OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Frequent painful crises are associated with psychological issues and poor engagement in normal daily activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frequent", "painful", "crises", "are", "associated", "with", ...
PMC11310713	However, all pharmaceutical HRT groups expressed a notable rise in the number of p53-positive mammary gland epithelial cells (Fig. 7A and B), whereas there was a decrease in the number of PTEN-positive mammary gland epithelial cells compared to the GTB-injected OVX rats (Fig. 7A and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	TRIzol (Cat# 15596018, ThermoFisher Scientific) was used for RNA isolation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRIzol", "(", "Cat", "#", "15596018", ",", "ThermoFisher", "Scie...
PMC11760643	The gating strategy used to identify live and dead cells is demonstrated in Figure S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "used", "to", "identify", "live...
PMC9119314	However, 1 has been shown to inhibit DNA synthesis and topoisomerase II (Bonjean et al., 1998) and to intercalate into DNA with a preference for non-alternating G-C sites (Bonjean et al., 1998; Lisgarten et al., 2002), and there is evidence that 1 may carry a genotoxic risk (Ansah et al., 2005; Gopalan et al., 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7369657	The DCFH-DA diluent was then removed, and the cells were washed three times with serum-free medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DCFH-DA", "diluent", "was", "then", ...
PMC11626627	Fig 5 The positive feedback mechanism between ERβ and TWIST1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig", "5", "The", "positive", "feedback", "mechanism", "between", "ERβ", "and", "TWIS...
PMC3274243	The multiwell Oncoprobe technology provides true real-time monitoring of the electrochemical signal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "multiwell", "Oncoprobe", "technology", "provides", "true", "real-time", "monito...
PMC11354225	Skin cancer has two main types, melanoma and nonmelanoma (NMSC), which are the most prevalent neoplasms worldwide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Skin", "cancer", ...
PMC7039683	Furthermore, three-way alignments of the human and mouse plus-strand sequences with each of the zebrafish test and control sequences indicates that the zebrafish plus-strand engenders a need for a number of null characters (dashes) in the three-way alignments that is almost one standard deviation smaller than the controls (158 insertions versus an average number of insertions of 200.2 +/- 44.1 s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5443223	Results demonstrated that CEP164 protein expression levels increased following IR and inhibition of CEP164 resulted in the increased radiosensitivity of rhabdomyosarcoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "d...
PMC11650848	The results showed increased power in the beta (13–30 Hz) and high gamma (49–70 Hz) bands in neuronal responses to language tasks in the children of the FA-supplemented mothers, indicating more efficient semantic processing of language compared to placebo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Error bars represent the relative SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "relative", "SEM", "." ] } ]
PMC11701801	Expression of KREMEN2 mRNA was compared with gene expression data derived from SWI/SNF-proficient, SMARCB1-deficient, ARID1A-deficient, PBRM1-deficient, SMARCA4-deficient, SMARCA2-deficient, SMARCA4/SMARCA2-deficient, and SS18–SSX fusion cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	The slides were imaged using the LABOMED Opti CX biological microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "slides", "were", "imaged", "using", "the", "LABOMED", "Opti", "CX", "biologica...
PMC9841531	Mean ± SEM values of at least three independent experiments are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "±", "SEM", "values", "of", "at", "least", "three", "independent", ...
PMC9847912	Plasmids were maintained in Escherichia coli strains XL10-Gold (Agilent Technologies; Santa Clara, CA) or TOP-10 (Invitrogen Life Technologies; Carlsbad, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	7 ABC transporters (ABCA2, ABCA5, ABCB1, ABCB6, ABCC1, ABCC3, ABCG2) were selected from literature for expression, methylation, genotype and efflux activity analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Combination therapy was well tolerated in both cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combination", "therapy", "was", "well", "tolerated", "in", "both", "cohorts", "." ] } ]
PMC6684588	Here we confirm that intramuscular administration of ACE-083 exerts a similar localized effect on the gastrocnemius muscle but have extended that finding in the context of a different skeletal muscle – the tibialis anterior – to show the growth-promoting effects of ACE-083 in normal mice are due to muscle fiber hypertrophy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	This activation results in the production of cathelicidins, AMPs that are excessively expressed in rosacea and contribute to both the condition’s pro-inflammatory and vasoactive properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	Possibly, this mechanism underlies the long-term inflamed tissues like human UC colonic mucosa .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Possibly", ",", "this", "mechanism", "underlies", "the", "long-term", ...
PMC9352806	Quantitative PCR amplification for all of the genes included pre-incubation at 95 °C for 10 s, followed by 40 cycles at 95 °C for 5 s, and 95 °C for 30 s, and then calculation of the fold change by the 2 method (Xiao et al., 2020b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Platelet activation markers (activation of fibrinogen receptor determined through PAC1-binding, and TRAP-induced P-selectin and CD63 exposure) and active caspase-3, -7, -8 or -9 were evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547972	Very strong synergism has been observed even at amygdalin concentrations of 1 and 10 µg/mL .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Very", "strong", "synergism", "has", "been", "observed", "e...
