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PMC10440586
It was found that in glioma samples with a high cuproptosis signature, both VEGFA and CD99 were highly expressed .
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PMC9429973
Aims: To determine the number, the functions and the abilities of haematopoiesis and immune regulation of BM EPCs in patients with different stages of MDS.
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PMC11348300
Examining PpIX concentration over time in different tissue types reveals a rapid increase until the 1-h time point, followed by saturation and a subsequent decline around the 4 h mark.
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PMC9473868
In this paper, we further confirmed that BAI could inhibit the migration of SW982 cells by a cell scratch healing experiment, and its migration mechanism might be related to the downregulation of the MMP2/9 expression, EMT-related proteins, and PI3K/Akt/mTOR signaling pathway.
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PMC11634027
Blots were rinsed with PBT four times (10 min each) and then imaged using a LI-COR Odyssey CLX machine.
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PMC9429973
Aims: We aimed to establish a robust and low-cost murine HSPC in vitro model system that allows maintenance and expansion of functional LSK (lin, Sca-1, c-Kit) cells, and guarantees long-term multipotency.
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PMC9429973
Image: Summary/Conclusion: Crossover patients had the same magnitude and time course of clinical improvement seen in patients receiving olipudase alfa for 1 year, while 2-year olipudase alfa patients had sustained or further improvements.
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PMC8409415
Based on our immunohistochemistry data, we hypothesized that platinum administration may induce CD70 expression in women with OvCA and this finding was confirmed in vitro.
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PMC11641630
These findings broaden the differential mycobacterium-driven anti-invasive effect on BC cells related to anchorage independent growth, suggesting that there is room for improvement of the M. bovis BCG antitumor capacity and warranting further studies to consolidate non-tuberculous mycobacterium-triggered antitumor effects.
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PMC11502443
This could be due to different cellular backgrounds or receptor overexpression, compared to endogenous expression in the physiologically relevant cell lines.
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PMC11394112
To assess organ-specific engraftment of DLBCL cells in NSG-IL6 mice, we euthanized four xenografted mice per week at weeks 2–6 post-injection and performed ex vivo imaging of the excised organs.
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PMC11045125
The following day the antibodies were removed and the membrane was washed with wash buffer (1X PBS, 0.1% Tween 20) three times for 5 minutes.
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PMC11733919
At that point, the MNPs were washed from the excess reagents using ultracentrifugal filters (Amicon, 100 kDa cutoff) and stored at 4 °C.
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PMC11643491
To further demonstrate relevance to drug delivery, elongated paclitaxel-loaded biodegradable, slow-releasing poly(lactic-co-glycolic) acid (PLGA) particles were synthesized.
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PMC8978939
Protein levels for both P138R and L163R cell lines ( Figure 2B , lanes 3 and 4) were intermediate for HIF-2α assessed by Western blot, although mRNA levels did not change in the different cell lines ( Figure 2B ).
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PMC10047551
In conclusion, we only observed a negligible inverse correlation between PD-L1 methylation and expression, which indicates that in samples representing a complex tumor milieu harboring various cell types and cytokines/IFNs, the PD-L1 methylation level does not strongly inverse correlate with the PD-L1 expression level.
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PMC9429973
R. Cameron, L. Swart, M. Rasouli, O. Heidenreich Prinses Maxima Centrum, Utrecht, Netherlands Background: Patients harbouring MLL (KMT2A)-rearrangements with AF4 remain a high-risk subgroup in acute lymphoblastic leukaemia cases, with currently <40% event free survival in infants (<1 year).
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PMC8358176
Carbon nanotubes (CNTs) are man-made nanomaterials ( 1 , 2 ) that possess special physical and chemical features and have wide applications in modern science and technology ( 2 , 3 ).
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PMC11401358
AFM characterization of (GAGSGA)2 self-assembled after shaking for 8 h at 37 °C in water (Scale bar = 400 nm). (
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PMC11283030
Combination of ACLY and immune checkpoints may be a novel anticancer strategy.
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PMC9398137
These data might be important in the future to design new therapeutic approaches following treatment with MCL1 inhibitors.
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PMC11765678
While these are promising findings, additional research is needed to fully understand the relationship between ER-induced NO formation, iNOS, and ABC transporters in vivo and other tumor models.
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PMC10809689
A significant difference in GLS protein expression in the PG48 group compared to PMA and control group was perceived (p = 0.0001) (Fig. 4 (c., d.)).
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PMC7709199
PNGase F treatment of DSCAM is efficient both for material produced in HEK293T and GD cells, leading to a further size reduction of ∼5 kDa.
