OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11522251	Image J software was used for calculating the colonies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "J", "software", "was", "used", "for", "calculating", "the", "colonies", "." ] } ]
PMC11506670	No. CCL-247), which were both obtained from the American Type Culture Collection (Manassas, VA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "CCL-247", ...
PMC11707577	A refactored M13 phage, engineered by phage display (M13EGFR), was used to selectively recognize the epidermal growth factor receptor (EGFR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11615101	However, the fold change expression level (2.1-fold) of TLR-2 was observed to be highest at lower doses (6.25ng/ml) and decreased the expression (0.62-fold) as the dose of α-Taxilin increased to 100ng compared to 6.25ng, and it remained significantly upregulated through all the doses compared to the untreated group (0ng/ml) (Figure 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11548041	HL-60 cells were not subject to endogenous biotin blocking.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HL-60", "cells", "were", "not", "subject", "to", "endogenous", "biotin", "blocking", "." ] }...
PMC5417661	Fluorescent and phase-contrast images (10×) were gathered every 6 h for up to 8 days and analyzed for cord length and number of branch points from 3 to 6 separate samples for each treatment condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11537649	A bilateral P < .05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "bilateral", "P", "<", ".05", "was", "considered", "statistically", "significant", "." ] } ]
PMC9429973	No pharmacological GvHD prophylaxis was given post-transplant (clinicaltrials.gov: #NCT03977103).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "pharmacological", "GvHD", "prophylaxis", "was", "given", "post-transplant",...
PMC9429973	Finally, generation of DCleu by treatment with KitM triggers immune responses in MLC alongside with reduced ICM-expressions on T-cells, possibly reducing their inhibitory effects and therefore improving antileukemic responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766309	YKT6 (1:50, #ab236583, Abcam) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YKT6", "(", "1:50", ",", "#", "ab236583", ",", "Abcam", ")", "was", "used", ...
PMC11531744	Limitations existed in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limitations", "existed", "in", "this", "study", "." ] } ]
PMC7841189	In general, increased motility and invasion are positively correlated with EMT, which is characterized by repression of epithelial markers and induction of mesenchymal markers20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11655536	When the cell is stimulated, TFE3 is dephosphorylated and activated, and subsequently translocated to the nucleus to promote autophagy and lysosomal gene transcription, leading to lysosome biogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	Similar results were obtained for p40Tax-pMHC-stimulated p40Tax-GMCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "obtained", "for", "p40Tax-pMHC-stimulated", "p40Tax-GMCs", "." ] } ]
PMC9622879	The daily energy cost of each home in the community with three CEMSs is shown in Fig. 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "daily", "energy", "cost", "of",...
PMC11252033	Paired-end clean reads were aligned to the reference genome (hg38) using Hisat2 v2.0.5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired-end", "clean", "reads", "were", "aligned", "to", "th...
PMC9429973	A. Bagashev, J. Loftus, L. Niswander, S. Ross, C. D. Falkenstein, J. Junco, K. R. Rabin, T. Fry, S. K. Tasian Oncology, Children’s Hospital of Philadelphia, Philadelphia; Children’s Hospital Colorado, Denver; Children’s Hospital of Philadelphia, Philadelphia; Texas Children’s Hospital, Houston, United States of America Background: CRLF2 (cytokine receptor-like factor 2; encoding the thymic stromal lymphopoietin receptor [TSLPR]) rearrangements occur in 50% of children with Down Syndrome-associated B-acute lymphoblastic leukemia (DS-ALL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9318744	Since several published studies have reported that the cleavage of the SARS-CoV-2 S protein at a putative furin cleavage site (RRARS) at R685/S686 is critical for virus entry , we investigated the efficacy of the furin inhibitor decanoyl-RVKR-CMK and observed a moderate inhibition of infection in the WT SARS-CoV-2-infected cells as determined by immunofluorescence and plaque assays (Figure S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	f, Expression of Ccr7.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", ",", "Expression", "of", "Ccr7", "." ] } ]
PMC9429973	Prior to the study entry, during first line (1L), 31.6% of pts received a stem cell transplant (SCT) (34.9%, 27.6% and 25.0% respectively for the 3 cohorts).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	ER stress is associated with the Calcineurin/nuclear-factor-of-activated-T-cells (NFAT) signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ER", "stress", "is", "associated", "with", "the", "Calcineurin/nuclear-factor-of-activated-T-cells", ...
PMC11697065	Protein concentration was quantified using a BCA assay (Thermo Fisher, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "concentration", "was", "quantified", "using", "a", "BCA", ...
PMC2118063	Infected cells were selected with 4 μg/ml puromycin for 72 h and cloned for 2 mo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infected", "cells", "were", "selected", "with", "4", ...
