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OTAR3088
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BioData-CellLine_annotated

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PMC9250505
Formalin-fixed, paraffin-embedded (FFPE) tissues were accessed from HKU-SZH.
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PMC7369657
Mitochondria are the main source of ROS production and excess ROS induce apoptosis by destroying the MMP.
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PMC11806182
C Leave-one-out sensitivity analysis for PCOS.
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PMC11745823
Transwell migration assays indicate that RIT1 knockdown inhibited cell migration, n = 5.
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PMC11763111
C CFSE assay exhibited the proliferation of CAR-T/PCDH-T cells in unstimulated and antigen-stimulated condition for 72 h. The right diagram shows the level of CAR-T proliferation in response to antigenic stimulation (n = 4).
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PMC9429973
Aims: In this work, we evaluated a cohort of intensively treated adults with non-promyelocytic AML in order to assess the thrombosis rate and baseline factors that might be associated with this event.
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PMC4369959
In animal model, ginger suppresses ethionine-induced liver carcinogenesis by scavenging the free radical formation and by reducing lipid peroxidation.
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PMC11064533
Adhesion and (B) motility assays. (
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PMC6160470
A2780/Adr cells treated with verapamil, DAC-2Amide, DAC-3Amide, cyclosporine A and PSC-833. (
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PMC11486946
To achieve a highly accurate screening, MSDΔt was determined for every plate with the time duration (Δt) that provides the highest Z’-factor.
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PMC11661040
Fig. 3Overexpression of CGREF1 facilitates cell cycle progression and enhances cellular proliferation in osteosarcoma. (
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PMC11534035
Although the role of SERPINE1/PAI1 is not undisputed, it has been found to be oncogenic in breast, gastric, ovarian and lung cancer and may serve as a prognostic factor (17,18).
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PMC11594588
However, their serious limitation is the phenomenon of resistance.
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PMC7685376
In conclusion, this study demonstrated alterations in expression after Huaier treatment in HCC cells.
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PMC10958426
Tissue obtained immediately after tumor resection was used to prepare cell suspension.
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PMC11512230
The virions of plant viruses and their structurally modified particles (SP) represent valuable platforms for recombinant vaccine epitopes and antitumor agents.
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PMC6379402
For each cell type and for each gene, bars represent the average of the relative changes of cell viability over the triplicate experiments, and the error-bars show the corresponding standard deviations.
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PMC9429973
Additional symptoms, functioning, and GHS/QoL were assessed with the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30).
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PMC11643491
PLGA microparticles were prepared using a microfluidic device as previously described (Micronit Microtechnologies, Enschede, The Netherland) .
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PMC11740207
Collaborative efforts integrating advanced sequencing technologies, SC biology, and oncology are essential to translate these findings into clinical applications that benefit patients with regenerative needs and malignancies.
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PMC11453018
A β-Gal and H&E staining in SKES1 cells at 24 and 72 hours of treatments with iP300w.
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PMC11541409
Additionally, the reversibility of binding exhibited by most currently approved TKIs contributes to the persistence of GIST cells.
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PMC11088135
These results imply that lncRNA NUTM2A-AS1 and miR-376a-3p may be potential targets for glioma, providing a new strategy for the treatment of glioma.
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PMC4443654
Analogously to the TAD boundary analysis, we then sought significant enrichments or depletions in 36 chromatin features over these compartment boundaries (Figure 6, Additional file 1: Figure S13).
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PMC9927933
Induction of apoptosis was confirmed by the cleavage of poly(ADP-ribose) polymerase (PARP) and caspase-3 (Figure 1K).
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PMC11779605
While our study provides proof-of-principal that our approach can identify candidate drug target and predictive biomarkers, the other differentially expressed genes could also be evaluated one-by-one or using a bioinformatic approach.
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PMC11406030
Following incubation, 10 μL of the MTT solution was added to each well and incubated for 2 h, followed by the addition of 100 μL of the detergent solution to each well and incubation for an additional 2–4 h. Absorbance was measured at 570 nm.
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PMC9429973
Almost all the cases were previously diagnosedand were either on follow up with a pediatric unit and got their service transferred to our unit or came with ableeding emergency or for preoperative assessment.
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PMC11413393
d Normalized gene counts (DESeq2’s median of ratios normalization) for mitotic checkpoint protein BUB1B and centromere proteins CENPA and CENPI in RCC243 and 786-0 cells following 5μM MS023 treatment for 3 days (left, n = 2 technical replicates per cell line), and for RCC243 and 786-0 cells expressing PRMT1 targeting shRNAs treated with or without 1.0 μg/mL Dox for 4 days (right, n = 3 technical replicates per cell line).
