PMCID string | Sentences string | ner list |
|---|---|---|
PMC11721064 | This algorithm infers co-expression regulatory networks between TFs and candidate target genes from scRNA-seq datasets. | [
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PMC4485648 | Dual-luciferase results were calculated for each transfectant and analyzed by the data analysis software (SABioscience). | [
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PMC11472639 | All conditions were seeded in triplicate wells and relative fluorescent units were converted to a percentage of specific lysis using the following equation:%SpecificLysis=((Sample–Spontaneous)/(TritonX−100–Spontaneous))x100 Sodium heparin-treated whole blood (300 μL for tubes used to identify plasma cells, and 100 μL for tubes used to identify monocytes and T-cells) were labelled with surface staining antibody-fluorochrome cocktails for 30-min (discussed later) at room temperature and subsequently treated with 1 × FACS Lysing Solution (BD Biosciences, Wokingham, UK) for 10-min at room temperature. | [
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PMC11577421 | Conversely, in pgsA-745 cells, the difference in uptake levels between NP_BSA+ and NP_BSA was much less pronounced. | [
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PMC8633974 | Human embryonic kidney cells (HEK293FT) cells were grown in Dulbecco's Modified Eagle's Media (DMEM) containing 10% v/v fetal bovine serum (FBS), 100 units/mL penicillin and streptomycin (PenStrep), 0.5 mg/mL Geneticin®, 1% v/v MEM non-essential amino acids (MEM NEAA), and 1 mM sodium pyruvate. | [
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PMC11680562 | The Mueller–Hinton agar solutions were initially autoclaved at 121 °C and 15 PSI for 15 min. | [
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PMC10452486 | They are upregulated on immune cells upon activation by proinflammatory cytokines, anti-CD3 antibodies, antibiotics (e.g., ionomycin), phytohemagglutinin, retinoic acid, and phorbol myristate acetate. | [
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PMC11788920 | We designed DNA constructs in which the PQS and dCas9 target sites were placed downstream of the TSS in order to probe their propensity to stall T7 RNAP progression . | [
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PMC11803149 | The volcano plot shows DEGs between OT-I T cells with Epas1-Crispr and control-Crispr (log2 fold change > 0.5 or < -0.5 and adjusted p < 0.05). | [
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PMC11604768 | Orange and gray projection lines indicate the positive and negative directions of the treatment projection, respectively. | [
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PMC8540611 | However, this is lower than for HeLa cells and amounts to 16.5 ± 3.1% and 25.7 ± 1.3% for HL-60 and CEM-SS cells, respectively. | [
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PMC11653533 | Belonging to the class Magnoliopsida and subclass Dilleniidae, it is classified under Urticales and the family Moraceae, demonstrating its close evolutionary connection to nettles and mulberries. | [
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PMC9429973 | Adverse events (AEs) were monitored throughout the study. | [
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PMC8839885 | Results demonstrated that co-culture caused a significant reduction in the level of cleaved PARP as expected (Figure 3). | [
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PMC11705547 | Cisplatin can reverse the immunosuppressive conditions in the tumor microenvironment by promoting M1 polarization of the TAMs . | [
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PMC11790971 | For the experiments, CHO cells were thawed and cultured at 5% CO2 at 37 °C in a shaking incubator rotating at 140 rpm. | [
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PMC10652261 | Based on the data, compounds 2e, 2f, and 2h caused caspase 3 induction more than bortezomib. | [
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PMC11696659 | A summary list of TAV is presented in Supplementary Table 1. | [
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PMC10813895 | The primary goal of cancer prevention trials is to reduce cancer incidence, which can be difficult to measure due to the long timespans required to do so. | [
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PMC11758416 | The number of L cells for a 10:1 (Effector:Target) ratio would then be 5E3 L cells per well.b. | [
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PMC11483468 | The purified recombinant protein GST-TAT-LPTS39 entered the BEL-7404 cell nucleus, as detected by Western blot. | [
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PMC11754436 | At 1 month after the injection, the nude mice were sacrificed. | [
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PMC9429973 | N. Aggarwal, A. L. Manley, J. Durrani, R. Shalhoub, O. Rios, J. Lotter, B. Patel, C. Wu, N. Young, E. Groarke Hematology Branch; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, United States of America Background: Aplastic anemia (AA) is characterized by pancytopenia and a hypocellular bone marrow from immune-mediated bone marrow destruction. | [
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PMC11629461 | Further, SALPC photodynamic action triggered persistent calcium oscillations in DUOX2‐CHO‐K1 cells (Figure 6), similar to those observed in NOX5‐CHO‐K1 cells (Figure 3). | [
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PMC9429973 | Our findings highlight that specific CD8+ T cells against SARS-CoV-2 might be induced by vaccination but do not correlate positively with serological responses. | [
