OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Lastly, several miRNAs are predicted to be sequestered by circRNAs of either of these apoptosis-related genes, including miR-181 family members that have been associated with chemosensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	A very recent study by Dell’Anno et al. also showed that siRNA-mediated depletion of RAN expression in MPM cell lines abrogated cellular growth and colony formation, suggesting that RAN signaling acts as a positive regulator of survival and proliferation in MPM .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No differences between the two groups were observed in the average time to neutrophil (N≥0.5 x 10/L) and platelet (PLTs ≥20x 10/L) recovery (10.4 vs 10 days and 12.5 vs 11.7 days, respectively), as well as in the number of transfused RBCs and PLTs units.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	Overall, this extensive analysis revealed a multifaceted landscape of the identified genes’ potential roles, encompassing not only disease-related processes but also fundamental cellular mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	HDCT is of utmost importance, with BeEAC, LEAM and CLV conditioning regimens being considered as viable alternatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDCT", "is", "of", "utmost", ...
PMC7039683	Although the sets of enriched transcription factor binding sites enriched in the three sets of enhancer were similar, only the classifier trained on zebrafish periderm enhancers yielded a deltaSVM for SNP2 that met formal significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	ONX-0914 is an inhibitor of the LMP7 and LMP2 subunits of immunoproteasomes and has activity in multiple models of autoimmune diseases in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ONX-091...
PMC9545474	These 18‐electron complexes were designed with four water‐soluble phosphine ligands to increase the water‐solubility character of the corresponding electron‐deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	For EBV-associated tumors, analysis of LMP2A, mTOR activation, and/or HIF-1α levels may allow for optimized chemotherapeutic approaches that target multiple pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9250505	Xenografts were generated by subcutaneous injection of A2780 and A2780CisR cells into immunocompromised mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Xenografts", "were", "generated", "by", "subcutaneous", "i...
PMC11762280	Recently, the pattern of coexistence of pyroptosis, apoptosis, and necroptosis has been termed PANoptosis; however, whether PANoptosis occurs in keratinocytes in UVB-induced skin injury remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	Given these data, we first fit the relationship between relative 10-formyl-THF abundance and growth rate for these 10 genotypes (Eq. 1), yielding four parameter values for , , , and (Fig. 1d, Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591052	According to the results of a randomized, placebo-controlled, phase 2/3 trial, 20E significantly reduced the risk of death or respiratory failure in adults hospitalized with severe respiratory symptoms due to COVID-19 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	Amino acid variations can directly modify the secondary structure of HP1 or the CSD binding affinity to peptide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amino", "acid", "variations", "can", "...
PMC10114490	This is usually accomplished by ectopic expression of key liver enriched transcription factors, most frequently HNF4A and either FOXA1, FOXA2 or FOXA3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11351758	NARP cybrids can be established when human osteosarcoma 143B cells are depleted and mtDNA is eliminated by exposing the cells to ethidium bromide, which results in a cell line that is devoid of mtDNA termed rho zero (ρ) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	Kirschsteiniotheliadendryphioides (HKAS 135651, paratype) a, b colonies on natural substrate c, d conidiophores, conidiogenous cells bearing conidia e–g conidiogenous cells bearing conidia h–l conidia m upper surface view of culture n lower surface view of culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	When the expression of some serpins reduces, psoriasis can be treated with its recombinant protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "expression", "of", "some", "serpins", ...
PMC6364197	Cell proliferation reduced to 89.58±3.26, 62.86±6.84 and 53.36±3.37% for 48, 144 and 168 h respectively on TCPS, according to the CCK-8 results (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742231	Ha introduced MDMF, a computational framework that predicts miRNA-disease associations using matrix factorization with a disease similarity constraint.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ha", "introduced", "MDMF", ",", ...
PMC10936243	Understanding why the appropriate care is not always given is important.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "why", "the", "appropriate", "care", "is", "not", "always", "given", ...
PMC10495912	aaaP<0.001 vs. TQ (18.5 μM) group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "aaaP<0.001", "vs.", "TQ", "(", "18.5", "μM", ")", "group", "." ] } ]
PMC11279397	This suggests that these molecular functions may play a crucial role in enhancing Perilla frutescens’ antiviral capability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "these", "m...
PMC11763126	H Western blot analysis showing YTHDF2 levels after CHX treatment in each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "Western", "blot", "analysis", "showing", "YTHDF2", "levels", "after", ...