PMC11507371	Although these findings might seem contradicting, it appears reasonable that elevations in Keap1’s abundance might have completely divergent effects on the cellular systems of both cell lines since Keap1 is known to have more than a dozen binding partners possessing a motif akin to the Nrf2 ETGE motif .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	These regions mark the early wave of DSBs in the sequence of internucleosomal DNA fragmentation mediated by apoptotic nucleases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "regions", "mark", "the",...
PMC9429973	All patients had leptomeningeal involvement and 8 (23%) additionally had parenchymal CNS disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "had", "leptomeningeal", "involvement", ...
PMC11719944	Low-density lipoprotein cholesterol (c-LDL) was calculated with the Friedewald formula, c-LDL (mg/dL) = CT mg/dL − (c-HDL mg/dL + triglycerides mg/dL/5), if triglycerides were <400 mg/dL. Prolactin in plasma was measured using a human PRL (Prolactin) ELISA kit (FineTest, Wuhan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11011837	Nonetheless, it is still necessary to verify and validate these results on primary tumor cells or on samples taken directly from patients in order to translate these findings into potential clinical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	To determine apoptosis and chemoresistance, levels of cPARP were evaluated by immunoblotting and densitometry was quantified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", "apoptosis", "and", "chemoresis...
PMC10604092	The locomotive activities of the SLC-transplanted rats were also significantly lower than those of the control rats (p < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "locom...
PMC6901583	Tumor volume growth curves from day 1 to 19 of treatment are presented. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volume", "growth", "curves", "from", "day", "1", "to", ...
PMC11470381	Major = length of the major axis of the ellipse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Major", "=", "length", "of", "the", "major", "axis", "of", "the", "ellipse", "." ] }...
PMC7709199	The DSCAM gene is situated on chromosome 21 and is overexpressed in Down syndrome patients (Yamakawa et al., 1998 ▸).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11395280	By day 10, the integrity of the monolayer began to deteriorate as reflected in a decrease in the TEER (Figure 3); therefore, all the transmigration studies were carried out between days 4 and 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	To target the Wnt signalling pathway, it was decided to specifically repress the expression of the FZD5 and FZD7 receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "target", "t...
PMC11746948	The protein concentration in the supernatant was quantified using the BCA Protein Assay Kit (Thermo Fisher Scientific, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", ...
PMC11323699	Statistical significance is indicated by ****p < 0.0001 (two-tailed Mann–Whitney test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "is", ...
PMC11761919	The effects of inulin and PINs on the growth of recombinant E. faecalis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effects", "of", "inulin", "and", "PINs", "on", "the", "growth"...
PMC10729469	Tresp cells alone with and without Dynabeads served as controls for baseline Tresp proliferation without Treg suppression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tresp", "cells", "alone", "with", "and", "w...
PMC8584666	These results suggested that the proliferation of GPI-80-expressing cells was sensitive to extracellular redox balance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggested", "that", "the", "proliferation", ...
PMC11401350	This is a very time-consuming and labor-intensive process resulting in a very costly medical product, which is therefore not available for all patients in need of CAR T cell therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	For the CLDX model, NB4 PML A216V cells were transplanted into NSG mice, and after chimerism detection (hCD45) in the peripheral blood, mice were equally distributed into 4 groups of treatment: vehicle, VEN (25mg/kg/day), S64315 (20mg/Kg/day) and combination (n=5/group) for 21 consecutive days.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC6034753	We observed that there was no change in number of apoptin and Meq co-localized cells in presence (1.70 ± 1.25%) or absence (2 ± 1.25%) of Meq synthetic peptide 130–140 (M ± SD, n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	Fanoni et al. (2011) analyzed the expression of SLAMF1/CD150 by immunohistochemistry in 25 patients with primary cutaneous (PC) B cell lymphomas including 10 PC-follicular center lymphoma (PC-FCL), 10 PC-marginal zone lymphoma (PC-MZL), and 5 PC-DLBCL-LT (leg type) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	Scale bars, 500 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "500", "nm", "." ] } ]
PMC11543935	The temperature was monitored during the treatment with a fiber optic temperature sensor (Optocon TS5/A366 by Weidemann Technologies, Germany) and a multi-channel thermometer (FOTEMP4-16 by Weidemann Technologies, Germany), which can be accessed via a laptop.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	PBMCs were cryopreserved at a concentration of 2–10 × 10 cells/mL in freezing medium (heat-inactivated foetal calf serum [HI-FCS] + 10% [v/v] dimethyl sulfoxide [DMSO] [Invitrogen™, Thermo Fisher Scientific, Loughborough, UK]) in Mr. Frosty™ (Thermo Fisher Scientific, Loughborough, UK) at −80 °C for a minimum of 5-h and a maximum of 24-h and transferred to a −150 °C freezer for long-term storage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	Last but not least, a specific antiviral immune reconstitution was frequently associated to the decrease or clearance of the viral load (59).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11760643	This effect was attributed to the blockade of human P2X7 and increased survival of human Tregs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "attributed", "to", "the", ...
