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PMC11461874
Ubiquitination analysis have revealed that TRAF7 enhances K48-linked polyubiquitination of DBP in cultured cells.
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PMC9960565
This is the case even though, with the increase of generation, the metallodendrimers become less and less anionic and more neutral.
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PMC9429973
Funding PI20/00926, GRS2135/A/2020, GRS2314/A/2021, FMM AP172142019 D. Polokhov, A. Ignatova, E. Ponomarenko, A. Poletaev, P. Zharkov Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia Background: Patients with Wiskott-Aldrich syndrome (WAS) have a reduced platelet count.
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PMC9429973
Recommendations for diagnosis and treatment of methemoglobinemia was published in collaboration with EHA.
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PMC10547921
Sanjeev Gangwar conjugated the uncialamycin analog 52 to an anti-mesothelin (meso) antibody.
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PMC9429973
Previous results from this ongoing phase 2 study, BGB-3111-215 (NCT04116437), show that zanubrutinib was well tolerated in pts who discontinued ibrutinib and/or acalabrutinib due to AEs (Blood 2021;138[suppl 1]:1410).
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PMC11618052
The results of this test are the same as the results of the antiproliferative test, which found that compounds 8g (R1 = p-tolyl, R2 = OMe), 8h (R1 = p-tolyl, R2 = Me), and 8j (R1 = m-tolyl, R2 = Cl) were the best antiproliferative agent.
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PMC11773391
This could potentially elucidate the mechanism underlying the acquisition of drug resistance.
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PMC11751675
All active compounds with an EC50 of 10 μM or less possessed the exo-α-methylene-γ-lactone moiety, which appeared essential for anti-HCV activity, as seen in compounds (1–5) or their substituted analogs that retained this structural feature (11–18).
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PMC9429973
NRM was infrequent at 4% through 1 year.
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PMC11791432
The results verified that ANXA1 is indeed highly expressed in glioma cells, moderately expressed in immune cells, and almost not expressed in normal cells.
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PMC9587298
The antiglycation potential of elderberry rich-phenolic extracts (M) obtained by SPE was evaluated by measuring their capacity to trap methylglyoxal (MGO).
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PMC10454535
Our study led to a combination of PIN and BTZ, and synergistic effects were confirmed using CI values.
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PMC11769516
Of the large variety of known mycotoxins, the major Fusarium spp.
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PMC11594641
However, based on our data, we cannot find a simple relation between the type of tetraspanin or ESCRT protein loading in sEVs and the invasiveness of melanoma cells.
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PMC11438317
Anti-V5 Ig (mouse monoclonal IgG2a) from Invitrogen (Carlsbad, CA, USA).
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PMC5925824
Medium was removed from the assay plate the following day and serially diluted test and control antibodies were added at 40 μl per well in the assay buffer.
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PMC9429973
Results: After filtering and data integration we retained 14,848 cells.
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PMC8996378
Some jatrophane diterpenoids, including compounds 11 and 12, were isolated from the latex of Euphorbia nicaeensis, together with seven previously undescribed jatrophanes (Table 1), among which compounds 18 and 19 were the most active compounds (FAR = 4.52 and 5.02 at 5 μΜ on non-small cell lung carcinoma NCI-H460/R, FAR = 5.89 and 4.39 on colorectal carcinoma DLD1-TxR) (Krstic et al., 2018).
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PMC5963610
Images of EGFR (G) and NGcGM3 ganglioside (H) expression (brown color) by immunohistochemistry assay.
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PMC11587606
TetON-RH cells were treated with 2 µg/mL Doxycycline (Dox, MedChemExpress) for 96 h to induce overexpression of RHBDF1.
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PMC11628904
Representative images of frozen skin sections stained with LDH to assess tissue viability. (
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PMC11367146
Furthermore, binding free energy calculations using the MM/PBSA (Molecular Mechanics/Poisson-Boltzmann Surface Area) method were performed to quantify the thermodynamic stability of the docked complexes.
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PMC11754432
Then treated with cytokine cocktail with or without 10 µM ML351 (Cayman chemicals) for 2 days.
