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PMC11796104
Low activity of osteoblasts resulted in decreased bone formation while high that of osteoclasts for increased bone resorption .
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PMC11627133
Therefore, cells were incubated with premixed J18‐RhoBAST (500 nM) and SpyRho (100 nM) for 10 min and imaged.
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PMC5673060
Total lysate peptides were subjected to wideband activation to co-fragment precursor ions undergoing neutral loss of up to − 20 m/z from the parent ion, including loss of water/ammonia.
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PMC6379402
For illustration purposes, we used spatial analysis of functional enrichment (SAFE) on the iCell of breast control tissue to highlight regions of iCells that are enriched in reactome pathway (RP), KEGG pathway (KP), or gene ontology biological process (GO-BP) annotations (bottom).
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PMC9429973
The study was approved by the Ethical Committees from the participating centers.
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PMC7433824
Also, 11 genes were found to be common between 100 µM P4 and 300 µM P4 administered the U87 cell line.
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PMC9429973
Multivariate logistic regression analysis showed that genotype (SCA vs SC/Sb+), splenectomy history and age at check-up were all strong significant (P<0.001) and independent risk factors for HBJ score >1 (>0.2% RBCs containing HJBs).
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PMC11496491
In this study, we collected marginal tissue samples from patients with diabetic foot ulcers.
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PMC11742864
For example, α-linolenic acid can be desaturated by the delta 5 and 6 desaturase enzymes and elongated by Elovl 2 and 5 elongases, transforming into DHA and eicosapentaenoic acid (EPA) in multiple organs (liver, brain, testicles, and so forth).
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PMC11787651
The total number of histone peptides identified by both the 5-min and 10-min methods is higher than that achieved by the Orbitrap analysis, with 178 and 184 peptides identified respectively, as shown in Figure 2A.
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PMC9429973
Image: Summary/Conclusion: The single-cell profiling of a subset of MF pts enrolled in the MANIFEST study suggests that pelabresib alone and in combination with RUX induces an improvement of the myeloid-lymphoid imbalance in both JAKi-naïve and r/r MF pts.
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PMC8839885
Moreover, dasatinib significantly increased the sensitivity of ABCB1-overexpressing cells, increased the intracellular accumulation, inhibited doxorubicin efflux, and significantly enhanced doxorubicin-induced apoptosis in ABCB1-overexpressing MCF-7 cells .
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PMC8557138
For example, both transcriptional and translational upregulation of VEGF-A and vascular endothelial growth factor receptor-2 (VEGFR2) in diabetic vasculopathy, such as proliferative retinopathy, results in excessive angiogenesis.
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PMC11224020
DC migration to lymph nodes at steady state helps maintain peripheral tolerance.
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PMC11774112
The combination effect was analysed by CompuSyn software (F). *
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PMC9712534
TOP2B with L185F is ICRF-insensitive and partially retains the catalytic activity.
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PMC9424261
MDM2 is in cancer cell types, including lung, breast, colorectal adenocarcinoma, and osteosarcoma.
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PMC8345486
Adenosine derivatives or unmodified metalla bis(dicarbollides) were weak inducers of programmed cell death with the exception of compound 23.
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PMC7642379
The top ten most enriched biological GO terms of the 38 common DE genes between adherent and suspension cells based on gene enrichment analysis.
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PMC11295144
as described previously (Brown et al., 2014).
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PMC9444294
Bottom row: PLA assay performed in the osteosarcoma cell line, U2OS.
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PMC11093197
We observed a reduction in Ki67‐positive cells and a decrease in the expression of cyclin D1 and E in RB1‐depleted MCF10A cells (Figure 1E–G).
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PMC9429973
Aims: The study aims to evaluate the telomere length in BM-MSC of AA patients in comparison to that of controls.
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PMC11718031
Overall, we note that CD-FortiCHO, IS CHO-CD G17.4, and IS CHO-CD G17.7 are better at supporting cell growth to achieve a high viable cell count within the investigated cultivation time.
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PMC10798140
HRMS ESI, ([M + H]): calculated m/z 398.1863; found, 398.1887.
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PMC9429973
Methods: The study included 42 employees infected during the 09/17/2020 - 01/01/2021 outbreak, which corresponded to the 2nd wave of COVID-19 worldwide.
