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OTAR3088
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BioData-CellLine_annotated

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PMC10578720
The data for clinical patients were statistically analyzed using a paired Student t test.
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PMC11352311
The results revealed that increased concentrations of esculin significantly reduced glucose uptake in 786-O and A498 (Figure 6C,D), indicating that esculin affects glucose metabolism in RCC cells.
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PMC11172027
At 72 h of incubation, only the highest concentration of 500 µg/mL (85.7 ± 6.1%; n = 3) was able to significantly reduce the mitochondrial activity relative to the 72 h control (100 ± 2.1%; p < 0.05).
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PMC11638255
The immunosuppressive tumor microenvironment is supported by soluble cytokines and chemokines, that exert pleiotropic effects on immune cells by regulating migration, infiltration, and effector activity to facilitate tumor progression.
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PMC10652261
Compound 2f showed cytotoxic activity against the HL-60 cell line similar to bortezomib.
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PMC11694109
For many BCL subtypes, these therapies have altered the standard of care.
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PMC11718109
The representative EM images (B, D) are depicted on the right of each panel.
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PMC11767725
By simultaneously correcting underlying metabolic disturbances and stabilizing microbial communities, clinicians may achieve more durable and long-lasting improvements in the cutaneous ecosystem.
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PMC9388315
In this study, we showed that Cinnamon reduced the expression of ErbB2, HSF1, and LDHA at transcriptional and translational levels.
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PMC10878518
Relationship between the GFP intensity and cell viability in bone and soft-tissue sarcoma cells and fibroblasts infected with OBP-401.
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PMC11607764
Significant upregulation of PTBP1 mRNA expression was also found in a melanoma tumorigenic nude mouse (Tumor) model using normal nude mouse skin (Control) as a control group (Figure 2D).Figure 2.qRT-PCR validation of PTBP1 expression within cell lines and mice after modeling. (
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PMC10114490
A Representative phase contrast images of iHDF-THMM and diHLC-T after 12 days culture.
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PMC11726183
Yield = 88, yellow solid, m. p.: 195–197 °C, IR (KBr) cm 3483, 3196, 2839, 1949, 1683, 1375, 1263, 1116, 788, 690, δH (600 MHz, DMSO-d6) 13.89 (1H, s), 7.99–7.90 (2H, m), 7.74–7.59 (4H, m), 7.45–7.38 (3H, m), 7.38–7.32 (2H, m), 7.32–7.27 (1H, m), 7.17 (1H, td, J = 7.5, 0.9 Hz), 7.09 (1H, d, J = 8.0 Hz), 5.03 (2H, s); C NMR (151 MHz, DMSO) δ 161.72, 143.18, 136.09, 133.44, 132.44, 132.12, 129.69, 129.21, 128.14, 127.96, 127.93, 127.90, 123.92, 121.32, 119.80, 111.03, 43.08.
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PMC10551595
Moreover, GinA affected the mRNA and protein expression levels of P21 conducting T‐ALL cells to cell cycle suspension.
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PMC11531744
Kaplan-Meier curve showing the survival difference between low-risk and high-risk groups. (
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PMC11365427
Interference with VAPB expression impacted the restorative effects of phenylalanine on MM cells (Fig. 5G and H), affecting cellular processes such as proliferation, cell cycle, and apoptosis (Fig. 5I–K).
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PMC6600592
ESIMS: m/z 380.2223 [M + H], 402.2037 [M + Na], calculated for C24H29NO3 (379.50).
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PMC10968586
OLE and HT may participate in control of cancer-associated and chemotherapy-dependent tissue inflammation by acting on non-tumor cells.
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PMC11518702
Effects on candidate DLBCL co-driver gene expression were also defined, including Rgs1, an inhibitor of lymphocyte migration (60), and GTPase Rab10, which (like HGAL) is elevated in DLBCL patients with extended OS (61).
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PMC7823217
A proof-of-concept of bioprinted vascularized tumor constructs was provided by Cui et al in their interesting research on 3D printed breast-bone metastatic model .
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PMC7351993
The inset shows representative SRS images of cells in the sort (n = 26) and unsort regions (n = 7760).
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PMC11721295
Differences in overall survival were statistically significant between all groups.
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PMC11693599
Further studies are needed to clarify the nature and composition of the EV particles secreted from cancer spheroids.
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PMC9429973
CT/PET-CT scans were conducted to assess efficacy in 2,4,6 cycles.
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PMC8336407
We suggest investigating the effects of commercial arbutin, or other antioxidants reported in extract or the separated fractions of extract in further in vitro and in vivo investigations.
