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OTAR3088
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PMC11098378
C. Superposition of native (blue) and S-nitrosylated (brown) Ceg10 structures.
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PMC9954564
To ensure that the analyses were not influenced by chance or by initial conditions, each analysis was repeated 5 times using 5 different random seeds (permutation = 1.000; adjust = ancestry covariates; family = binomial; significance level = 0.05).
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PMC11755467
Whether hsa-miR-132 represents such a bona fide critical host factor, or whether it is simply useful by (re-)shaping the cellular milieu for optimal HIV-1 replication or even if it is negligible, remains an important question for potential future therapeutic applications .
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PMC11610461
A498 cells were cultured in Dulbecco’s modified Eagle’s medium (Gibco, Grand Island, NY, USA) supplemented with 10% fetal bovine serum (Gibco, Grand Island, NY, USA) and 1% penicillin-streptomycin (Gibco, Grand Island, NY, USA) in a humidified incubator at 37 °C with 5% CO2.
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PMC11742231
Accurate predictions can aid in selecting the most effective drugs for specific cancer types, thereby advancing precision medicine.
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PMC11764090
Chlorophyll content is a key indicator of plant cold resistance.
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PMC9429973
The median age of the 167 infused patients was 67 years (range 34-89) and 76% were male.
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PMC11790971
After a 735 nm dichroic mirror (FF735-Di02-25) separated excitation from emission, four separate channels were used to collect emitted nonlinear optical signals from the cells (THG intensity, three-photon excited NAD(P)H autofluorescence intensity and lifetime, SHG intensity, and two-photon excited FAD autofluorescence intensity), with optical filters used to separate the channels listed in Table S7.
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PMC9000591
Accordingly, apoptosis is considered a major target in the development of effective anticancer therapy and represents the most successful nonsurgical treatment for all cancers to manage or stop the uncontrolled growth of cancer cells .
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PMC10938336
Similarly, the KEGG pathway analysis highlighted the enrichment of CASP3 and PARP1 in pathways closely linked to carcinogenesis, metabolic pathways, and pathways integral to cancer progression, further emphasizing their pivotal roles in the complex network of cancer-related molecular interactions.
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PMC6222726
All the isolated compounds were found to be active against tumor cell lines tested, especially 5′-demethoxy-β-peltatin A-methyl ether (14), which exhibited greater activity than camptothecin and podophyllotoxin against PC-3 (ED50 = 1.0 × 10 μg/mL) and KB (ED50 = 1.0 × 10 μg/mL) cell lines .
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PMC11591038
During hypoxia, translocation of the heterodimeric HIF-1α/β into the nucleus then drives the expression of target genes with the hypoxia-response elements (HREs) in their promoters .
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PMC10656496
Black arrows indicate concentration used in drug treatment of spheroids. (
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PMC7917457
A plasmid with the modified E3 region containing the human OX40L gene, 2A self-cleaving peptide sequence, and CD40L gene, as well as the 14.7K deletion (pOX40L/CD40Ldelta14.7K), was synthesized by a commercial vendor (Thermo Fisher Scientific).
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PMC11461874
The whiskers mark the minimum and maximum values.
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PMC9429973
Similar results were found in a US cohort, including approximately 7000 patients, between the years 2010-2014 vs 2014-2019 (59.71% vs 64.20%, p<0.0001, HR 1.154 (1.074- 1.241) (figure 1).
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PMC9684669
Caspase-3/7 activity assay (Caspase-Glo, Promega) and ATP content cell viability assay (CellTiter-Glo, Promega) were conducted according to the manufactures’ protocols.
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PMC7840816
Knockdown of SOX9 inhibited the proliferation of BCPAP cells in a time-dependent manner. (
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PMC11306019
Drawing from the distinctive features of potent antagonists, it is plausible that flavonoids not included in this study, such as flavonols (azaleatin, gossypetin, rhamnetin), flavone (baicalein, negletein, norwogonin, 6-hydroxyluteolin, scutellarein, sorbifolin, isoscutellarein, tricetin, nepetin, pedalitin, nodifloretin, cirsiliol, hypolaetin, onopordin), and flavan-3-ols (fisetinidol, mesquitol, robinetinidol), may harbor antagonistic effects against BTZ.
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PMC9429973
Since most of our patients deferred follow-up, it would be ideal to counsel the patients regarding significance of regular follow-up, to ensure better outcomes.
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PMC9964635
Figure 2 shows that compounds 7f and 7a produced the best results at a 25 µg/mL dose among all of the compounds.
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PMC11694066
As JN1 tumors do not grow in nude mice, we used NSG mice that carry the Prkdc mutation, which confers exquisite sensitivity to DNA damaging agents and chronic exposure to ATRi.
