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OTAR3088
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PMC11597291
For the delivery of PCT, non-covalent loading through physical adsorption was performed for all the nCGO-PEG particles, exploiting the π–π stacking interactions between the nCGO lattice and PCTs’ aromatic rings .
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PMC11489351
Fluorescence intensity from individual cells is shown in a scatter plot (medians shown in red line) from five biological replicates.
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PMC11574271
Similarly, J82 cells were transfected with the RON Lentiviral vector or the corresponding empty lentiviral vector to establish stable cell lines with overexpressed RON (designated as J82-NC and J82-oeRON, respectively).
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PMC11699178
SK-OV-3 ovarian cancer cells treated with GEM (cultured in RPMI-1640 medium containing 1 ΞΌM GEM at 37 Β°C for 5 days) and untreated SK-OV-3 ovarian cancer cells were collected, with three replicates for each group.
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PMC9429973
The multivariate logistic regression analysis found that miRNAs retained their significance when established clinical prognostic factors were included.
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PMC11300639
l IHC staining of the tissue microarray of ccRCC (n = 38) with CDK4 or TSC1 antibodies.
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PMC9429973
Plasma and CSF sample from 4 of 13 patients were collected at 2 h after 15 days orelabrutinib administration.
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PMC10237474
This is particularly important when recombinant proteins require PTMs for function.
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PMC11755519
It was observed that the proliferation and invasiveness of 5637 cells significantly increased while treated with wild-type UM-UC-3 released EVs, compared to a sample of EVs released by CRK-silenced cells.
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PMC10759659
For predicting the therapeutic efficacy of ICBs, PD-L1 expression, tumour-infiltrating lymphocytes, TMB, dMMR, and MSI-H are the most commonly explored biomarkers .
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PMC11730320
Table 1Laboratory evaluationsPatientAge 1 month (ref range/control)Age 7 months (ref range/control)Age 28 months (ref range/control)WBC (Γ—10/L)5.81 (5.75–13.5)4.73 (5.75–13.5)5.44 (5.75–13.5)Lymphocyte immunophenotyping (cells/Β΅L) CD3+975 (3180–5401)1072 (2271–4776)1143 (1578–3707) CD4+633 (2330–3617)569 (1523–3472)538 (870–2144) CD8+210 (712–1361)183 (524–1583)218 (472–1107) CD16+CD56+710 (201–870)336 (230–801)227 (155–565) CD19+1097 (315–1383)1255 (776–2238)871 (434–1274)Recent Thymic emigrants Absolute (Γ—10/L)0.29 (1.0–4.9)NA0.16 (0.19–2.60) Percentage50 (50–100)NA29 (37–100)T regulatory cells Absolute (Γ—10/L)NANA31.6 (39–150) PercentageNANA5 (3–17)Responses to mitogens (Stimulation Index; P/C) PHA592 (1448)2362 (2652)NAImmunoglobulins IgG (g/L)NA2.0 (1.1–7.0)5.4 (3.2–11.5) IgA (g/L)NA0.1 (0.0–0.3)0.3 (0.0–0.9) IgM (g/L)NA0.5 (0.2–0.9)0.9 (0.5–1.9) IgE (IU/mL)NA<25 (<440)NASpecific antibodies Tetanus (IU/mL)NA1.66 (>0.10)0.67 (>0.10) Diphtheria (IU/mL)NA0.84 (>0.10)0.89 (>0.10) Measles/Mumps/RubellaNANA+ve/-ve/+ve (+ve/+ve/+ve)ND not done.
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PMC9220170
Since, according to previously obtained data , mRNA expression of the SELENOM and SELENOT genes is quite high in the brain, we chose human glioblastoma cells (line A-172) to achieve the most pronounced knockdown of these selenoproteins.
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PMC11739504
Despite Kat2b defects, the structural maturation of primary cilia was possible; however, the expression and accumulation of some IFTs and Smo within primary cilia appeared abnormal. (
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PMC11706776
Furthermore, it appears that KCNN1 expression renders ES cells susceptible to hypoosmotic solutions.