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PMC3813807
In the present study, the expression of miR-373 was detected in human gastric adenocarcinoma tissue samples and gastric cancer cell lines and observed to be upregulated compared to levels in normal gastric tissues.
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PMC10988555
APT-C NMR [(CD3)2CO, Me4Si, 100.62 MHz] δ/ppm: 159.32 [C1]; 158.36 [C5]; 142.27 [C3]; 134.27 [d, Cortho(PPh3), JPC = 9.60 Hz]; 133.63 [d, Cpara(PPh3), JPC = 2.99 Hz]; 130.82 [d, Cmeta(PPh3), JPC = 10.89 Hz]; 129.48 [C2]; 126.38 [d, Cipso(PPh3), JPC = 49.42 Hz]; 126.32 [C4]; 94.30 [CCp].
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PMC11787381
The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice, which can be correlated with locomotive function.
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PMC11731614
Study approval.
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PMC11657744
The efficiency of gene knockdown was confirmed by quantitative reverse transcription PCR (qRT-PCR) analysis, showing significant reductions in mRNA expression levels (Supplementary Fig. 3).
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PMC11490153
C. citratus-AlgNPs and citral-AlgNP with less than 10% cell viability at 1000 µg/mL showed the best efficacy (P < 0.05) under normoxic conditions.
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PMC9429973
ELN cytogenetic risk included favorable (6%, n=6), intermediate (50%, n=52) or adverse (44%, n=45).
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PMC10667689
Considering the heterogeneous nature of AML (69–71), which resulted in different expression patterns in THP-1 and HL-60 cell lines, and the sharp effect of PMA on the expression of ATGL, studying the role of TIM-3 on lipolysis requires a different study design, such as examining overexpressed or knocked-out cells.
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PMC10955424
A2780cisR, cisplatin resistant OC cells were treated with 5μM RJY13 in the absence of 50 % tumor activated HS-5 CM or 20 % As001 (A).
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PMC11541241
The proteins SIN1/AVO1 are absent from the genome of C. graminicola, F. graminearum, M. oryzae, P. infestans, and P. striiformis f. sp. tritici, indicating that SIN1/AVO1 may play less crucial parts or be replaced by some other components in the evolutionary history and life strategies of these pathogens.
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PMC9429973
The most common grade 3/4 AEs were neutropenia (39%), thrombocytopenia (39%), anemia (13%), and infections: pneumonia (30%), neutropenic fever (17%), diverticulitis (9%), sepsis (9%), cellulitis (4%), and splenic abscess (4%).
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PMC10605143
Only MDA-MB-468 cells expressed CDH1 (and lacked VIM and SNAI2) (Figure 5b) and showed the CD44/CD24 (epithelial-like) phenotype (Figure 5c).
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PMC11803918
Fluorescence imaging of tumor tissues and major organs ex vivo 24 h after injection. (
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PMC11742290
A recent study found a combination treatment with oxaliplatin-loaded magnetoliposomes functionalized with LGR5 antibody reduced the proliferation of CRC cell lines compared to free drug .
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PMC9684669
In the presence of tariquidar, a specific ABCB1 inhibitor, their anticancer effectiveness against A2780-ADR cells also increased (34) ( Figure 1D and Figures S1D–F ).
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PMC9429973
The mutational profile of AEL cases was compared to that of 409 cases with non-erythroid AML (non-AEL).
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PMC11545868
The B-cell lymphoma 2 (BCL-2) protein family is also closely related to cell death and includes the anti-apoptotic proteins Bcl-2, Bcl-xL, Bcl-w, and Mcl-1, as well as pro-apoptotic proteins BAX, BAK, and Bim .
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PMC10850553
Scale bar: 50 μm. (
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PMC3995603
The concentrations of histamine and IgE were measured by ELISA (mean ± SEM, n = 5), : P < 0.01 compared with the normal group, *: P < 0.05 compared with the D. farinae-induced control group.
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PMC11087055
Embryos were electroporated with lissamine-tagged oligo (red), implanted with either control-GFP/COS or Vg1/COS at the anterior marginal zone (AMZ), and treated with 100 μM of aphidicolin at pre-streak stage IX to X. Live imaging performed at a 2 x objective lens with a wide-field epifluorescent microscope.
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PMC11453018
The retroviruses were produced in 293 T packaging cells using pVSV-G (Clontech).
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PMC9429973
Only somatic mutations were included in the final analysis (based on the VAF value).
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PMC9429973
Further data were extracted from the National Health Laboratory Service laboratory information system, patients’ hospital files and the operating theatre records.