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PMC11766309
Furthermore, an analysis of the coexpression of YKT6 and immune-related genes was conducted.
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PMC11745823
In addition, under normoxic conditions, the factor Inhibiting HIF1 (FIH1) promotes asparagine hydroxylation at position 804 of HIF‐1α, thereby inhibiting its binding to P300 and inhibiting the transcriptional activation function of HIF‐1α.
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PMC11357960
Similarly, researchers found that both T and B cell development exhibited severe defects in SUMO specific protease 1 gene knockout mice (52).
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PMC11025866
There were 10 genes upregulated and 15 genes downregulated by both VPA and VPM, but not by NaB. Further refinement of those gene lists was conducted by comparing genes altered by VPA or VPM alone with genes that were still altered similarly when butyrate was combined with VPA or VPM (Fig 4B).
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PMC11754436
Protein samples (100 µg) were subjected to SDS-PAGE (KGP113; Nanjing KeyGen Biotech Co., Ltd.) and transferred to PVDF membranes (IPVH00010; MilliporeSigma).
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PMC11588085
Hypoxia treatment of XIST KD in ovarian cancer cells induces higher stemness and hypoxia-cell death resistance. (
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PMC11023271
This supportive role may be mediated by loss of RIPK4.
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PMC7334607
Performing this experiment in a greater number of cell lines would provide improved insight into the spectrum of responses across various EWS cases.
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PMC9429973
The main analysis of hematologic response (ie, percentage of pts with platelet count thresholds of ≥30, ≥50, and ≥100 ×10/L achieved at least once without rescue therapy) was restricted to data from the first 2 mo (~Day 57) to ensure pts were on treatment.
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PMC9429973
Among the 473 patients analyzed: 238 were women, the median age was 49.5 years [IQR 36.6-59.7]), 184 (38.9%) were intermediate risk and 51 (10.8%) with not evaluable cytogenetic and molecular data.
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PMC11711127
Apoptosis is executed by the serial activation of several caspases, a type of cysteine-aspartic proteases, which cleave cellular components and irreversibly cause cell death.
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PMC8010066
3The expressions of lasI (a), lasR (b), algD (c), KPC (d), and mexR (e), in P. aeruginosa.
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PMC11412752
Membranes were blocked and incubated with STING antibody (19851-1-AP; Proteintech) and β-actin (SAB1305554; Sigma-Aldrich) at 4°C overnight.
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PMC9503669
While antiretroviral drugs have transformed the lives of HIV-infected individuals, chronic treatment is required to prevent rebound from viral reservoir cells.
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PMC11026382
e The position-averaged log10 catalytic power (as inferred from the growth rate data) across measured mutations.
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PMC11366496
Collectively, RNF122 might enhance the progression of GBM by JAK/STAT signaling activation.
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PMC4816271
Significance of differences between experimental groups was determined using the Mann-Whitney U test.
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PMC9429973
All groups were treated for 48h at the same time.
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PMC7171147
Firstly, ovarian cancer cells might oscillate between periods of FAO and fatty acid synthesis activation.
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PMC10809689
After binding of the Gal-9 ligand to the TIM-3 receptor on the surface of AML leukemic cells through autocrine or paracrine pathways, the PI3K/AKT/mTORC signaling pathway is activated.
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PMC11352666
The combination of two targeted therapies to inhibit MERTK and BCL-2, however, may be better tolerated.
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PMC11633763
C, E) ECAR data showing the glycolytic rate and capacity in USP22‐silenced (C) or USP22‐overexpressing (E) osteosarcoma cells.
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PMC9429973
Focusing on the group of patients with DLBCL (excluding primary CNS lymphoma, primary mediastinal B cell lymphoma and Burkitt lymphoma), there were 43 patients with refractory (n=26) or relapsed (n=17) DLBCL.
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PMC10587429
Recent clinical safety evaluation data showed that magrolimab was well tolerated using a priming dose at 1 mg/kg followed by maintenance doses ranging from 3 to 45 mg/kg (24).
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PMC11775197
They function as transcription factors and can participate in tumorigenesis, cell proliferation, angiogenesis, cell death, invasion, migration, and tumor metabolic processes.