PMC7192625	GARDEN-NET is available at https://pancaldi.bsc.es/garden-net/ and on GitHub https://github.com/VeraPancaldiLab/GARDEN-NET while ChAseR can be downloaded at https://bitbucket.org/eraineri/ChAseR/ Code to generate all examples is available at https://github.com/VeraPancaldiLab/ChAseR_demo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11490153	The process of apoptosis was investigated to assess the treatments’ effectiveness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "process", "of", "apoptosis", "was", "investigated", "to", "assess", "the"...
PMC11335267	Since the MC3R receptors act predominantly regulating feed-back loops between Agrp and Pomc neurons with the arcuate nucleus, this question will require specific approaches to determine their functions relative to their specific neuronal type and location.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Based on this interim analysis, continuous followed by intermittent dosing (Arm 1) and intermittent dosing (Arm 2) are both safe and effective in patients with iNHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612508	indicates a schematic of magnetic microspheres and drug release under a magnetic field.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "indicates", "a", "schematic", "of", "magnetic", "microspheres", "and", "dru...
PMC11591030	No significant changes were observed in any of these indices in the PDTC-treated group (p > 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "changes", "w...
PMC11185260	Kaplan–Meier survival curves of mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", "survival", "curves", "of", "mice", "." ] } ]
PMC11772585	Dot blot results revealed that the overexpression of WT METTL1 significantly elevated m7G methylation levels, while the overexpression of Mut METTL1 did not (Supplementary Fig. S5A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190238	These two studies support the notion that LADs and possibly the interface between the heterochromatin and euchromatin at the compartment level serve as the crucial chromatin structural organizing sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5415764	Organic solvent residue in the LPN solution was finally removed by vacuum rotary evaporation at 40 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Organic", "solvent", "residue", "in", ...
PMC11742047	At the end of the analytical run, 20 Iterative-MS/MS runs were performed for both ion modes, 10 iterative-MS/MS runs were set with a collision energy of 20 eV, and the subsequent 10 runs were performed at 40 eV. They were operated with an MS and MS/MS scan rates of 3 spectra/s, 40–1700 m/z mass window, a narrow (∼ 1.3 amu) MS/MS isolation width, 3 precursors per cycle, and 5000 counts and 0.001% of MS/MS threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614415	Our results suggest that Aurora kinase inhibitors could be useful for treatment of taxane resistant ovarian tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "suggest", "that", "Aurora", ...
PMC7823217	Intestinal spheroid models and organoid models with human colon adenocarcinoma, adenoma, and Barrett's epithelium were developed showing promising cancer models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intesti...
PMC9429973	Randomization will be stratified by 17p deletion (yes/no) and prior BTKi experience (discontinuation due to progressive disease vs due to other reasons vs no prior BTKi exposure).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7153288	Flow cytometry analysis of the A549 cell apoptosis caused by the 24 h of treatment with the Streptomyces sp. SS1-1 culture broth.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC4395774	The reconstitution results presented in Figure 4 show one representative experiment (experiment 2) from a series of three experiments where three mice were corrected with PGK.PRF and three mice were corrected with PRF.PRF transduced cells, the results from experiments 1 and 3 are shown as Supplementary Figures S5 and S6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	However, malignant cells demonstrate weakened cell-cell contacts, which prevents association of the EphA2 receptor with ephrin and leads to EphA2 receptor upregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11574029	Moreover, aberrant activation of the PI3K/AKT pathway by SPP1 leads to the malignant progression of BLCA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "aberrant", "activation", "of", ...
PMC11411004	Measure the relative mRNA expression and protein levels (c, d) of HDAC5 gene in CHO-ADM cells treated with NC (vector control) or siHDAC5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	Phevor PhoRank algorithm, which ranks the genes based on their phenotypic relevance as defined by diverse biomedical ontologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phevor", "PhoRank", "algorithm", ...
PMC11552389	Furthermore, Chen et al reports that loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.16 At present, a comprehensive investigation into the intricate regulatory mechanisms underlying the action of FISP1 in melanoma remains elusive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	Data are presented as the mean ± SEM of three replicates. ***,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", ...
PMC11180402	In addition, the interplay between non-coding RNA and DNMT3b can significantly influence tumor cell fate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "interplay", "between", ...
PMC10758402	E, F) Multistep (MOI, 0.01) and single-step (MOI, 3) growth curves.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "F", ")", "Multist...
PMC9412887	Firstly, positively charged mitochondrial-targeting lipid-polymer hybrid nanoparticles (PLGA/CPT) were prepared from PLGA and C18-PEG2000-TPP (CPT) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "positively",...
PMC11591052	To balance the concentration, samples were then diluted using a Laemli buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "balance", "the", "concentration", ",", "samples", "were", "then", ...