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PMC11802855
These results suggest that increased CXCL7 expression enhances its binding to CXCR2 and activates the JAK/STAT3 pathway.
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PMC11089031
4ZNF692 targeted G3BP2 and TM9SF2.
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PMC10506676
So the increase in the expression of this gene has been reported in many malignancies (20, 21).
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PMC11804588
One such enzyme, M.CviPI, methylates cytosines at GpC dinucleotides.
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PMC11434983
The reacting mixture was refluxed for 3 h. Then, the volume of the solution was reduced to 5 mL, followed by adding 30 mL of diethyl ether.
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PMC11599565
0.5 µg of total RNA isolated from SKOV3 and SKOV3 exposed to cisplatin for 72 h were subjected to sequencing using Illumina next-generation sequencing (NGS) system (BGI Genomics, Hong Kong, China).
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PMC11013014
NMR (400 MHz, CD3COCD3), δ (ppm): 7.86 (br, 1H), 7.74 (br, 1H), 7.37 (d, JHH = 8.5 Hz, 2H), 7.27 (d, JHH = 9.0 Hz, 1H), 7.18 (d, JHH = 9.0 Hz, 1H), 6.80 (d, JHH = 8.5 Hz, 2H), 6.02 (br, 1H), 5.91 (s, 1H), 5.59 (s, 1H), 4.72 (s, 2H), 3.74 (s, 3H), 3.44–3.37 (m, 4H), 2.44 (q, JHH = 7.4 Hz, 2H), 1.13 (t, JHH = 7.4 Hz, 3H).
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PMC11725127
We then discovered that GA could covalently bind to USP2 in an allosteric manner, thereby inhibiting its activity.
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PMC11680562
The results suggest that incorporating the metal and drug in a 1:1 ratio in the PXFCu6 gel dramatically increases its effectiveness.
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PMC11322866
Epigenetic modifications play an important role in cellular senescence, and enhancer of zeste homolog 2 (EZH2) is a key methyltransferase involved in epigenetic remodeling in multiple myeloma (MM) cells.
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PMC11224020
Data were analyzed by ordinary one-way ANOVA; *P = 0.0175.Source data a–d, Bulk RNA-seq analysis of cPLA2 and cPLA2 DCs; NC NS, nonconfined nonstimulated.
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PMC11766332
Glycosylation (the glycoconjugate synthesis pathway) is a necessary process for the optimal development of the central nervous system (CNS).
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PMC11621565
The cytotoxicity was evaluated by lactate dehydrogenase (LDH) release (CytoTox 96® Non-Radioactive Cytotoxicity Assay, Promega).
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PMC11365427
Figure 4Phenylalanine deprivation inhibits MM in vivo. (
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PMC11529598
A. Expression of miR-3154 in paired glioblastoma tissue and adjacent normal tissue (n = 28) detected by quantitative real-time polymerase chain reaction (qRT-PCR). *
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PMC9429973
S. Bougherira, S. Bentorki, F. Grifi Hematology, University hospital, Annaba, Algeria Background: Polycythemia Vera (PV) is a typical Philadelphia-negative (Ph) myeloproliferative disease.
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PMC11740207
Pathogenicity might have also occur earlier in previous developmental stages, such as ESCs, or even originated in gametes—either the sperm or egg—during the parents’ lifetime.
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PMC11577421
Additionally, fluorescence anisotropy revealed that the binding affinity between BSA+ and heparin was much stronger as expected, yielding an apparent KD of 0.65 μM (Figure 2B).
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PMC9014716
Bel-7404 cells, Bel-7404 cells treated with an miR-224-5p inhibitor or a negative control (NC), HepG2 cells, and HepG2 cells treated with an miR-224-5p inhibitor or NC in suspension were carefully plated in 6-well plates at a density of 0.80 × 10/well (Bel-7404 cells) or 2.0 × 10/well (HepG2 cells) and treated with drugs at various concentrations for 24 hours.
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PMC11467800
These data show that surviving cells (10%) in the K562 population have a higher potential for metastatic/invasive progression.
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PMC10810426
Another unresolved issue for all retroviruses is the timing and location of host restriction during infection, particularly in natural targets of infection (e.g., lymphocytes, macrophages, dendritic cells) and how these factors coordinate with reverse transcription.
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PMC11306331
While prior studies established that fusion to the FUS domain controls both phase separation and oncogenicity, our results hint at a causal link between FUS-CHOP condensate state and its function as a transcription factor, in line with other recent studies using distinct tools and transcription factor targets.