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PMC10154881
The tumor volume was calculated according to the formula (width Γ— width Γ— length)/2.
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PMC11476106
Cluster circularity analysis yielded interesting data regarding cellular migration.
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PMC11638255
BioRender.com/c53h577.
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PMC9275501
Zhang et al. (2017b) prepared iRGD peptide modified lipid-polymer hybrid nano system (LPN) to couple PTX and TET in a 1:1 ratio.
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PMC11317131
Expression of gIII enables the generation of infectious progeny and the formation of plaques (45).
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PMC9739791
Moreover, by using a PDT agent as an axial ligand for light-controlled activation of Pt(IV) prodrugs, a dual-action antitumor agent could be obtained that releases Pt(II) species and generates cytotoxic ROS species under light irradiation.
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PMC10933092
Differential expression analysis was conducted using the R package β€œDESeq2.”
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PMC9429973
Methods: We analyzed the composition of the hematopoietic compartment of CDK4/CDK6 double knock-in mice under homeostatic conditions.
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PMC11764090
Actinidia eriantha Benth.
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PMC11033180
Here, we studied the role of semaphorin 5A (Sema5A), previously characterized in the central nervous system, on ENS neuronal connectivity.
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PMC11787381
The concentration of the compound Bambuterol and Terbutaline in the plasma and in the brain of mice was quantified using an exploratory LC-MS/MS assay method.
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PMC9429973
Aims: To compare baseline characteristics and survival outcomes for patients with MF receiving FEDR vs those not receiving FEDR after discontinuing RUX in routine US clinical practice.
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PMC9739791
This intermediate then absorbs the photon and reduces the Pt(IV) prodrug 1 with the elimination of the axial ligands (Figure 2).
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PMC11653168
All mice were euthanized on day 23 for subsequent analyses.
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PMC8751435
Feature of pyroptosis is defined in cell morphology, including cell lysis, cell bubbling, and inflammation.
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PMC9429973
In comparison, there was an increase in specific T cell response by any assay (IGRA and Flow) in 49% of patients (n = 34).
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PMC8873393
Although it has been suggested that modulation of specific transcriptional programs by lncRNAs might be another mechanism that regulates the DNA damage responses, the lncRNA transcriptional portrait in response to genotoxic stress is largely unknown.
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PMC7868205
After visual observation of colour change to brown, the hydrosol was centrifuged at 10,000 rpm for 20 minutes at 4 Β°C to derive a pellet that contains AgNPs.
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PMC9516447
Regarding physical loss of the oncoprotein, stable suppression of oncogenic KRAS tumorigenicity by virus-mediated RNA interference against specific mutant KRAS allele in pancreatic cancer has been reported .
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PMC11604015
The efficacy of CAR-T cells is evaluated by CR rate within 1 month CAR: chimeric antigen receptor; CR: complete response; CRS: cytokine response syndrome; TRBC: T cell receptor beta constant; ICANS: immune effector cell-associated neurotoxicity syndrome; CMV: cytomegalovirus; TKIs: tyrosine kinase inhibitors; EBV: Epstein-Barr virus; ER: endoplasmic reticulum; HSCT: hematopoietic stem cell transplantation; HLA: human leukocyte antigen; GvHD: graft versus host disease; CPISPR: clustered regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; KO: knockout; TCR: T cell receptor Pan-T antigens, specifically CD5 and CD7, are the most widely used target antigens for T cell-derived malignancies in current clinical practices .
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PMC9429973
The observed HbF level was plotted against the predicted and the model linearity assessed, R = 0.45.
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PMC11798926
Therefore, we made a deletion mutation of amino acids surrounding the YXXΙΈ signal, and this further decreases the interaction (F = 11.38, p = 0.0091) (Figure 1D).
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PMC11759543
The survival rate of the 4 groups is presented in Fig. 8E.