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PMC11377827
Figure 5USP43 regulates HIF-1α nuclear accumulation.(A, B) Confocal immunofluorescence microscopy of USP43 overexpressing HeLa cells stained for USP43 (488 nm) and HIF-1α (647 nm).
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PMC11791203
Fig. 7(A) Three dimensional docking interaction images of 1,2-benzenedicarboxylic acid, Cyclododecanol, 2,4-Ditert-Butylphenol and Sulfurous acid, hexyl octyl ester onto Caspase 9. (
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PMC10522430
This suggests that GACP holds potential as an anticancer agent, particularly in triggering late apoptosis.
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PMC11803918
Similarly, after hybrid exosome treatment without light irradiation, the apoptosis results also showed dose-dependent cytotoxicity toward tumor cells and high biocompatibility toward normal cells (Figure 4C,D).
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PMC11321678
Genes (23 274) were paired to 870 motifs and 20248380 pairs of correlation were calculated in the total.
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PMC11803149
FMO for analysis of CD62L and CD44 expression is shown in Supplementary Figure S1C . (
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PMC5854676
The same type of experimental study was reported in previously published research.
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PMC9429973
Possible impact of ICM profiles on clinical outcome in a particular casePT1 suffered from early relapse both after 1 and 2 SCT from her healthy father.
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PMC11604768
We also noted the degree of induction of THRB-1 and Mafb TRE activity was dependent upon the paired minimal promoter (Supplementary Fig. 4D).
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PMC11711871
Patients with hypertension exhibit low plasma levels of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) and show an inverse association between plasma PUFA content and blood pressure .
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PMC11656657
Culture media of 143B, U-2OS, MG-63, HOS, SAOS, RD cell lines were comparatively analyzed at 72 h from cell plating (Fig. 5D), while plasma derived from orthotopic mouse models was collected when tumor bioluminescent signal reach 10E6 p/s/cm/sr (Fig. 5E).
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PMC8609870
a Showed that the top 10 enriched GO pathways of DEGs were sorted by significance in biological process (BP), cellular component (CC) and molecular function (MF), respectively.
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PMC11670407
Following injection, PBS and Cisplatin at a dosage of 3 mg/kg were administered via the intraperitoneal route, commencing from day 4 onwards, with subsequent administrations being repeated at an interval of three days.
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PMC11693599
The CM of sphere-forming CSCs isolated from ovarian cancer cell lines (A2780 and SKOV3) had higher levels of CD109 than those isolated from their adherent cultured parental cells.
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PMC10040136
These cells all expressed MSC-associated markers CD73, CD90, and CD105 and did not expressCD45 (Fig. 2C).
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PMC11763111
CD38 and CD38-LLT1 CAR were cloned into a PCDH lentiviral vector driven by the EF1a promoter.
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PMC11204465
In 1964, the structure of AFB1 (73) was elucidated .
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PMC9429973
If five or more pts in stage I (13 pts) achieved ORR, the study would enroll 34 additional pts in stage II (47 pts).Secondary endpoints included safety, and survival outcomes.
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PMC8164677
The aim of this study was to investigate if wedelolactone could perform better in resistant ovarian cancer cells when used in combination with cisplatin.
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PMC11705862
at 37 °C with HEPES-buffered saline (HBS) (0,44 mM KH2PO4, 1,2 mM MgCl2, 2 mM CaCl2, 4,2 mM NaHCO3, 20 mM HEPES, 137 mM NaCl, 5 mM KCl, 5 mM glucose, 0.2 mM pargyline, 0.2 mM ascorbic acid, pH 7,4).
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PMC11672142
Scanning electron microscopy-energy-dispersive spectroscopy (SEM-EDS) data confirm the presence of Fe, C, N, O, and S atoms in the compound (Figure S12).
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PMC11740573
The results of the present study indicated that calcitriol treatment either pre- or post-bacterial exposure of vaginal A431 epithelial cells significantly reduces the secretion of these two cytokines.
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PMC5941560
Problems were first noticed in the form of gene expression defects.
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PMC9812014
In a pharmacological context, this can be the drug concentration required to provide half of the maximum feasible effect.
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PMC9429973
Therefor healthy fresh washed platelets were incubated with patient or HC serum, stained with erythrina cristagalli lectin (ECL) and ricinus communis agglutinin (RCA) and analyzed via flow cytometry.
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PMC11802855
B The cell subpopulation profiles of bone marrow samples from three patients with NDMM.
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PMC11429241
Conventional 3D-printing wisdom would dictate that such overhangs would require additional support when printing in liquid resin.
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PMC9429973
Results: A total of 71 patients whose median age of diagnosis was 40 (IQR: 29-55) and median follow-up time was 11,4 months (minimum 0,33, maximum 243,67 months) were included in our study.