PMC10545062	The proportion of time with MAP less than 60 mm Hg and MAP greater than 70 mm Hg was similar between SCC and SCC+, p = 1.0 and p = 0.24, respectively (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	Of note, the suppression of USP39 impairs the migratory cell abilities with inhibition of slug and E-cadherin leading to EMT inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note",...
PMC9784246	Molecular docking of various polyphenolics of the MeOH fraction with HDAC6 and PDK3 enzymes demonstrates high binding affinity of the epicatechin 3-O-β-D-glucopyranoside and catechin-7-O-β-D-glucopyranoside toward HDAC6, and procyanidin C2, procyanidin B5 toward PDK3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416	With BLASTP 2.2.15 [Oct-15-2006], mapping now includes NCBI RefSeq database , and Ontologies are found in four databases: GR, UniProt, UNIPROT and RefSeq (Figure 7 (Panels A and B)); Ontologies found in this mapping are much less – essentially half of the number found previously in Figure 1 (Panels A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	For these patients, the prognosis remains poor, with a five-year survival rate of <10 % .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "these", "patients", ",", "the",...
PMC10604092	The chemiluminescent signals from spots on the membrane were captured (LAS 4000; GE Healthcare Japan Corporation, Tokyo, Japan) and quantified using Image Gauge version 4.0 (GE Healthcare Japan Corporation, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	By using home-made (i.e. influenza virus) or existing vaccines (CMV or VZV vaccines) to stimulate the native TCR, several teams showed continuous activation and expansion of CAR-VST, maintaining their expansion and effector functions while preventing exhaustion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Patients who received ≥1 dose of bosutinib (n=268) or imatinib (n=265) 400 mg/day in BFORE were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods...
PMC10728200	The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h, and subjected to Western blot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	The virus contained within the cleared supernatant was combined with the pellets of the first supernatant and purified using a 36% sucrose gradient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11687167	The coding sequence (CDS) of the gene spans 2079 base pairs (bp) and encodes a protein comprising 692 amino acids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11607638	The SKR mRNA levels in mosquito head tissue after SK1, SK1 + SK2, SK2, injection. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SKR", "mRNA", "levels", ...
PMC11741906	For instance, overexpression studies demonstrated that miR-519d, miR-155, miR-708, miR-34c, miR-200b, miR-200c, miR-29, and miR-1305 increase cisplatin cytotoxicity in A2780 or SKOV3 cells [, , , , , , ].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	Several studies have reported that transgenic plants engineered to give stable HIGS targeting of the pathogen TOR gene can block the occurrence of plant disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11746942	B Western blot and quantification of S1PR3 expression in HaCaT cells treated with the STAT3 inhibitor Stattic (10 μM) in the presence or absence of 25 μg/mL IL-6 or 25 μg/mL IL-22.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055323	Data are mean ± s.d.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean", "±", "s.d", ".", "," ] } ]
PMC11741906	Conducting comprehensive functional studies will also address the ambiguity and the context-dependent functions of miRNAs in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conducting", "comprehensive", "function...
PMC11434983	IR spectra were recorded on a Brucker™ Alpha II™ FT-IR/ATR Spectrometer (Bruker, Billerica, USA) between 4000 and 400 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11777207	Hydrogen bonds were identified in PyMol, the hydrophobicity surface coloring was identified, and images were generated using UCSF Chimera software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydrogen", "...
PMC7723249	CD14 cells were positively selected using anti-CD14 MACS beads (Miltenyi Biotec) according to manufacturer instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD14", "cells", "were", "positively", "selected",...
PMC11700165	In the next set of experiments, we compared the phosphorylation capacity of the kinases in the presence or absence of different inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11519567	Then, resuspend cell pellet in 200 µl ice-cold lysis buffer (10 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.1% SDS, 1% Triton X-100) supplemented with protease inhibitor cocktail and 1 mM PMSF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	This is reminiscent, at least partially, of our prior results .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "reminiscent", ",", "at", "least", "partially", ",", "of", "o...
PMC10944868	They alter the monomer-to-polymer ratio, impacting cellular functions without significant changes in total MT polymer at low concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "alter", "the", "monomer-t...