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PMC11225860
The 500nM alisertib treated group saw a sharp decline in viability to 67%, along with the 1000nM and 5000nM at 54% and 39% respectively.
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PMC11075223
A pinene monoterpene compound paeoniflorin (304) and an iridoid compound geniposide (305) were isolated from the 70% ethanol/H2O (v/v) of C. dahurica .
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PMC8992508
Chalcone and flavone derivatives Some synthetic derivatives of the natural compound schizandrin extracted from Schisandra chinensis, have the ability to restore drug sensitivity at non-toxic concentrations via direct interaction with P-gp.
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PMC9429973
Methods: NA Results: A 57 year-old woman was diagnosed in August 2019 with germinal-center type DLBCL, IVs-A, IPI score 3, CSN-IPI 4, BCL6 and cMYC negative was treated with 4 cycles of R-CHOP and one more cycle of R-MAD, achieving clinical and PET scan complete remission (CR).
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PMC9429973
Patients previously receiving autologous or allogeneic stem cell transplantation also did not significantly differ in survival in comparison to non-transplanted patients (P=0.425).
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PMC9429973
Results: Baseline characteristics were balanced between the 2 cohorts.
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PMC10705095
We used pLKO.1-TRC cloning vector (#10878; Addgene, Watertown, MA, USA) to generate shRNA constructs against HBQ1.
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PMC4270159
HEK293:pMET.MET.Ξ²-tubulin [additional control].A. Loading control.b.
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PMC11590870
These concentrations range between 10 and 800 Β΅g/mL for hydrolysates from plants such as Phaseolus vulgaris L. and soybean .
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PMC9429973
Descriptive statistics were used for predefined post–allo-SCT complications of interest.
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PMC11714165
The following procedures were used to synthesize the fluorous‐tagged NBD peptides.
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PMC11545737
In C57BL/6 mice, however, IL-1Ξ² secretion was dependent on both NLRC4 and NLRP3 inflammasomes .
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PMC10847511
Fig. 1Association between BRCA1/2 alterations and drug sensitivity.
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PMC6337547
The primary phytochemical constituents of Chinese Salvia species include sesquiterpenes (e.g., plebeiolide C and trijugins A), diterpenoids (e.g., tanshinone IIA and dihydrotanshinone I), triterpenoids (e.g., 1Ξ²,11Ξ±-dihydroxyolean-18-en-3-one and 1Ξ²,11Ξ±,20-trihydroxy-lupan-3-one) , phenolic acids (e.g., 3,4-dihydroxycinnamicacid (caffeic acid) and 3-[3,4-dihydroxyphenyl]lactic acid (danshensu)) , flavonoids (e.g., luteolin and gardenin-B) , alkaloids (e.g., isosalvamines C and salvianan) , and saccharides .
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PMC11774747
As mentioned previously, the methods used for the generation of VST (co-culture or isolation of IFNΞ³ secreting cells) lead to the enrichment in mature T cells.
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PMC11585587
It can cause a variety of complications, such as bone damage, kidney damage, anemia, and hypercalcemia.
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PMC9429973
POM was administered at 4 mg on days 1 – 21; IXA 4 mg on days 1, 8 and 15; and DEX 20 mg (>75 years (yrs)) or 40 mg (≀75 yrs) on days 1, 8, 15 and 22 of a 28-day cycle.
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PMC11411131
Cos-7 cells were purchased from KAC.
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PMC11502962
As expected, GIST-882 cell line secreted MIF, and MIF gradually increased with time.
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PMC10048572
Now there are a lot of information about the change in the genetic landscape of the tumor from diagnosis to relapse in pediatric acute lymphoblastic leukemia and about mutational dynamics of early and late relapsed childhood all .
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PMC11682525
Moreover, SH-SY5Y cell lines have played a pivotal role in the study of neurological disorders for many years.
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PMC9587298
The in vitro free-cell trapping ability of MGO was determined based on experimental conditions described by Gobert and Glomb, 2009, Sang et al., 2007 with some modifications.