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PMC11342785
H, MT bundling activity for the variants in (F) was quantified as an EC50 from full titration curves measuring the fraction of microtubules in bundles as a function of variant concentration.
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PMC8348645
Significant peaks were observed in all the samples, with the differing retention times and peaks suggesting the presence of the different bioactive compounds in each sample.
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PMC11345828
The reaction was cooled to room temperature and diluted with 1:1 EtOAc/H2O.
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PMC11437637
Two millilitres of fresh early morning fasting peripheral blood were obtained from patients, stored in the blood collection tubes, and sent to the Center for Clinical Molecular Medical Detection at the First Affiliated Hospital of Chongqing Medical University, which conducted the flow cytometry, to complete the analysis.
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PMC7602170
The overactivation of AKT and MAPK in both GIST cell lines with mono-allelic PTEN loss demonstrated that PTEN dysfunction caused the upregulation of PI3K/AKT and MAPK signaling .
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PMC4277423
E. Relative fluorescent intensity of DDAO-labeled CCR5-/CR2 and CCR5+/GF1 cells as compared to parental CEMss-CCR5 cells at 0, 12, 24 and 36 hours post culture.
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PMC11763533
Fluorescent indicators are divided into those based on intensity and ratiometric.
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PMC11462929
In contrast, in KOPN68, which showed relatively low MYC gene expression and no amplification of BENC‐CNA, no significant interaction was observed.
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PMC9429973
Mean scores improved while on treatment with crovalimab, from baseline to Week 10 in Part 2 patients (8.8, SD=10.2) and to Week 20 in Part 4A patients (6.0, SD=6.1), exceeding the threshold for clinically meaningful improvement (5 points; Cella et al. ASH 2021).
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PMC8526701
The significant difference between the two groups was assessed using a two-tailed t test, and for multiple groups, one-way ANOVA was used.
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PMC10440586
These results suggested that overexpression of CD99 is an indicator of glioma recurrence.
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PMC11190538
There is one peak that can be translated to one molecular weight.
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PMC9429973
The median numbers of CD34 cells of PBSCs were 11.6 × 10 /kg (range, 6.1–24.9 × 10 /kg).
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PMC11055510
These non-coding RNAs can regulate tumor initiation and progression.
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PMC8708099
The statistical significance level was set at a p-value of 0.05.
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PMC10761571
Therefore, it can be concluded that treating lung adenocarcinoma cells with Fe3O4@Glu-Gingerol can activate of the extrinsic apoptosis pathway and subsequently triggers the intrinsic pathway as well.
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PMC11481779
The average Pearson correlation score for the insulation (predicted/real) was 0.63 for chromosome 8.
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PMC9429973
Methods: Between January 2018 and February 2022, dried blood spots (DBS) samples were collected and tested for the acid β-glucosidase (glucocerebrosidase) enzyme activity from MGUS patients, both adult and pediatric, followed in seven hematology units of Sicily, Calabria and Naples.
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PMC11457557
A data from GAA in DKD using CGA approach in (Table 2).Table 2Data from GAA in DKD using CGA approachMechanismCandidate genePopulationRefsRAASACE1BrazilianAsiansGlucose metabolismGLUT-1ChineseAlbuminuriaFABP2Insulin ResistanceENPP1European, AsianCNDP1FRMD3 Data from GAA in DKD using CGA approach Brazilian Asians DN is a condition shared by people with both T1DM and T2DM.
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PMC11471157
However, the phosphorylation rate of ERK1/2 was significantly higher in the DFP-HaCaT group compared to the PD-HaCaT group.
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PMC11756514
A quick and efficient immune response requires the recognition of bacterial pathogens through PRRs of the innate immune system.
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PMC11745823
Before the experiment, a suitable cell line was cultured to a suitable density, and both the constructed reporter plasmid and internal reference plasmid were transfected into the cells, thereby improving the transfection efficiency with an appropriate transfection reagent (such as liposome).
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PMC11502327
In the study of Melzer et al., researchers isolated EXO containing PTX from mesenchymal stromal cells (MSC) treated with sublethal concentrations of PTX for 24 hours and applied it to lung, ovarian, and breast cancer cells (176).
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PMC11678130
Another study also revealed the enhanced capacity of the 5-FU (10 µM) + QUE (10 µM or 40 µM) treatment to suppress the ability of two CRC cell lines (HCT-116 and HCT-116R) to grow colonies .
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PMC7823217
Pre-formed breast spheroids maintained their architecture, viability and cellular function after bioprinting.
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PMC11095939
Liver and body weights were recorded at the time of death for calculating liver-to-body weight ratios.
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PMC9027909
To analyze the effects of B3STA on the inflammatory biomarkers and TJ, the expression levels of IL-8, IL-15, occludin, and claudin-7 were evaluated (Table 2).