PMC11594641	Taking into account the oncogenic role of MITF in malignant melanocytes, this sheds light on the involvement of Rab27 in melanoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taking", "in...
PMC11543853	However, diffusion of the ~7500-nucleotide-long RNA genome through an opening in a capsid and a putative transmembrane pore would be a slow process, which has not been verified in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11354225	Methyl aminolevulinate (MAL) is metabolized by cells by the heme synthesis pathway and it accumulates in mitochondria as protoporphyrin IX (PpIX) , a PDT photosensitizer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	Left, lipid peroxides levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Left", ",", "lipid", "peroxides", "levels", "." ] } ]
PMC11760643	Regarding DC subsets, a previous study utilising the anti‐P2X7 mAb (clone L4) revealed similar amounts of expression of P2X7 on human blood mDCs and pDCs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	In summary, these data demonstrate that STAU1 overabundance-induced excessive formation of STAU1 condensate and the subsequent hyperactivation of mTOR signaling impair lysosomal function and autophagic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	We generated mice carrying a conditional ready Hp1g (Hp1g) allele and crossed them with Cd4-cre mutant mice to generate a conditional HP1γ-deficient (Hp1g) strain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	3-year overall survival (OS) was 55.4±7.7%, 55.0±7.2% and 87.0±7.1%, respectively (р=0,008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3-year", "overall", "surviva...
PMC9874064	Subsequently, an intraperitoneal cisplatin resistant tumor model of standard liver cancer cells (7404DDP-LUC) and a patient derived liver cancer (PDX) animal model were established for drug screen in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	Morphological effects in cancerous (A549, NCI-H460) and non-cancerous (MRC-5, CHO-K1) cells treated with R. junceus scorpion venom. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	Red dots represent autolyasosomes.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Red", "dots", "represent", "autolyasosomes", "." ] } ]
PMC11075223	In summary, phenolic acids in Cimicifugae Rhizoma had antioxidant function due to its highly conjugated system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "phenolic", "acids", "...
PMC9429973	In 12 patients (34%) BNS was the de novo presentation of the IgM-related disorder, of which 3 (25%) had no detectable bone marrow (BM) infiltration of LPL at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637820	Gram-positive and gram-negative laboratory strains that are commonly found in DFU were sensitive to CAP exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gram-positive", "and", "gram-negative", "laboratory", "strai...
PMC9118379	To demonstrate these examinations, we first conducted a comprehensive variant peptide identification study on the HEK293 cell line to acquire the maximized number of identified variant peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834	While upregulation of TLE1 expression potently inhibited the proliferation inhibitory and apoptotic effects of gefitinib in A549 cells, downregulation of endogenous TLE1 in these cells enhanced their sensitivity to gefitinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291697	We identified a ~67 kb de novo intragenic deletion on chromosome 2q22.3 in a female individual showing a developmental encephalopathy characterised by epilepsy, severe intellectual disability, speech delay, microcephaly, and thin corpus callosum with facial dysmorphisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10898159	Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: This study aimed to clarify the molecular pathogenesis of DDX41 mutated myeloid neoplasms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "study", "aimed", "to", "clarify", ...
PMC11756907	Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	Hence, it is very important to precisely assess the selectivity and effectiveness of compounds for human β3-ARs in the preclinical stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",",...
PMC10994876	The expression of the YAP5SA protein was achieved using the CMV early enhancer/chicken β actin (CAG) promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "the", ...
PMC11604768	By profiling promoter activity changes in response to GPCR activation, we expect this system to help uncover novel regulatory elements and pathways of GPCR signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The post-transfusion reaction evaluation was non-significant showing negative antibody screen and also negative DAT, both for immunoglobulin G and C3d; No bacterial growth was seen in the transfused product and patient blood culture was sterile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	Human IFN-γ-secreting cells detected by Elispot assay in the PBMCs from humanized mice with different treatments. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "IFN-γ-secreting", "cells", "detected", "...
PMC11587606	The underlying molecular mechanism thus warrants in-depth investigations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "underlying", "molecular", "mechanism", "thus", "warrants", "in-depth", "investigations", "." ] } ]
PMC11087301	As a model, Snail1 which is a member of Snail family and bear a fundamental role in EMT initiation is regulated by several TFs including NF-κB, LOXL2, HMGA2, PARP1 and Gli1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11522251