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PMC10387886
TGFΞ² activates EMT through SMAD-dependent and SMAD-independent pathways, which are mediated by the phosphorylation and activation of SMAD and MAPK (mitogen-activated protein kinases) proteins, respectively .
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PMC11420784
B, Colocalization of LC3 with UPEC at 6 hpi in mouse bladders pretreated with vehicle or 35 mM 3-MA.
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PMC7887261
Primers used included GAPDH (housekeeping gene) forward: CAA TGA CCC CTT CAT TGA CC; GAPDH reverse: GAT CTC GCT CCT GGA AGA TG; POMC forward: GCC AGT GTC AGG ACC TCA C; POMC reverse: GGG AAC ATG GGA GTC TCG G; CHEK2 forward: TCT CGG GAG TCG GAT GTT GAG; CHEK2 reverse: CCT GAG TGG ACA CTG TCT CTA A; ATM forward: GGC TAT TCA GTG TGC GAG ACA; ATM reverse: TGG CTC CTT TCG GAT GAT GGA; MPZL2 forward: TTA ATG GGA CAG ATG CTC GGT; MPZL2 reverse: AAG ACA CCC GGT CCT TAA ACC; MME forward: AGA AGA AAC AGC GAT GGA CTC C; MME reverse: CAT AGA GTG CGA TCA TTG TCA CA; MLNR forward (siRNA): CTG AGC GCA TCT ATC AAC CCA; MLNR reverse (siRNA): TCC CAT CGT CTT CAC GTT AGC; MLNR forward (overexpression): GTG GTG ACC GTG ATG CTG AT; MLNR reverse (overexpression): AGC AGG ATG AGT AGG TCG GA.Flow-cytometric DNA damage assays.
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PMC10391797
To validate whether VPA could enhance CAR-T cytotoxicity in vivo, we generated an AML xenograft model using the THP-1 cells expressing firefly luciferase (THP-1-FFluc) by tail vein injection.
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PMC11551844
The enhanced anticancer activity of AuNPs-extracts could be attributed to the synergistic role of AuNPs and the extracts, the sustained released of bioactive compounds from the extracts, the size and surface of the AuNPs and their interactions with cancer cells.
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PMC9164404
Vt” refers to the mean tumor volume at a desirable day when tumor volumes were collected. β€œ
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PMC11381192
Next, qRT‐PCR was conducted using AceQ qPCR SYBR Green Master Mix (Vazyme, China) on a StepOnePlus real‐time PCR system (Applied Biosystems, USA).
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PMC7334607
Right: Top, a plot of the dose-response curves for Replicate 3 and all control replicates (Replicates 6, 7, 8) in response to SP-2509 (SP) at the VDC4 time point.
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PMC9429973
FACT-GOG/NTX survey completion was high in both arms (96% at baseline; >80% at other timepoints).
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PMC11615828
VAMP2 (Vesicle‐associated membrane protein 2), a target protein of synaptic vesicles, was tagged with FKBP.
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PMC11699465
The mechanism of its nuclear targeting is worthy of attention.
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PMC11740399
RNA sequencing was done to provide complementary insights into the underlying transcriptional changes, furnishing a deeper understanding of the regulatory mechanisms at play.
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PMC11746942
To further explore the link between S1PR3 and Src activation, we discovered that the GΞ±i subunit couples with S1PR3 to initiate STAT3 signaling .
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PMC11515150
CD5 blockade with anti-CD5 monoclonal antibody or CD5 knockout could be therapeutically beneficial to enhance T cell-mediated anti-tumor immunity .
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PMC11739670
Finally, we demonstrate an inverse relationship between the affinity of CD8 and TCR for pMHCI alleles, a feature that is potentially of functional importance during thymic selection.
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PMC11297139
c Top 10 enriched gene ontologies in ARID1A LLPS-dependent upregulated DEGs.
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PMC10165258
Drug resistance is a notorious factor that thwarts the effectiveness of current chemotherapeutic agents alone, including those currently used in the first-line chemotherapy.