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PMC11711127
Although these cells have lost their proliferative capacity, they have potent cytotoxic activity (7984).
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PMC9429973
The significance of these is compared.
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PMC11507371
The proliferation-promoting factor transforming growth factor beta 1 (TGFB1) was downregulated upon treatment.
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PMC11615101
After incubation, the coverslip was washed and incubated with Alexa Fluor 546 secondary antibody (Thermo Fisher, USA) along with 4′, 6-diamidino-2-phenylindole (DAPI).
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PMC10135767
The positive fraction of RPMI 8226 cells silenced by Kindlin-3 shRNA in the stably transfected cell lines was found to be >90%, as detected by flow cytometry after screening with puromycin (Figure 6A,B).
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PMC11082662
Thus, ACER2 may be a potential therapeutic target in patients with ovarian cancer who have high levels of the SMPDL3B protein.
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PMC11774251
Immunoblotting of K1, K6 and K17 in HaCaT cells.
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PMC11244823
The Icelandic samples were kindly provided by Dr. Vilhjálmur Svansson (Institute for Experimental Pathology, University of Iceland, Iceland) and included 47 male and 3 female horses.
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PMC11750696
CD4 T cells play central roles in human immunity.
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PMC10092581
TrxR activity was assayed by measuring at 412 nm NADPH‐dependent reduction of DTNB (Figure 3, panel C) and GR activity was assayed at 340 nm (Figure 3, panel D).
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PMC9429973
Summary/Conclusion: Anemia is associated with distinct clinical behaviors and disease progression in SSc.
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PMC11301095
The abdomen was soft and flat, without hepatosplenomegaly, and bowel sounds were normal.
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PMC10944868
These studies not only save time and resources but also help in the identification of potential safety concerns associated with a drug candidate.
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PMC11489351
This cell line was then supplemented with either WT NHE1 to produce a cell line (LAPN) with a normal pHi of 7.35 or a transport-dead NHE1 variant (NHE1-E266I) to produce a cell line (LAPE) with a decreased pHi of 7.16 (20).
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PMC11040965
To assess whether CD28 binding to its ligands CD80 and CD86 triggers PI3K signaling, we cultured U266 and RPMI 8226 myeloma cells (which constitutively express CD28, Supplemental Fig. 1) with anti-CD28-coated beads (to mimic stimulation by ligands expressed on antigen-presenting cells), in the absence or presence of a CD28-blocking mAb, and used Western blotting to examine the expression of components of the PI3K/AKT signaling pathway (Fig. 1A, B).
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PMC10198699
Accordingly, in this scenario too, the research institution would become the owner of the cell line.
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PMC11591052
In terms of clinical translation, 20E seems to be a very suitable adjuvant for anticancer therapy, as it is a low-toxic compound with an LD50 > 9 g/kg in mice .
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PMC11731161
These findings indicate that elevated USP7 expression is associated with decreased sensitivity to SEL.
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PMC10810426
For fractionation assays, NIH-3T3 cells were collected in ice-cold PBS, and fractionated into nuclear, cytoplasmic, and whole cell extracts by the Rapid, Efficient, and Practical (REAP) method (47).
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PMC8806312
The heatmap of the four signature genes expression profiles. (
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PMC7081114
All the experiments were conducted in triplicate.
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PMC5833712
In this study, treatment of A2780cis and SKOV3 cells with a fixed concentration of KB9520, on top of increasing concentrations of cisplatin, resulted in an additive effect over the full range of cisplatin concentrations (Fig. 4a, S1A, B), whereas PPT was without effect.
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PMC11740207
All these cells stages can play significant roles in the regenerative processes of adult tissues (Alanazi et al., 2023; Velasco et al., 2023).
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PMC11627133
Typically, a primary antibody binds to the POI and is visualized with a fluorophore‐labeled secondary antibody, binding the primary antibody.
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PMC11591030
Moreover, the present study revealed that under stress conditions, the LPS group significantly increased the related gene expression of the NF-κB signaling pathway compared to the control and AOP groups.
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PMC9874064
After NP-Pt-USP1i enters the cells, they can be triggered by the overexpressed GSH in the cancer cells, resulting in the breakdown of the disulfide bonds in the polymer carrier PHHM, and dissociation of nanoparticles as well as further reduction of platinum (IV) prodrug into cisplatin and release of C527.
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PMC9429973
In July and August 2021 she received two doses of mRNA vaccination against COVID-19.
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PMC7153288
These gene clusters in Streptomyces sp. SS1-1 shared most of the similar genes with known gene clusters in Streptomyces species (terpene, siderophore, type 2 polyketide gene clusters) or at least contained core biosynthetic genes and additional biosynthetic genes with known gene clusters in Streptomyces species (melanin, hitachimycin gene clusters).
