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OTAR3088
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BioData-CellLine_annotated

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PMC11513011
In T24, DIB increased E-cadherin expression both in vitro and in vivo.
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PMC7136814
Of this population, 10–25% and 1–10% are also positive for MYOD1 (MYOD1+ NOG+) in RD and A-204, respectively.
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PMC10926885
Hence, it was postulated that NDE1 could be implicated in the pathogenesis and advancement of tumours.
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PMC11499955
Finally, the technique was tested in vivo with the hope of characterizing tumours in their native environment and without the need for tissue removal.
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PMC11632064
Our analyses also revealed that the ABC transporter ABCD1 is linked to resistance to PLK1 targeting in melanoma.
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PMC9429973
M. Fujita, H. Itamura, M. miyazaki, K. Ishii, A. Sugihara, H. Sano, S. Okamoto, M. yoshimura, H. Katsuya, H. Ureshino, T. Ando, S. Kimura Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga University, Saga, Japan Background: Overexpression of c-myc and bcl-2 and/or bcl-6 in diffuse large B-cell lymphomas, defined as double-expressor lymphoma (DEL) and triple-expressor lymphoma (TEL), are considered to have a poor prognosis.
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PMC9220170
Control of cell migration to the “wound” area using a microscope was carried out after 24, 48, and 72 h. To detect changes in [Ca]i, cancer cells were grown at round coverslips in DMEM medium supplemented with 10% fetal calf serum for 48 h in a CO2 incubator to confluency 80–90%.
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PMC11088135
Previous reports have demonstrated that lncRNA NUTM2A-AS1 binds directly to miR-376a in gastric cancer cells and acts as an oncogene .
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PMC11718109
All mice were maintained on a 12 h light/dark cycle with standard mouse chow and water ad libitum.
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PMC5673060
Pazopanib resistant cells display elevated phosphorylation in cytoskeletal regulatory pathways while dasatinib resistant cells show an upregulation of the insulin receptor/IGF-1R signalling pathway.
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PMC11361748
Whole cell lysates (250 μg of total protein) were incubated with antibody-beads complex at 4°C overnight.
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PMC11502066
This resulted in the suppression of NA-induced reactive oxygen species (ROS), cAMP, MAPKs and NF-κB, with a decrease in the activity of downstream products such as MMP-9, eventually leading to the inhibition of NA-promoted invasion of malignant cells (Table 1).
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PMC11301242
Duplicated aligned reads were removed.
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PMC9429973
W. Tang, Y. Li, X. Zhong, Q. Liang, Y. Liu, Y. Zeng, B. Fang, L. Zheng, T. Niu Department of Hematology, West China Hospital, Sichuan University, Chengdu; Department of Hematology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou; Department of Hematology, First Affiliated Hospital of Kunming Medical University, Hematology Research Center of Yunnan Province, Kunming; GCP Center/National Institute of Drug Clinical Trial, West China Hospital, Sichuan University, Chengdu, China Background: The proteasome inhibitor is an effective treatment strategy for multiple myeloma (MM).
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PMC9503669
Binding and antiretroviral activity data for each compound were then integrated as a single ‘activity score’ which permitted ranking of overall analog efficacy.
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PMC11794847
For the detection of CD69 expression, cells were incubated with a PEcy7 conjugated anti-CD69 monoclonal antibody sourced from Biolegend (San Diego, CA, USA).
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PMC7452526
The surface morphology (size and shape) of silver nanoparticles was characterized by SEM (JSM-6700F JEOL GmbH).
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PMC11621565
The effect of rhamnolipid on the viability and cytotoxicity of dopaminergic-differentiated SH-SY5Y cells after 48 h of treatment was assessed in a concentration range from 1.25 to 320 µg/ml in ½ dilution series (Fig. 2A).
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PMC10854447
Compound 7k was more potent than Erlotinib against the breast cancer (MCF-7) cell line, having an IC50 value of 35 ± 3 nM versus 40 ± 3 nM for Erlotinib.
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PMC10808409
Thus, FA-loaded TPGS mixed micelles could be a potential therapeutic agent for colorectal cancer by targeting miRNA-221/TP53INP1 axis-mediated autophagy.
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PMC11697703
We found that miR-193b oligonucleotides significantly repress MapK8 luciferase reporter gene expression with wild-type, but not mismatch, miR-193b target sequences (Figure 2B).