PMC5600151	Still, lower biocompatibility was seen for G5 compared to G3 and G4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "lower", "biocompatibility", "was", "seen", "for", "G5", ...
PMC11742290	RSPO1 decorated with liposomes have been constructed to interact with LGR5 via WNT/β-catenin pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RSPO1", "decorated", "with", "liposomes", "have", "been", "constructed...
PMC9429973	2 pts were suspended infusion due to rapid disease progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2", "pts", "were", "suspended", "infusion", "due", "to", "rapid", "disease", "progression", ...
PMC3734024	Co-staining for CD5 and CD1d showed that CD5CD1d B cells were more frequent among FasL B cells than FasL B cells (Figures 2B and 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thirteen patients (29%) had high-risk cytogenetics and 6 (13%) had extramedullary disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thirteen", "patients", "(", "29", "%",...
PMC11754432	Western analysis of NRF2 (B), EGFR (D) compared to total protein, phospho ERK compared to total ERK (E), and gene expression of EGFR (C), NQO1 (F) and HMGCR (G) in keratinocytes transfected with control or ALOX15B siRNA for 72 h followed by 24 h treatment with 100 nm CDDO-Imidazole (CDDO-Im).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	We have examined the transcription of the above ligands in GIST cells in the co-culture system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "examined", "the", "transcription", "of",...
PMC11143482	Osteosarcoma, a bone cancer that typically affects children and young adolescence, is a high-grade malignancy characterised by severe metastases to the lungs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11261875	Moreover, the usefulness of F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and findings about the glycolytic system as a biomarker in GIST are presented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	Donepezil (DPZ) served as a positive control (blue).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Donepezil", "(", "DPZ", ")", "served", "as", "a", "positive", "control", "...
PMC10957991	Normal TRPV4 function thus appears to be important for mammary epithelial structures both in 2D and 3D. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "TRPV4", "function", "thus", ...
PMC11674891	The gastrin-releasing peptide receptor (GRPR), also known as bombesin receptor 2 (BB2), is a member of the GPCR family, recognized for its binding ligand, gastrin-releasing peptide (GRP) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674834	The remaining cells were replated and sub-cultured for 7 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "remaining", "cells", "were", "replated", "and", "sub-cultured", "for", "7", "days", ...
PMC10728200	In conclusion, This study is the first to demonstrate that IM induces ferroptosis by promoting STUB1-mediated GPX4 ubiquitination in GIST, and the combination of RSL3 and IM emerges as a promising therapeutic strategy for GIST.Gastrointestinal stromal tumor (GIST) is the most common tumor of mesenchymal origin in the gastrointestinal tract, with an annual incidence of 1/100,000–2/100,000 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6442998	We therefore investigated YAP expression in human GIST tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "therefore", "investigated", "YAP", "expression", "in", "human", "GIST", "tumors", "." ] } ]
PMC5311252	All the staining solutions were removed and plates were rinsed with water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "staining", "solutions", "were", "removed", "and", "plates", "were"...
PMC11201989	Our results give us a better understanding of the roles of PD-L1 in primary cilia function that may be disrupted in the context of disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11637276	For 384-well plates, 2.5 μl of 500 nM siGENOME siRNA and 2.5 μl Opti-MEM per well were added into CellCarrier Ultra 384-well plates (Perkin Elmer), and 4.95 μl Opti-MEM was incubated with 0.05 μl Dharmafect IV for 5 min, and 5 μl of the Dharmafect IV solution was added into each well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835428	This comparison was limited to the effects on animal survival, which indicated extended animal survival for PLGA–HA–siFAK–PTX compared to PLGA–HA–PTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10706275	These aspects constrain the advancement of the CHO cells as a system for pharmaceutical protein expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "aspects", "constrain", "the", "advancement...
PMC10976516	The study is completed.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "is", "completed", "." ] } ]
PMC11757230	The LL cells were then collected and stained using an FITC Annexin-V Apoptosis Detection Kit with propidium iodide (PI) (BioLegend, San Diego, CA, USA), following the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	The mechanisms and the outcomes of the studies are provided in Table 1 and are schematically represented in Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanisms", "and", ...
PMC11476106	Our findings could also have significant implications for designing therapeutic strategies (mechanotherapies) that modulate ECM–cell interactions, i.e., by blocking components such as VN in ES treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476264	FBXO11 was also found to inhibit lung cancer cell migration and invasion in vivo in xenograft mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FBXO11", "was", "also", "found", "to", "inh...