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PMC8992508
The resistance of cancer cells to antineoplastic agents represents a substantial limitation to effective chemotherapy.
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PMC10094992
The blood neutrophil-to-lymphocyte ratio (NLR) has been studied in several solid tumours to predict survival and response to cancer therapies.
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PMC11377827
n = 3 biological replicates, *P = 0.0322, two-way ANOVA. (
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PMC10761218
The cells were then incubated at 37°C and 5% CO2 for 24 h. The untreated cell lines served as the negative control, and the cells treated with the anticancer drug doxorubicin served as the positive control.
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PMC10878518
OBP-401-mediated GFP expression was compared between clinical tumor specimens with different expressions of CAR and hTERT.
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PMC11392912
The dietary intake of miRNAs, their absorption, and circulation in the blood raised various questions about their stability in the biological fluids such as in blood, milk, as well as in extreme pH conditions during the digestion process .
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PMC10870498
p < 0.01 vs. vector + si-NC group; p < 0.01 vs. KIF23 + si-NC group).
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PMC10547921
In chronic mouse arthritis models, α-TNF-GRM ADCs are more effective than α-TNF monoclonal antibodies and homotype controls with the same GRM payload.
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PMC9429973
Four of five pts had a relapse of B-ALL and one had refractory disease.
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PMC11767793
The presence of trace amounts of PEI in the test solution may distort the toxicity assessment of AuPEI@NIST, resulting in a false positive reading.
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PMC11064533
Wilcoxon rank-sum test was used to determine the significance between different strains.
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PMC9895440
Images were visualized using Imaris 9 (Bitplane) and OMERO (www.openmicroscopy.org, managed by Biozentrum Basel) was used to generate figures.
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PMC11795610
After that, the cells were washed with PBS and blocked with immunostaining closure solution for 30 min at room temperature.
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PMC11093197
In general, the RB1‐E2F complex acts as a guardian that prevents excessive cell proliferation, and RB1 deletion leads to uncontrolled cell growth.
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PMC11394730
It has been shown that by independently blocking the PI3K/Akt/mTOR pathway, plumbagin and curcumin both have anticancer action.
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PMC11694625
Additionally, molecular docking also suggests that CDK2 may be one of the targets for 3b and 3c.
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PMC11476264
Primer and shRNA sequences are reported in Supplementary Tables S1 and S2.
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PMC11698348
p < 0.05; **p < 0.01; ***p < 0.001; unpaired Student’s t-test.
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PMC7812570
Subsequently, the cells were stained with antibodies and analyzed by FACS analysis as described above.
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PMC9599726
Primary antibodies raised in different species and secondary antibodies, coupled with different fluorochromes (800 Li-Cor and 680 Li-Cor), were sequentially imaged on an Azure c500 imaging system (Azure Biosystems, Dublin, CA, USA) and displayed in green and red, respectively.
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PMC11789597
These results indicate that CAV1 inhibition by statins appears to offer a promising strategy to enhance the therapeutic effect of bortezomib for MM treatment.
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PMC10589262
Pharmacological inhibition of ATF6 significantly decreased chaperone expression, including HSP90, and resensitized GIST cells, even under mild ER stress.
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PMC9429973
Results: The primary endpoint is the best overall response (BOR) per independent review committee using the IMWG criteria.
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PMC11495567
Cells were seeded at a density of 2.0 × 10 cells/mL on each side of the insert on a 12-well plate with serum-free media to limit excessive cell growth and to initiate a state of starvation.
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PMC9444294
We expanded its documented value to immunofluorescence and proximity ligation assay applications, while also establishing its ability to specifically detect the human protein in a murine background using tissues from genetically engineered synovial sarcoma conditional mouse models.
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PMC11464982
Therefore, a second study was carried out using the ‘treat and wash’ method in TA98 and TA1537 without S9‐mix or in TA1535 with S9‐mix, using seven concentrations up to 5640 U/plate (corresponding to 10,100 μg TOS/plate) of the food enzyme, respectively.