PMC9429973	Paired pre/post–CAR T samples did not show dominant enrichment for ≥ 1 HR features at progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired", "pre/post", "–", "CAR", "T", ...
PMC10158546	Representative Z-stacked projection of ReN neural progenitor cells stained with Nestin (NES; green) before differentiation. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "Z-stacked", "projecti...
PMC11766174	On the other hand, the average numbers of CA-positive cells observed by flow cytometry in the serial dilutions described above were 498, 415, 110, 1105, 11,021, and 61,148, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	Thus, FGF18 orthologs are evolutionarily conserved targets of the canonical Wnt/β-catenin signaling pathway based on comparative genomics of the 5’ -promoter region of FGF family genes, FGF18 and WNT signaling pathways are networked together during carcinogenesis and embryogenesis (10, 11, 69, 70, 191).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	On the other hand, peaks in short LOCKs, which exhibit the lowest nearest gene expression, are enriched in common HMDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", ...
PMC9429973	The median OS was 57 months (95% CI 38-75) in the MBVP arm and 85 months (95% CI 43–104) in the R-MBVP arm (HR 0.87, 95% CI = 0.61-1.26, p=0.47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9786247	These results suggest that mammary gland epithelial cells could be a replicative niche for C. burnetii infection in cattle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "th...
PMC3274243	Similarly, in HepG2 cells treated with the cytotoxic, apoptosis inducing agent camptothecin (Figure 5) differences in the OCP are apparent less than six hours into the experiment.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	Eventually, the chips were filled 3 times with Novec Surface Modifer (3M), a fluoropolymer coating agent, for 30min at 110°C on a hot plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3019555	Cells were transfected with 10 nM of each siRNA for 48 h using the AMAXA nucleofector system (Lonza).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "transfected...
PMC11770130	30 μL of serum, 120 μL of water, 1.5 mL of methanol and 5 mL of MTBE were added to a clean glass centrifuge tube, and 12 μL of lipid internal standards were added in each sample at the same time, including 2 μL of 0.82 mM PC (17:0/17:0), 2 μL of 0.77 mM PC (19:0/19:0), 2 μL of 1.40 mM PE (14:0/14:0), 2 μL of 4.91 mM LPC (17:0), 2 μL of 3.49 mM SM (d18:1/17:0) and 2 μL 4.53 mM of Cer (d18:1/17:0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705067	mol.	[ { "tags": [ "O", "O" ], "tokens": [ "mol", "." ] } ]
PMC7351993	Figure 2d shows histograms of event rates in two separate sorting experiments with nominal throughput values of 50.2 eps and 85.6 eps (see “sorting throughput” in the Methods section for details, Supplementary Movie 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	N. ANWAR, Z. ZIAD, N. FATIMA, A. KHALID, L. MAJEED, M. BORHANY HEMATOLOGY; RESEARCH AND DEVELOPMENT, NATIONAL INSTITUTE OF BLOOD DISEASES AND BONE MARROW TRANSPLANTATION, KARACHI, Pakistan Background: Chronic myelomonocytic Leukemia (CMML) is a clonal stem cell disorder characterized by the presence of sustained (>3 months) peripheral blood monocytosis (≥1 x 10/L; monocytes ≥10% of white blood cell count) along with dysplastic features in the blood/bone marrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	Determination of the IC50 values for these compounds in CHO K1 cells expressing human TRPV1 revealed that exendin 9–39 had the lowest IC50 value for inhibiting CAP-induced TRPV1 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11478724	The number of living cells almost doubled from the number in the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "living", "cells", "almost", "doubled", "f...
PMC11747467	When the tumor diameter exceeded 0.8 cm, it was recorded as the endpoint, and the survival curve of the mice was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Overall median time from randomization to allo-SCT was 76 (21-179) and 95 (37-310) days in haplo and UD group respectively (P=NS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	It was reported that Wnt/β-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer (Wang et al. 2022a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "repo...
PMC9429973	Correspondence to: Dr Jian Huang, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correspondence", "to", ...
PMC11786767	This article contains supplemental data.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "article", "contains", "supplemental", "data", "." ] } ]
PMC11699465	Briefly, Concanavalin A-coated magnetic beads were rinsed in the binding buffer while cells were collected, counted, and rinsed in the wash buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11518994	Fig. 2Cytofluorimetric analysis of B cell repertoire in healthy PAX5 variant carriers.a B cell repertoire on fresh peripheral blood mononuclear analysis showed a reduction in memory B cells IgD− CD27+ (mean ± SD of PAX5 mutated carriers vs wild-type healthy donors: 9 ± 6% vs 27% ± 11%; p = 0.07).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	5-Aza-2’ trapped DNMT1 to DNA and SUMOylation inhibition prevented clearing of trapped DNMT1, leading to induction of DNA damage and consequently impaired cell survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11743316	Furthermore, increasing glutamate dehydrogenase concentrations cause more fumarate to be produced, which in turn triggers and binds the glutathione peroxidase enzyme, boosting the ROS detoxification process in different cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A.