PMC9429973	A. Abulafia, G. Spectre, E. Ziv, K. R. Geiger, Z. Sarsor, N. Ron, E. Beery, S. Revel-Vilk, M. Naamad, P. Raanani, O. Uziel, U. Rozovski Institute of Hematology, Rabin Medical Center, Petah Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv; Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva; Gaucher Unit, Pediatric Hematology/Oncology Unit, Shaare Zedek Medical Center; Faculty of Medicine, Hebrew University of Jerusalem; Flow Cytometry Unit, Shaare Zedek Medical Center, Jerusalem, Israel Background: Polycythemia vera (PV) is characterized by clonal proliferation of myeloid progenitor cells that is caused by activating mutation in the Janus Kinase (JAK)2 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Slides were subsequently quickly rinsed with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "subsequently", "quickly", "rinsed", "with", "PBS", "." ] } ]
PMC11715644	In this study, we use MCF10A (WT 10A) human mammary epithelial cells and their derivative cell lines with constitutively active RhoA (10A + RhoA) and overexpressed ErbB2 (10A + ErbB2) to form epithelial monolayers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	PCR analysis suggested that CBDP1 modulated YTHDF2 post-transcriptionally, as it did not affect YTHDF2 mRNA levels (Fig. 6G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCR", "analy...
PMC11155445	One of the most common way to synthesize acyl thiourea needs the employment of acid chloride in the reaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "most", ...
PMC11680982	This compelling evidence led to the classification of ZR-75-1 as an HR/HER2-low breast cancer cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ ...
PMC7185206	Box plots quantifying flow cytometry shown, compared statistically by Student’s t-test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "plots", "quantifying", "flow", "cytometry", "shown", ",", ...
PMC9429973	Image: Summary/Conclusion: In conclusion, primary plasma cell leukemia (pPCL) defined by the new revised diagnostic criteria (CPCs≥5%), remains an aggressive disease characterized with poor prognosis despite the advancement of treatment regimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	The obtained results manifested that in the CXCL7-OE group, TRAP and MMP13 presented conspicuous co-localization, inferring that MMP13 assumes a crucial role in the activation of osteoclasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Indeed, active caspase 3 increased after ruxolitinib and chloroquine (autophagy inhibitor) combination(+20% vs ruxolitinib alone, p<0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ","...
PMC11502443	Similarly, tirzepatide appeared to be biased away from pAKT, pERK and pCREB (2.6, 2.5 and 2.3-fold, respectively) compared to cAMP, but these differences were not significant (Supplementary Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	The reaction mixtures were thoroughly mixed and incubated for 30 min in the dark at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "mixtures", "were", "thoroughly...
PMC11281366	Cells were cultured in RPMI-1640 medium containing 10% FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "in", "RPMI-1640", "medium", "containing", "10", "%", "FBS", "...
PMC11367146	A voucher specimen (2536/CBT Dt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "voucher", "specimen", "(", "2536/CBT", "Dt", "." ] } ]
PMC11577421	This proof-of-principle demonstration underscores the importance of ABNP-GAG interactions in designing more efficient drug delivery systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "proof-of-principle", "demonstration", "underscores", ...
PMC9479186	Complex I with mitochondrial leakage in the supernatant was taken and 400 μl of extraction reagent was added to the precipitate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Complex", "I", "w...
PMC11803918	Our work provides a promising strategy through combining γδ-T exosomes and PDT for photoimmunotherapy, which may expand the applications of γδ-T exosome therapy in cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Additionally, wound healing and transwell assays demonstrated that si-KCNN4 significantly inhibited the migratory and invading capabilities of SMMC-7721 and BEL-7404 cells, whereas si-ACYP2 + si-KCNN4 significantly increased these functions in the aforementioned cells (Fig. 3G and Fig. S4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11012313	As pointed out by Yang et al., numerous EBV-encoded oncogenes have been analyzed for their impact on metabolic enzymes, including HIF-1α .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC11767725	In obesity and T2DM, AGEs accumulate in the skin, binding to RAGE receptors on keratinocytes and endothelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "obesity", "and", ...
PMC9503685	Cytotoxicity has not been demonstrated at any concentrations of magainin and cecropin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "has", "not", "been", "demonstrated", "at", "any", "concentrations", ...
PMC11661040	Furthermore, western blot analysis revealed a significant reduction in the activation level of the wnt signaling pathway in the CGREF1 knockdown group compared to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10993311	A previous study from our research group showed that the maternal methylome of pregnant women with excessive gestational weight gain (EGWG) was altered at 46 differentially methylated positions and in 11 differentially methylated regions (DMRs) (Argentato et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10174970	Datasets from the same cell lines or from PAAD patients were pooled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Datasets", "from", "the", "same", "cell", "lines", "or", "from", "PAAD", "...
PMC6364197	To investigate the effect of PCL scaffold on cell proliferation, we compared proliferation of Jurkat cells on TCPS, UPS and 80 µg/ml CTCPS for 168 h. CCK-8 reagent was used to analyze the extent of cell proliferation/viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Lastly, several miRNAs are predicted to be sequestered by circRNAs of either of these apoptosis-related genes, including miR-181 family members that have been associated with chemosensitivity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7504302

