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PMC10667689
Further investigations to reveal the role of GSH in AML relapse are the subject of interest of an ongoing project as well.
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PMC11721587
WB analysis of the phosphorylation of Ci in S2R cells cotransfected with the indicated Sufu and Fu constructs. (
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PMC11513571
Notably, both Poly I:C (500 ng/mL) and RSV induced an increase in TSLP levels after 48 h; respectively (54.9 pg/mL; p =0.02, Figure 3B) and (76.7 pg/mL; p =0.01, Figure 3C).
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PMC11806613
The in vivo activity of OST-01 was tested in four murine models: a triple-positive BC CDX (BT474), a TNBC CDX (MDA-MB-231), a TNBC PDX, and a luciferase-expressing MDA-MB-231 fat pad xenograft.
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PMC10936243
Instead of focusing purely on education, interventions to increase post-operative cat care provision could include targeted elements that support behaviour change to overcome the barriers found here.
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PMC11401358
Putting together, (GAGSGA)2 plays an antioxidant role by changing its secondary structures, particularly β-sheet structure changes are responsible for its ROS scavenging rather than amino acid oxidation.
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PMC11705862
This study shows the presence of both IRIS-1 and 2 proteins in the human brain, specifically in neurons and astrocytes.
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PMC11506670
In the context of clinical management, ethnic nuances in the mutational profiles of cancer patients across the globe may further add to the already complex challenges posed by tumor heterogeneity.
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PMC9429973
CR rate was 40/50 in patients treated with CPX-351 (80)% significantly higher when compared to patients receiving FLAI (55/101, 54.5%, p<0.05).
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PMC11638288
b NKp46 unknown ligands expressed by Fusobacterium nucleatum, microorganisms-infected cells, pancreatic beta cells, immature myeloid dendritic cell, and fibroblast-like synoviocytes.
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PMC11791264
Scale bars, 10 μm.
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PMC9429973
Most infected patients suffer from mild to moderate illness, however some patients progress rapidly to acute respiratory distress syndrome, respiratory failure, sever sepsis, multiorgan failure and death.
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PMC11348300
Illustration of the operating principle of pressure-enhanced sensing tissue oxygenation (PRESTO). (
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PMC5963610
In this work, we explored the impact of combining an anti-EGFR (7A7 mAb) with either active (NGcGM3/VSSP vaccine) or passive (14F7 mAb) therapies targeting NGcGM3.
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PMC6627640
The GSK126 treatment resulted in decreased H3K27me3 levels and conferred cisplatin resistance to NT2/D1, 2010EP, and 833K cells (Figure 4B,C).
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PMC10443665
Up to date, several herbal components such as glycosides and flavonoids have been identified that can act as P-gp inhibitors (1213).
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PMC11544122
Cells were washed three times with 500 µl TBS, followed by incubation for 45 mins at room temperature in TBS supplemented with 0.1% w/v bovine serum albumin (BSA) (Gold Bio cat.
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PMC11766332
In one study, a patient with Asperger syndrome was reported with a de novo 380 kb gain in band p22.3 of chromosome 7 .
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PMC11803918
Pellets were then resuspended in cold PBS (∼pH 7.4) for storage at −80 °C.
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PMC9429973
Subjects ≥16 years with SCD (HbSS, HbS/β or HbS/β), 1-10 vaso-occlusive crises (VOCs) in the prior year and/or prior SCD-related complications, a Hb level >6.1 g/dL and ≤11.1 g/dL, and not receiving chronic transfusions are eligible.
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PMC7334607
Of note, the EC50 of olaparib in Replicate 5 at the VDC5 time point is indeterminate owing to a poorly fit dose-response model.
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PMC9429973
K. Kropivsek, P. Kachel, S. Goetze, R. Wegmann, Y. Severin, B. D. Hale, Y. Festl, J. Mena, A. van Drogen, N. Dietliker, J. Tchinda, B. Wollscheid, M. G. Manz, B. Snijder Department of Biology, Institute of Molecular Systems Biology, ETH Zurich; Department of Medical Oncology and Hematology, University Hospital Zurich; Department of Health Sciences and Technology, Institute of Translational Medicine; Swiss Multi-Omics Center, PHRT-CPAC, ETH Zurich, Zürich; Swiss Institute of Bioinformatics, Lausanne; Pediatric Oncology, Children’s Research Centre, University Children’s Hospital Zurich, Zürich, Switzerland Background: Multiple myeloma (MM) is a cancer of plasma cells, defined by complex genetics and extensive intra- and inter-patient heterogeneity.