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PMC11361748
Strategy for UVB and TPA combination Tx and skin tissue sampling. (
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PMC10024132
The Plat-A packaging cell line (Cell Biolabs) was transiently transfected with pMYs-Blin retroviral vector using Lipofectamine Plus (Invitrogen) to produce retroviruses containing blinatumomab-encoding DNA.
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PMC11519077
When the cells had reached around 80% confluency, trypsinization, subculturing, and cell passage were performed.
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PMC11064533
The ffp and fimH genes were also widely distributed, present in more than 80% of strains in each class, with the exception of DAEC, typical EPEC (tEPEC), and uropathogenic E. coli (UPEC) for ffp, and EAEC pathotype for fimH. The pilV and spnT genes were rare in all pathotypes of E. coli.
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PMC11468365
Each fold is used once as the testing dataset, while the remaining four folds serve as the training dataset for the model.
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PMC11599565
These cell clusters grow within an extracellular matrix that supports their 3D structural architecture and are cultured in optimized, tissue-specific growth media.
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PMC8494202
Further, studies have reported that blocking N-polysaccharide precursor biosynthesis can inhibit the growth of U87 glioblastoma cells and significantly inhibit glioma size in vivo .
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PMC11730305
Fig. 6EDS-mapping assay, Co3O4@Glu-Ellagic acid NPs contained C, Co, and O atoms.
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PMC9874064
Body weight change curve of nude mice bearing PDX tumors treated with different drugs.
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PMC11459296
In addition, the immunodeficient mouse strain used may influence the efficiency and persistence of the humanized graft.
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PMC6461034
If the pH is below 6 (remaining TFA), neutralize with 5–10 μl 1 M Tris.
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PMC4369959
Therefore, more extensive and well-controlled human studies are required to demonstrate its efficacy as an anticancer agent, as it is a safe and cost-effective alternative.
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PMC11591030
After the cell culture and treatment were completed, 10 μL of CCK-8 reagent was added to each culture well.
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PMC10329074
After the hazard ratio (HR), 95% confidence intervals (95% CI) and log-rank P-values were computed, the Kaplan–Meier survival plots with visualized parameters were generated.
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PMC11736898
Real-time quantitative PCR (qPCR) was performed using gene-specific primers purchased from Qiagen (Catalog No. 330001).
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PMC3681794
A number of other cellular pathways are differentially regulated in hypoxia and may also contribute to hypoxia-induced drug resistance.
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PMC9596868
Colonies were stained with crystal violet solution and photographed. (
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PMC7887261
Abnormal expression of POMC was a poor prognostic marker for LC.
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PMC11794568
In contrast, the opposite results were observed in CRIP1 knockdown melanoma cells.
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PMC6468656
Aurora A (STK15/BTAK/hARK1/Aurora-2), a member of the serine/threonine Aurora kinase family, plays an important role in ensuring genetic stability in cell division.
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PMC11092418
In conclusion, of targeting agents employed in this study, we found that the irreversible pan-HER TKI neratinib, CDK1/2/5/9 inhibitor dinaciclib and the Src targeting TKI dasatinib were the most effective at inhibiting the growth of brain cancer cells, blocking cell signaling through HER family members and reducing the migration of brain cancer cells.
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PMC10965680
In contrast, the Xiangdong goats were relatively close to the Jintang goats and Chengdu goats (Figure 3A).
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PMC11420784
By reducing intracellular phosphatidylinositol 3-phosphate levels, UPEC PldA increases the accumulation of NDP52 granules and decreases the targeting of NDP52 to autophagy, hence stalling preautophagosome structures.
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PMC11785489
Within an individual, identical TCR sequences likely reflect an expanded T cell clone, comprised of cells that tend to be transcriptionally similar.
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PMC11633763
N6 methyladenosine METTL3 has been shown by Wang et al. to upregulate HK2 protein expression through altering YTHDF1/HK2, increasing levels of glycolysis and encouraging the onset and progression of cervical cancer .
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PMC11055510
The results of EdU showed that the EdU incorperation in the inhibitor group was significantly higher than that in the inhibitor nc group.
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PMC11533140
Table 6 shows the IC50 value of 17p, and no obvious inhibition of hERG potassium currents was observed, but PI3K activity was inhibited.
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PMC5311252
Stably transduced cells were fluorescence-activated cell-sorted based on green fluorescent protein (GFP) expression from the miR-372 and control vectors.