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PMC11092382
Further investigation is warranted to elucidate the therapeutic and protective effects of sophocarpine on other types of heart diseases such as myocardial hypertrophy and ventricular remodeling, as well as to uncover the underlying mechanisms of action.
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PMC11658074
Both types of EVs were labelled with PKH26 and incubated with NIH3T3 cells for 30 min.
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PMC10040136
Analysis was done on the wound's size and its closure.
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PMC11763111
Based on this, we hypothesize that LLT1 maintains the stemness phenotype of CAR-T cells by enhancing TCF7 expression.
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PMC9429973
The safety profile of vaccine is similar for CML patients and general population.
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PMC11453018
Pharmacological inhibition of P300/CBP disrupts the EWS::FLI1 transcriptional complex in Ewing sarcoma, leading to senescence and vulnerability to senolytics, providing a promising therapeutic strategy for this challenging cancer.
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PMC8992508
An amino metil-1,2,3-triazole moiety was inserted instead of the phenylamido group and the second amide of the tariquidar (59) structure was inverted.
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PMC10571053
P-gp-overexpressing MDR-19 cells and ABCG2-overexpressing R-5 cells were derived from HEK293 cells and have been previously characterized and described.
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PMC11377827
40 and 60 min and analysed by immunoblotting for HIF-1α degradation.
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PMC11711345
Six selective and three specific cell lines were proposed to evaluate the anticancer activity of the compounds in addressed studies, mainly involving those with Pa≥0.50.
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PMC10547921
Peter S. Dragovich explored the dimer of PBD containing disulphin prodrugs as the payload of antibody-drug conjugates and found that many PBD monomers containing disulfide prodrugs exhibit strong antiproliferative activity against cells (such as KPL-4 cells) with relatively high intracellular GSH levels.
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PMC5673060
Furthermore, the phosphotyrosine (pTyr)-based proteomics employed in our previous study was only able to identify < 5 tyrosine phosphorylated proteins that were upregulated in the two TKI resistant cell lines , limiting our ability to determine the signalling pathways enriched as a result of acquired drug resistance.
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PMC8481254
P < 0.01, ***P < 0.001.
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PMC11680982
Characterization of ZR-75-1 as an HR/HER2-low breast cancer cell line. (
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PMC9429973
J. Yang, J. Li, X. Zhang, L. Qiu, P. Lu Hebei Yanda Lu Daopei Hospital, Langfang, China Background: T cell malignancies represent a group of hematologic cancers with high relapse and mortality rates.
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PMC11052306
Gathering several metal complexes in a single, larger entity may provide enhanced properties.
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PMC9429973
A 30-year time horizon and the Social Security’s payer’s perspective were assumed.
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PMC9429973
Methods: We used the Scikit-Learn python library and LightGBM to test several ML models and develop techniques for generating new variables and selecting hyper-parameters.
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PMC11461874
HEK293T cells were transiently transfected with plasmids for DN mutant of UBE2G1/UBE2T (c) or DBP (d) together with expression plasmids for shRNA targeting these E2s.
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PMC6133382
Cas9, CRISPR-associated protein 9; CHO, Chinese hamster ovary; CRISPR, clustered regularly interspaced short palindromic repeat; DIC, differential interference contrast; GNA, Galanthus nivalis lectin; GnTI, N-acetylglucosaminyltransferase I; HEK 293, human embryonic kidney 293; MGAT1, Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase.
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PMC9429973
Safety endpoints include the incidence of treatment-emergent adverse events (AEs), serious AEs, infections and CMV and EBV reactivation.
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PMC6267596
After final library QC was completed, samples were equimolar-pooled and clustered for sequencing on the HiSeq2500 machine.
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PMC10006224
a Top, contour plot profiles of chromatin-bound STAG1 and STAG2 in A673 cells with (WT) or without (KO) STAG1 in control (gray) and NIPBL KD (colored) condition.
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PMC9429973
Overall response rate was 60% with a complete remission (CR) rate of 53% (78% for treatment-naïve group and 49% for R/R group, p 0.017).
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PMC9429973
An exploratory analysis of the ibrutinib-treated rrMZL study showed mutations in genes regulating NF-kB signalling pathway: TNFAIP3 (A20) and MYD88 predicted response, whereas KMT2D (MLL2) and CARD11 were associated with primary resistance.