-I. Gkioka, M. Tsota, M. Papadatou, A. Gkiokas, A. Alexandropoulos, V. Bartzi, G. V. Dedousis, M.-C. Kyrtsonis Laikon University Hospital Athens Hematology Section - 1st Department Of Propaedeutic Internal Medicine Athens, National and Kapodistrian University of Athens, Greece, National and Kapodistrian University of Athens; Nutrition and Dietetics School of Health Sciences and Education, Harokopeio University, Athens, Greece Background: MicroRNAs (miRNAs) are short, noncoding RNAs of 19–22 nucleotides that participate in gene expression regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	After 2 weeks, the transplanted mice were treated with ethanol control or OST-01 (1 µL/g, oral gavage, BID) for 5 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8759873	The current treatment methods are mainly surgery plus biological therapy and radiotherapy and chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "current", "treatment", "methods", "are", "mainly", "surgery", ...
PMC9599726	Data Analysis by Estimation Statistics” (DABEST) software (https://www.estimationstats.com/#/ (accessed on 22 July 2022)) was used as a Python script (https://github.com/ACCLAB/DABEST-python, accessed on 22 July 2022), running on a local PC to generate Cumming plots, for experiments that share one reference control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7185206	In the present work, we showed that tumor-associated metzincin metalloproteinases ADAM10 and ADAM17 cleave PD-L1 from the surface of tumor cells to induce apoptosis in CD8 + T cells and dampen anti-tumor immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11351758	Researchers presume that mitochondrial Ca uptake is dependent on the membrane potential and the intracellular distribution of the organelle, both of which may be altered in mitochondrial diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	Percentage cell survival after 24 h treatment of 1 nM, 5 nM, 10 nM, 25 nM, 50 nM and 100 nM PTX. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506827	Quantification was performed using an Agilent 1100 HPLC system coupled with an API 2000 LC-MS/MS system in multiple reaction monitoring (MRM) mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11766309	The results of the GO functional annotation, KEGG pathway analysis, and GSEA enrichment analysis are shown in Figure 10A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", ...
PMC11194678	As expected, endogenous STAU1 showed dense and small puncta in WT STHdh cells, while larger and more obvious STAU1 puncta were observed in HD STHdh cells (Fig. 1 D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	All chemicals and solvents used were of analytical quality and were obtained from commercial suppliers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "chemicals", "and", "solvents", "used", "were", "of",...
PMC11463018	HR-MS (ESI) calcd.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "HR-MS", "(", "ESI", ")", "calcd", "." ] } ]
PMC11453018	In contrast, when encountering single GGAA motifs, it tends to facilitate gene repression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "when", "encountering", "single", "GG...
PMC10454535	Treatments were done in triplicates, and three independent experiments were conducted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatments", "were", "done", "in", "triplicates", ",", "and", "three", "independ...
PMC8557138	Crosslinking of alginate molecules are much faster compared to other biomaterials and hence are widely used to produce 3D matrix in tissue engineering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Crossli...
PMC11413393	Cell lines were engineered to express doxycycline (Dox)-inducible PRMT1 targeting or non-targeting (NT) shRNAs and treated with or without 1.0 μg/mL Dox for 3 and 6 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	Smart engineered nanoparticles respond according to the cellular pH, for the release of chemotherapeutic drugs at the tumor site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Smart", "engineered", "nanop...
PMC11733919	Indeed, at the same time points, MNP@CD26@17D and MNP@CD26 also promoted an increase in the levels of the cell cycle inhibitor p27 that was not promoted by the drug alone; however, the effects of MNP@CD26@17D were more pronounced (Figure 5c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twelve patients (80%) had received prior intensive chemotherapy, 3 patients (20%) had prior Venetoclax exposure and 9 patients (60%) had been previously treated with FLT3 inhibitors (Midostaurin – 7, Sorafenib – 1, Gilteritinib – 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	c closed state, o open state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "closed", "state", ",", "o", "open", "state", "." ] } ]
PMC11772585	n = 5. **	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ".", "", "" ] } ]
PMC9429973	However, prolonged product manufacturing times and a need for longer duration of response are a major obstacle in this population, necessitating fast manufacture of a reliable and durable CAR-T cell product.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	Difference in expression of immune checkpoint‐related genes in high TNFSF11‐expressing and low TNFSF11‐expressing groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Difference", "in", "expression", "of", "immune", "checkpoint‐rela...
PMC9646302	The antibodies used in this study are listed in Table S3 in the Supplementary Material.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antibodies", "used", "in", "this", "study", "are", ...
PMC9429973	ECOG score greater than 3 and receiving bridging therapy before CAR-T may be the risk factors of GI bleeding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ECOG", "score", "greater", "than"...