A very recent study by Dell’Anno et al. also showed that siRNA-mediated depletion of RAN expression in MPM cell lines abrogated cellular growth and colony formation, suggesting that RAN signaling acts as a positive regulator of survival and proliferation in MPM .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

No differences between the two groups were observed in the average time to neutrophil (N≥0.5 x 10/L) and platelet (PLTs ≥20x 10/L) recovery (10.4 vs 10 days and 12.5 vs 11.7 days, respectively), as well as in the number of transfused RBCs and PLTs units.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10938336

Overall, this extensive analysis revealed a multifaceted landscape of the identified genes’ potential roles, encompassing not only disease-related processes but also fundamental cellular mechanisms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

HDCT is of utmost importance, with BeEAC, LEAM and CLV conditioning regimens being considered as viable alternatives.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDCT", "is", "of", "utmost", ...

PMC7039683

Although the sets of enriched transcription factor binding sites enriched in the three sets of enhancer were similar, only the classifier trained on zebrafish periderm enhancers yielded a deltaSVM for SNP2 that met formal significance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612626

ONX-0914 is an inhibitor of the LMP7 and LMP2 subunits of immunoproteasomes and has activity in multiple models of autoimmune diseases in mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ONX-091...

PMC9545474

These 18‐electron complexes were designed with four water‐soluble phosphine ligands to increase the water‐solubility character of the corresponding electron‐deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11012313

For EBV-associated tumors, analysis of LMP2A, mTOR activation, and/or HIF-1α levels may allow for optimized chemotherapeutic approaches that target multiple pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9250505

Xenografts were generated by subcutaneous injection of A2780 and A2780CisR cells into immunocompromised mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Xenografts", "were", "generated", "by", "subcutaneous", "i...

PMC11762280

Recently, the pattern of coexistence of pyroptosis, apoptosis, and necroptosis has been termed PANoptosis; however, whether PANoptosis occurs in keratinocytes in UVB-induced skin injury remains unclear.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11026382

Given these data, we first fit the relationship between relative 10-formyl-THF abundance and growth rate for these 10 genotypes (Eq. 1), yielding four parameter values for , , , and (Fig. 1d, Supplementary Table 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11591052

According to the results of a randomized, placebo-controlled, phase 2/3 trial, 20E significantly reduced the risk of death or respiratory failure in adults hospitalized with severe respiratory symptoms due to COVID-19 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11723947

Amino acid variations can directly modify the secondary structure of HP1 or the CSD binding affinity to peptide.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amino", "acid", "variations", "can", "...

PMC10114490

This is usually accomplished by ectopic expression of key liver enriched transcription factors, most frequently HNF4A and either FOXA1, FOXA2 or FOXA3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11351758

NARP cybrids can be established when human osteosarcoma 143B cells are depleted and mtDNA is eliminated by exposing the cells to ethidium bromide, which results in a cell line that is devoid of mtDNA termed rho zero (ρ) cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11535726

Kirschsteiniotheliadendryphioides (HKAS 135651, paratype) a, b colonies on natural substrate c, d conidiophores, conidiogenous cells bearing conidia e–g conidiogenous cells bearing conidia h–l conidia m upper surface view of culture n lower surface view of culture.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11683130

When the expression of some serpins reduces, psoriasis can be treated with its recombinant protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "expression", "of", "some", "serpins", ...

PMC6364197

Cell proliferation reduced to 89.58±3.26, 62.86±6.84 and 53.36±3.37% for 48, 144 and 168 h respectively on TCPS, according to the CCK-8 results (Fig. 5A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742231

Ha introduced MDMF, a computational framework that predicts miRNA-disease associations using matrix factorization with a disease similarity constraint.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ha", "introduced", "MDMF", ",", ...