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PMC9429973
They were all diagnosed with ALL, 79.5% had B-ALL, and 20.5% had T-ALL.
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PMC11471157
In the absence of DFP, the spheroids observed on Day 1 were small for HaCaT, NIH/3T3 and CAF cells.
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PMC11680982
Optical density (OD) was measured at 450 nm on a microplate reader (Bio-Rad Model550, CA) after a 2-hour incubation.
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PMC10582828
In vitro genetic recombination is a process by which chimera of two or more virus strains from the same virus family are created through co- cultivation.
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PMC8750422
Additionally, treatment with PF-04691502 significantly reduced intracellular NO production in A549 cells (Figure 4d).
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PMC11585254
Data represent the mean ± S.D. from three independent experiments.
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PMC9429973
Median age was 69 (range 50-87) years for MCL pts.
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PMC11762280
Our results suggest that all of the above proteins are involved in the assembly of PANoptosome in UVB-irradiated mouse keratinocytes, but which molecules are essential in this process remain to be further elucidated by protein interaction analysis.
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PMC11655498
Secondly, TERT activates the NOTCH promoter in a dose-dependent manner (Giunco et al., 2015).
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PMC8557138
3D models employing all these heterogenous cell types would better simulate the autocrine, paracrine, and juxtacrine signaling pathways regulating tumor angiogenesis.
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PMC11401358
Overall, our results demonstrated that β-sheet structures play the same role in SF antioxidant activity (Fig. 5K).Fig.
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PMC8592717
After absorption, they pass into the bloodstream and are then distributed to the organs, including the brain, to exert their pharmacological and biological effects (Figure 2) .
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PMC9693627
Mitochondrial translation products were labeled as described in .
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PMC9545474
Coordination of four water‐soluble phosphines (1,3,5‐triaza‐7‐phosphaadamantane (PTA), 3,7‐diacetyl‐1,3,7‐triaza‐5‐phosphabicyclo[3.3.1]nonane (DAPTA), triphenylphosphine‐3,3′,3′′‐trisulfonic acid trisodium salt (TPPTS), and bis(3‐sulfonatophenyl)(4‐trifluoromethylphenyl)phosphine disodium dihydrate (p‐DANPHOS)) are achieved to form complexes (η‐p‐cymene)(PTA)Ru(Mnt) (4), (η‐p‐cymene)(DAPTA)Ru(Mnt) (5), (η‐p‐cymene)(TPPTS)Ru(Mnt) (6), (η‐p‐cymene)(p‐DANPHOS)Ru(Mnt) (7), respectively (Figure 2).
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PMC11767817
Compound 2a-B led to phosphatidylserine translocation, increased caspase 3/7 activity, and decreased mitochondrial membrane potential, suggesting a mitochondrial apoptosis pathway.
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PMC11789597
Kaplan–Meier curve showing mice survival.
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PMC11699042
To confirm the extensive homogeneity in drug response of the fusion-driven EwS cells as compared to carcinoma cell lines, we additionally performed a Spearman’s correlation test among each cell line’s strains and once again observed that EwS strains showed a higher similarity than carcinoma cell lines (X̃Spearman’s ρ A-673 = 0.94, 0.95 < X̃ < 0.93; X̃Spearman’s ρ HeLa = 0.87, 0.91 < X̃ < 0.83; X̃Spearman’s ρ MCF-7 = 0.88, 0.92 < X̃ < 0.85) (Fig. 1j).
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PMC8427838
Moesin plays critical roles in TMIGD1-dependent acetylation of α-tubulin, mitotic spindle organization and cell migration.
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PMC10808409
The optimized formula was prepared and characterized in terms of EE% and particle size, in order to calculate the % prediction error.
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PMC9429973
Image: Summary/Conclusion: In the real-world setting, glofitamab remains an effective salvage treatment for patients with heavily pretreated relapse/refractory DLBCL and B-cell lymphomas.
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PMC6617630
cDNA was synthesized using total RNA with SuperScript III First-Strand Synthesis SuperMix (Invitrogen, Grand Island, NY, USA) according to the manufacturer’s instructions.
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PMC11367146
In addition, daucosterol demonstrates antioxidant, anti-apoptotic, neuroprotective, anti-diabetic, and immunomodulatory properties [, , ].Fig.
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PMC9712534
Representative images of FRAP analysis of EGFP-TOP2B H58Y.
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PMC11240448
When the data dimensionality is comparable with the number of observations, then KNN or SVM with different non-linear kernels show the most accurate results.
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PMC11742231
An adaptive fusion module that concatenates drug representations with cancer cell line and fingerprint embeddings (obtained via convolutional and fully connected layers with ReLU activations), applies a gating mechanism using a Sigmoid function to adaptively weight features and incorporates an attention mechanism followed by a fully connected layer to produce the final output.
