OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11767725	SD is a chronic inflammatory skin disorder that affects 1–3% of the population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SD", "is", "a", "chronic", "inflammatory", "skin", "disorder", "...
PMC8751435	On the contrast, inhibitory effect of CME is reversed in present of AC‐Dc 270pM, and this reversion is more significant in the high concentration of CME (600 and 800 μg/ml).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11298021	Furthermore, it was found that miR-3143, miR-3182, and rapamycin significantly induced G1/sub G1 arrest (* P<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", ...
PMC10213179	The next day, cells were washed, incubated with the secondary antibody, and finally mounted using ProlongGold antifade reagent with DAPI (Invitrogen, no. P36935).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	Fig. 3Inhibitory activity of GPI-anchored antibodies during cell–cell HIV-1 transmission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Inhibitory", "activity", "of", "GPI-anchored", "antibodies", "during", "cell"...
PMC9429973	Mutations in the SF3B1 and ATM genes were significantly more common in IGLV3-21 patients, compared to other patients (SF3B1: 49% vs. 21%, P=0.0008; ATM: 36% vs. 18%, P=0.02).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508	These compounds stimulated the ATPase activity of BCRP at nanomolar concentrations and inhibited the photolabeling of BCRP with iodoarylazidoprazosin, suggesting that they are able to inhibit the function of BCRP by directly interacting at the substrate-binding site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	RNA and protein expression were validated 72 h after transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "and", "protein", "expression", "were", "validated", "72", "h", "after", "transfection", ...
PMC3164356	This result suggests that many other unexpressed glycosylation genes in the CHO genome can be potentially activated or silenced to alter the repertoire of glycan structures from CHO cells (Fig. 5a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	The siRNA (10 pmol) of MYC or the control was transfected into Huh 7 cells and Bel-7404 cells in a 6-well dish, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O"...
PMC7762347	Among the most studied cyanotoxins are MCLR and CYN that frequently occur in cyanobacterial blooms simultaneously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "most", "studied", "cyanotoxins", "are"...
PMC7192625	It is in fact interesting to observe the difference between these cross-ChAs values in the two separate PP and PO subnetworks and to consider the values obtained by distance-preserving randomizations (Supplementary Figure S6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411	Clinical model construction based on PRPCDGs risk signature in E-MTAB-1980 and TCGA-KIRP datasets. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "model", "construction", "based", "on", "PRPCDGs", "risk", ...
PMC11489275	A, B The survival rate of patients within one month in different lymphocyte groups was obtained by log-rank test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "B", "The", ...
PMC11683240	Here, we searched for novel PT-inhibitors in the human peptidome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "searched", "for", "novel", "PT-inhibitors", "in", "the", "human", ...
PMC9429973	Results: A total of 41 pts were included in the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "A", "total", "of", "41", "pts", "were", "included", "in", ...
PMC6222726	It is also used as incense .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "used", "as", "incense", "." ] } ]
PMC11802855	In the CXCL7-OE group, a significant upregulation of the JAK/STAT3 pathway, MMP13, C-myc and CXCR2 was observed (E); while in the CXCL7-KD group, a notable downregulation was witnessed (F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11252553	The samples were irradiated at room temperature with doses of 4, 8, and 12 Gy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "irradiated", "at", ...
PMC11371627	However, thorough work-up revealed longer-standing changes including neuropathy, muscle atrophy with fatty involution and raised CK, indicating longer-standing neuropathy and myopathy most likely due to the underlying genetic defect in the XK gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10391797	To further track tumour-infiltrating immunophenotypes, the cancer–immunity cycle seven steps/immune cell infiltration in patients with AML was evaluated by the TIP method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11321678	We found that clusters C6‐C9 had higher accessibility of motifs for SPI1, SPIB, JUN family, and FOS family transcription factors, which are involved in myeloid or lymphoid cell development (Figure S1E, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	By regulating the expression of ERβ in different ccRCC cell lines, we found that the change of ZEB1 is directly related to ERβ (Fig. 4A), which indicates that ERβ is likely to affect the VM formation in RCC through ZEB1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	Mutation site; (B) Mutation type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutation", "site", ";", "(", "B", ")", "Mutation", "type", "." ] } ]
