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OTAR3088
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BioData-CellLine_annotated

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PMC8097906
Notably, cisplatin is used in RMS regimes in some clinics but will be in future not the most promising chemotherapeutic drug.
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PMC11725127
P < 0.05, P < 0.01, P < 0.001, P < 0.0001 versus control group.
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PMC10907726
Use FITC Annexin V Apoptosis Detection Kit I (#556547, BD Biosciences, USA), and analyze by CytoFLEX S flow cytometer (Beckman Coulter, USA) following by the manufacturer's instructions.
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PMC11342785
However, our droplet-based design provides straightforward paths going forward to further equip these structures with additional activities based on co-condensation of IDR-matched client proteins into the structure (14, 66).
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PMC9844987
The locations and fuzziness scores of nucleosomes were called with DANPOS2 (version 2.2.2) (Chen et al., 2013) using the dpos command on each LCL separately.+1 nucleosomes were defined as the closest downstream nucleosome of the dominant TSS position (derived from pooled CAGE data) of each CAGE-inferred promoter.
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PMC11269792
After diagnosis by a pathologist, tissue specimens were frozen in liquid nitrogen and then stored at -80 °C to determine gene expression.
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PMC8735881
After incubation for 24 h, the culture media were replaced with Freestyle 293 expression media (Invitrogen) and cultured for additional 48 h. Then, the cells and supernatants were harvested, respectively.
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PMC11704135
Pyrimidine compounds have been reported as promising antitumor compounds, making them suitable anticancer candidates.
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PMC9672323
The graphs show the mean ± SD.
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PMC11754432
Exogenous 13-hydroperoxyoctadecadienoic acid or 15-HETE have been shown to enhance EGFR-mediated ERK and AKT signalling [43–47].
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PMC11345828
Compound 33 (510 mg, 0.94 mmol, 1.0 equiv) and ethyl 7-iodo-4-methoxy-1,5-dimethyl-1H-indole-2-carboxylate (335 mg, 0.94 mmol, 1.0 equiv) were coupled following General Procedure B (400 mg, 52% yield).
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PMC11678130
Considering that the antineoplastic activity of 5-FU in A375 cells was improved by its co-administration with QUE, the study continued by exploring the potential mechanisms underlying the cytotoxicity of QUE + 5-FU in this cell line.
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PMC5810978
This was consistent with the requirement of bile acids for the growth of porcine SaV Cowden strain in cell culture , and certain strains of HuNoVs in human enteroids .
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PMC10606998
Cells were seeded into 24-well plates at 10 cells per well.
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PMC4395774
Prf mice were injected with lentivirally transduced LSKs (2.5–5.0 × 10 cells/animal) after lethal irradiation.
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PMC3203927
Large variations indicate either hybridization errors or problems with the quality of the RNA used.
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PMC9429973
Afterwards we therefore focused the Round 2 and 3 questionnaires among principal investigators, coinvestigators and trial methodologists.
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PMC11531744
The data filtering parameters were set as follows: 1.
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PMC11756514
Second, 5 µg plasmid DNA was diluted in OptiPRO SFM, and then 10 µl P3000 reagent was added.
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PMC11711345
Given that the server does not analyze ionic molecules , the cytotoxicity of sodium cuminate could not be predicted.
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PMC8526701
D Combination index (CI) and fraction affected of GSK602 and imatinib combining at different concentration in GIST-T1 cells treated for 48 h were analyzed by the CompuSyn program (ComboSyn).
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PMC10253973
As many therapies fail due to the development of resistance of tumors to platinum compounds, there is great interest in identifying alternative anticancer drugs with mild side effects.
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PMC9964654
However, these complexes have poor solubility in water, which poses some challenges regarding their in vivo administration.
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PMC11300639
Reverse transcription was performed using Evo M-MLV reverse transcription premixed kit (#AG11728, Accurate Biology, Hunan, China), and qRT-PCR was subsequently performed using Evo M-MLV one-step RT-qPCR kit (#AG11732, Accurate Biology, Hunan, China), following the manufacturer’s instructions.
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PMC2944824
Also, the anti-apoptotic effects of Hr were lessened in p53 knockout cells compared to wild-type cells.