PMC10936243

Understanding why the appropriate care is not always given is important.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "why", "the", "appropriate", "care", "is", "not", "always", "given", ...

PMC10495912

aaaP<0.001 vs. TQ (18.5 μM) group.

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PMC11279397

This suggests that these molecular functions may play a crucial role in enhancing Perilla frutescens’ antiviral capability.

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PMC11763126

H Western blot analysis showing YTHDF2 levels after CHX treatment in each group.

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PMC7192625

GARDEN-NET is available at https://pancaldi.bsc.es/garden-net/ and on GitHub https://github.com/VeraPancaldiLab/GARDEN-NET while ChAseR can be downloaded at https://bitbucket.org/eraineri/ChAseR/ Code to generate all examples is available at https://github.com/VeraPancaldiLab/ChAseR_demo.

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PMC11490153

The process of apoptosis was investigated to assess the treatments’ effectiveness.

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PMC11335267

Since the MC3R receptors act predominantly regulating feed-back loops between Agrp and Pomc neurons with the arcuate nucleus, this question will require specific approaches to determine their functions relative to their specific neuronal type and location.

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PMC9429973

Image: Summary/Conclusion: Based on this interim analysis, continuous followed by intermittent dosing (Arm 1) and intermittent dosing (Arm 2) are both safe and effective in patients with iNHL.

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PMC11612508

indicates a schematic of magnetic microspheres and drug release under a magnetic field.

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PMC11591030

No significant changes were observed in any of these indices in the PDTC-treated group (p > 0.05).

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PMC11185260

Kaplan–Meier survival curves of mice.

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PMC11772585

Dot blot results revealed that the overexpression of WT METTL1 significantly elevated m7G methylation levels, while the overexpression of Mut METTL1 did not (Supplementary Fig. S5A, B).

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PMC11190238

These two studies support the notion that LADs and possibly the interface between the heterochromatin and euchromatin at the compartment level serve as the crucial chromatin structural organizing sites.

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PMC5415764

Organic solvent residue in the LPN solution was finally removed by vacuum rotary evaporation at 40 °C.

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PMC11742047

At the end of the analytical run, 20 Iterative-MS/MS runs were performed for both ion modes, 10 iterative-MS/MS runs were set with a collision energy of 20 eV, and the subsequent 10 runs were performed at 40 eV. They were operated with an MS and MS/MS scan rates of 3 spectra/s, 40–1700 m/z mass window, a narrow (∼ 1.3 amu) MS/MS isolation width, 3 precursors per cycle, and 5000 counts and 0.001% of MS/MS threshold.

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PMC2614415

Our results suggest that Aurora kinase inhibitors could be useful for treatment of taxane resistant ovarian tumors.

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PMC7823217

Intestinal spheroid models and organoid models with human colon adenocarcinoma, adenoma, and Barrett's epithelium were developed showing promising cancer models .

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PMC9429973

Randomization will be stratified by 17p deletion (yes/no) and prior BTKi experience (discontinuation due to progressive disease vs due to other reasons vs no prior BTKi exposure).

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PMC7153288

Flow cytometry analysis of the A549 cell apoptosis caused by the 24 h of treatment with the Streptomyces sp. SS1-1 culture broth.

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PMC4395774

The reconstitution results presented in Figure 4 show one representative experiment (experiment 2) from a series of three experiments where three mice were corrected with PGK.PRF and three mice were corrected with PRF.PRF transduced cells, the results from experiments 1 and 3 are shown as Supplementary Figures S5 and S6.

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PMC10213179

However, malignant cells demonstrate weakened cell-cell contacts, which prevents association of the EphA2 receptor with ephrin and leads to EphA2 receptor upregulation.

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PMC11574029

Moreover, aberrant activation of the PI3K/AKT pathway by SPP1 leads to the malignant progression of BLCA.

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PMC11411004

Measure the relative mRNA expression and protein levels (c, d) of HDAC5 gene in CHO-ADM cells treated with NC (vector control) or siHDAC5.

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PMC7887261

Phevor PhoRank algorithm, which ranks the genes based on their phenotypic relevance as defined by diverse biomedical ontologies.

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PMC11552389

Furthermore, Chen et al reports that loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.16 At present, a comprehensive investigation into the intricate regulatory mechanisms underlying the action of FISP1 in melanoma remains elusive.

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PMC11300639

Data are presented as the mean ± SEM of three replicates. ***,

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PMC11180402

In addition, the interplay between non-coding RNA and DNMT3b can significantly influence tumor cell fate .