Image J software was used for calculating the colonies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "J", "software", "was", "used", "for", "calculating", "the", "colonies", "." ] } ]

PMC11506670

No. CCL-247), which were both obtained from the American Type Culture Collection (Manassas, VA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "CCL-247", ...

PMC11707577

A refactored M13 phage, engineered by phage display (M13EGFR), was used to selectively recognize the epidermal growth factor receptor (EGFR).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11615101

However, the fold change expression level (2.1-fold) of TLR-2 was observed to be highest at lower doses (6.25ng/ml) and decreased the expression (0.62-fold) as the dose of α-Taxilin increased to 100ng compared to 6.25ng, and it remained significantly upregulated through all the doses compared to the untreated group (0ng/ml) (Figure 5E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11548041

HL-60 cells were not subject to endogenous biotin blocking.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HL-60", "cells", "were", "not", "subject", "to", "endogenous", "biotin", "blocking", "." ] }...

PMC5417661

Fluorescent and phase-contrast images (10×) were gathered every 6 h for up to 8 days and analyzed for cord length and number of branch points from 3 to 6 separate samples for each treatment condition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11537649

A bilateral P < .05 was considered statistically significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "bilateral", "P", "<", ".05", "was", "considered", "statistically", "significant", "." ] } ]

PMC9429973

No pharmacological GvHD prophylaxis was given post-transplant (clinicaltrials.gov: #NCT03977103).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "pharmacological", "GvHD", "prophylaxis", "was", "given", "post-transplant",...

PMC9429973

Finally, generation of DCleu by treatment with KitM triggers immune responses in MLC alongside with reduced ICM-expressions on T-cells, possibly reducing their inhibitory effects and therefore improving antileukemic responses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11766309

YKT6 (1:50, #ab236583, Abcam) was used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YKT6", "(", "1:50", ",", "#", "ab236583", ",", "Abcam", ")", "was", "used", ...

PMC11531744

Limitations existed in this study.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limitations", "existed", "in", "this", "study", "." ] } ]

PMC7841189

In general, increased motility and invasion are positively correlated with EMT, which is characterized by repression of epithelial markers and induction of mesenchymal markers20.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11655536

When the cell is stimulated, TFE3 is dephosphorylated and activated, and subsequently translocated to the nucleus to promote autophagy and lysosomal gene transcription, leading to lysosome biogenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10502403

Similar results were obtained for p40Tax-pMHC-stimulated p40Tax-GMCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "obtained", "for", "p40Tax-pMHC-stimulated", "p40Tax-GMCs", "." ] } ]

PMC9622879

The daily energy cost of each home in the community with three CEMSs is shown in Fig. 10.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "daily", "energy", "cost", "of",...

PMC11252033

Paired-end clean reads were aligned to the reference genome (hg38) using Hisat2 v2.0.5.

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PMC9429973

A. Bagashev, J. Loftus, L. Niswander, S. Ross, C. D. Falkenstein, J. Junco, K. R. Rabin, T. Fry, S. K. Tasian Oncology, Children’s Hospital of Philadelphia, Philadelphia; Children’s Hospital Colorado, Denver; Children’s Hospital of Philadelphia, Philadelphia; Texas Children’s Hospital, Houston, United States of America Background: CRLF2 (cytokine receptor-like factor 2; encoding the thymic stromal lymphopoietin receptor [TSLPR]) rearrangements occur in 50% of children with Down Syndrome-associated B-acute lymphoblastic leukemia (DS-ALL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9318744

Since several published studies have reported that the cleavage of the SARS-CoV-2 S protein at a putative furin cleavage site (RRARS) at R685/S686 is critical for virus entry , we investigated the efficacy of the furin inhibitor decanoyl-RVKR-CMK and observed a moderate inhibition of infection in the WT SARS-CoV-2-infected cells as determined by immunofluorescence and plaque assays (Figure S3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11224020

f, Expression of Ccr7.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", ",", "Expression", "of", "Ccr7", "." ] } ]

PMC9429973

Prior to the study entry, during first line (1L), 31.6% of pts received a stem cell transplant (SCT) (34.9%, 27.6% and 25.0% respectively for the 3 cohorts).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

ER stress is associated with the Calcineurin/nuclear-factor-of-activated-T-cells (NFAT) signaling.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ER", "stress", "is", "associated", "with", "the", "Calcineurin/nuclear-factor-of-activated-T-cells", ...