PMC2777936	Also, human ES cells may respond differently than human EC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "human", "ES", "cells", "may", "respond", "differently", "than", ...
PMC11699178	All RNA samples were extracted from cells and tissues using a lysis buffer (Vazyme, R401-01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "RNA", "samples", ...
PMC11490153	SPSS software version 22 (IBM Corp., Armonk, USA) was used for this analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SPSS", "software", "version", "22", "(", "I...
PMC5673955	Time‐dependent and (F) dose‐dependent changes of hTERT protein amounts measured by western blotting. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Time‐dependent", "and", "(", "F", ")", "dose‐dependent...
PMC11596967	Among these, four potential peptides, named Ddes-P1 to Ddes-P4, were selected, located in the 5′-UTRs of Deide_10410, Deide_11090, Deide_19720, and Deide_23310, respectively (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11085211	Moreover, given that secondary mutations in both KIT or PDGFRα have been found in imatinib-resistant GISTs, multi-target TKIs, such as sunitinib, regorafenib, and ripretinib, are administered as further treatment lines after the onset of resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11350568	Reports suggest that the transport of iron ions is initiated by the endocytosis of the TfR1-transferrin complex, entering the endosome through receptor-mediated internalization pathways, then fusing with lysosomes to release iron ions in acidic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9813422	CFP1 binds to CGIs and recruits the methyltransferase SET1 responsible for H3K4me3 deposition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CFP1", "binds", "to", "CGIs", "and", "recruits", "the", "methyltransferase"...
PMC11679033	From Figure 7 it can be seen that lymphocyte proliferation was highly disturbed in the positive control, where the most of cells were mononucleated and binucleated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11675244	Peptides that target the Dvl-binding domain of Fzd-7 have also induced apoptosis selectively and promoted β-catenin degradation in HCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptides", "that", "target", "the...
PMC9429973	P. SESQUES, R. DI BLASI, S. LE GOUILL, G. CARTRON, G. MANSON, D. BEAUVAIS, F. LE BRAS, F. X. GROS, S. CHOQUET, P. BORIES, M. T. RUBIO, R. O. CASASNOVAS, L. BOUNAIX, M. MOHTY, M. JORIS, J. ABRAHAM, C. CASTILLA LLORENTE, M. LOSCHI, S. CARRAS, A. CHAUCHET, L. DRIEU LA ROCHELLE, J. ZERBIT, O. HERMINE, S. GUIDEZ, T. GASTINNE, J. J. TUDESQ, P. FOGARTY, F. BROUSSAIS, F. MORSCHHAUSER, R. HOUOT, C. THIEBLEMONT, E. BACHY CHU LYON SUD, LYON; Hematology, Assistance Publique Hôpitaux de Paris; Hematology, INSTITUT CURIE, PARIS; HEMATOLOGY, Département d’Hématologie clinique, CHU de Montpellier, MONTPELLIER; CHU de Rennes, RENNES; Hématologie clinique, CHU de Lille, LILLE; Lymphoid Malignancies, CRETEIL; Hématologie Clinique et Thérapie cellulaire, MERIGNAC; APHP la Pitié Salpêtriere, PARIS; Hematology Laboratory, Onco-occitanie Network, TOULOUSE; Service Hématologie, NANCY; Department of Hematology, DIJON; Department of Hematology, Clermont-Ferrand University Hospital, CLEMRONT FERRAND; Hôpital St Antoine, PARIS; Hematology department, CHU Amiens, AMIENS; CHU DE LIMOGES - HOPITAL DUPUYTREN, LIMOGES; GUSTAVE ROUSSY CANCER CAMPUS GRAND PARIS, VILLEJUIF; CHU NICE, NICE; CHU DE GRENOBLE, GRENOBLE; CHU JEAN MINJOZ, BESANCON; CHU BRETONNEAU, TOURS; APHP HOPITAL COCHIN; APHP HOPITAL NECKER, PARIS; CHU DE POITIERS - HOPITAL DE LA MILETRIE, POITIERS; Nantes University Hospital Clinical Hematology, NANTES; Hematology Department, Montpellier University Hospital, Univ Montpellier, MONTPELLIER; biostatistics; LYSARC, LYON; Maladies du Sang CHRU Lille, LILLE; CHU de Rennes, Université de Rennes, INSERM U1236, EFS, RENNES; Saint Louis Hospital, PARIS, France Background: Cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) are common immune-related toxicities associated with chimeric antigen receptor (CAR)–T-cell therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	Additionally, RIP assay confirmed that YTHDF2 binds to TRPM3 mRNA (Fig. 7H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "RIP", "assay", "confirmed", "that", "Y...
PMC11750165	Transient transfections were performed using FuGENE6 transfection reagent (Roche, Basel, Switzerland).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transient", "transfections", "were", "performed", "using", "FuGEN...