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PMC9118379 | Adopting proteogenomics approach to validate single nucleotide variation events by identifying corresponding single amino acid variant peptides from mass spectrometry (MS)-based proteomics data facilitates translational and clinical research. | [
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PMC11806182 | Differential miRNA expression was analyzed using the R software to preprocess and normalize the data. | [
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PMC9429973 | The unadjusted median duration of 2L for the 3 cohorts was of 6.0, 8.1 and 9.9 months (log rank test, p=0.01). | [
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PMC11394730 | The cell cycle is a series of events that take place inside the cell in order to divide into 2 separated identical daughter cells. | [
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PMC11144382 | Nuclear factor I/X (NFIX) mutations are associated with 2 skeletal dysplasias, Marshall-Smith (MSS) and Malan (MAL) syndromes. | [
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PMC11474209 | The most typical cyanotoxin among the ten analogs is NOD-R. NODs were first discovered in cyanobacteria's freshwater and coastal environments, known as Nodularia . | [
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PMC10376064 | These results prompted us to evaluate DMF at more advanced pathological stages of β-amyloidosis in this model, as several differences between early- and late-stage amyloidosis mice exist (e.g., the integrity of BBB, the regulation and function of BBB-located proteins, or altered CNS penetration of drugs and/or metabolites amongst other factors). | [
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PMC9429973 | At diagnosis, most pts had higher-risk MDS with IPSS-R high (29%) or very high (39%) disease, and complex karyotype was seen in 44%. | [
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PMC11566417 | Vimentin, aSMA and CK14 represent basal markers, and CK18 and ERα are luminal markers. | [
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PMC9910796 | Interestingly, the cryo-EM structure of faustovirus has unveiled an internal icosahedral capsid layer (besides the outer one) but not an interposed internal lipid membrane . | [
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PMC10728535 | The expression of this gene is inversely related with drug resistance, which confirms the results of our study. | [
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PMC10958426 | UMAP visualization of 101,065 cells from tumor tissue and normal colorectal tissue, colored by tissue. ( | [
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PMC9786247 | The public health risk in Belgium was linked to specific genomic groups, which were mostly found in small ruminant strains . | [
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PMC11200978 | Culture medium was then added to neutralize TrypLE, and the detached cell population was added to their respective 15 mL tube (pooled population). | [
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PMC11409031 | Single-cell RNA sequencing is a revolutionary technology that has significantly enhanced our understanding of the diversity and behavior of cellular transcriptomes across various organisms. | [
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PMC9429973 | According to the naive ITC, fedratinib was numerically favored over pacritinib in terms of SVR ≥ 35% (RR, 1.67 [95% CI, 0.94–2.97]). | [
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PMC11363012 | 40-enzyme biosynthetic pathway of the anticancer drug vinblastine (15) (Figure 1a), a natural product that is produced in Catharanthus roseus (Madagascar periwinkle), occurs in only three types of leaf cells: the first part of this alkaloid biosynthetic pathway is found in internal phloem-associated parenchyma (IPAP) cells, the middle module of the pathway occurs in epidermal cells, and finally, the last steps occur in idioblast/laticifer cells. | [
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PMC10968586 | THP-1 is probably the most known acute monocytic leukemia cell line. | [
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PMC11402217 | 1 × 10ˆ5 143B and MG63 cells were seeded in a 12-well plate at 70–80% confluence, followed by 0.5 μM XD23 treatment for 24 or 48 h. Cells were lysed with TRIZOL (Thermo Fisher, US), reverse transcribed using PrimeScript RT Master Mix (TaKaRa, RR036A#, JP), and RT-qPCR was performed on a LightCycler96 with TB Green dye (TaKaRa, RR820A#, JP), using primers listed in Table S1. | [
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PMC9592219 | The primary antibodies were used for the analysis after incubating the proteins with the following secondary antibodies: rabbit anti-TOP2A (1 : 2,500; CST, 12286), rabbit anti-E-cadherin (1 : 10,000) (ab40772), rabbit anti-N-cadherin (1 : 10,000) (ab18203), rabbit anti-vimentin (1 : 5,000; Abcam ab92547), rabbit anti-Snail1 (1 : 1,000; Boster, PB0449), rabbit anti-Snail2 (1 : 2,000; Boster, PB9439), rabbit anti-β-actin (1 : 10,000; Boster, BM0627), and rabbit anti-GAPDH (1 : 2,000; Boster, A00227-1). | [
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... |
PMC11543885 | Clarify the samples via centrifugation at 10,000 g for 10 min at 4°C to remove the cell debris. | [
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PMC9964635 | Because of its low bioavailability of 38–49%, Sorafenib necessitates a significant daily dose in cancer therapy. | [
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PMC11502327 | Of the drug release days included in the calculation, a total of 70% of CPT was released from the hydrogel within 18 days, and the drug delivery system maintained a good anti-tumor effect even at lower drug concentrations. | [