PMC11697065

Protein concentration was quantified using a BCA assay (Thermo Fisher, USA).

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PMC2118063

Infected cells were selected with 4 μg/ml puromycin for 72 h and cloned for 2 mo.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infected", "cells", "were", "selected", "with", "4", ...

PMC11507371

Although these findings might seem contradicting, it appears reasonable that elevations in Keap1’s abundance might have completely divergent effects on the cellular systems of both cell lines since Keap1 is known to have more than a dozen binding partners possessing a motif akin to the Nrf2 ETGE motif .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11592837

These regions mark the early wave of DSBs in the sequence of internucleosomal DNA fragmentation mediated by apoptotic nucleases.

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PMC9429973

All patients had leptomeningeal involvement and 8 (23%) additionally had parenchymal CNS disease.

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PMC11719944

Low-density lipoprotein cholesterol (c-LDL) was calculated with the Friedewald formula, c-LDL (mg/dL) = CT mg/dL − (c-HDL mg/dL + triglycerides mg/dL/5), if triglycerides were <400 mg/dL. Prolactin in plasma was measured using a human PRL (Prolactin) ELISA kit (FineTest, Wuhan, China).

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PMC11011837

Nonetheless, it is still necessary to verify and validate these results on primary tumor cells or on samples taken directly from patients in order to translate these findings into potential clinical applications.

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PMC10955424

To determine apoptosis and chemoresistance, levels of cPARP were evaluated by immunoblotting and densitometry was quantified.

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PMC10604092

The locomotive activities of the SLC-transplanted rats were also significantly lower than those of the control rats (p < 0.01).

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PMC6901583

Tumor volume growth curves from day 1 to 19 of treatment are presented. *

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PMC11470381

Major = length of the major axis of the ellipse.

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PMC7709199

The DSCAM gene is situated on chromosome 21 and is overexpressed in Down syndrome patients (Yamakawa et al., 1998 ▸).

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PMC11395280

By day 10, the integrity of the monolayer began to deteriorate as reflected in a decrease in the TEER (Figure 3); therefore, all the transmigration studies were carried out between days 4 and 8.

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PMC2777936

To target the Wnt signalling pathway, it was decided to specifically repress the expression of the FZD5 and FZD7 receptors.

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PMC11746948

The protein concentration in the supernatant was quantified using the BCA Protein Assay Kit (Thermo Fisher Scientific, USA).

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PMC11323699

Statistical significance is indicated by ****p < 0.0001 (two-tailed Mann–Whitney test).

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PMC11761919

The effects of inulin and PINs on the growth of recombinant E. faecalis.

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PMC10729469

Tresp cells alone with and without Dynabeads served as controls for baseline Tresp proliferation without Treg suppression.

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PMC8584666

These results suggested that the proliferation of GPI-80-expressing cells was sensitive to extracellular redox balance.

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PMC11401350

This is a very time-consuming and labor-intensive process resulting in a very costly medical product, which is therefore not available for all patients in need of CAR T cell therapy.

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PMC9429973

For the CLDX model, NB4 PML A216V cells were transplanted into NSG mice, and after chimerism detection (hCD45) in the peripheral blood, mice were equally distributed into 4 groups of treatment: vehicle, VEN (25mg/kg/day), S64315 (20mg/Kg/day) and combination (n=5/group) for 21 consecutive days.

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PMC6034753

We observed that there was no change in number of apoptin and Meq co-localized cells in presence (1.70 ± 1.25%) or absence (2 ± 1.25%) of Meq synthetic peptide 130–140 (M ± SD, n = 3).

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PMC11012012

Fanoni et al. (2011) analyzed the expression of SLAMF1/CD150 by immunohistochemistry in 25 patients with primary cutaneous (PC) B cell lymphomas including 10 PC-follicular center lymphoma (PC-FCL), 10 PC-marginal zone lymphoma (PC-MZL), and 5 PC-DLBCL-LT (leg type) .

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PMC11718109

Scale bars, 500 nm.

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PMC11543935

The temperature was monitored during the treatment with a fiber optic temperature sensor (Optocon TS5/A366 by Weidemann Technologies, Germany) and a multi-channel thermometer (FOTEMP4-16 by Weidemann Technologies, Germany), which can be accessed via a laptop.