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PMC9429973
Methods: Through a collaboration with a biotech company that develops inhibitors of the one-carbon metabolism, we tested new MTHFD1/2 inhibitors, which we believe, are promising in the context of CLL.
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PMC11224020
f, Left, representative images of DCs from LmnA/C and LmnA/C DCs.
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PMC10547921
However, compound 99 was poorly permeable, which might be due to the presence of alkaline amines in the chemical structure and thus weakens its cell efficacy.
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PMC11472569
Heparin, a glycosaminoglycan, can inhibit EV binding to cell surface proteins, thereby reducing EV uptake.
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PMC11502443
GIP (1-42), GIP (1-30), and tirzepatide were serially diluted in cAMP assay media.
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PMC11574271
Taken together, these results suggest the presence of a potential signaling and functional axis among RON, HIF-2α, and MMP12 in the bladder cancer cells, which coordinately regulate bladder cancer cell migration and matrix invasion.
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PMC11001582
A total of 5 × 10 iPSNs were nucleofected with 4 µg of plasmid DNA (Origene) in suspension as previously described.
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PMC8592717
It was found in the plasma in the form of PAL, PCA, and their conjugates, and the conjugates were detected in the intestine, liver, and kidney.
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PMC11725127
Conversely, overexpressing USP2 stabilizes KRAS and partially abrogates GA-induced apoptosis in MM cells.
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PMC8708099
no. 06402712001), according to Kordulewska et al. .
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PMC10898159
Over-expression of p55PIK in GIST882 cells bind the promoter and increase the expression of NF-κB p65 (Ser536), leading to resultant KIT upregulation.
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PMC8623816
Most mycoviruses possess either double-stranded RNA (dsRNA) genomes or positive sense (+) single-stranded RNA (ssRNA) genomes, and some have negative-sense (−) ssRNA or single-stranded DNA (ssDNA) genomes .
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PMC11656657
These gene-modified Tcells have been previously tested preclinically in NBL , H3K27M-mutated diffuse midline gliomas and medulloblastoma models.
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PMC8469018
No changes of mitochondrial membrane potential at any drug concentrations were observed.
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PMC11745823
RIT1 gene mutations display a close connection with tumour occurrence and development , especially in some malignant tumours , showing an important carcinogenic effect .
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PMC11489275
The disease often progresses rapidly and the treatment is difficult for these patients, despite receiving high-intensity systemic glucocorticoid and immunosuppressive therapy, the survival rate is still poor.
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PMC11247842
The multi-trait meta-analysis using MTAG of CM (Fig. 3a) and SCS (Fig. 3b) showed mostly consistent results regarding QTL location for these two mastitis-related traits.
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PMC11361748
Sections of WT and Krt17 mouse skin treated with double TPA, 24 h apart, immunostained stained for K14, Ly6g, and nuclei (DAPI).
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PMC9027909
Accordingly, most of studies have associated the presence of ST1 and ST3 with some clinical manifestations such as gastrointestinal disorders and urticarial [10–12].
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PMC9596868
γ-H2AX accumulates at damaged DNA sites and appear as foci when observed microscopically using immunofluorescence (IF) assay.
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PMC6742971
Twenty-five microliter of 35% ethanol/well was put in 96 well PVDF plates (MSIPS4510, Millipore) and incubated at room temperature (RT) for 30 s. The wells were emptied by flicking the plate over a sink and gently tapping on absorbent paper.
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PMC9454852
After treatment with BOLD-100, we observed a 50% increase in the expression of ERO1α in REN cells.
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PMC11301242
However, these results also indicate that a substantial portion of ecDNA formations occur through mechanisms other than chromothripsis.
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PMC11727062
Furthermore, artemisinin can contribute to the reversal of drug-resistant melanoma by enhancing PD-L1 immunotherapy efficacy and promoting the infiltration and proliferation of anti-tumor T cells (Zhang et al. 2022).
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PMC11763764
We designed a screening experiment in which the control and SORL1 knockdown cell lines were treated with ten growth factors that were associated with chemoresistance in ovarian cancer.
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PMC11078693
Add ATTO-643 phalloidin conjugate and primary antibodies to the 0.2 mL cell suspension.