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PMC10976516
The study is ongoing.
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PMC6892818
The co-cultures involved a defined number of effector cells (10,000/well) and three different densities of HRPT cells (6000, 8000 and 10,000/well).
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PMC11470381
Store at 4 °C.
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PMC9429973
To determine the effects of genetic disruption of the TLR, BCR and CXCR4 pathways, the IRAK4, IgM heavy chain (IGHM) and CXCR4 genes were disrupted by CRISPR/Cas9 editing in the murine Eμ-TCL1 CLL cells or the human RS-PDX lines RS9737, RS1316 and IP867/17 prior to transplantation.
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PMC11544122
All relevant information regarding statistical tests and post hoc tests is included in the figure legends.
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PMC11470999
To test this possibility, we used the protein synthesis inhibitor cycloheximide (CHX) to block protein synthesis.
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PMC10887351
Moreover, they evaluated the effects of mirabegron in the prostate, isolated from either healthy rabbits or BPH patients , demonstrating that the β3-ARs agonist clearly counteracted the contractions of prostate smooth muscles induced by EFS and α1-adrenoceptor activation.
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PMC11790971
This resulted in FLIM images with a temporal bin size of 64 picoseconds.
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PMC11194678
After incubating for 15 min on ice, protein-bound and free RNAs were separated by electrophoresis on nondenaturing 2% polyacrylamide gels running in a 0.5 × TBE buffer at 100 V at 4°C.
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PMC11344246
All five proteins had clear, established roles in cancer, and three out of the five targets had known selective inhibitors available.
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PMC10936243
For example, Standard Operating Procedure (SOP) questions were included in this questionnaire with the aim of investigating the availability of any guidelines that assist veterinary professionals in providing good cat care in practice.
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PMC11264242
Most, if not all, of patients that contract synovial sarcoma carry a unique gene mutation called SS18-SSX, which serves as a diagnostic biomarker in the clinic.
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PMC7812570
We verified that both GPI-m36.4 and GPI-FluIgG03 were efficiently expressed within the plasma membrane lipid raft sites of transduced TZM-bl cells without interfering with the expression of HIV receptors; however, GPI-m36.4 but not GPI-FluIgG03 specifically rendered target cells highly resistant to divergent HIV-1 infections, viral Env-mediated cell–cell fusion, and cell-associated virion-mediated cell–cell transmission.
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PMC11317131
Upon crossover between the att sites the AP and CP join to form a single recombined plasmid (RP) and the promoter, leader sequence, and C-terminal portion of gIII join to permit the expression of pIII.
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PMC7642379
In order to develop a deeper understanding of such changes, we evaluated differences in gene expression levels between adherent and suspension progeny HEK293 cells.
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PMC11770746
The sensitivity to noxious heat was assessed by placing the mice on a hot plate (54 ± 1 °C) and measuring the latency (s), the time until the mice began licking their paws, shaking, or jumping to avoid the heat.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677
The stock solutions were serially diluted with freshly prepared RPMI-1640.
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PMC11657744
Scale bars, 20 μm.
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PMC9429973
This information is summarized in a 3-category risk classification model (Figure 1).
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PMC11676670
These features, together with the high proliferation rate, ease of cultivation, and exceptional transfection efficiency of OVAR79, make it a readily available and versatile tool for various studies in the laboratory.
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PMC11730320
F qPCR results confirming that unrelated controls have copy number 2 at the deletion locus, whereas the parents have copy number 1 and the proband has copy number 0.
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PMC11756907
The performed physicochemical analysis of graphene complexes with 2-ME correlates with the cytotoxicity parameters, indicating a significantly greater reduction in the viability of cancer cells for the GO-2ME in DMSO as compared to the rGO-2-ME in DMSO in certain concentration ranges.
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PMC11544771
CPX acts as an anticancer agent by targeting a variety of signaling molecules .
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PMC11543853
A selected virion is indicated by a green arrowhead.
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PMC10878518
Cells were seeded into 96-well plates at 10 cells per well 24 h before infection.
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PMC7192625
Other ends often overlap with intronic regions, in which case the name of the gene harbouring the intron is shown in the tool-tip.
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PMC10344560
We observed that there was no growth of any microorganisms after the catheter removal; however, we found no significant improvement in the clarity (Fig. 2) and leucocyte count of the effluent 3 weeks after adequate antimicrobial treatment despite the relatively stable clinical condition.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019
The AI takes into account MAC, the concentration of BTZ, and the reversing levels.
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PMC11472639
Adam J. Causer: Methodology.