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PMC10758402

E, F) Multistep (MOI, 0.01) and single-step (MOI, 3) growth curves.

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PMC9412887

Firstly, positively charged mitochondrial-targeting lipid-polymer hybrid nanoparticles (PLGA/CPT) were prepared from PLGA and C18-PEG2000-TPP (CPT) .

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PMC11591052

To balance the concentration, samples were then diluted using a Laemli buffer.

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PMC5600151

Still, lower biocompatibility was seen for G5 compared to G3 and G4.

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PMC11742290

RSPO1 decorated with liposomes have been constructed to interact with LGR5 via WNT/β-catenin pathway.

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PMC9429973

2 pts were suspended infusion due to rapid disease progression.

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PMC3734024

Co-staining for CD5 and CD1d showed that CD5CD1d B cells were more frequent among FasL B cells than FasL B cells (Figures 2B and 2C).

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PMC9429973

Thirteen patients (29%) had high-risk cytogenetics and 6 (13%) had extramedullary disease.

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PMC11754432

Western analysis of NRF2 (B), EGFR (D) compared to total protein, phospho ERK compared to total ERK (E), and gene expression of EGFR (C), NQO1 (F) and HMGCR (G) in keratinocytes transfected with control or ALOX15B siRNA for 72 h followed by 24 h treatment with 100 nm CDDO-Imidazole (CDDO-Im).

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PMC10040136

We have examined the transcription of the above ligands in GIST cells in the co-culture system.

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PMC11143482

Osteosarcoma, a bone cancer that typically affects children and young adolescence, is a high-grade malignancy characterised by severe metastases to the lungs.

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PMC11261875

Moreover, the usefulness of F-Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and findings about the glycolytic system as a biomarker in GIST are presented.

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PMC11787381

Donepezil (DPZ) served as a positive control (blue).

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PMC10957991

Normal TRPV4 function thus appears to be important for mammary epithelial structures both in 2D and 3D. (

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PMC11674891

The gastrin-releasing peptide receptor (GRPR), also known as bombesin receptor 2 (BB2), is a member of the GPCR family, recognized for its binding ligand, gastrin-releasing peptide (GRP) .

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PMC11674834

The remaining cells were replated and sub-cultured for 7 days.

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PMC10728200

In conclusion, This study is the first to demonstrate that IM induces ferroptosis by promoting STUB1-mediated GPX4 ubiquitination in GIST, and the combination of RSL3 and IM emerges as a promising therapeutic strategy for GIST.Gastrointestinal stromal tumor (GIST) is the most common tumor of mesenchymal origin in the gastrointestinal tract, with an annual incidence of 1/100,000–2/100,000 .

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PMC6442998

We therefore investigated YAP expression in human GIST tumors.

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PMC5311252

All the staining solutions were removed and plates were rinsed with water.

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PMC11201989

Our results give us a better understanding of the roles of PD-L1 in primary cilia function that may be disrupted in the context of disease.

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PMC11637276

For 384-well plates, 2.5 μl of 500 nM siGENOME siRNA and 2.5 μl Opti-MEM per well were added into CellCarrier Ultra 384-well plates (Perkin Elmer), and 4.95 μl Opti-MEM was incubated with 0.05 μl Dharmafect IV for 5 min, and 5 μl of the Dharmafect IV solution was added into each well.

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PMC6835428

This comparison was limited to the effects on animal survival, which indicated extended animal survival for PLGA–HA–siFAK–PTX compared to PLGA–HA–PTX.

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PMC10706275

These aspects constrain the advancement of the CHO cells as a system for pharmaceutical protein expression.

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PMC10976516

The study is completed.

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PMC11757230

The LL cells were then collected and stained using an FITC Annexin-V Apoptosis Detection Kit with propidium iodide (PI) (BioLegend, San Diego, CA, USA), following the manufacturer's instructions.

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PMC6600253

The mechanisms and the outcomes of the studies are provided in Table 1 and are schematically represented in Figure 1.

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PMC11476106

Our findings could also have significant implications for designing therapeutic strategies (mechanotherapies) that modulate ECM–cell interactions, i.e., by blocking components such as VN in ES treatment.

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PMC11476264

FBXO11 was also found to inhibit lung cancer cell migration and invasion in vivo in xenograft mice.