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PMC11206502
Therefore, HB effects on autophagy induction in BC cells, together with the inhibition of cell proliferation, indicate its high antitumor potential.
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PMC9429973
Aims: To analyze trends in hospital length of stay, total costs and co-morbidities in Medicaid patients with Acute Lymphoblastic Leukemia (ALL).
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PMC10079526
Using an unbiased proteomics approach, we identified SUMO2 target proteins induced by 5-Aza-2’ treatment.
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PMC8358006
In addition to peak breadth encoding information on gene function, we showed that its breadth dysregulation is also a link between H3K27me3 and changes to gene expression.
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PMC11757230
Representative histograms and the proportions of cells in the G0/G1, S, and G2/M phases under different culture conditions are shown for (a) CLC, (b) CLK, (c) Ema, (d) CL-1, (e) UL-1, and (f) GL-1.
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PMC11194678
Consistent with a previous report (Paul et al., 2021), levels of STAU1 proteins were significantly elevated in HD cells (Fig. 1 E; ∼twofold compared with those in WT cells).
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PMC11402217
To confirm that XD23 induces apoptosis in OS cells via the ER stress pathway, we first noted structural changes in the ER using an ER fluorescent probe (Figures 2H and S2).
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PMC9429973
We observed a clear increase in its use from 2015-2020, in parallel with increased use of LenM. We also noted reducing rates of lenalidomide-based relapse therapies in later years, correlating with increased LenM. Importantly, neither DRD or PVD combinations were reimbursed for prescription in Irish healthcare during the period of audit and are notable absences from the relapse treatment regimens used.
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PMC11222184
Fig. 5).
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PMC11758416
Determine cell count using a hemocytometer.b.
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PMC10907726
Epidermal growth factor (EGF) was first discovered by Dr. Cohen in 1962, and subsequent research revealed that EGF activates its receptor, EGFR, which plays important roles in cell differentiation, apoptosis, proliferation, and migration .
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PMC9429973
Taking the number of CD34+ cells in a volume of 2x10/6/kg of the patient’s weight as a suboptimal value that provides fast and reliable graft engraftment, it remains unclear whether this number will be sufficient for subsequent transplantation, if tandem AutoHSCT assumes an interval of 6 months, and repeated - not earlier 36 months.
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PMC11738017
BCMA shedding that is mediated by the gamma secretase complex reduces its surface expression on MM cells and generates a sBCMA fragment that comprises the full ECD of BCMA.
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PMC11365427
Tumor volumes were measured after one week of model construction to assess tumor burden and the therapeutic effect of phenylalanine deprivation by observing weight, tumor weight, and tumor morphology (Fig. 4B and C).
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PMC9429973
Image: Summary/Conclusion: Preliminary results show that a 10-day regimen of BGB-11417 plus azacitidine resulted in a majority of CR observed by the end of Cycle 1 and was well tolerated in pts with AML.
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PMC11697065
For example, site-specific gene integration would ensure that the expression locus remains fixed; inducible expression systems might yield finer control over specific expression parameters; and deriving antibody expressing cell lines using a clonal host with a pre-characterised genetic background could limit variability.
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PMC11040965
D Levels of DNMT3B mRNA and miR29b normalized to those of GAPDH and RNU44, respectively, and expressed as fold change relative to the average value for untreated cells (real-time PCR).
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PMC9429973
Follow-up showed that 18 patients in the HLH group died, with a mortality rate of 48.65%, and 19 patients in the non-HLH group died, with a mortality rate of 37.25%.
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PMC9712534
A mobile fraction and t1/2 of fluorescence recovery were calculated for each curve.
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PMC11544122
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins.
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PMC9118379
The spectrum viewer parameter settings only consider matching b- and y-ions of charge +1 to spectrum peaks that have intensities at least 10% of the most intense peak and are within 0.02 Da tolerance.
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PMC11786600
Collagen is the main ingredient of the ECM, which dynamically anchors the cellular components of the tissue.34 MT staining (collagen: blue, myofibrils: red), as depicted in Figure 5d and f, indicates the arrangement and composition of these fibers.
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PMC9429973
Further research is required.