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PMC11472639

PBMCs were cryopreserved at a concentration of 2–10 × 10 cells/mL in freezing medium (heat-inactivated foetal calf serum [HI-FCS] + 10% [v/v] dimethyl sulfoxide [DMSO] [Invitrogen™, Thermo Fisher Scientific, Loughborough, UK]) in Mr. Frosty™ (Thermo Fisher Scientific, Loughborough, UK) at −80 °C for a minimum of 5-h and a maximum of 24-h and transferred to a −150 °C freezer for long-term storage.

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PMC11774747

Last but not least, a specific antiviral immune reconstitution was frequently associated to the decrease or clearance of the viral load (59).

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PMC11760643

This effect was attributed to the blockade of human P2X7 and increased survival of human Tregs.

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PMC10545062

The proportion of time with MAP less than 60 mm Hg and MAP greater than 70 mm Hg was similar between SCC and SCC+, p = 1.0 and p = 0.24, respectively (Table 2).

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PMC11489175

Of note, the suppression of USP39 impairs the migratory cell abilities with inhibition of slug and E-cadherin leading to EMT inhibition.

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PMC9784246

Molecular docking of various polyphenolics of the MeOH fraction with HDAC6 and PDK3 enzymes demonstrates high binding affinity of the epicatechin 3-O-β-D-glucopyranoside and catechin-7-O-β-D-glucopyranoside toward HDAC6, and procyanidin C2, procyanidin B5 toward PDK3.

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PMC2614416

With BLASTP 2.2.15 [Oct-15-2006], mapping now includes NCBI RefSeq database , and Ontologies are found in four databases: GR, UniProt, UNIPROT and RefSeq (Figure 7 (Panels A and B)); Ontologies found in this mapping are much less – essentially half of the number found previously in Figure 1 (Panels A and B).

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PMC11626627

For these patients, the prognosis remains poor, with a five-year survival rate of <10 % .

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PMC10604092

The chemiluminescent signals from spots on the membrane were captured (LAS 4000; GE Healthcare Japan Corporation, Tokyo, Japan) and quantified using Image Gauge version 4.0 (GE Healthcare Japan Corporation, Tokyo, Japan).

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PMC11774747

By using home-made (i.e. influenza virus) or existing vaccines (CMV or VZV vaccines) to stimulate the native TCR, several teams showed continuous activation and expansion of CAR-VST, maintaining their expansion and effector functions while preventing exhaustion.

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PMC9429973

Methods: Patients who received ≥1 dose of bosutinib (n=268) or imatinib (n=265) 400 mg/day in BFORE were included.

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PMC10728200

The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h, and subjected to Western blot analysis.

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PMC10758402

The virus contained within the cleared supernatant was combined with the pellets of the first supernatant and purified using a 36% sucrose gradient.

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PMC11687167

The coding sequence (CDS) of the gene spans 2079 base pairs (bp) and encodes a protein comprising 692 amino acids.

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PMC11607638

The SKR mRNA levels in mosquito head tissue after SK1, SK1 + SK2, SK2, injection. (

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PMC11741906

For instance, overexpression studies demonstrated that miR-519d, miR-155, miR-708, miR-34c, miR-200b, miR-200c, miR-29, and miR-1305 increase cisplatin cytotoxicity in A2780 or SKOV3 cells [, , , , , , ].

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PMC11541241

Several studies have reported that transgenic plants engineered to give stable HIGS targeting of the pathogen TOR gene can block the occurrence of plant disease.

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PMC11746942

B Western blot and quantification of S1PR3 expression in HaCaT cells treated with the STAT3 inhibitor Stattic (10 μM) in the presence or absence of 25 μg/mL IL-6 or 25 μg/mL IL-22.

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PMC11055323

Data are mean ± s.d.,

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PMC11741906

Conducting comprehensive functional studies will also address the ambiguity and the context-dependent functions of miRNAs in ovarian cancer cells.

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PMC11434983

IR spectra were recorded on a Brucker™ Alpha II™ FT-IR/ATR Spectrometer (Bruker, Billerica, USA) between 4000 and 400 cm.

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PMC11777207

Hydrogen bonds were identified in PyMol, the hydrophobicity surface coloring was identified, and images were generated using UCSF Chimera software.

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PMC7723249

CD14 cells were positively selected using anti-CD14 MACS beads (Miltenyi Biotec) according to manufacturer instructions.

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PMC11700165

In the next set of experiments, we compared the phosphorylation capacity of the kinases in the presence or absence of different inhibitors.

