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PMC11626627
Validation of the effects of circATP2B1 and TWIST1 using Western blotting in 786-O cells transfected with pLKO.1+pLVTHM, oe-circATP2B1+pLKO.1, oe-TWIST1+pLVTHM, and oe-circATP2B1+oe-TWIST1. (
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PMC11711127
In 2014, Miller et al. (36) revealed that the survival of quiescent T cells is, in part, reliant on the interaction between the soluble factor IL-7, produced by various stromal cells, and the IL-7 receptor (IL-7R) present on the surface of T cells.
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PMC11731161
Consistent with our findings in NCI-H929 cells, proteasome inhibitors effectively reversed the protein reduction induced by SEL in MM.1S, U266, and RPMI-8226 cells, while lysosomal inhibitors showed no reversing effect (Supplementary Fig. S1).
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PMC11612315
At the end of the experiment, the cells were identified on the basis of their response to high concentrations of KCl.
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PMC11612508
However, proximity in the presence of a magnetic field leads to a significant decrease in viability (P < 0.01 for 24 h and P < 0.001 for 48 h).
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PMC9919300
Scientists believe that medicinal plants could be used for the prevention of NALFD .
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PMC9429973
Hematopoietic stem and progenitor cells (HSPCs) compartment analysis revealed increased granulocyte/macrophage progenitors (GMPs), and megakaryocyte /erythroid progenitors (MEPs) in spleens of Asxl1-/-Jak2, not in BM compared with Jak2 mice (Figure 1A), in line with increased spleen weights of Asxl1-/-Jak2 mice (Figure 1B).
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PMC8973085
Anal.
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PMC11732628
The recurrent and metastatic osteosarcoma poses great challenges for cancer treatment (6).
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PMC10213179
The fitting curve, in which the binding values in terms of MFI are plotted against the increasing concentration of radioligand, was designed using GraphPad Prism 7 after subtraction from the blank (MFI values of the SCR aptamer).
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PMC9275501
When liposomes deliver therapeutic drugs in vivo, the change of pH can make some new liposomes release drugs in specific pathological tissues.
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PMC4355729
Moreover, the PIK3R1 depletion promoted the phosphorylation of AKT in the cells.
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PMC11790599
These changes are similar to methuosis-like cell death associated with catastrophic macropinocytosis (Overmeyer et al., 2011; Sun et al., 2017).
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PMC11354239
Therefore, Bosken et al. suggested that c-KIT may also negatively influence mTOR signaling in NK cells, as an inverse correlation between the level of c-KIT and mTOR phosphorylation has been found in NK cells activated by the exposure to heat-killed bacteria S. aureus .
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PMC11477621
RPMI-8226 cells were treated with indicated compounds for 48 h. Annexin V-FITC and PI double-staining detection kits were used to determine apoptotic cells.
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PMC10671321
Following the nomenclature of the Human Genome Variation Society (HVGS) for the ColQ protein resulting from this splice site mutation, we refer to the mutated protein as p.E428HfsX58, where p stands for protein, E428H for the first amino acid modified by the mutation in 428 (E) and replaced by an histidine (H), fs for frameshift, and X58 for the first stop codon selected 58 aa downstream the first aa modified (H).
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PMC11806182
Retinoic acid down-regulated cell migration while up-regulating programmed cell death, indicating its potential as an anti-tumor agent.
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PMC11371747
: concentration-dependent potentiation of inhibition of in situ TS activity in SW1398 cells by 5FU in the absence or presence of 5 µM l-LV.
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PMC11128598
A dose- and time-dependent effect was observed in all the cell lines analyzed (Figure 3), with the lowest IC50s observed in the glioblastoma cell lines (11.47 nM in A-172 and 15.6 nM in LN-18) and the highest in the breast cancer cell line HCC1937 (231.6 nM).
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PMC9429973
Three patients who were followed up with severe GvHD during PRES died due to complications of GvHD.
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PMC9429973
Ruxolitinib starting dose was decided accordingly to prescribing information.
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PMC11588085
Only a few genes were reactivated: 15 X-linked genes were significantly up-regulated by sgXIST7 and 16 genes by sgXIST9 among 500 X chromosome genes (adjusted p-value cut off = 0.01, log2 fold change cut off = 1) (SI Appendix, Fig. S3), consistent with other reports that indicate XIST loss does not cause chromosomal-wide X-linked gene reactivation (21, 22, 46).