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PMC5716223
The assay was performed in presence or in absence of NGF (20 ng/ml) on proliferating myoblasts (24 h from seeding) or cells grown in DM for 2, 5 and 9 days.
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PMC9429973
The Cmin prior to the PEf was >3nM in 8/15 pts.
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PMC11699178
The data were obtained from at least three independent experiments, and the results are presented as mean ± standard deviation (Mean ± SD); for comparisons between the two groups, a two-sample independent t-test was employed; for comparisons involving three or more groups; one-way analysis of variance (ANOVA) was conducted.
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PMC9429973
A. Baranwal, A. Mangaonkar, M. Shah, M. Litzow, W. Hogan, M. Patnaik, H. Alkhateeb Mayo Clinic, Rochester, United States of America Background: The endothelial activation and stress index (EASIX) score has been shown as a predictor of non-relapse morality (NRM) after allogeneic stem cell transplantation (alloSCT) [Luft, et al. Bone Marrow Transplant.
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PMC11742290
LGR5 is involved in promoting tumor progression via EMT and WNT/β-catenin pathways and increased LGR5 expression is associated with chemotherapy resistance and recurrence in different cancers including breast, cervical, CRC, gastric, HCC and ovarian carcinoma.
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PMC11143482
Representative photo of mice induced with (A and B) 1 × 10 and (C and D) 3 × 10 of HOS-143B cells.
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PMC11794568
Each experiment was repeated three times, and the relative expression of target genes was expressed as 2-ΔΔCt.
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PMC11640476
By measuring this conversion, cell viability can be estimated.
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PMC11705067
Our data indicated that the likelihood of mutations in FDX1 (with no mutations observed) and DLAT (0.3%) is very low in ccRCC.
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PMC10968586
On the contrary, HT did not modify doxorubicin-mediated growth inhibition of human osteosarcoma cells U-2 OS .
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PMC11680982
Tumor photographs in animals treated with normal saline (control group), CDK4/6 inhibitor (palbociclib, 150 mg/kg, i.g.)
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PMC9046263
Created with BioRender.com.
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PMC10998613
When both CXCL12 and epinephrine were added, we observed a significant reduction of the diffusion coefficients (SI Appendix, Table S3).
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PMC10142392
The mechanical characteristics of the produced samples showed uniform and unique properties for micro-diameter fibers, which increases the fibers’ ability to trap drugs and can be used in clinical applications .
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PMC3122064
Finally, we demonstrate that Nutlin-3 strongly augmented cisplatin-induced apoptosis and cell kill via the Fas death receptor pathway.
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PMC9429973
They have revolutionized the future of patients because of their ability to prevent, in the majority of cases, the once inevitable progression of CML into fatal acute leukemia.
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PMC8978939
The arrow points toward a tumor (upper panel).
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PMC7553912
C57BL/6 J mice were given intraperitoneal injection of GOx (80 mg/kg) once daily for three, six, or nine days. (
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PMC11209164
Lastly, we examined the effects of TPF and DMF on the transduction of AAV2-GFP in HT1080 and HepG2 cell lines.
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PMC5600151
Structures of PAMAM with higher generations become more compact and spherical.
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PMC11661040
Scale bar: 200 μm. (*
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PMC10454535
In this study, we aimed to compare the cytotoxic effects of RES and derivatives PIN and PIC in MM cells and identify a combination treatment of a RES derivative with BTZ that synergistically reduces MM cell viability.
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PMC11387401
Normalized quantities of RNA expression relative to the condition treated with the scrambled control ASO, 48 h post ASO treatment and 48 h post infection.
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PMC11604015
It is divided into antigen-positive and antigen-negative relapses according to the presence or absence of surface target antigens.
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PMC9429973
Methods: Since July 2016 we conducted a multicentre randomized interventional study comparing the use of a PD (Arm A) vs NRD (Arm B) in hematological patients aged≥18 years hospitalized to receive autologous or allogenic HSCT.
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PMC11707832
Despite decades of research, its role in pathogenic infections, autoimmune conditions, cancers and neurodegenerative pathologies is highly ambiguous.
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PMC11718031
An initial viable cell count of 0.5 × 10 cells/mL was used.