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PMC11519788
Our analysis revealed a positive correlation between SPOP and VEZF1 (Figure 7B-C), an endothelial cell-specific transcription factor 31, which was further confirmed in another four independent datasets (Figure S4B-H).
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PMC11519077
The most frequently used human cell line in studies on the activity and integrity of the barrier around the intestines is Caco-2 .
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PMC10125312
Cancer cell lines (786-0, A549, and HepG2) experienced larger increases in temperature compared to noncancerous ones (Hek293, NL20, and THLE-3).
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PMC10317042
EWSR1::ATF1 mRNA levels in CCS cells were quantified using qRT-PCR (normalized to GAPDH; n = 3).
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PMC11078693
Fill each tube with 40 mL of permeabilizing solution at RT.c.
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PMC11066331
In summary, we demonstrate that spectral fingerprints generated by intact cell MALDI-TOF mass spectrometry coupled to a machine learning classifier can reveal minute changes induced by alteration of a single gene, and therefore contribute to the portfolio of quality control applications in routine cell and tissue cultures.
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PMC11633763
p < 0.05. (
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PMC9429973
Methods: This is a retrospective study including 32 patients with refractory HL treated during the period from 2015 to 2020.
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PMC11574271
The only exception is plasmid GV492, which harbors a short hairpin RNA oligonucleotide sequence (shRNA) for silencing the RON gene expression.
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PMC11297139
Fig. 5ARID1A LLPS links EWS/FLI1-associated cREs and oncogene activation.a A heatmap showing significantly (P value < 0.05) altered long-range chromatin contacts between the DEGs and the dysregulated cREs in an ARID1A LLPS-dependent manner.
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PMC10994876
The Hippo pathway comprises an upstream cascade of serine kinases (MST1/2 and LATS1/2) that govern the activity of co-transcriptional activators, such as YAP (Fu et al. 2022).
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PMC11525028
In addition, the suppression of proliferation and metastasis induced by NAT10 knockout (NAT10-KO) could be attenuated by overexpression of ATF4 and ASNS or supplementation with Asn.
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PMC11576293
The exact structure was determined and confirmed by NMR, HRMS, and X-ray diffraction investigation.
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PMC10936243
The questionnaire was pilot-tested on five small animal practitioners in Malaysia.
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PMC11787651
Differentially expressed histone PTM marks for HDACi-treated samples.
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PMC10728535
The normalization quality and data distribution were assessed by drawing the pre‐ and post‐normalization boxplots.
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PMC9954564
A SureDesign tool (Agilent Technologies, Inc., Santa Clara, CA, USA) was employed to design a set of probes that ensured the capture of 488.658 bp, including the HLA-G (5′URR—upstream regulatory region, coding sequencing (CDS, only exons), and 3′UTR), and LILRB1/2 (CDS, only exons) genes, as well as other loci of interest for the research group, such as the regions encompassing the SNPforID 34-plex ancestry informative marker (AIM) set of SNPs .
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PMC8839885
Results demonstrated that the different amplicons were obtained only from human RNA, but not from murine RNA (Figure 5).
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PMC11337594
The role of GSDME in TER-induced apoptosis was subsequently investigated.
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PMC7553912
Fibroblasts are mainly responsible for the synthesis of extracellular matrix (ECM) proteins, such as collagen and elastin, in both physiological and pathological conditions.
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PMC11252033
ASA-treatment or CryZ silencing were able to increase and restore the chemosensitivity in both sensitive and resistant A2780 ovarian cancer cells, respectively.
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PMC11794568
Rotenone reversed the proliferative and invasive capacity of melanoma cells promoted by silencing CRIP1. (
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PMC6461034
○For faithful aliquoting of equal amounts of beads, it is essential to apply a stepwise strategy: ‒invert the “stock” vial with beads 10 times and distribute a fraction (e.g., 1/4) of the “stock” to the “IP” tubes—restore the volume of the “stock” vial with IP buffer;‒perform a second distribution round by again distributing (only) a fraction of the “stock” and restoring the volume of the “stock” vial with IP buffer, etc.;‒in a final round (e.g., round 4) completely distribute the contents of the “stock” vial, emptying it.
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