PMC11093197	The ectopic expression of oncogenic RAS in fibroblasts causes cellular senescence due to replication stress and subsequent DNA damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ectopic", "expression", "o...
PMC11481779	We first use an encoder composed of residual 1D convolutions that transfer 1D sequence into latent space; furthermore, we use a transformer encoder to allow the model to learn long-range context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	The membrane was then transferred to the appropriate horseradish peroxidase (HRP)-conjugated secondary antibody (Sigma-Aldrich, Burlington, MA, USA) diluted in blocking buffer and incubated for 2 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There was statistically significant risk of mortality due to all malignant cancers combined (SMR 58.35, 95% CI 49.03-68.94), largely due to mortality from lymphocytic leukemia (SMR 2587, 95% CI 2021-3264, AER 1757), non-Hodgkin lymphoma (SMR 100, 95% CI 45.88-190.45, AER 220), stomach and duodenal ulcers (SMR 73.74, 95% CI 1.87-410.84, AER 24.43), uterine cancer (SMR 66.55, 95% CI 1.68-370.78, AER 24.39), and pneumonia and influenza (SMR 11.88, 95% CI 2.45-34.71, AER 68.04).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8978939	Although VBC: HIF-1α complexes still form as evidenced in vitro ( Figure 2A ), binding strength is significantly reduced in all the cases under hypoxia, particularly for variant P138R ( Table 2 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042	In total 526,610 variants out of 696,726 passed the QC filters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", "526,610", "variants", "out", "of", "696,726", "passed", "the", "QC", ...
PMC11727907	Glucose consumption in the growth medium was assessed by measuring NADP reduction at 340 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glucose", "consumption", "in", "the", "growth", "medium", "...
PMC11786704	CLSM images of PC capsules. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CLSM", "images", "of", "PC", "capsules", ".", "(" ] } ]
PMC11617590	However, in our study, the value of IC50 for SFN was 111.0 μM when SFN was treated for 72 h. Although the effect of SFN in this study is minimal, SFN has an inhibitory effect on the proliferation of Mia PaCa‐2 cells, which is consistent with the findings of previous studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients with RRMM had received ≥3 prior lines of therapy (LOT) or were refractory to a proteasome inhibitor (PI) and immunomodulatory drug (IMiD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496728	The stable expression results indicated that pCMV-SEAP-1 and pCMV-SEAP-2 were 1.49- and 1.55-fold higher than pCMV-SEAP, respectively (Fig. 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "stabl...
PMC9243326	C. chinensis is an aquatic animal product with high economic value and has potential for medicinal development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "chinensis", "is", "an", "aquatic", "a...
PMC10820104	Regions for NI-siderophones were also found on one contig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regions", "for", "NI-siderophones", "were", "also", "found", "on", "one", "contig", "." ] } ]
PMC11739504	Graphs on right side indicated fluorescence intensity of Arl13b normalized ac-α-tubulin, ac-α-tubulin and Arl13b, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphs", "on", "right", "side", "indicated", ...
PMC11087055	As verified by BrdU incorporation assay, the aphidicolin-treated embryos exhibited little or no mitotic activity (Figure 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "verified", "by", ...
PMC10443665	All the concentrations of tragacanthin, bassorin, and APS (except at 0.8-100 μg/mL in CCRF-CEM) decreased the viability of all the cells compared to the negative control group; and against the positive control (MTX-treated cells), only bassorin at 20-100 μg/mL in CCRF-CEM/R and tragacanthin at 50 and 100 μg/mL in CCRF-CEM/MTX and at 2-100 μg/mL in CCRF-CEM/R decreased cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	The principal component analysis was applied to the transcript counts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "principal", "component", "analysis", "was", "applied", "to", "the", "transcript", "counts...
PMC11655498	TERT maintains EBV latency through the NOTCH2/BATF pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TERT", "maintains", "EBV", "latency", "through", "the", "NOTCH2/BATF", "pathway", "." ] } ]
PMC11394386	Commercial cervical cell lines HeLa, SiHa, and HaCat were obtained from the Functional Genomics Laboratory of the National Cancer Institute of México.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11237030	Magnification: ×20.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Magnification", ":", "×20", "." ] } ]
PMC11752740	After this period, the culture medium in the wells was replaced with fresh medium containing various concentrations of the treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "this", "...
PMC11216402	This indicates that single-cell clusters 2 and 5 include stomach cells, whereas cluster 6 is composed of fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "that", "sing...
PMC11731614	Plexins, the surface receptors for semaphorins, are involved in neuron axonal growth and guidance, as well as a host of other functions (Alto and Terman, 2017, Janssen, 2010, Takamatsu and Kumanogoh, 2012, Li, 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718809	It is reported that circRNA-02191 promotes the generation of triglycerides and fatty acids in cow mammary gland cells by adsorbing miR-145 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "repor...
PMC10582049	Illustrations are created with BioRender.com.) (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illustrations", "are", "created", "with", "BioRender.com", ".", ")", "(" ] } ]