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PMC9985266
A Detecting methylation in MRC-5 cells by MSP; B Detecting MEG3 mRNA levels in different treatment groups by RT‒qPCR; C, D Detecting DNMT1 expression in different treatment groups by RT‒qPCR and Western blotting; E RT‒qPCR to detect MEG3 expression levels; F chromatin immunoprecipitation to detect DNMT1 enrichment in the MEG3 promoter region. *
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PMC11459296
A drawback of PB-MNC humanization is the high risk of GvHD and an incomplete representation of the immune system in the mice.
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PMC11422150
Gentamicin was used in the primary culture but not in subsequent cultures.
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PMC10812665
LUHMES cells were treated essentially similar as in the screen: toxicants were added on day 2 of differentiation (d2) for up to 24 h (Figure 1A).
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PMC9325715
The importance of iron in the organism cannot be overestimated, as it makes up heme of hemoglobin and myoglobin which take part in oxygen transport and storage.
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PMC5925824
Volcano plots show Log2 fold-change of gene expression in the LY3300054 treated group compared to control group.
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PMC11726848
This type of cancer is treated in combination with radiotherapy, and brachytherapy methods are also used for treatment .
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PMC10706275
The film was evenly coated with 200 µL of ECL hypersensitive developer and developed.
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PMC11489175
USP14 has been shown to confer cisplatin resistance as its inhibition results in enhanced cisplatin cytotoxicity 69.
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PMC11518702
This includes the reinforcement of such signaling events due to increased levels of HGAL in DLBCL and Burkitt lymphoma cells (for details, see Section 5).
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PMC11607764
Therefore, PTBP1 can be used as an important therapeutic target.
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PMC10547921
To reduce the alkalinity at P2, the team replaced the P2 methyl sulfone moiety of carmaphycin B (115) with 4-thioaniline or 4-sulfonylaniline to obtain compounds 118 or 119.
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PMC10391797
HDAC is involved in diverse cellular regulatory mechanisms including non-canonical functions outside the chromatin environment.
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PMC8469018
Teriflunomide was significantly toxic to RPMI 8226 cell line in concentration of 50 µM and higher, IC50 = 99.87 µM (Figure 3B).
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PMC6461034
○When requiring more than 80 μl slurry (1 supplier vial) to cover all IPs, pool the required volume of slurry into a 1.5‐ml LoBind Eppendorf tube as a “stock” vial, and put it on ice.○Collect as many remaining beads from the supplier vials as possible by rinsing all empty vials with one volume of 1 ml cold IP buffer (50 mM MOPS pH 7.2, 10 mM sodium phosphate, 50 mM NaCl) and add to the “stock” vial.
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PMC11574271
Furthermore, has-miR-659-3p was found to impede tumor metastasis, although this inhibitory effect was exacerbated following RON overexpression (Fig. 7).
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PMC11267830
Comprehensive cross-analysis of these findings facilitated the identification of downstream effectors and subsequent validation of their functional roles.
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PMC11536589
The nude mice were subcutaneously implanted with 3 × 10 KPC210-MR cells subjected to knockout of MGST1.
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PMC11547917
Our results were consistent with those described in previous research, where the flavonoid content in A. tagala methanolic extract was estimated at 51.65 ± 0.11 mg QE/g , and around 50 mg QE/g in hydroalcoholic and methanolic leaf extracts’ TFC .
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PMC11627060
Similar findings were reported by Ghazy and Hanafy and Salim et al., who assessed the cytotoxicity of Cetuximab and Propolis-loaded serum albumin NPs against various cancer cell lines, including Caco-2, breast, and lung cancer cells .
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PMC9516447
As the master regulator of the UPR, GRP78 depletion can trigger ER stress and activate the UPR leading to attenuation of protein synthesis via the PERK/eIF2α pathway .
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PMC11512230
Three types of FITC-labeled SP were used for this study: TMV SP, AltMV SPV, and AltMV SPVLP.
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PMC11576293
These intermediates were subsequently alkylated with alkyl, allyl, and/or aralkyl halides to yield the target pyrimidines 9–29.
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PMC9895440
Size = percentage of cells with detected expression for each cluster.
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PMC11627060
The precipitated solution was stirred at 500 rpm for 15 min.
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