PMC11474209	It is widely recognized that mitochondria are MCs' most susceptible target organelles because the mitochondria regulate the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS), which is notably comprised of five multi-protein complexes and are responsible for energy production .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	The membrane topology of VKORC1 was determined only by analogy to the bacterial protein from Synechococcus sp. The spatial electron transport chain to cysteine residues in the VKORC1 active site has not been described yet, as opposed to its homolog, VKORC1L1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11049548	Moreover, our method can be used to test other OV cell lines, in order to find the most appropriate in vitro model for metabolic studies of HGS tumours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739696	After incubation, the cell-dye mixture was placed on a clean slide and analyzed under an epi-fluorescent microscope at 200× magnification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "inc...
PMC9895440	2SNX9 is a potential mediator of T cell exhaustion.a Schematic description of the targeted-pooled CRISPR-Cas9 KO screen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2SNX9", "is", "a", "potential", "mediator", ...
PMC11680049	The explants were cultivated on a nutrient medium containing mineral salts according to the Murashige and Skoog (MS) formulation or Woody Plant Medium (WPM), supplemented with growth regulators at various concentrations—2,4-dichlorophenoxyacetic acid (2,4-D) (Merck, Darmstadt, Germany) at a concentration of 2.5 mg/L combined with 6-benzylaminopurine (BAP) (Merck, Darmstadt, Germany) at 2.5 mg/L, 2% sucrose, and 0.7% agar.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	A precipitate (JC-2) was isolated from one of the combined fractions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "precipitate", "(", "JC-2", ")", "was", "isolated", "from", "one"...
PMC7192625	Since ChAseR offers the possibility to calculate the combined correlation of two features, we decided to use the cross-ChAs and AND-ChAs options to evaluate ChAs of all the possible combinations of epigenomic marks included in this dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	The slices were washed three times in PBS for 10 min each and then incubated for 1 h at room temperature with fluorescein (FITC)-conjugated Affinipure goat anti-Rabbit secondary antibody (1:500, Cat# SA00003-2, RRID:AB_2890897; Proteintech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659734	In this study, the cytotoxicity and genotoxicity of BPA, BPE and BPP were assessed using the comet assay in HepG2 cell cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "token...
PMC11682525	Hence, in this study, we investigated the impact of hypoxic preconditioning on the survival and resilience of these two distinct human cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10898159	This is followed by asymmetric arrangements of the cytoplasmic region of the KIT dimers associated to trans-autophosphorylation and final kinase activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "fol...
PMC9250505	However, the low response of platinum-resistant EOC, the emergence of resistance in BRCA-deficient cancer, and therapy-associated toxicities in patients limit the clinical utility of PARPis in recurrent EOC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Interestingly, the proportion of FC+ patients in our cohort is comparable to (24% vs 25%), showing that although in our method we lose fewer cells, we identify the same proportion of FC+ patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	Despite this, it’s debated whether BTZ therapy necessitates avoiding polyphenol-rich products, given the low bioavailability of polyphenols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "this", ",", ...
PMC8345486	PI incorporation without annexin binding indicated rapid cell death due to acute cytotoxicity of the compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI", "incorporation", "without", "annexin", "binding", ...
PMC11507371	Additionally, p65 is also able to directly interact with Keap1 to repress Nrf2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "p65", "is", "also", "able", "to", "directly...
PMC9429973	Methods: A retrospective study was carried out, in patients aged between 18 and 65 years old, with hematological onco diseases who went to the Blood Bank of the National Cancer Institute for the collection of HPCs from peripheral blood by apheresis for ASCT, between January 2017 and December 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678841	The quantification of bands was performed with a ChemiDoc Imaging System, Bio-Rad, and protein levels were normalized against housekeeping proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quant...