PMC9429973

Frequent painful crises are associated with psychological issues and poor engagement in normal daily activities.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frequent", "painful", "crises", "are", "associated", "with", ...

PMC11310713

However, all pharmaceutical HRT groups expressed a notable rise in the number of p53-positive mammary gland epithelial cells (Fig. 7A and B), whereas there was a decrease in the number of PTEN-positive mammary gland epithelial cells compared to the GTB-injected OVX rats (Fig. 7A and C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11770130

TRIzol (Cat# 15596018, ThermoFisher Scientific) was used for RNA isolation.

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PMC11760643

The gating strategy used to identify live and dead cells is demonstrated in Figure S2.

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PMC9119314

However, 1 has been shown to inhibit DNA synthesis and topoisomerase II (Bonjean et al., 1998) and to intercalate into DNA with a preference for non-alternating G-C sites (Bonjean et al., 1998; Lisgarten et al., 2002), and there is evidence that 1 may carry a genotoxic risk (Ansah et al., 2005; Gopalan et al., 2011).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7369657

The DCFH-DA diluent was then removed, and the cells were washed three times with serum-free medium.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DCFH-DA", "diluent", "was", "then", ...

PMC11626627

Fig 5 The positive feedback mechanism between ERβ and TWIST1. (

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PMC3274243

The multiwell Oncoprobe technology provides true real-time monitoring of the electrochemical signal.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "multiwell", "Oncoprobe", "technology", "provides", "true", "real-time", "monito...

PMC11354225

Skin cancer has two main types, melanoma and nonmelanoma (NMSC), which are the most prevalent neoplasms worldwide.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Skin", "cancer", ...

PMC7039683

Furthermore, three-way alignments of the human and mouse plus-strand sequences with each of the zebrafish test and control sequences indicates that the zebrafish plus-strand engenders a need for a number of null characters (dashes) in the three-way alignments that is almost one standard deviation smaller than the controls (158 insertions versus an average number of insertions of 200.2 +/- 44.1 s.d.

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PMC5443223

Results demonstrated that CEP164 protein expression levels increased following IR and inhibition of CEP164 resulted in the increased radiosensitivity of rhabdomyosarcoma cells.

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PMC11650848

The results showed increased power in the beta (13–30 Hz) and high gamma (49–70 Hz) bands in neuronal responses to language tasks in the children of the FA-supplemented mothers, indicating more efficient semantic processing of language compared to placebo .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11188874

Error bars represent the relative SEM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "relative", "SEM", "." ] } ]

PMC11701801

Expression of KREMEN2 mRNA was compared with gene expression data derived from SWI/SNF-proficient, SMARCB1-deficient, ARID1A-deficient, PBRM1-deficient, SMARCA4-deficient, SMARCA2-deficient, SMARCA4/SMARCA2-deficient, and SS18–SSX fusion cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11770746

The slides were imaged using the LABOMED Opti CX biological microscope.

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PMC9841531

Mean ± SEM values of at least three independent experiments are shown.

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PMC9847912

Plasmids were maintained in Escherichia coli strains XL10-Gold (Agilent Technologies; Santa Clara, CA) or TOP-10 (Invitrogen Life Technologies; Carlsbad, CA).

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PMC9429973

7 ABC transporters (ABCA2, ABCA5, ABCB1, ABCB6, ABCC1, ABCC3, ABCG2) were selected from literature for expression, methylation, genotype and efflux activity analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Combination therapy was well tolerated in both cohorts.

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PMC6684588

Here we confirm that intramuscular administration of ACE-083 exerts a similar localized effect on the gastrocnemius muscle but have extended that finding in the context of a different skeletal muscle – the tibialis anterior – to show the growth-promoting effects of ACE-083 in normal mice are due to muscle fiber hypertrophy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767725

This activation results in the production of cathelicidins, AMPs that are excessively expressed in rosacea and contribute to both the condition’s pro-inflammatory and vasoactive properties.

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PMC11519077

Possibly, this mechanism underlies the long-term inflamed tissues like human UC colonic mucosa .