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PMC8567602
In human synovial sarcoma cell lines, BAF-family complexes reside at actively transcribed chromatin and can extend across gene bodies in broader or longer peaks than otherwise typical for BAF localization (29–31).
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PMC10454535
MM cell growth causes suppression of erythropoiesis, resulting in decreased levels of red blood cells .
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PMC11748335
Peaks not identified as part of any LOCKs by CREAM were designated as typical peaks (Fig. 1A, Fig. S1A-B).
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PMC7504302
Among these genes, TMEM30B, KAZALD1, and MAPK13 were specifically methylated in MPM tissues and have been proposed as putative diagnostic markers.
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PMC8996378
According to the experimental results, compounds 1 and 2 were the most powerful inhibitors of ABCB1 efflux-pump activity, whose efficacy was 2–5 times higher than that of the standard modulator verapamil [Fluorescence activity ratio (FAR) = 52.5 at 40 μg/ml and 119.9 at 40 μg/ml].
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PMC11471176
Finally, the absorbance optical density (O.D.) was measured at a wavelength of 450 nm using an ELISA microplate reader (BioTek, Winooski, VT, USA).
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PMC8708099
We suspect that Caco-2 cells experience an increase in pro-IL-1β cleavage in response to stimulation by histamine and/or histamine + osthole, in relation to control, leading to an increased secretion of the active IL-1β form.
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PMC10667689
The maximum increase was observed at 48 h after treatment with Gal-9 in THP-1, while the rising trend of G6PD mRNA level continued for 72 h ( Figures 2G, H ).
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PMC11474209
The PP1 holoenzyme and Nek2 kinase make a complex.
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PMC11462673
The H3K27ac histone modification mark indicates the activity of transcriptional gene promoters and enhancers.
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PMC9429973
Pts in Gr1 showed the highest rate of CR1 (Tab.1), better RFS and OS (Fig. 1), whereas dmCEBPA pts in Gr2-4 did significantly worse.
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PMC11787355
In addition, MHCI expression was maintained in recurrent tumors (Fig. 4j).
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PMC11703992
The expression of IFN-γ, TNF-α and IL-6 in the serum-free culture medium of DDIT4-OE/Blank and DDIT4-OE/Blank-PMA groups showed that after PMA induction, the secretion of inflammatory factors increased, while DDIT4 overexpression slightly inhibited this upregulation trend (Fig. 8F, G).
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PMC11240448
Here, we focus on basal BC cell lines, because of the unmet clinical need for novel, synergistic treatments of basal BCs.
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PMC10812665
This may lead to an increased sensitivity, as, e.g., the rise of saccharopine levels or the depletion of aspartate upon c-I inhibition is stronger in the mitochondrial matrix than in whole cells .
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PMC10728535
We matched six publicly available microarray data sets comprising a total of 57 arrays to our pre‐specified criteria for inclusion.
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PMC11803210
Gene expression values are identified by TPM and gene changes represented as log2(fold change) as detected by RNA-Seq by Expectation Maximization (RSEM).Data source locationTulane University School of Medicine, New Orleans, LA, USA (29.95° N, -90.08° W)Data accessibility1 Raw, and processed data were submitted in Gene Expression Omnibus (GEO, accession number GSE277758).2 Analyses of genes differentially expressed and signaling pathways altered in MCF-7 cells treated with naringenin compared to vehicle control were deposited to figshare.
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PMC11634027
Dachs was also normally polarized in ds wing discs (Fig. 5E,E′).
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PMC11655536
As expected, knockout of NHE1 decreased the viability and increase the percentage of apoptosis in RPMI-8226 cells (Fig. S1A–C).
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PMC11394227
When BFA was employed to impede the transfer and secretion of antibodies from the ER, the (HC-LC)2 in CHO-PAb-QS cells increased from 40.8% to 73.5%, representing a 32.65% increase, which was considerably higher than that observed in CHO-PAb cells.
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PMC10698968
For ultrastructural evaluation, MF-R 3 cells were fixed with 2.5% glutaraldehyde in 0.1 M cacodylate buffer pH 7.4 for 1 h at room temperature.
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PMC11106977
This result can be explained by considering the complex off-target effects of inhibitors in different cell environments under different treatment regimens.