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PMC11487720 | α-Tubulin was shown in the bubbles (right panel; red arrows) (D). | [
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PMC11013014 | The binding affinity values of 2 and 3 are −6.7 kcal/mol and 7.0 kcal/mol, respectively. | [
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PMC11742231 | Ultimately, a fully connected layer is employed to predict the response of the drug–cell interaction. | [
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PMC9429973 | The median PFS was 13.4 months (95% CI: 11.1-16.7), with 6-month and 12-month PFS rates of 78.7% (95% CI: 67.5-86.3) and 53.1% (95% CI: 40.3-64.3). | [
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... |
PMC10969097 | Although participant recruitment is closed, no results are yet available. | [
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... |
PMC9599726 | The ferroptosis database used for the analysis was retrieved on http://www.zhounan.org/ferrdb/ (accessed on 19 September 2022). | [
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... |
PMC11387401 | Significant correlations are indicated with asterisks and p values are derived from the Spearman correlation analysis, all correlation results and p values can be found in Appendix Table S5 (p < 0.05:*, p < 0.001: **, and p < 0.0001: ***). | [
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... |
PMC7189327 | These datasets would be used for the following integrated analyses, which consisted of 48 BCC tissues and 85 normal tissue samples. | [
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"tokens": [
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PMC9429973 | In fact, most of imatinib side effects are moderate and subside over time. | [
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... |
PMC11377827 | Rabbit IgG was used as a control for non-specific binding. | [
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PMC11585994 | Primary cells from de novo T-ALL patients (n = 3) were treated with G5, G5-siNC, G5-sgc8, G5-siBCL11B, and G5-sgc8-siBCL11B nanoparticles for 48 hours, and the percentage of apoptotic cells was detected by flow cytometry (left panel), with quantitative analyses of the apoptosis rate shown in the right panel. ( | [
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... |
PMC9429973 | Methods: Adults with R/R LBCL after first-line treatment were eligible. | [
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PMC8097906 | Fig. 3VSM treatment effects on RH-30 cell morphology. | [
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] |
PMC11473843 | Mutant KRAS: mutKRAS; n = 3. ( | [
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"O",
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PMC11248911 | VEGF which is secreted by tumor cells binds to and activates its receptor VEGFR2, promoting vascular growth and supplying the hypoxic areas of tumor tissues with oxygen and nutrition. | [
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"O",
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... |
PMC6948907 | This yields purple formazan crystals that detected colorimetrically at 570 nm. | [
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... |
PMC11049294 | To assess the AGAL activity, 1 × 10 Jurkat cells were seeded into 96-well plates and incubated for different times (5 min, 1 h, 3 h, 5 h, 6 h, 8 h, 16 h and 24 h) with a substrate working solution (final concentration in 2.83 nmol/mL) at 37 °C in the dark, in 96-well plates. | [
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... |
PMC11585565 | The homozygous Cnnm4-knockout mice exhibited low serum and urine magnesium levels and a high fecal magnesium level, compared with those in wild-type mice, indicating that Cnnm4 plays an important role in magnesium absorption. | [
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"tags": [
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... |
PMC11594806 | Connexin43 (Cx43), a gap junction protein facilitating intercellular communication, suppresses the proliferation of human OS U2OS cells by inhibiting the G1-to-G2 cell cycle transition. | [
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PMC6267596 | To identify polyploidy specific proteins responsible for DNA repair, DNA replication and immune response, Log2 fold change and -Log10 P-value were co-visualized in a volcano plot for each gene using DIAP cells compared to DMSO control cells (Figure 3e). | [
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... |
PMC3995603 | Plasma samples were collected after centrifugation at 10000 rpm and stored at -80°C until they were further assayed. | [
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... |
PMC11770746 | All reagents were purchased from Biological Industries. | [
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]
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] |
PMC9243326 | Families and numbers of the top 10 TFs produced by SMRT. ( | [
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... |
PMC11637716 | SBDS‐sequencing analysis revealed a wild‐type sequence. | [
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"O",
"O"
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] |
PMC2193049 | Implication of these findings on the modulatory effect of proteasome inhibitor on the generation of peptides presented by HLA class I is discussed. | [
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PMC9878278 | In brief, the siRNA-Lipofectamine RNAiMAX complexes (siRNA in 50 μl of Opti-MEM medium mixed with 3 μl of Lipofectamine RNAiMAX) were added to each well and mixed gently. | [
{
"tags": [
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... |
PMC11661040 | Cell counting kit-8 (CCK-8) assay, colony formation assay, flow cytometry, wound healing assay, and Transwell assay were conducted for in vitro functional experiments. | [