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PMC9352806

Quantitative PCR amplification for all of the genes included pre-incubation at 95 °C for 10 s, followed by 40 cycles at 95 °C for 5 s, and 95 °C for 30 s, and then calculation of the fold change by the 2 method (Xiao et al., 2020b).

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PMC9429973

Platelet activation markers (activation of fibrinogen receptor determined through PAC1-binding, and TRAP-induced P-selectin and CD63 exposure) and active caspase-3, -7, -8 or -9 were evaluated.

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PMC11547972

Very strong synergism has been observed even at amygdalin concentrations of 1 and 10 µg/mL .

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PMC9429973

Paired pre/post–CAR T samples did not show dominant enrichment for ≥ 1 HR features at progression.

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PMC10158546

Representative Z-stacked projection of ReN neural progenitor cells stained with Nestin (NES; green) before differentiation. (

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PMC11766174

On the other hand, the average numbers of CA-positive cells observed by flow cytometry in the serial dilutions described above were 498, 415, 110, 1105, 11,021, and 61,148, respectively.

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PMC10203589

Thus, FGF18 orthologs are evolutionarily conserved targets of the canonical Wnt/β-catenin signaling pathway based on comparative genomics of the 5’ -promoter region of FGF family genes, FGF18 and WNT signaling pathways are networked together during carcinogenesis and embryogenesis (10, 11, 69, 70, 191).

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PMC11748335

On the other hand, peaks in short LOCKs, which exhibit the lowest nearest gene expression, are enriched in common HMDs.

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PMC9429973

The median OS was 57 months (95% CI 38-75) in the MBVP arm and 85 months (95% CI 43–104) in the R-MBVP arm (HR 0.87, 95% CI = 0.61-1.26, p=0.47).

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PMC9786247

These results suggest that mammary gland epithelial cells could be a replicative niche for C. burnetii infection in cattle.

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PMC3274243

Similarly, in HepG2 cells treated with the cytotoxic, apoptosis inducing agent camptothecin (Figure 5) differences in the OCP are apparent less than six hours into the experiment.

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PMC10165258

Eventually, the chips were filled 3 times with Novec Surface Modifer (3M), a fluoropolymer coating agent, for 30min at 110°C on a hot plate.

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PMC3019555

Cells were transfected with 10 nM of each siRNA for 48 h using the AMAXA nucleofector system (Lonza).

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PMC11770130

30 μL of serum, 120 μL of water, 1.5 mL of methanol and 5 mL of MTBE were added to a clean glass centrifuge tube, and 12 μL of lipid internal standards were added in each sample at the same time, including 2 μL of 0.82 mM PC (17:0/17:0), 2 μL of 0.77 mM PC (19:0/19:0), 2 μL of 1.40 mM PE (14:0/14:0), 2 μL of 4.91 mM LPC (17:0), 2 μL of 3.49 mM SM (d18:1/17:0) and 2 μL 4.53 mM of Cer (d18:1/17:0).

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PMC11705067

mol.

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PMC7351993

Figure 2d shows histograms of event rates in two separate sorting experiments with nominal throughput values of 50.2 eps and 85.6 eps (see “sorting throughput” in the Methods section for details, Supplementary Movie 1).

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PMC9429973

N. ANWAR, Z. ZIAD, N. FATIMA, A. KHALID, L. MAJEED, M. BORHANY HEMATOLOGY; RESEARCH AND DEVELOPMENT, NATIONAL INSTITUTE OF BLOOD DISEASES AND BONE MARROW TRANSPLANTATION, KARACHI, Pakistan Background: Chronic myelomonocytic Leukemia (CMML) is a clonal stem cell disorder characterized by the presence of sustained (>3 months) peripheral blood monocytosis (≥1 x 10/L; monocytes ≥10% of white blood cell count) along with dysplastic features in the blood/bone marrow.

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PMC11612315

Determination of the IC50 values for these compounds in CHO K1 cells expressing human TRPV1 revealed that exendin 9–39 had the lowest IC50 value for inhibiting CAP-induced TRPV1 activation.

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PMC11478724

The number of living cells almost doubled from the number in the control group.

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PMC11747467

When the tumor diameter exceeded 0.8 cm, it was recorded as the endpoint, and the survival curve of the mice was calculated.

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PMC9429973

Overall median time from randomization to allo-SCT was 76 (21-179) and 95 (37-310) days in haplo and UD group respectively (P=NS).

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PMC11536589

It was reported that Wnt/β-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer (Wang et al. 2022a).

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PMC9429973

Correspondence to: Dr Jian Huang, Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine.

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PMC11786767

This article contains supplemental data.

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PMC11699465

Briefly, Concanavalin A-coated magnetic beads were rinsed in the binding buffer while cells were collected, counted, and rinsed in the wash buffer.