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PMC9429973

A. Abulafia, G. Spectre, E. Ziv, K. R. Geiger, Z. Sarsor, N. Ron, E. Beery, S. Revel-Vilk, M. Naamad, P. Raanani, O. Uziel, U. Rozovski Institute of Hematology, Rabin Medical Center, Petah Tikva; Sackler School of Medicine, Tel Aviv University, Tel Aviv; Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva; Gaucher Unit, Pediatric Hematology/Oncology Unit, Shaare Zedek Medical Center; Faculty of Medicine, Hebrew University of Jerusalem; Flow Cytometry Unit, Shaare Zedek Medical Center, Jerusalem, Israel Background: Polycythemia vera (PV) is characterized by clonal proliferation of myeloid progenitor cells that is caused by activating mutation in the Janus Kinase (JAK)2 gene.

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PMC11787355

Slides were subsequently quickly rinsed with PBS.

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PMC11715644

In this study, we use MCF10A (WT 10A) human mammary epithelial cells and their derivative cell lines with constitutively active RhoA (10A + RhoA) and overexpressed ErbB2 (10A + ErbB2) to form epithelial monolayers.

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PMC11763126

PCR analysis suggested that CBDP1 modulated YTHDF2 post-transcriptionally, as it did not affect YTHDF2 mRNA levels (Fig. 6G).

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PMC11155445

One of the most common way to synthesize acyl thiourea needs the employment of acid chloride in the reaction.

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PMC11680982

This compelling evidence led to the classification of ZR-75-1 as an HR/HER2-low breast cancer cell line.

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PMC7185206

Box plots quantifying flow cytometry shown, compared statistically by Student’s t-test. (

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PMC9429973

Image: Summary/Conclusion: In conclusion, primary plasma cell leukemia (pPCL) defined by the new revised diagnostic criteria (CPCs≥5%), remains an aggressive disease characterized with poor prognosis despite the advancement of treatment regimens.

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PMC11802855

The obtained results manifested that in the CXCL7-OE group, TRAP and MMP13 presented conspicuous co-localization, inferring that MMP13 assumes a crucial role in the activation of osteoclasts.

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PMC9429973

Indeed, active caspase 3 increased after ruxolitinib and chloroquine (autophagy inhibitor) combination(+20% vs ruxolitinib alone, p<0.01).

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PMC11502443

Similarly, tirzepatide appeared to be biased away from pAKT, pERK and pCREB (2.6, 2.5 and 2.3-fold, respectively) compared to cAMP, but these differences were not significant (Supplementary Table S2).

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PMC11746948

The reaction mixtures were thoroughly mixed and incubated for 30 min in the dark at room temperature.

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PMC11281366

Cells were cultured in RPMI-1640 medium containing 10% FBS.

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PMC11367146

A voucher specimen (2536/CBT Dt.

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PMC11577421

This proof-of-principle demonstration underscores the importance of ABNP-GAG interactions in designing more efficient drug delivery systems.

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PMC9479186

Complex I with mitochondrial leakage in the supernatant was taken and 400 μl of extraction reagent was added to the precipitate.

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PMC11803918

Our work provides a promising strategy through combining γδ-T exosomes and PDT for photoimmunotherapy, which may expand the applications of γδ-T exosome therapy in cancer treatment.

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PMC11391695

Additionally, wound healing and transwell assays demonstrated that si-KCNN4 significantly inhibited the migratory and invading capabilities of SMMC-7721 and BEL-7404 cells, whereas si-ACYP2 + si-KCNN4 significantly increased these functions in the aforementioned cells (Fig. 3G and Fig. S4E).

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PMC11012313

As pointed out by Yang et al., numerous EBV-encoded oncogenes have been analyzed for their impact on metabolic enzymes, including HIF-1α .

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PMC11767725

In obesity and T2DM, AGEs accumulate in the skin, binding to RAGE receptors on keratinocytes and endothelial cells.

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PMC9503685

Cytotoxicity has not been demonstrated at any concentrations of magainin and cecropin.

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PMC11661040

Furthermore, western blot analysis revealed a significant reduction in the activation level of the wnt signaling pathway in the CGREF1 knockdown group compared to the control group.

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PMC10993311

A previous study from our research group showed that the maternal methylome of pregnant women with excessive gestational weight gain (EGWG) was altered at 46 differentially methylated positions and in 11 differentially methylated regions (DMRs) (Argentato et al., 2023).

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PMC10174970

Datasets from the same cell lines or from PAAD patients were pooled.

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PMC6364197

To investigate the effect of PCL scaffold on cell proliferation, we compared proliferation of Jurkat cells on TCPS, UPS and 80 µg/ml CTCPS for 168 h. CCK-8 reagent was used to analyze the extent of cell proliferation/viability.

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