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PMC9429973
HM43239 inhibited FcγR-induced SYK and JAK/STAT5 activation in KG-1a (FLT3-WT) cells that upregulate RAS signaling which is a mechanism of acquired resistance to gilteritinib.
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PMC11792090
After washing, the membrane was incubated with a secondary antibody for 1 hour, and protein expression levels were detected using autoradiography.
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PMC9429973
At diagnosis only the lymphocyte to monocyte ratio < 2.5 had prognostic value (p=0.04).
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PMC11297139
e Left: wound healing assay conducted on WT, ARID1A, ARID1A + WT, and ARID1A + ΔDD A673 cell lines.
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PMC11534035
Cell culture.
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PMC9429973
Methods: We queried the Nationwide Readmission Databases 2016-2018 using ICD-10-CM codes to identify all adult patients admitted for IBD.
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PMC11727000
Data are from the SEQC dataset (GSE62564), Primary NRC (GSE85047) and TARGET (https://ocg.cancer.gov/programs/target) (accessed 1 November 2024).
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PMC8382973
The main findings of this study include the following: (1) the inhibitory effect of 2P23 gel on HIV infection was stable and effective against a broad spectrum of HIV strains, as evidenced by IC50 values ranging from 0.5908 to 2.084 nM in vitro; (2) the potency of anti-HIV infection of 2P23 gel was stable when kept at different temperatures, different pH values, and different H2O2 concentrations; (3) 2P23 gel did not induce cell death in PBMCs or immune cells in vitro; and (4) when administered to rabbits, 2P23 gel did not influence physical rectal or vaginal bacterial expansion.
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PMC11632064
Reverse transcription was performed using the LunaScript RT SuperMix Kit (#E3010; NEB) according to the manufacturer’s protocol on a SimpliAmp thermal cycler (Applied Biosystems).
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PMC8973085
Found: C, 66.35; H, 4.08; N, 13.43.
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PMC10812665
In this reaction, cells can utilize Gln in the absence of an ETC and under conditions of NADH overload.
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PMC11787651
Calculated ratios for single histone PTMs as observed using either the previous 55-min Orbitrap Exploris method or the 10-min ZenoTOF 7600 method.
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PMC10006224
Contacts at higher resolution (10-kb, 20-kb, 100-kb, etc.)
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PMC11126803
After signing the “Scientific Ethical Consent”, tumor and para-cancer samples were collected during the operation and immediately frozen at −80 °C.
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PMC10376064
The reaction mixture [3-(N-morpholino)propanesulfonic acid-(MOPS)-Tris (40 mM; pH 7.0; Sigma–Aldrich, Oslo, Norway), KCl (50 mM; Sigma-Aldrich), dithiothreitol (2 mM; Alfa Aesar), EGTA-Tris (500 µM; pH 7.0; Sigma–Aldrich), sodium azide (5 mM; Sigma–Aldrich), ouabain (1 mM; Alfa Aesar,) was supplemented with 10 µg of the ABCC1 membrane preparation (2 mg/mL).
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PMC11783017
After incubation with PBS, a slight decrease in the weight of the hydrogels was observed (≈23 %), possibly due to the hydrolysis of ester bonds and gelatin matrix.
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PMC9927933
In summary, our study showed that UBE2C is a growth-essential gene in lung cancer cells harboring a Kras mutation, and Ube2c is required for lung tumorigenesis induced by Kras.
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PMC11767725
Microvascular complications, a hallmark of diabetes, significantly impact skin homeostasis.
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PMC8873393
B Size of each biotype of non-coding RNA transcripts identified per cell line per condition is shown.
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PMC11718109
A Fluorescence image of DA neurons (day 55) immunolabeled with antibodies directed against VGLUT2 (green) and synapsin (magenta).
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PMC11488203
For potential clinical use, appropriate EV isolation methods require an optimized yield and chemotherapeutic effectiveness.
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PMC11754094
Cell culture was performed whenever the cells had grown to 90% of the cell plate.
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PMC11626627
Univariate Cox analysis was conducted to assess the relationship between the TWIST1, clinical characteristics, and overall survival.
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PMC10936243
Participants were invited to discuss their clinical practice and their role therein.
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PMC11406030
The sequences of the other 18 LMTK3BP are not shown (patent disclosure).
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PMC11194678
Each cell lysate was subjected to centrifugation at 14,000 revolutions per minute (RPM) for 20 min at 4°C.