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PMC11518994

Fig. 2Cytofluorimetric analysis of B cell repertoire in healthy PAX5 variant carriers.a B cell repertoire on fresh peripheral blood mononuclear analysis showed a reduction in memory B cells IgD− CD27+ (mean ± SD of PAX5 mutated carriers vs wild-type healthy donors: 9 ± 6% vs 27% ± 11%; p = 0.07).

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PMC10079526

5-Aza-2’ trapped DNMT1 to DNA and SUMOylation inhibition prevented clearing of trapped DNMT1, leading to induction of DNA damage and consequently impaired cell survival.

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PMC11743316

Furthermore, increasing glutamate dehydrogenase concentrations cause more fumarate to be produced, which in turn triggers and binds the glutathione peroxidase enzyme, boosting the ROS detoxification process in different cancer cells.

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PMC9429973

A.-I. Gkioka, M. Tsota, M. Papadatou, A. Gkiokas, A. Alexandropoulos, V. Bartzi, G. V. Dedousis, M.-C. Kyrtsonis Laikon University Hospital Athens Hematology Section - 1st Department Of Propaedeutic Internal Medicine Athens, National and Kapodistrian University of Athens, Greece, National and Kapodistrian University of Athens; Nutrition and Dietetics School of Health Sciences and Education, Harokopeio University, Athens, Greece Background: MicroRNAs (miRNAs) are short, noncoding RNAs of 19–22 nucleotides that participate in gene expression regulation.

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PMC11806613

After 2 weeks, the transplanted mice were treated with ethanol control or OST-01 (1 µL/g, oral gavage, BID) for 5 weeks.

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PMC8759873

The current treatment methods are mainly surgery plus biological therapy and radiotherapy and chemotherapy .

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PMC9599726

Data Analysis by Estimation Statistics” (DABEST) software (https://www.estimationstats.com/#/ (accessed on 22 July 2022)) was used as a Python script (https://github.com/ACCLAB/DABEST-python, accessed on 22 July 2022), running on a local PC to generate Cumming plots, for experiments that share one reference control group.

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PMC7185206

In the present work, we showed that tumor-associated metzincin metalloproteinases ADAM10 and ADAM17 cleave PD-L1 from the surface of tumor cells to induce apoptosis in CD8 + T cells and dampen anti-tumor immunity.

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PMC11351758

Researchers presume that mitochondrial Ca uptake is dependent on the membrane potential and the intracellular distribution of the organelle, both of which may be altered in mitochondrial diseases .

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PMC11680578

Percentage cell survival after 24 h treatment of 1 nM, 5 nM, 10 nM, 25 nM, 50 nM and 100 nM PTX. (

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PMC11506827

Quantification was performed using an Agilent 1100 HPLC system coupled with an API 2000 LC-MS/MS system in multiple reaction monitoring (MRM) mode.

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PMC11766309

The results of the GO functional annotation, KEGG pathway analysis, and GSEA enrichment analysis are shown in Figure 10A.

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PMC11194678

As expected, endogenous STAU1 showed dense and small puncta in WT STHdh cells, while larger and more obvious STAU1 puncta were observed in HD STHdh cells (Fig. 1 D).

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PMC11013014

All chemicals and solvents used were of analytical quality and were obtained from commercial suppliers.

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PMC11463018

HR-MS (ESI) calcd.

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PMC11453018

In contrast, when encountering single GGAA motifs, it tends to facilitate gene repression .

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PMC10454535

Treatments were done in triplicates, and three independent experiments were conducted.

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PMC8557138

Crosslinking of alginate molecules are much faster compared to other biomaterials and hence are widely used to produce 3D matrix in tissue engineering.

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PMC11413393

Cell lines were engineered to express doxycycline (Dox)-inducible PRMT1 targeting or non-targeting (NT) shRNAs and treated with or without 1.0 μg/mL Dox for 3 and 6 days.

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PMC9509578

Smart engineered nanoparticles respond according to the cellular pH, for the release of chemotherapeutic drugs at the tumor site.

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PMC11733919

Indeed, at the same time points, MNP@CD26@17D and MNP@CD26 also promoted an increase in the levels of the cell cycle inhibitor p27 that was not promoted by the drug alone; however, the effects of MNP@CD26@17D were more pronounced (Figure 5c).

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PMC9429973

Twelve patients (80%) had received prior intensive chemotherapy, 3 patients (20%) had prior Venetoclax exposure and 9 patients (60%) had been previously treated with FLT3 inhibitors (Midostaurin – 7, Sorafenib – 1, Gilteritinib – 1).

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PMC11612315

c closed state, o open state.

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PMC11772585

n = 5. **

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PMC9429973

However, prolonged product manufacturing times and a need for longer duration of response are a major obstacle in this population, necessitating fast manufacture of a reliable and durable CAR-T cell product.