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PMC11787355
Together, these data reveal a patient-derived vaccine-induced PTPRZ1-reactive TCR that binds to both exogenous and intracellularly processed and presented antigen on MHCI and does not react against AI-predicted low-risk off-targets.
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PMC11680578
ns2 non-significant, p < 0.001 as compared to that of RGZ alone.
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PMC11683240
Cells were left untreated as further control.
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PMC9960565
In fact, one may expect to have in solution the free cisplatin, fully functionalized dendrimers, and dendrimers that have already partially lost the metallic fragment.
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PMC10994876
Therefore, in this study, we first aim to address this gap by developing modified CHO cell lines through the overexpression of YAP5SA, which is assumed to have constitutive activity.
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PMC3675084
BPR0L075 started to block the OVCAR-3 cells at G2/M phase as early as 12 hour, and progressed to complete arrest from 24 to 48 hours in both OVCAR-3 and OVCAR-3-TR cells.
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PMC11496491
KEGG analysis showed that differential genes were most significantly enriched in Adherens junction, Inflammatory mediator regulation of TRP channels and Wnt signaling pathway.
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PMC11224206
Integrate the conclusions to provide sound advice to mitigate heat stress during conception in vivo and in vitro.
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PMC2196094
cDNA clones for 10 different serine proteases (RMCP-1-10), and the MC carboxypeptidase A were isolated and characterized.
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PMC11695546
Characterization and classification of ozonized vegetable oils depend on an understanding of their physical and chemical characteristics (Ugazio et al. 2020; Radzimierska-Kaźmierczak et al. 2021).
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PMC11637820
This showed that the device produced both reactive oxygen and nitrogen species like N2, O, N OH and NO (Fig. 1B).
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PMC9119314
Compounds 3–6 all demonstrated improved potency against the A2780 wild-type ovarian adenocarcinoma cell line when compared to the parent compound 1, with compound 3 demonstrating the best chemosensitivity of the new analogues (Table 2).
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PMC7840816
Cells that migrated to the lower surface of the filters were washed, fixed, stained with crystal violet, and counted under a microscope.
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PMC11756907
Interestingly, the cytotoxicity of the GO-2ME in DMSO (Figure 2B) at a concentration of 0.0181 mg/mL (1:10 dilution) against A375 cells was comparable to that of 2-ME (at more than a sevenfold higher concentration).
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PMC11621493
This mix was pooled with 90 μl Opti-MEM Reduced Serum Medium containing 30 μg polyethyleneimine (26292, Polysciences, Warrington).
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PMC6901583
A sterile 200-μm plastic pipette tip was employed to softly scratch the monolayer once cells were 95% confluent, followed by documentation of the wound with photographs.
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PMC11361748
Dashed lines depict the dermo-epidermal interface. (
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PMC10873328
The protein expression level of TGFBI after time gradient of cisplatin in A2780 (IC50 as 119.2 μM). (
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PMC9429973
This descriptive analysis included pts initiating treatment ≥6 months before the cut-off date (14/01/2022); the median (95% confidence interval [CI]) OS was obtained by Kaplan-Meier analysis.
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PMC11754784
All methods were performed in accordance with these approved guidelines.
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PMC11279397
The antiviral activity of additional compounds found in Perilla frutescens is presented in Table 16.
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PMC11317131
Donor plasmids pCMV PhiC31 attB DsRed Hygro, pCMV Bxb1 attP DsRed Hygro and pCMV Pa01 attP DsRed Hygro contain att sites for PhiC31, Bxb1, and Pa01 integrases, respectively.
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PMC11725127
The ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) hydrolysis assays were performed at 25 °C in the assay buffer (50 mmol/L Tris/HCl, 150 mmol/L NaCl, 2 mmol/L EDTA, 2 mmol/L DTT, 1 mg/mL bovine serum albumin (Roche), pH 7.5).
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PMC9429973
Aims: To analyze the safety and efficacy of HDC for palliation of patients with HC.
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PMC10114490
Lowering the concentration of reduced glutathione (GSH) is acknowledged as an oxidative stress biomarker and is a key metabolite participating in conjugation reactions .
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PMC11281366
A mix of sera from three to five healthy donors was used as a source of complement.
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PMC11087766
When cells were infected with PhiKZ, PhiPA3 RecA was imported into the PhiKZ nucleus, while the other four PhiPA3 proteins were excluded from the PhiKZ nucleus (Fig. 1A), demonstrating that PhiKZ does not import the majority of PhiPA3 nuclear proteins.
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PMC9250505
Densitometries of protein bands were determined using ImageJ software (https://imagej.nih.gov/ij/).