PMC11767793	For the DLS, ZP, and TEM measurements; stability test; and in vitro study, the final concentration of the AuNPs@NISTs in suspension, referred to here as the ‘test suspension’, should be around 50 µg/mL and diluted by appropriate media, such as DIW or physiological media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	For the preliminary combinatorial study, 5637 cells were seeded in 96-well plates at a density of 15 × 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "preli...
PMC9473868	In this study, we found that BAI enhanced the apoptosis of SW982 cells while inhibited the proliferation of SW982 cells, which might provide a new basis for the treatment of RA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11703992	TNF Receptor Superfamily Member 1A (TNFRSF1A) activates the NF-κB, mitogen-activated protein kinase (MAPK), and other inflammation-related pathways to promote inflammation, while Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) and C–C Motif Chemokine Receptor 4 (CCR4) regulate the overstimulated T cells and inhibit the immune response during inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Even in the Rituximab era, patients continue to experience relapse and refractory disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Even", "in", "the", "Rituxi...
PMC10812665	Accordingly, our analysis clearly identified several important up-regulated ATF4 target genes (MTHFD2, PSAT1 and SLC7AC) and also transcripts known to be under a strong control by NRF2 (ABCC4, ME1 and NQO1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792740	Additionally, tumor cells can deplete tryptophan through the expression of IDO, affecting T-cell proliferation and differentiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "tumor", "cells", ...
PMC5025404	Neutralizing activities of adalimumab against human TNF-α were measured on the mouse WEHI 164 cell line treated with actinomycin D according to the method described previously (Austgulen et al. 1986; Khabar et al. 1995).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9424261	Liver cancer cells that knockout HERPUD1 produced less lipid reactive oxygen species and cell death after treatment with the CA or ferroptosis inducers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Liver",...
PMC9429973	Methods: Following pilots with the Withings Steel HR and VitalPatch (Table 1.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Following", "pilots", "with", "the", ...
PMC11473750	h–j Comparison of RNF121 mRNA expression levels for patients subdivided by either the age at diagnosis (<18 months or >18 months), disease stage (INSS stage 1,2,3,4s vs stage 4) or MYCN amplification status (MYCN non-amplified vs amplified) in the Kocak dataset (n = 649).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	It is a robust cell line that can be grown in suspension culture, enabling large-scale production, and tolerates changes in environmental factors like pH and temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	A pyroassay was designed using the PyroMark Q48 Autoprep software (Qiagen) to analyse the DNA methylation percentage for each CpG site covered by the primers and an in-assay bisulfite conversion technical control was incorporated according to the manufacturer’s recommendations to ensure efficient conversion of all CpG sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	The reaction takes place in the lumen of the endoplasmic reticulum and precedes proprotein translocation to the Golgi compartment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "takes", "place...
PMC11240448	For each cell line-specific model, this was achieved by minimizing the sum of squares of the differences between the experimental and simulated data points using the Differential Evolution algorithm provided by SciPy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7961460	8701-BC epithelial cells derive from a primary ductal infiltrating carcinoma (DIC) of human breast.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "8701-BC", "epithelial", "cells", "derive", "from", ...
PMC2944824	The protein concentration was determined by Bradford assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "concentration", "was", "determined", "by", "Bradford", "assay", "." ] } ]
PMC11707577	A 96‐multiwell plate was loaded with 96 µL of each solution and mixed with 4 µL of ABMDMA stock solution (5 mM in DMSO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10772747	During the analysis of potential target genes, we identified 156 pathways related to cancer, immune system, inflammation, and metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During"...
PMC11588085	Our study showed that ovarian cancer cells with XIST KD were more plastic and adapted to hypoxic conditions more easily.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "showed", ...
PMC10998613	This is due in part to the inherent challenges of demonstrating the presence of those receptor complexes in physiologically relevant cellular context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is",...