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PMC11659921

Difference in expression of immune checkpoint‐related genes in high TNFSF11‐expressing and low TNFSF11‐expressing groups. (

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PMC9646302

The antibodies used in this study are listed in Table S3 in the Supplementary Material.

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PMC9429973

ECOG score greater than 3 and receiving bridging therapy before CAR-T may be the risk factors of GI bleeding.

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PMC11093197

The ectopic expression of oncogenic RAS in fibroblasts causes cellular senescence due to replication stress and subsequent DNA damage.

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PMC11481779

We first use an encoder composed of residual 1D convolutions that transfer 1D sequence into latent space; furthermore, we use a transformer encoder to allow the model to learn long-range context.

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PMC10380508

The membrane was then transferred to the appropriate horseradish peroxidase (HRP)-conjugated secondary antibody (Sigma-Aldrich, Burlington, MA, USA) diluted in blocking buffer and incubated for 2 h at room temperature.

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PMC9429973

There was statistically significant risk of mortality due to all malignant cancers combined (SMR 58.35, 95% CI 49.03-68.94), largely due to mortality from lymphocytic leukemia (SMR 2587, 95% CI 2021-3264, AER 1757), non-Hodgkin lymphoma (SMR 100, 95% CI 45.88-190.45, AER 220), stomach and duodenal ulcers (SMR 73.74, 95% CI 1.87-410.84, AER 24.43), uterine cancer (SMR 66.55, 95% CI 1.68-370.78, AER 24.39), and pneumonia and influenza (SMR 11.88, 95% CI 2.45-34.71, AER 68.04).

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PMC8978939

Although VBC: HIF-1α complexes still form as evidenced in vitro ( Figure 2A ), binding strength is significantly reduced in all the cases under hypoxia, particularly for variant P138R ( Table 2 ).

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PMC11699042

In total 526,610 variants out of 696,726 passed the QC filters.

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PMC11727907

Glucose consumption in the growth medium was assessed by measuring NADP reduction at 340 nm.

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PMC11786704

CLSM images of PC capsules. (

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PMC11617590

However, in our study, the value of IC50 for SFN was 111.0 μM when SFN was treated for 72 h. Although the effect of SFN in this study is minimal, SFN has an inhibitory effect on the proliferation of Mia PaCa‐2 cells, which is consistent with the findings of previous studies .

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PMC9429973

Patients with RRMM had received ≥3 prior lines of therapy (LOT) or were refractory to a proteasome inhibitor (PI) and immunomodulatory drug (IMiD).

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PMC11496728

The stable expression results indicated that pCMV-SEAP-1 and pCMV-SEAP-2 were 1.49- and 1.55-fold higher than pCMV-SEAP, respectively (Fig. 2C).

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PMC9243326

C. chinensis is an aquatic animal product with high economic value and has potential for medicinal development.

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PMC10820104

Regions for NI-siderophones were also found on one contig.

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PMC11739504

Graphs on right side indicated fluorescence intensity of Arl13b normalized ac-α-tubulin, ac-α-tubulin and Arl13b, respectively.

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PMC11087055

As verified by BrdU incorporation assay, the aphidicolin-treated embryos exhibited little or no mitotic activity (Figure 2D).

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PMC10443665

All the concentrations of tragacanthin, bassorin, and APS (except at 0.8-100 μg/mL in CCRF-CEM) decreased the viability of all the cells compared to the negative control group; and against the positive control (MTX-treated cells), only bassorin at 20-100 μg/mL in CCRF-CEM/R and tragacanthin at 50 and 100 μg/mL in CCRF-CEM/MTX and at 2-100 μg/mL in CCRF-CEM/R decreased cell viability.

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PMC10940855

The principal component analysis was applied to the transcript counts.

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PMC11655498

TERT maintains EBV latency through the NOTCH2/BATF pathway.

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PMC11394386

Commercial cervical cell lines HeLa, SiHa, and HaCat were obtained from the Functional Genomics Laboratory of the National Cancer Institute of México.

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PMC11237030

Magnification: ×20.

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PMC11752740

After this period, the culture medium in the wells was replaced with fresh medium containing various concentrations of the treatments.

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PMC11216402

This indicates that single-cell clusters 2 and 5 include stomach cells, whereas cluster 6 is composed of fibroblasts.

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PMC11731614

Plexins, the surface receptors for semaphorins, are involved in neuron axonal growth and guidance, as well as a host of other functions (Alto and Terman, 2017, Janssen, 2010, Takamatsu and Kumanogoh, 2012, Li, 2022).

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PMC11718809

It is reported that circRNA-02191 promotes the generation of triglycerides and fatty acids in cow mammary gland cells by adsorbing miR-145 .

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PMC10582049

Illustrations are created with BioRender.com.) (

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