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PMC10729469
Lonza, Basel, Switzerland) and electroporated using the DN-100 program.
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PMC8873393
Blue stippled lines demarcate thresholds of lowly transcribing cells.
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PMC9884169
These results showed that knockdown of MCT4 aggravates ferroptosis in 5637 cells.
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PMC9429973
Maintenance treatment after transplant has also proven to positively impact event free survival in multiple clinical trials.
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PMC11724582
Subsequently, 500 µL of 4% paraformaldehyde solution was added to each well for fixation for 20 min, followed by the addition of 500 µL of 1% crystal violet solution for staining for another 20 min.
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PMC9429973
Infectious SAEs 14.8% vs 19.9% and cardiac SAEs 11.9% vs 8.1% of pts for I+V & I respectively.
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PMC11476837
Expression of the CAS-3 gene was decreased by 1 and 10 nM doxorubicin (p < 0.05).
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PMC10218459
It is assumed that, due to alterations in metabolism, cancer cells are more susceptible to CPP-mediated extracellular ROS .
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PMC10969097
Unfortunately, it can result in undesired side effects and a risk of recurrence as well as the development of chemoresistance .
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PMC11753435
AlphaFold2-predicted structure of SS18-SSX1. (
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PMC9268620
The yellow band that appeared after the major orange band of fraction B was then separated using chromatotron eluted with CHCl3 to produce 196.4 g of damnacanthal.
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PMC11768927
Recently, Geoffroy et al. tested the effectiveness of VSV-ΔM51 on 33 human epithelial ovarian cancer cell lines derived from patients who had failed conventional chemotherapy for ovarian cancer.
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PMC11441402
The LC50 value is the concentration where 50% of cell death is achieved.
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PMC9429973
Among SCA-children, 138 were transplanted with MSD at a mean age (SD) of 9.0 years (4.9).
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PMC11787651
In this study, we observed hyperacetylation of lysine residues in H3 and H4 histones induced by entinostat and M344 at specific sites, such as H3K18acK23ac, H3K14ac, H4K8acK12ac, and H4K12acK16ac‚ along with the acetylation of H2A variants as shown in volcano plots (Fig. 4, A and B).
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PMC11715644
Images of P120 immunostaining (or those overlaid with F-actin images as necessary) were first used to determine cell outlines.
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PMC11632064
Model depicting the impact of mitochondrial signatures on the response to RSK and PLK inhibitors.
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PMC7433824
VIME/VIM is a type III intermediate filament (IF) protein present mostly in mesenchymal cells, which regulates the anchoring and position of the cytosolic organelles.
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PMC9019892
At a predefined time point, animal body weights and tumour volumes were measured, and tumour volume was calculated (width× length/2).
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PMC11347429
Influenza infections cause a range of disease phenotypes that range from asymptomatic to severe.
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PMC11036064
.
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PMC11755624
Research has indicated that polymorphisms in the ATG16L1 gene are associated with an elevated risk of developing plaque psoriasis, and that ATG16L1 expression is augmented in the dendritic cells of patients with psoriatic arthritis .
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PMC9635307
The localization of BCR and CEACAM1 expressions in the cells at 0min and 3min after the stimulation/staining were observed under a confocal microscopy, Fluoview 10i (Olympus, Tokyo, Japan).
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PMC9429973
Pts received a median of 3 prior lines of therapy, with 28% (ZO) and 25% (O) of pts receiving >3 lines.
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PMC8978939
Ding et al. (61) have shown that W117A and F148A mutations form less VBC complex and also lose their ability to interact with HIF-2α.
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PMC11687663
Fig 16SB in S1 File displays the hydrophobicity map of the human PPAR-δ protein in the study.
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PMC11539788
Although great advancements have been made in these strategies in the last few decades, the prognoses for patients with MIBC and advanced tumours are still extremely poor, with 5-year disease-free survival rates of less than 30% .
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PMC8916024
16S rRNA is ubiquitous in prokaryotic cells, and has the advantages of good stability, high sequence conservation, large amount of information, and easy extraction, so it is widely used as an ideal material for the study of animal intestinal flora (Langille et al., 2013; Hu et al., 2018; Li et al., 2019).
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PMC5963610
As a result of this interaction an alternative signaling cascade is triggered, which somehow compensate the reduction of signaling via EGFR .