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PMC11694066
and PARPi have shown disappointing efficacy in pediatric malignancies so far.
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PMC2777936
Untreated NT2/D1, NT2/D1-R1 and Tera-1 cells expressed similar amounts of FZD5 mRNA relative to the GAPDH expression levels and 833K cells expressed 2-4-fold higher levels.
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PMC11519077
Earlier studies using in vivo animal model systems as well as in vitro cell culture model systems have demonstrated that IL-1 increases intestinal epithelial tight junction (TJ) resistance .
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PMC9429973
Results: We first validated the two HSP110 inhibitors in DLCBL since they efficiently disrupted the binding of HSP110 to MyD88 in DLBCL cell lines.
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PMC11594588
Venous congestion is the most important of the three factors, although congestion alone seems to be insufficient to cause thrombus formation .
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PMC11470999
Chemical structure of PF‐Biotin. (
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PMC10968586
After treating HepG2 cells with 50 ΞΌM OLE for 24 h, the measured reduction in cell viability seemed related to OLE-mediated accumulation of ROS .
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PMC11367146
Estrogen can protect articular cartilage from damage during OA development by promoting chondrocyte autophagy .
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PMC9429973
Image: Summary/Conclusion: In this single center retrospective analysis, intensification of post-transplant Len maintenance did not show an improvement in the outcomes for patients with HRMM.
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PMC10538569
Further inquiries can be directed to the corresponding authors.
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PMC3681794
Despite functional inhibition of HIF-1 (Figure 8B) reduction in p53 phosphorylation on serine 15 and p21 protein levels after etoposide exposure in hypoxia were not altered (Figure 8C).
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PMC3019555
Immunoreactivity was visualized using an infrared imaging system (Odyssey; LI-COR Biosciences).
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PMC11803918
It is initiated by the absorption of photon energy by a photosensitizer, which can be activated from the ground state to the excited singlet state, either decaying back to the ground state through fluorescence emission or undergoing intersystem crossing to the triplet state.
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PMC8409415
To date, more than 150 ADCs have been investigated in clinical trials and more than 35 ongoing clinical trials for treatment‐refractory solid tumors have been published to date;, , however, the currently available ADCs demonstrate modest survival effects in patients with OvCA.
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PMC10174970
Data on mRNA expression in PAAD cell lines and patient tumor tissues were obtained from the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/).
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PMC11407042
CRITICAL: Wells with cell clusters cannot be further used.
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PMC9812014
The addition of anisomycin alkaloid to the infected cell culture showed 99.9% inhibition of DENV-2 when added at 8 h p.i, but when added later at 18 h p.i no inhibition was observed which indicates anisomycin exerts its inhibitory activity in the initial stages of the viral infection.
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PMC6461034
H2228 and SK‐Mel‐28 were cultured in DMEM supplemented with 10% fetal bovine serum and 2 mM L‐glutamine.
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PMC9429973
Methods: Dose response curves were performed in DND-41 and SUPT-1 T-ALL cell lines, which were treated with DMSO/MRK-560 alone or in combination with different concentrations of chemotherapy.
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PMC11687167
The molecular recognition of the NF-ΞΊB pathway in Treg cells holds promise for novel immunotherapeutic strategies for autoimmune or cancer therapies.
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PMC11285179
Increased CCL28 could promote tumor vascular normalization through recruiting and metabolic reprogramming pericytes in the tumor microenvironment.
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PMC11200978
Phospho-MLKL levels did not differ significantly between controls and gemcitabine-treated samples (p = 0.7).
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PMC11739670
Inverse relationship between TCR:pMHCI and pMHCI:CD8 affinity.
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PMC9429973
At 47.3 mo median follow-up (range 1.0–82.0), median PFS was not reached (NR) in TN pts with del(17p)/TP53m with A-based regimens; PFS rates at 48 mo suggest similar efficacy with A and A+O in TN pts with del(17p)/TP53m (76% and 77%, respectively) (Fig 1A).
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