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PMC9429973
Results: At data cut-off, median (range) follow-up was 9.6 mo (2.5-21.2).
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PMC7887261
This is a large pooled sample was assembled consisting of 10 independent case–control studies which previously described elsewhere.
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PMC11394730
Compounds such as resveratrol, found in grapes, and curcumin, derived from turmeric, have demonstrated the capacity to interfere with glycolysis, the Warburg effect, and mitochondrial function.
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PMC11732635
Related therapies for other viruses, including for HCV (8) and CMV (9), are still in the early stages of preclinical research.
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PMC11026382
TYMS R127A was not included in the deep mutational scan.
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PMC11588085
These findings suggest that XIST is essential for maintaining cellular identity in ovarian cancer, highlighting its role beyond embryonic development in influencing cancer outcomes.
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PMC11627060
UV-visible (UV–Vis) spectroscopy, Fourier transform infrared spectrophotometer (FT-IR), scanning electron microscopy (SEM), and dynamic light scattering (DLS) were employed to verify the biogenic TQ-BSA NPs’ size, shape, and distribution.
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PMC7685376
Overexpression of MCM2, MCM6, and MCM7 was closely associated with adverse tumor features and poorer outcomes.
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PMC11551844
After 24 h, the media was removed and replaced with fresh media containing AuNPs, from stock solutions (i.e. the final concentration of the AuNPs in the well was approx.
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PMC9429973
We describe our initial experience in this patient population at our centre, the Princess Margaret Cancer Centre (PM).
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PMC9429973
Statistical analyses were performed using SPSS v24.0 (IBM, Somer, NY).
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PMC11742670
model MAE for the A-375 cell line. (
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PMC11365427
Finally, the cells were analyzed using a Zeiss LSM800 confocal laser microscope.
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PMC11754094
P = 0.0002 for LIG IV KO HeLa cell line, P = 0.0229 for POLQ KO HeLa cell line and P = 0.0038 for RAD52 KO HeLa cell line compared to the wild-type HeLa cell line.
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PMC11747467
Human bladder cancer cells representing luminal type (SW780, HT1376, and RT4) and basal type (5637, T24, and J82) were purchased from Procell Life Science&Technology Co. Ltd. (Wuhan, China).
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PMC11683240
For sample illumination, a randomly polarized super-continuum laser source (repetition rate 1 MHz) was split into the excitation wavelengths of 568 nm and 633 nm and their respective depletion wavelengths of 710 nm and 750 nm.
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PMC11707577
In terms of spheroid integrity, a clear loss of the 3D structure with the presence of numerous single cells detached from the spheroid was observed after photoactivation of M13EGFR(TNP).
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PMC11738017
Case MM-19 was notable for a templated insertion that caused a focal gain of a key transcription factor, POU2AF1 (Figure 1F), which is a canonical plasma cell transcription factor known to positively regulate TNFRSF17 expression.
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PMC8557138
Hydrogels are formed under different conditions by modifying their constituent materials such as polyethylene glycol, polyvinyl alcohol, polyhydroxy ethyl methacrylate, and polyacrylamide based on their cellular compatibility.
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PMC8759873
Liposome-mediated gene transfection is currently the most commonly used in vitro transfection method.
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PMC11799620
Then, HepG2 and HEK 293 cells pre-treated with OFAE (100 µg/ ml) diluted in MEM medium at 37°C for 24 hours.
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PMC10237474
Sample pump, affinity and SEC columns were cleaned with 0.2 M NaOH and re-equilibrated with TBS or HBS after each run.
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PMC11683240
The left lung lobe and spleen were homogenized in PBS, and serial dilutions were plated on BG agar supplemented with streptomycin to quantify bacterial load.
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PMC11320834
The lower cytotoxic activity of TLL than the standard formulation on normal patient-derived ovarian cells suggests the possibility of better therapeutic efficacy and safety profile.
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PMC11711871
On the other side, a more subtle phenotype may be even closer to what is found in the human population harboring GR mutations.
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