PMC11240571	Furthermore, irradiation to control mice increased exosomal PD-L1 derived from normal cells, and irradiation to tumor-bearing mice enhanced exosomal PD-L1 release derived from normal cells of mice and implanted tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Management strategies include von Willebrand factor concentrates either as on-demand treatment (ODT) of bleeds or long-term prophylaxis (LTP) to prevent bleeds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9503669	Combining Nef inhibitors with latency reversal agents and therapeutic vaccines may provide a path to clearance of viral reservoirs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combining", "Nef", "inhibitors", ...
PMC10243817	The iRIP clusters represent predicted binding sites in all potential target RNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "iRIP", "clusters", "represent", "predicted", "binding", "sites", "in", "a...
PMC11064533	yggT has been implicated in antibiotic resistance in Salmonella enterica, where yggT-deleted D14 mutant showed a decrease in streptomycin resistance (fourfold).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11767793	Only one type of Au-PEG-COOH was obtained from C1 for this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "one", "type", "of", "Au-PEG-COOH", "was", "obtained", "from", "C1", ...
PMC11252553	Flow cytometry analysis can identify different cell populations, such as live, early-apoptotic, late-apoptotic, and necrotic lymphocytes, by analyzing the staining patterns and their location in the quadrants of Annexin V and PI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5035325	Here, we described for the first time, a positive staining of NeuGcGM3 expression in lung metastasis induced by 4T1-cells, as second model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ],...
PMC11519567	Meanwhile, SS18-SSX (AR Mut) no longer promotes cell proliferation compared to wild-type SS18-SSX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "SS18-SSX", "(", "AR", "Mut", "...
PMC11806613	Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10443665	CCRF-CEM and CCRF-CEM/MTX were maintained in RPMI-1640 medium supplemented with 10% FBS.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCRF-CEM", "and", "CCRF-CEM/MTX", "were", "maintained", "in", "...
PMC10849234	To determine which promyelocytic cell line could differentiate into NLCs with greater degranulation activity, we differentiated HL-60 and PLB-985 cells into NLCs using traditional methods .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11530949	The present study demonstrated that the biosynthesized Ag-doped CuO NPs using Ephedra intermedia extract exhibit significant anticancer effects on the HepG2 liver cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "token...
PMC11544771	Cells treated with vehicle alone were used as a control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "treated", "with", "vehicle", "alone", "were", "used", "as", "a", "control", "." ...
PMC11543935	B: Temperature curve measured in the center of a hydrogel with a fiber optic temperature sensor during treatment with the IGEA GeneDrive at E = 1000 V/cm with 25 cycles of 8 pulses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556	ND = not determined.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ND", "=", "not", "determined", "." ] } ]
PMC11429241	Similarly, the A2780 cell line migrated towards the printed scaffolds, though these cells formed looser 3D structures.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "the", ...
PMC5311252	Fixed modifications were TMT-10plex on lysines and N-termini, and carbamidomethylation on cysteine residues, a variable modification was used for oxidation on methionine residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6901583	For the activation of M1 macrophages in vitro, 2 × 10 cells/l of the isolated cells (as described above) were treated for 1 day with 25 μg/ml LPS (lipopolysaccharide; Sigma) to the above-isolated cells, while for the activation of M2-polarized macrophages, 45 ng/ml recombinant human interleukin-4 (IL-4, R&D) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Collect the remaining cells in the culture plate by adding 100 μL of 1X PBS to each well of the culture plate, mix thoroughly, and transferring to the staining plate or FACS tubes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556	Representative membranes.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Representative", "membranes", "." ] } ]
PMC9429973	Aims: We aimed to assess the risk of thrombotic and bleeding events in patients with ALL treated with PEG-Asp and compare the treatment modalities with either AT3 + fibrinogen repletion vs the addition of prophylactic anticoagulation (AC) with either subcutaneous heparin 5000 TID or subcutaneous lovenox 30-40mg/day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	The univariate Cox regression was performed to assess the prognostic value of hub HRGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "univariate", "Cox", "regression", "was", "performed", "to", ...