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PMC9954564
Since the genetic risk depends on the type of inheritance, SNPs were analyzed using additive and dominant models.
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PMC11351758
Furthermore, another limitation of this study is that we used Ca-free HEPES solutions and HEPES containing Ca as our source of Ca.
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PMC11549062
OE, Overexpression; RNAi, RNA interference. (
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PMC11697703
Combined expression of both antisense constructs also resulted in increased Mapk8 expression compared to scrambled controls and compared to antisense miR-365 (Figure 2E; miR-193b-365-AS 3.85-fold upregulation).
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PMC11802855
In the CXCL7-OE RPMI8226 (I) and H929 (J) cell lines, the administration of JAK1 inhibitors elicited a significant attenuation of the cell proliferative capacity.
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PMC11401358
The scavenging capacity of intracellular ROS in the SF and GCT groups was then found to be significantly different from the scavenging capacity of intracellular ROS in the other groups.
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PMC7504302
As shortly discussed earlier, individuals carrying germline mutations in the BAP1 gene are predisposed to MPM.
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PMC11093197
In this study, we observed a quiescent state in MCF10A cells following RB1 depletion.
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PMC10812665
Indeed, a clear signal for changes in AA metabolism was derived from the transcriptome data (pathway enrichment factors of up to 500%), but the adjusted significances remained low (Figure 8B).
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PMC11075223
As an effective antioxidant, Cimicifugae Rhizoma protected DNA and lipids from oxidative damage.
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PMC11745823
Scale bars: 50 μm. (
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PMC9429973
One patient developed transient grade 1 dyspnoea and liver dysfunction.
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PMC10565698
In brief, three 1.5 mL EP tubes were prepared for each plasmid.
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PMC8041314
In the case of ABC transporter inhibition, the corresponding substrate accumulates inside the cell.
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PMC11298021
Jurkat cells were cultured in 6-well plates with a cell density of 250 000 per well and then incubated at 37 °C.
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PMC11733919
Peroxidation of a sample of 5 mL of aqueous dispersion of methyl linoleate in TritonX-100 micelles was initiated by injection of 100 mL of aqueous solution of 2,2′-azobis(2-methylpropionamidine) dihydrochloride (ABAP, final concentration 10 mM).
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PMC7987994
Extraction surface-to-volume or mass-to-volume ratio recommended by ISO 10993-12 is 125 mm · ml or 0.2 g · ml, respectively.
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PMC9429973
The SMAC mimetics birinapant and LCL-161 were the most potent enhancers of NK cell cytotoxicity and had no effect on target cells alone.
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PMC11583010
Intratumoral exatecan concentrations were consistent with the kinetics of ADC tumor penetration (Fig. 5C).
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PMC9429973
Granulocyte recovery within 14 days may be a predictor of clinical success.
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PMC11093197
The expression of these protein complexes is typically suppressed in quiescent cells, resulting in RB1 being under‐dephosphorylated.
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PMC11615743
These findings demonstrate the utility of L‐DNA sequences for the associative activation of HCR amplification for the first time.
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PMC10759659
This observation implied that the activity of the TIM-3/Galectin-9 pathway was upregulated only in HBV-HCC.
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PMC11578343
We employed a four‐zone device with L zone = 6 mm.
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PMC11739504
7Summary illustration of this study.
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PMC11052306
Among the nanometric objects suitable for such purpose are dendrimers, precisely engineered hyperbranched macromolecules, which are outstanding candidates for improving therapy and diagnosis.
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PMC11078693
Note: Have the T75 flask sit vertically for a least 1 min to allow all cells to accumulate in media at the bottom.
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PMC11087301
Circulating tumor cells (CTCs) have emerged as a valuable target for investigation due to their ease of accessibility and potential for predicting disease prognosis .
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PMC4695073
So we splitted stage III into two subgroups (IIIA, T1-2N2M0 or T3N0M0; IIIB: T3N1-2M0) (Figure 5A).
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PMC11323699
Addressing both these challenges will require a better understanding of the unique tumor immune landscape of OC and the intricate mechanisms triggering PARPi resistance, along with the emergence of reliable biomarkers that are easy to use in clinical trials .
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PMC6024716
Cells grown to confluence were enumerated, and the total amount of polyamine in the equivalent numbers of cells was quantified using UHPLC.