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PMC11576293
VEGFR-2, a constituent of VEGFRs, has been demonstrated to be the primary mediator in tumor angiogenesis, a process essential for the growth of solid tumors.
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PMC11611077
DNA fragments of His-tagged prestin were prepared by polymerase chain reaction (PCR).
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PMC11286266
After 72 hr, mTurquoise cells were sorted as single cells into 96-well plates.
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PMC11594806
Under hypoxic conditions, hypoxia-inducible factor-1 alpha (HIF-1α) induces the accumulation of extracellular ADO and activates the hypoxia response and cAMP response elements, promoting the production of immunosuppressive cytokines and molecules such as transforming growth factor-beta (TGF-β), interleukin-10 (IL-10), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) .
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PMC6442998
Our results highlight the potential use of compounds targeting PDE3A or YAP in combined multitherapy to tackle GIST resistance.
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PMC10968586
On the basis of these pieces of data, it becomes evident that cytotoxicity and anti-cancer effects of OLE and HT were recorded at concentrations largely exceeding those reachable with diet/olive oil consumption, and OLE and HT pharmacokinetics does not match the requested treatment duration to exert an anti-proliferative effect.
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PMC11173119
For immunofluorescence staining, cells growing on chambered coverglass 8-well plates (Thermo Fisher Scientific, Waltham, MA, USA) were fixed with 4% PFA (Sigma-Aldrich, Darmstadt, Germany), permeabilized with 0.5% Triton-X (Thermo Fisher Scientific, Waltham, MA, USA) in PBS for 30 min, and incubated in blocking buffer containing 1% BSA (Sigma-Aldrich, Darmstadt, Germany) in PBS at room temperature.
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PMC7351993
Figure 2a shows SRS spectra of polystyrene (PS) particles and poly(methyl methacrylate) (PMMA) particles obtained by an SRS microscope.
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PMC11609529
Collectively, these results indicate that the YM fusion not only activates the YAP1-dependent transcriptional program but also contributes to cell growth and survival and potentially modulates the inflammatory response.
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PMC9019892
Several new KIT inhibitors against imatinib‐resistant secondary mutations are currently being evaluated in clinical trials, such as pazopanib , anlotinib and dovitinib .
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PMC11506670
The RLU values in the context of the 3D spheroid assay are measures of the luminescent signal produced by spheroid structures, and they are used to quantify cell viability.
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PMC6442998
cAMP accumulation in GIST882 (left panel) and GIST48 cells (right panel) treated for 72h with imatinib (1μM), cilostazol (10μM), imatinib + cilostazol (1μM + 10μM) and forskolin (25μM or 50μM).
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PMC9429973
Aims: The aim is to test the sensitivity of imatinib-resistant (IR) clones of KCL-22, model of BC-CML, and primary blast cells to BH3-mimetics and describe a mechanism of sensitivity/resistance using protein analysis of apoptotic pathways.
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PMC11770199
Human colon cancer cell lines HCT8, LOVO, SW480 and the mouse colon cancer cell line MC38 were obtained from Gastroenterology of Affiliated Hospital of Xuzhou Medical University.
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PMC9429973
Among them, neutrophil count recovery was better in the attriboma group than in the historical control group at 1 month, 3 months, 6 months, 9 months and 12 months after the application of ATG, the difference was statistically significant (P < 0.05), while platelet and hemoglobin recovery was not different.
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PMC8427838
Image magnification, 50 µM. 786-0 cells expressing Ctr.
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PMC11761919
LAB can colonize the surface of intestinal mucosa and have shown significant potential in developing mucosal vaccines, particularly as food-grade vehicles for delivering antigens (Michon et al., 2016; Takahashi et al., 2019).
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PMC11534377
Compared to control cells, treated cells had irregular shapes and less contact between them, indicating altered cellular arrangement.
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PMC11522251
Silencing or overexpression of HOXB8 both resulted in changes in the transcript level of p-STAT3 in colorectal neoplasms cells, thereby affecting the cellular response to cetuximab.
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PMC11412721
Means ± SEM from four mice per genotype.
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PMC9596868
MST-312 is a chemical derivative of epigallocatechin gallate (EGCG), the primary catechin present in green tea.
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PMC9429973
Median age at baseline was 58.7 years, male prevalence (57.1%).
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PMC9429973
We hypothesized that early incorporation of blinatumomab and INO in patients (pts) with newly diagnosed Philadelphia chromosome (Ph)-negative B-cell ALL would lead to deeper and more durable responses, reduce relapses, and improve survival.