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PMC11758416
In our experience, measurement of cell death by Annexin V staining using flow cytometry works well to assess death of the L cells.
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PMC9429973
In addition, we emphasize that persistence of CSH mass lesions does not imply failure of lymphoma treatment.
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PMC9429973
Although kinase inhibitors can improve outcomes for some patients with relapsed and refractory disease, not all patients have access to these novel drugs.
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PMC9874064
Semi-quantitative analysis of the uptake.
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PMC11469524
We used the perturbation data set together with a literature-based starting network for our modeling pipeline to reverse engineer the signaling network downstream of the BCR (Fig 1B).
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PMC11413393
Intriguingly, in the drug-treated condition, more genes were significantly upregulated (FDR ≤ 0.01, log2(FC) ≥ 1) than down regulated (FDR ≤ 0.01, log2(FC) ≤ −1) − 1005 vs 664 respectively.
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PMC11400680
Besides, the performance of those methods is highly dependent on user or developer-defined parameters and thus they are limited in adaptability, and low in generalization capabilities.
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PMC9429973
The cumulative incidences of day 100 grade II-IV aGVHD (39.9% vs. 39.0%, p=0.86), grade III-IV aGVHD (9.2% and 9.3%, p=0.99) and moderate/severe cGVHD (67.6% vs.58.4%, p=0.19) were also similar for patients receiving Mel ≥ 3.28 mg/kg vs. Mel < 3.28 mg/kg.
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PMC11694625
This work revealed that quinoline-based dihydrazone derivatives could be used as promising anticancer agents.
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PMC9429973
Eight of the studies reported data in patients with myeloproliferative diseases, and seven on other or multiple malignancies.
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PMC2118063
These cells are PNA in the mouse but do not express BCL6 or PAX5; instead, they are positive for CD138 (Syndecan), BLIMP1, and a member of the IFN regulatory factor (IRF) family, IRF4.
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PMC9429973
Z. Wang, S. Cui, J. Xu, X. Tan, Y. Tian, X. Tang, Y. Wang Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China Background: With the development and marketing of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccine, vaccination has become an effective way to block the novel coronavirus disease 2019 (COVID-19) the most efficient way to spread.
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PMC11721064
Skin samples were placed in a 100 mm Petri dish, and excess subcutaneous fat, blood vessels, hair, and connective tissue were meticulously removed.
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PMC9429973
The top five listed co-morbid conditions were were Chronic Pulmonary Disease (26%), Fluid and Electrolyte Disorders (18%), Hypertension (11%), Drug Abuse (11%) and Depression (9%).
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PMC9429973
It may offer a potential pathogenesis-oriented therapeutic approach for patients with poor hematopoietic function.
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PMC9780037
Other biosensors utilize quantum dots , whose fluorescence is quenched upon cyt c binding (Figure 2E).
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PMC11774747
Although improvements in the management of viral infections have been made thanks to the implementation of new antiviral drugs, prophylactic and pre-emptive administration and viral load monitoring, in the absence of specific antiviral immunity, antiviral strategies are often ineffective, leading to treatment failure.
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PMC11544771
The combination treatment remarkably decreased the percent cells in the S and G2/M phases and increased the percent cells in the G1/G0 phase, indicating a G1/G0 cell cycle arrest in the cells (Figure 4A,B).
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PMC11731161
Consequently, targeting XPO1 has emerged as an attractive strategy for treating MM, particularly in relapsed/refractory patients .
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PMC5874706
Nevertheless, by increasing the length of the hydrocarbonated chain, the affinity also increased (298 mol·L and 417 mol·L for α-C6H13 and α-C8H17, respectively), with the higher association constant being observed with the fluorinated analog α-C4F9 (828 mol·L).
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PMC11040965
B Representative western blot of PI3K/AKT pathway components.
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PMC11388384
We speculate that because mesenchymal cells are irregular and are tightly juxtaposed, cytonemes might represent a small fraction of the total extent of cell–cell contact, such that perturbations to cytonemes had minor consequence for the effective topology of the tissue.
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PMC10988555
A control of pDNA cleaved with Hind III endonuclease was also used.
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PMC9429973
Aims: In this project, we aimed to determine the distribution of individual subclones and even wild-type cells within the HSPC-compartment and the contribution of these subclones and wild-type cells to effective hematopoiesis in patients with MDS or CMML.
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PMC8557138
Although HBL cell line showed differentiation, however, NA8 cell line exhibited de-differentiation.
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