC cells, TNNT1 promoted migration, invasion and EMT process.
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PMC10887351
Furthermore, the β-AR expression in pediatric OS tumors and in neural macrophages has been evaluated, observing that only the β2- and β3-ARs were expressed in the neural macrophages of a syngeneic OS murine model .
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PMC10887351
An important challenge for the investigation of metastatic and localized diseases includes the identification of markers that can detect recurrences and metastasis in cancer.
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PMC9429973
Results: 80 pts were randomized (mitapivat N=40; PBO N=40).
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PMC11612315
d Schematic illustration of cell-attached patch recordings.
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PMC11786767
C: The distribution of numbers of intersections.
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PMC9429973
D. Nikolova, A. Yordanov, V. Damyanova, A. Radinov Department of medical genetics, Medical University - Sofia; Laboratory of Genetics; Department of Clinical hematology, University Hospital “St.Ivan Rilski”, Sofia, Bulgaria Background: Thrombotic incidents are the major cause of death for patients with Philadelphia negative myeloproliferative neoplasms (MPNs).
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PMC10253973
RM175 (22) (Figure 6) inhibited cellular translocation (haptotaxis) in the normal breast epithelial cell line (HBL100) and breast adenocarcinoma cells (MDA-MB-231).
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PMC11269792
Representative image of tumors, (B) Tumor volume, (C) Tumor weight, (D) IHC image of HK2, PKM2, and Ki-67 proteins in tumors, (E) Western blot detection of tumor CDV3 expression, (F) HE images of tumor liver metastases; data are expressed as mean ± SD (n = 6). *
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PMC7504302
Their study successfully demonstrated that the compound inactivation of PTEN and TP53 genes in mouse mesothelium, by intrathoracic injection of Adeno-Cre, could synergistically drive highly penetrant, rapid, and aggressive tumors, even in the absence of exposure to asbestos.
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PMC9429973
Although daratumumab plus pomalidomide and dexamethasone (DPd), and bortezomib and dexamethasone (DVd) are approved for RRMM, further disease control is still needed.
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PMC11680049
All of this is reflected in the abundant localization of secondary metabolites, the biosynthesis of which is linked to carbohydrate metabolism products.
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