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"tags": [
"O",
"O",
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... |
PMC10502403 | Metabolomic analysis of NGMCs and NE1-GMCs Three samples from three different healthy donors per group were assessed. | [
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... |
PMC11098378 | As a positive control for arbovirus rescue, siRNAs targeting transcripts encoding argonaute-2 (AGO2), which we have shown to restrict VSV and SINV replication in LD652 cells , were also transfected into cells. | [
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... |
PMC9268183 | It is however, worth mentioning that in some cases, the informants use local euphemisms to describe the origin of the illness, such as “mal dolent” or “mal lleig”, which literally translate to bad or ugly illness . | [
{
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... |
PMC11026382 | Folate, the DHFR substrate is indicated with yellow sticks. | [
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PMC9429973 | No differences in MRD rates were seen between treatment arms, and data was pooled for analysis. | [
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"O",
"O",
"O",
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"O",
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"O",
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"tokens": [
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"MRD",
"rates",
"... |
PMC9429973 | Prompt evaluation and appropriate treatment is necessary. | [
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"O",
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] |
PMC11201989 | Our results suggest that PD-L1 is a new player in ciliogenesis, contributing to PC-2-mediated sensory signaling and the Hh signaling cascade. | [
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PMC11733919 | Nonsenescent normal (BJ, WI-38) and cancer (A431) cells were treated with the drugs 17-AAG and 17-DMAG in a range of concentrations starting from 0.1 to 10 μM or the nanoplatforms (60 μg of Fe/mL) for 24 h, and metabolic activity was then assayed using MTT test. | [
{
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"O",
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"O",
"O",
"O",
"O",
"O"... |
PMC11657695 | B Gene expression (Log2 normalized expression) of KCNA2 in biopsies originated from patients with different tumours (Kruskal–Wallis and Dunn’s tests). | [
{
"tags": [
"O",
"O",
"O",
"O",
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... |
PMC10729469 | E. MHCII-IA.-KLVFFAEDVGSNKGA (Aβ T cell epitope) tetramer binding confirming the Aβ reactivity of engineered TCRAβ-Tregs incubated with Aβ-tetramer (blue) compared to TCRAβ-Tregs incubated with control-tetramer (orange) or polyclonal Tregs incubated with Aβ-Tetramer (red) Generation of TCRAβ-Tregs. | [
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... |
PMC9429973 | M. S. Davids, J. Richter, C. Anderson-Smits, M. Kamieniak, K. Ren, M. Hull, J. Multani, D. Shah, C. Siffel Dana-Farber Cancer Institute, Boston; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York; Takeda Development Center Americas, Inc., Lexington, United States of America; Takeda Pharma Sp.z.o.o., | [
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... |
PMC9024365 | Co-localization of SD4 with synaptic GluA1 is increased after chemical-LTP. ( | [
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PMC11092382 | Scattered studies have indicated that sophocarpine may protect other vital organs, such as the liver, kidney, brain, and lung. | [
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PMC11271278 | These data together suggest that cancer-type specific enhancers may be subject to translocations to activate oncogene expression. | [
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PMC11802929 | c Radar graphs of physicochemical properties for representative PG-TCR groups. | [
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PMC11422497 | P < 0.05, **P < 0.01, na: no statistical significance. | [
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PMC10669128 | Based on the established role of VEGF and its receptor VEGFR in angiogenesis, the authors tried to better clarify the role of VEGF165 in STS growth, metastasis, and chemoresistance. | [
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PMC11337594 | This distinction may prove valuable in future studies of apoptosis and pyroptosis. | [
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PMC11794847 | Then, we used PMA and Ionomycin to activate the Jurkat cells. | [
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PMC9429973 | On the contrary, age and ELN17 genetic risk were significantly associated with OS (Table). | [
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PMC9429973 | Median follow up was 3.1 months. | [
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PMC11522251 | D HCT116 and CACO2 cells with knockdown of HOXB8 were dealed with distinct concentrations of cetuximab (0, 100, 300 μg/ml), and their cell migration ability was determined. *** | [
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"O",
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"... |
PMC10560648 | Each experiment was repeated three times (triplicates). | [
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PMC9436459 | The relative configurations of 139a and 141a were the same as those of natrual MDAAs palodesangrens B and D (139 and 141). | [
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... |
PMC10055960 | For example, ligands bearing extended π-electron systems have been shown to bind to DNA via intercalation . | [
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... |
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