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PMC6892818
Thus, in addition to defining the pro-apoptotic capacity of CD40 ligation, signal ‘quality’ also determines the repertoire/extent of pro-inflammatory cytokine secretion in renal cells.
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PMC11767817
On the other hand, in unhealthy or apoptotic cells, the inside of the mitochondria becomes less negatively charged due to increased membrane permeability and consequent loss of electrochemical potential.
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PMC11271278
AmpliconArchitect analysis of WGS data predicted an ecDNA containing most of these HAPI genes and their hijacked enhancers (Fig. S6A, B).
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PMC11763533
Furthermore, whereas at pH 8.0 the spectrum was thermally stable, at pH 6.0 Amy-Luc showed higher temperature sensitivity, raising the possibility of using this luciferase as an intracellular temperature sensor.
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PMC10291556
These complexes were designed with the intention of enriching and improving the biological action of Pt(II) complex 1.
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PMC10547921
Steffen Goletz conjugated the carboxyl group of β-amanitin (89) to the amino group of IgG lysine, resulting in an ADC with good plasma stability and high cytotoxicity (Fig. 14A).
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PMC6600592
H NMR (MeOD) δ 7.58 (d, J = 8.9 Hz, 2H, H-2, 6), 7.41 (d, J = 7.1 Hz, 2H, H-25, 29), 7.36 (t, J = 7.5 Hz, 2H, H-26, 28), 7.30 (t, J = 7.3 Hz, 1H, H-27), 6.92 (d, J = 8.9 Hz, 2H, H-3, 5), 5.19 (s, 2H, H-23), 4.66 (dt, J = 8.7, 4.5 Hz, 1H, H-16), 3.81 (s, 3H, H-15), 3.06-3.03 (m, 2H, H-8), 2.52-2.49 (m, 2H, H-9), 1.75 (dd, J = 13.6, 6.0 Hz, 2H, H-17), 1.68 (dd, J = 9.2, 4.9 Hz, 2H, H-21), 1.55–1.50 (m, 1H, H-19), 1.39–1.32 (m, 4H, H-18,20), 1.30–1.24 (m, 1H, H-19).
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PMC11543935
During a study by Cannon et al. H&E staining was performed to identify burn depth on the skin of a pig which presented comparable purple sections with an increasing area for longer burn time.
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PMC7334607
However, given the vast genetic contingencies that lead to changes in drug response, observing said stability over many additional replicates would provide a more convincing argument for the consistent evolution of dactinomycin collateral resistance following exposure to VDC/EC.
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PMC10291556
To verify whether this aspect of ICD is also included in the effects of the investigated Pt(IV) complexes, a human in vitro model was used for testing the ability of macrophages to recognize human cancer cells treated with the tested compounds.
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PMC11599565
Moreover, PAX8 is a specific marker for these tumors, suggesting an important role in tumor development.
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PMC9429973
BMI does not significantly affect disease-free survival (DFS) (95% CI, p=0.408).
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PMC11591794
These findings highlight the significance of natural compounds in combating cancer progression and underscore the importance of further research to explore the clinical applications of GA and similar phytochemicals.
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PMC11543885
This reactivity may interfere with the proper functioning of the HA tag in proximity labeling experiments.
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PMC7171147
d Overall survival in patients with recurrent tumors expressing high levels of CPT1A compared to primary tumors vs. patients with recurrent tumors showing no increase in CPT1A expression compared to primary tumors. *,
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PMC11578343
Heatmap of the measured viscous G″ modulus for each single cell in each zone, grouped by Lat‐A‐treatment and untreated control conditions.
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PMC11367146
The Venn diagram was constructed to obtain intersecting genes between targets of VTE and OA-associated genes, which might be potential targets for treating OA using the web tool Venny 2.0.2 (https://bioinfogp.cnb.csic.es/tools/venny/).
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PMC3164356
For each GOslim biological process category, the fraction of all GO terms in that category is shown for human, mouse, rat and CHO genomes.
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PMC11700165
A,B) Fluorescence microscopy analysis of COS7 and SYF cells transfected with IS, BS, and TS.
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PMC11694625
The emission peaks near 450 nm are due to quinoline chromophore.
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PMC11706776
Bars indicate means ± SD of colonies numbers and the surface occupation. *:
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PMC11513011
And our cell proliferation and wound healing experiments had different DIB concentration because of the intension of wound healing assay is not killing cells.
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PMC10047551
Immunohistochemistry was performed on tissue sections (3–4 μm) using the 22C3 PharmDx assay (Agilent, Santa Clara, CA, USA), according to the manufacturer’s instructions.
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