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PMC9429973
Median age was 63 years.
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PMC11279397
Peppermint essential oil (PEO), containing menthol as its primary component, exhibited anti-inflammatory , antibacterial , antiviral , and antioxidant properties .
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PMC10667689
Cell culture supernatant was collected from the Ctrl, PMA, and Gal-9 groups of each cell line and lyophilized by freeze dryer (DorsaTech, Iran) for 24 h. Ultrasonication for 90 minutes after adding 3 ml of N-hexane (Pars Chemie, Iran) to each sample helped the dissolving of lipids in hexane.
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PMC8916024
Geobacter is an important Fe-reducing dissimilating bacterium, which has a significant impact on the community structure of iron-reducing dissimilating microorganisms in paddy field soil (Chen et al., 2019).
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PMC11700523
MR activation and IS accumulation in the 5/6 nephrectomy rat model First, a 5/6 nephrectomy (5/6 Nx) model was created to see if increased IS and MR activation could be observed in the CKD model.
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PMC8469018
The cell cycle phases at the single cell level were measured through the image analysis system NC-3000, using NC-3000 Two-step Cell Cycle Analysis Protocol (Denmark, Chemometec).
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PMC10213179
Interestingly, the affinity for these EphA2 aptamers, A40s and EA-3, does not reach the affinity reached by the ATOP aptamer.
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PMC6160470
Normalized median fluorescence intensity (MFI) upon treatment with compounds at concentrations as depicted.
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PMC11477621
Cell extracts were probed with antibodies Ac-Tubulin (#5335T, CST, Kansas City, MO, USA), α-Tubulin (#2144S, CST, Kansas City, MO, USA), AcH3 (#ab39139, active motif, Carlsbad, CA, USA), Histone H3 (#17168-1-AP, Proteintech, Chicago, IL, USA), GAPDH (#60004-1-1g, Proteintech, Chicago, IL, USA), Goat Anti-Mouse IgG, H&L Chain Specific Peroxidase Conjugate (#401215, Calbiochem, Darmstadt, Germany), Goat Anti-Rabbit IgG, or H&L Chain Specific Peroxidase Conjugate (#401353, Calbiochem, Germany), then detected using Bio-RAD power pal Basic (#041BR66615, BioRad Laboratories, Hercules, CA, USA), Bio-RAD Mini-PROTEAN Tetrade System (#IEC/EN 61010-1, BioRad Laboratories, Hercules, CA, USA), or Bio-RAD Chemi Touch Imagin (BioRad Laboratories, Hercules, CA, USA).
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PMC9429973
S. Renders, A.-M. Leppä, A. Waclawiczek, C. Reyneri, M. Janssen, E. Donato, J. Unglaub, C. Pabst, R. Schlenk, M. Hundemer, S. Raffel, T. Sauer, C. Müller-Tidow, A. Trumpp DKFZ/ Hi-Stem; Department of Hematology, University Hospital Heidelberg, Heidelberg; MVZ Hämatologische Diagnostik, Heppenheim, Germany Background: Treatment with Hypomethylating agents (HMA) in combination with the BCL-2 inhibitor Venetoclax (VEN) has recently become the standard of care for AML patients unsuitable for intensive induction chemotherapy and shows superior results to treatment with Azacitidine (AZA) alone (DiNardo et al., 2020, NEJM).
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PMC11509309
Screening scores were attributed as shown in Table 1.
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PMC9429973
The high concentration of hepcidin in patients with ACD, the presence of a correlation between it and erythrocytes confirms its importance in the development of anemia and the possibility of using it for the diagnosis of ACD.
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PMC7504302
Besides, the stable knockdown with a retroviral shRNA-expressing vector resulted in transcriptional derepression of E-cadherin and EpCAM, thus mesenchymal-to-epithelial (MET) transition.
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PMC10988555
Complexes were solubilized in DMSO and later diluted in RPMI medium without phenol red, at final concentrations of 25/50 μM. The spectra were obtained after 0, 24, and 48 h of incubation at 37 °C on the spectrophotometer Shimadzu mini-UV-1240 (Izasa Scientific) with a quartz cuvette with a 1 cm path length.
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PMC9429973
Moreover, SETD2 overexpression was able to restore DNA damage response, as demonstrated by WB and immunofluorescence detection of H2AX phosphorylation, RAD51 (HR) foci, THEX1 (DNA replication) and MSH6 (MMR) observed after UV exposure.
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PMC11612508
Figure 5B displays the SEM images of the surface of the magnetic microspheres at a higher magnification.
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PMC5600151
The use of antibodies as targeting molecules is one of these approaches.
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PMC11541241
This study further identified that SA fought against F. oxysporum by targeting the SNF1‐TORC1 pathway.
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