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PMC9429973
Overall PFS, EFS and overall survival data will be presented at the meeting.
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PMC11730320
Only one variant set was deemed compound heterozygous and had both alleles not occurring as homozygous in gnomAD and not overlapping multiple dbSNP entries; however, the corresponding gene (ECSIT) lacked an immune function or phenotype consistent with the patient’s (Supplementary Dataset 1).
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PMC11672142
GI50 measures the concentration of a compound that induces 50% inhibition of the cells to reach maximal cell count relative to the initial cell total under no compound treatment conditions.
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PMC6627640
In total eight, four and two independently acquired resistant clones of parental NT2/D1, 833K, and 2102EP embryonal carcinoma cells were generated, respectively (Supplementary Table S1).
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PMC11088135
B, C Flow cytometry was used to quantify the apoptosis of U251 cells.
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PMC11607638
Both peptides were synthesized commercially: SK1 at purity of 98.10% and SK2 at 98.19% (Sangon Biotech, Shanghai, China).
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PMC11240448
Next, we employed an 8-fold cross-validation to compute the mean accuracy.
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PMC6889484
C and D) Replication kinetics of recombinant subtype AE in parental (C) CEM and (D) PM1 cells, with no detectable virus up to 30 days post-infection in CEM/D128K and PM1/D128K cell lines.
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PMC11615101
The ELISA results revealed significantly upregulated (≈200pg/ml) concentrations of α-Taxilin in the RA (n = 106), compared to OA (100pg/ml), HC (≈ 100pg/ml), and SLE (≈ 80pg/ml) patient plasma samples (Figure 1A).
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PMC8382973
To test their thermal stability, 2P23 gels were stored at 60°C for 1 week, 40°C for 8 weeks, 25°C for 16 weeks, and 4°C for 24 weeks.
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PMC11764090
These condensates can directly respond to cold stress and form small droplet structures through protein phase transformation .
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PMC11532793
The absolute (relative) increase in the number of truly DE transcripts detected by each method was 108 (6%), 82 (5%), 42 (3%), 28 (1%) and 12 (1%) for sleuth-LRT, sleuth-Wald, Swish, edgeR-v4 and edgeR-v3 respectively, averaged over simulations.
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PMC11604015
According to previous studies, the poor persistence/cytotoxicity of CAR-T cells and the negative regulation of tumor microenvironment may contribute to antigen-positive relapse.
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PMC11394227
The SDS-PAGE utilized was 12% Tris-Glycine precast page gel (Adamas).
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PMC9221284
The SMARTer RACE 5′/3′ Kit (Takara Bio, Inc. Mountain view, CA 94043 USA), Catalog no 634860) was used to perform both 5′- and 3′-rapid amplification of cDNA ends (RACE) according to the manufacturer’s instructions.
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PMC11279397
This paper focuses on reviewing the antiviral activities of these primary components and their derivatives.
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PMC11782508
Conversely, both ammonium sulfate-precipitated and purified azurin displayed dose-dependent anticancer activity against the MCF7 breast cancer cell line (Fig. 7).
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PMC10079526
5-Aza-2’-deoxycytide (5-Aza-2’) is effective, however also resistance to therapy is common .
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PMC9429973
According to Frankel’s diagnostic criteria, 16 patients (18%) experienced a DS, with a mean age of 39 years [13-71 years], and a sex ratio of 0.6.
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PMC5311252
One of the most studied areas in cancer biology is related to cancer growth and oncogenic drivers of cancer cell proliferation.
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PMC11597291
Pegylation increased the biocompatibility of graphene oxide particles by reducing the available oxygen molecules on the matrix and by offering a protective surface layer that conceals the electrostatic interactions of oxygen molecules and the hydrophobic interactions of nCGO lattice with the RBCs.
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PMC11047729
It causes apoptosis by down-regulating the transcription of TERT and oncogenic c-Myc.
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PMC9000591
The results of SE3 showed that this fraction was rich in isoflavones, with four identified compounds.
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PMC11670954
After incubation, the cells were washed three times with PBS and then incubated at room temperature with fluorophore-labeled secondary antibodies (ab150081, 1:1000, Abcam) for 1 h. Finally, DAPI (P0131, Beyotime, China) was used to stain the nuclei in the dark.
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PMC9966931
To examine the potential bioactivity of these EO-based molecules, the cytotoxicity was assessed by means of the brine shrimp lethality assay, a well-established method to preliminarily test the bioactivity of plant extracts and nature-related pure compounds.
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PMC10728535
Progression of OC during the 6‐month period after the end of platinum‐based chemotherapy is normally related to platinum resistance.
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