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PMC11694346
Notably, when BT-DNBS was tested without biothiols, it exhibited stable weak fluorescence intensity between pH 6 and 8.
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PMC9100622
We show that EGR2, an Ewing-susceptibility gene and an essential direct target of EWSR1-FLI1, directly regulates the transcription of genes encoding key enzymes of the mevalonate (MVA) pathway.
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PMC11718274
In brief: after coating microgel electrophoresis slides with a layer of agarose (0.7%), a mixture of A-431 cells and agarose was carefully placed on these pre-coated slides and spread evenly.
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PMC9429973
Approximately 10% of patients had a clinically significant reduction in Hb levels after vaccination, especially those administered viral vector vaccines probably due to prevalent systemic reactogenicity.
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PMC11258145
The HL-60 cell line, obtained from the American Type Culture Collection, was cultivated in RPMI 1640 medium, supplemented with 0.01% penicillin–streptomycin and 10% fetal bovine serum (FBS).
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PMC11519567
Consequently, this leads to the downregulation of tumor suppressor genes occupied by SS18 physiologically, like CAV1 and DAB2.
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PMC11089031
Our IHC results showed that ZNF692 was expressed mainly in endothelial cells of the tubules (Fig. 5C, indicated by red arrows) and cells in the mesenchyme (Fig. 5C, indicated by red stars).
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PMC9429973
The incidence of grade 3-4 hematologic toxicities was 1.7%, 4.2%, and 2.2%.
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PMC9429973
RNA was extracted by TRI Reagent, reverse transcribed, and TMEM244 expression was analyzed by qRT-PCR.
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PMC11155445
The catalytic activity of the Ru(iii) acyl thiourea complex (86) for the reduction of differently substituted nitroarenes was investigated by Uysal et al. Results suggest that the optimal conditions for reduction are 0.01 mol catalyst and 4 eq. NaBH4 in ethanol at 50 °C.
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PMC11680982
After washing, the sections were incubated with goat anti-rabbit IgG-HRP secondary antibody (1:200; Beyotime, A0208, China) for 1 h at ambient.
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PMC8592717
When patients with chronic stable angina were treated with DHI, they showed a clinically significant change, defined as at least a 20-point improvement in the angina frequency score on the Seattle Angina Questionnaire.
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PMC9966931
Plants have been used by humans since ancient times due their antimicrobial and medicinal properties.
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PMC11604768
a Volcano plots of promoter responses following receptor agonism in HEK293 cells co-transfected with the TRE-MPRA library and GPCR expression plasmids.
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PMC11547972
The Bliss predicted inhibition rate IBliss was then calculated by the formula IBliss = Iamyg + ISFN − (Iamyg × ISFN) Synergism is defined by IBliss > observed inhibition by the drug combination.
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PMC9429973
The cumulative incidence of relapse, NRM, grade II-IV aGVHD, cGVHD and extensive cGVHD was estimated by competing risk model and compared by Gray test.
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PMC10421378
The analysis of glass transition involved the following steps: (1) holding for 1.0 min at 30 °C; and (2) heating from 30 °C to 300 °C at 5 °C/min.
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PMC8751435
However, it requires more scientific validation on its anticancer effect to facilitate clinic application of CME.
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PMC9429973
Among adults aged ≥60 years, HCT was reported for 55/151 (36%) patients, including 55/115 (48%) with ≥3 months of follow-up.
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PMC11756514
The treated bacteria were subsequently washed twice.
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PMC11397654
The same year, Wang and co-workers synthesised supramolecular nano-platforms (NPs) based on the imino-linked polymers formed by the bis-amine pillararene 78 and the ferrocene dicarbaldehyde monomers (Figure 25).
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PMC11739504
Acetylated α-tubulin and γ-tubulin were stained for primary cilia and basal body (red).
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PMC11787355
Notably, CD4 CAR-T cell persistence was associated with long-term survival in leukemia patients, but on the other hand, CD4 CAR-T cells are implicated in cytokine release syndrome.
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PMC11774112
Gross appearance of mice bearing MM xenografts after 32 days of treatment with different therapeutic regimens. (
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PMC10094992
Non-specific (NS) or specific CDKN2A siRNAs were from Qiagen (Hilden, Germany).
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