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PMC11448304
This finding aligns with Jiang et al.’s.
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PMC11757230
3Differential effects of canine adipose-derived mesenchymal stromal cells (cADSCs) on the cell cycle of leukemia/lymphoma (LL) cells.
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PMC11593084
NZ-1, an anti-PDPN mAb (rat IgG2a), showed a higher reactivity to those cancer cell lines (Figure 1B).
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PMC5025404
Consequently, the effective productivity after the first purification step reached 1.3 g/L. Certainly, such data as 1–1.3 g/L is a little low, however these are non-optimised conditions, wherein for one of the producer has been shown a high productivity and stability of expression of prolonged cultivation.
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PMC10957991
Examples of representative force maps are shown in the image. (
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PMC11789597
Bone marrow (BM) samples were collected from newly diagnosed MM patients after patients’ informed consent and the studies were conducted in accordance with the Declaration of Helsinki.
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PMC11612794
Middle: The transparent surface model of Mis12C, except for the basic motif of Dsn1, is overlaid on a cartoon model.
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PMC10854447
On the other hand, compounds 7h and 7i exhibited another orientation where m-chloro and m-bromophenyl moiety were better accommodated within the active site than 4-chloro and 4-bromo substituents.
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PMC3681794
To further investigate the role of HIF-1 in hypoxia-induced drug resistance in HOS and 791T cells, stable clones were generated in which HIF-1α was suppressed by short-hairpin RNA interference (shRNAi).
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PMC11419566
Triterpenoids found in P. cocos have been shown to be natural retinol X receptor selective agonists with potential anticancer properties.
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PMC10170482
Alexander and HepG2 cell culturing in soft 3D scaffolds resulted in shorter, fragmented filaments of F-actin and β-tubulin (Figure 3A–C).
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PMC10523483
Cell viability of A549 cells with or without H1.2 overexpression, measured by MTT assay 24 h posttransfection, n = 6. (
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PMC11509224
Their GC50 values (drug concentration causing a 50% reduction in the net protein increase) were over 27.5 and 33.3 µM, respectively, for all cell lines.
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PMC11697703
Each library produced approximately 200M, 150-bp paired-end reads.
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PMC10968586
For example, peracetylated OLE had a stronger anti-proliferative and antioxidant activity than OLE in thyroid and breast cancer in vitro ; iron oxide nanoparticles coated with glucose and conjugated with OLE showed a notable cytotoxic action against colorectal cancer cell line SW480 ; chitosan nanoencapsulation of HT was shown to be unaffected by time-dependent dynamic changes in efficacy observed for free HT in lung and breast cancer cell lines ; hydroxytyrosyl dodecyl ether, an HT alkyl ether derivative, had a very strong cytotoxic activity at low concentrations (IC50 = 19.9 ± 4.6 μM) in lung cancer cells in vitro ; hydroxytyrosyl oleate, an HT ester, exerted the same effects shown by HT on SH-SY5Y neuroblastoma cells at lower concentrations ; HT-loaded poly lactide-co-glycolide-co-polyacrylic acidnanoparticles exhibited cytotoxic and transcriptional regulating effects at lower concentrations (6 ppm) than free HT in colorectal cancer in vitro .
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PMC11798926
Membranes were washed three times with TBST and once with TBS prior to imaging.
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PMC3122064
Taken together, our results suggest that high sensitivity for cisplatin cytotoxicity and cisplatin-induced apoptosis is related to a reduction in MDM2–p53 complex formation and a change in p53 cellular localisation.
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PMC8751435
By contrast, protein expression of cleaved‐GSDME, which is substrate of caspase‐3, is significantly upregulated by CME.
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PMC11713609
Representative phase-contrast SYTOX staining images after TBH treatment for 8 h. Scale bar, 100 µm. (
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PMC11612794
Human CENP-T residues R209 and R210, corresponding to R192 and R193 of chicken CENP-T, are predicted to bind to the acidic surface of human Nsl1 (Figure S3H).
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PMC8193813
Flights (n=22) ranged from 11 to 24min in duration at two different sites.
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PMC11640419
In this study, we employed Luminex technology (MILLIPLEX MAP 7-plex DNA Damage/Genotoxicity Magnetic Bead Kit and MILLIPLEX MAP Early Apoptosis 7-plex Magnetic Bead Kit) to analyze protein analytes in Jurkat cell lysates.
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PMC11092382
These authors further confirmed its anti-HBV activity, as evidenced by reduced HBsAg and hepatitis B “e” antigen (HBeAg) secretion in the HepG2 2.2.15 cell line (Ding et al., 2006).
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