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PMC11047729
In most somatic cells, telomerase activity is not found, which makes their prolific ability limited.
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PMC11612626
Taken together, our results demonstrate the paradigm shifting impact of immunoproteasome activators to diversify the antigenic landscape, expand the immunopeptidome, potentiate T-cell–directed therapy, and reveal actionable neoantigens for personalized T-cell immunotherapy.
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PMC10079526
Combination dosing included 5-Aza-2’ dose escalation (low dose range values of Fig. 4B) in combination with 25 nM of TAK981 (Fig. 4D).
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PMC4485786
mRNA expression of surface molecules that direct NK-cell differentiation and activation strictly required the NHS-IL12 construct.
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PMC4005030
This compound is one of the biologically active components of some medicinal plants, including those used in natural medicine, such as sudan Mallow (Hibiscus sabdariffa L.) , Japanese ginkgo (Ginkgo biloba L.) , and St. John's wort (Hypericum perforatum L.) .
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PMC11754432
The study was approved by the ethics committee of the Clinic of the Goethe-University (116/11); written, informed consent was obtained from all patients and control participants.
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PMC11790971
PIMP is defined as the decrease in classification performance when the value of the selected feature is randomly shuffled.
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PMC8524093
Despite the complexity of CHIKV infection, animal model is important and indispensable.
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PMC9910796
Altogether, these results indicate that pEP84R plays a crucial role in core assembly by targeting the core shell polyproteins to the inner viral envelope, which enables subsequent genome packaging and nucleoid formation.
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PMC9429973
Few studies have investigated if earlier intervention with targeted MF therapies affects response and OS.
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PMC11653168
These results suggested that Stattic holds promise as a therapeutic agent in T-ALL by modulating key pathways involved in cell survival and proliferation.
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PMC9844987
The Coriell Institute for Medical Research frequently screens cells for mycoplasma contamination and verifies cell line identity.
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PMC11036064
Besides, this miR improves the chemosensitivity of A172 cells and increases the anti-tumoral effect of temozolomide on A172 cells.
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PMC6450504
Cells normally proceed toward mitosis, but tubulin stabilization leads to cell cycle arrest, with cells becoming multinucleated (Zhang et al., 2016).
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PMC11513011
Panel B. In T24, 10 nM DIB significantly inhibited wound healing after 72 h (p = 0.0478) and 50 nM after 6 h. Panel C. In 5637, after 24 h 10 nM DIB (24 h: p = 0.0279, 48 h: p < 0.001, 72 h: p = 0.058) and 50 nM DIB significantly inhibited wound healing.
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PMC9429973
The study included 87 patients.
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PMC11098378
786–0 cells were cultured in RPMI supplemented with 10% FBS.
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PMC11697065
H: Protein ratio of HC to LC plotted against the cell specific productivity (qP) from each clonal cell line.
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PMC11730311
1Overview of the effect of lipidation position and moiety on potency of lipidated hαCGRP8-37 analogues.
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PMC11597291
In order to increase biocompatibility and diminish safety concerns, GO nanomaterials have been functionalized with hydrophilic and biocompatible molecules, such as poly(ethylene glycol) (PEG) , dextran , bovine serum albumin (BSA) , heparin , chitosan , and polyacrylic acid .
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PMC8609870
DEL: Differentially expressed lncRNAs; DEMs: Differentially expressed miRNAs; DEGs: Differentially expressed genes Top 20 downregulated DELsand DEGs Log2FoldChange: Log2FC; DEL: differential expression LncRNAs; DEGs: differential expression genes Top 15 upregulated DEMs Log2FoldChange: Log2FC; DEMs: differential expression miRNAs To further study the transcriptome differences between the two groups, we performed GO and KEGG pathway analyses of DELs.
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PMC11806818
Traditional methods for detecting tumor biomarkers include enzyme-linked immunosorbent assay (ELISA) , real-time polymerase chain reaction (Real-time PCR) , spectroscopic techniques , and flow cytometry .
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PMC11750165
When KA” neurons are born from the neural progenitors in the most ventral p3 domain of spinal cord, it is required that Jagged2 expressed in pMN domain activates Notch signaling pathway in p3 progenitors (Yeo & Chitnis, 2007).
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PMC11185260
Comparison of tumor growth between treatment groups.
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PMC11555465
The apoptotic rate was determined using fluorescence microscopy.
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PMC9429973
Aims: To explore outcomes in pts with post-remission G-CSF use in the VIALE-A and VIALE-C studies.
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