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PMC11519567

Then, resuspend cell pellet in 200 µl ice-cold lysis buffer (10 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.1% SDS, 1% Triton X-100) supplemented with protease inhibitor cocktail and 1 mM PMSF.

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PMC10671321

This is reminiscent, at least partially, of our prior results .

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PMC10944868

They alter the monomer-to-polymer ratio, impacting cellular functions without significant changes in total MT polymer at low concentrations.

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PMC11594641

Taking into account the oncogenic role of MITF in malignant melanocytes, this sheds light on the involvement of Rab27 in melanoma.

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PMC11543853

However, diffusion of the ~7500-nucleotide-long RNA genome through an opening in a capsid and a putative transmembrane pore would be a slow process, which has not been verified in vivo.

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PMC11354225

Methyl aminolevulinate (MAL) is metabolized by cells by the heme synthesis pathway and it accumulates in mitochondria as protoporphyrin IX (PpIX) , a PDT photosensitizer.

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PMC11806613

Left, lipid peroxides levels.

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PMC11760643

Regarding DC subsets, a previous study utilising the anti‐P2X7 mAb (clone L4) revealed similar amounts of expression of P2X7 on human blood mDCs and pDCs .

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PMC11194678

In summary, these data demonstrate that STAU1 overabundance-induced excessive formation of STAU1 condensate and the subsequent hyperactivation of mTOR signaling impair lysosomal function and autophagic pathway.

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PMC11723947

We generated mice carrying a conditional ready Hp1g (Hp1g) allele and crossed them with Cd4-cre mutant mice to generate a conditional HP1γ-deficient (Hp1g) strain.

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PMC9429973

3-year overall survival (OS) was 55.4±7.7%, 55.0±7.2% and 87.0±7.1%, respectively (р=0,008).

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PMC9874064

Subsequently, an intraperitoneal cisplatin resistant tumor model of standard liver cancer cells (7404DDP-LUC) and a patient derived liver cancer (PDX) animal model were established for drug screen in vivo.

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PMC11792888

Morphological effects in cancerous (A549, NCI-H460) and non-cancerous (MRC-5, CHO-K1) cells treated with R. junceus scorpion venom. (

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PMC7090062

Red dots represent autolyasosomes.

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PMC11075223

In summary, phenolic acids in Cimicifugae Rhizoma had antioxidant function due to its highly conjugated system.

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PMC9429973

In 12 patients (34%) BNS was the de novo presentation of the IgM-related disorder, of which 3 (25%) had no detectable bone marrow (BM) infiltration of LPL at diagnosis.

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PMC11637820

Gram-positive and gram-negative laboratory strains that are commonly found in DFU were sensitive to CAP exposure.

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PMC9118379

To demonstrate these examinations, we first conducted a comprehensive variant peptide identification study on the HEK293 cell line to acquire the maximized number of identified variant peptides.

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PMC11704834

While upregulation of TLE1 expression potently inhibited the proliferation inhibitory and apoptotic effects of gefitinib in A549 cells, downregulation of endogenous TLE1 in these cells enhanced their sensitivity to gefitinib.

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PMC11291697

We identified a ~67 kb de novo intragenic deletion on chromosome 2q22.3 in a female individual showing a developmental encephalopathy characterised by epilepsy, severe intellectual disability, speech delay, microcephaly, and thin corpus callosum with facial dysmorphisms.

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PMC10898159

Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage.

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PMC9429973

Aims: This study aimed to clarify the molecular pathogenesis of DDX41 mutated myeloid neoplasms.

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PMC11756907

Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME.

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PMC10887351

Hence, it is very important to precisely assess the selectivity and effectiveness of compounds for human β3-ARs in the preclinical stage.

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PMC10994876

The expression of the YAP5SA protein was achieved using the CMV early enhancer/chicken β actin (CAG) promoter.

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PMC11604768

By profiling promoter activity changes in response to GPCR activation, we expect this system to help uncover novel regulatory elements and pathways of GPCR signaling.

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PMC9429973

The post-transfusion reaction evaluation was non-significant showing negative antibody screen and also negative DAT, both for immunoglobulin G and C3d; No bacterial growth was seen in the transfused product and patient blood culture was sterile.

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PMC11803918

Human IFN-γ-secreting cells detected by Elispot assay in the PBMCs from humanized mice with different treatments. (

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PMC11587606

The underlying molecular mechanism thus warrants in-depth investigations.

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PMC11087301

As a model, Snail1 which is a member of Snail family and bear a fundamental role in EMT initiation is regulated by several TFs including NF-κB, LOXL2, HMGA2, PARP1 and Gli1.

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