PMC11767725

SD is a chronic inflammatory skin disorder that affects 1–3% of the population.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SD", "is", "a", "chronic", "inflammatory", "skin", "disorder", "...

PMC8751435

On the contrast, inhibitory effect of CME is reversed in present of AC‐Dc 270pM, and this reversion is more significant in the high concentration of CME (600 and 800 μg/ml).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11298021

Furthermore, it was found that miR-3143, miR-3182, and rapamycin significantly induced G1/sub G1 arrest (* P<0.05).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", ...

PMC10213179

The next day, cells were washed, incubated with the secondary antibody, and finally mounted using ProlongGold antifade reagent with DAPI (Invitrogen, no. P36935).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7812570

Fig. 3Inhibitory activity of GPI-anchored antibodies during cell–cell HIV-1 transmission.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Inhibitory", "activity", "of", "GPI-anchored", "antibodies", "during", "cell"...

PMC9429973

Mutations in the SF3B1 and ATM genes were significantly more common in IGLV3-21 patients, compared to other patients (SF3B1: 49% vs. 21%, P=0.0008; ATM: 36% vs. 18%, P=0.02).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8992508

These compounds stimulated the ATPase activity of BCRP at nanomolar concentrations and inhibited the photolabeling of BCRP with iodoarylazidoprazosin, suggesting that they are able to inhibit the function of BCRP by directly interacting at the substrate-binding site.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11365427

RNA and protein expression were validated 72 h after transfection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "and", "protein", "expression", "were", "validated", "72", "h", "after", "transfection", ...

PMC3164356

This result suggests that many other unexpressed glycosylation genes in the CHO genome can be potentially activated or silenced to alter the repertoire of glycan structures from CHO cells (Fig. 5a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9621239

The siRNA (10 pmol) of MYC or the control was transfected into Huh 7 cells and Bel-7404 cells in a 6-well dish, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O"...

PMC7762347

Among the most studied cyanotoxins are MCLR and CYN that frequently occur in cyanobacterial blooms simultaneously .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "most", "studied", "cyanotoxins", "are"...

PMC7192625

It is in fact interesting to observe the difference between these cross-ChAs values in the two separate PP and PO subnetworks and to consider the values obtained by distance-preserving randomizations (Supplementary Figure S6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10713411

Clinical model construction based on PRPCDGs risk signature in E-MTAB-1980 and TCGA-KIRP datasets. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "model", "construction", "based", "on", "PRPCDGs", "risk", ...

PMC11489275

A, B The survival rate of patients within one month in different lymphocyte groups was obtained by log-rank test.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "B", "The", ...

PMC11683240

Here, we searched for novel PT-inhibitors in the human peptidome.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "searched", "for", "novel", "PT-inhibitors", "in", "the", "human", ...

PMC9429973

Results: A total of 41 pts were included in the analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "A", "total", "of", "41", "pts", "were", "included", "in", ...

PMC6222726

It is also used as incense .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "also", "used", "as", "incense", "." ] } ]

PMC11802855

In the CXCL7-OE group, a significant upregulation of the JAK/STAT3 pathway, MMP13, C-myc and CXCR2 was observed (E); while in the CXCL7-KD group, a notable downregulation was witnessed (F).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11252553

The samples were irradiated at room temperature with doses of 4, 8, and 12 Gy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "irradiated", "at", ...

PMC11371627

However, thorough work-up revealed longer-standing changes including neuropathy, muscle atrophy with fatty involution and raised CK, indicating longer-standing neuropathy and myopathy most likely due to the underlying genetic defect in the XK gene.

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PMC10391797

To further track tumour-infiltrating immunophenotypes, the cancer–immunity cycle seven steps/immune cell infiltration in patients with AML was evaluated by the TIP method.

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PMC11321678

We found that clusters C6‐C9 had higher accessibility of motifs for SPI1, SPIB, JUN family, and FOS family transcription factors, which are involved in myeloid or lymphoid cell development (Figure S1E, Supporting Information).

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PMC11126803

By regulating the expression of ERβ in different ccRCC cell lines, we found that the change of ZEB1 is directly related to ERβ (Fig. 4A), which indicates that ERβ is likely to affect the VM formation in RCC through ZEB1.

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PMC11607764

Mutation site; (B) Mutation type.

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PMC2777936

Also, human ES cells may respond differently than human EC cells.

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PMC11699178

All RNA samples were extracted from cells and tissues using a lysis buffer (Vazyme, R401-01).

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PMC11490153

SPSS software version 22 (IBM Corp., Armonk, USA) was used for this analysis.

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PMC5673955

Time‐dependent and (F) dose‐dependent changes of hTERT protein amounts measured by western blotting. (

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PMC11596967

Among these, four potential peptides, named Ddes-P1 to Ddes-P4, were selected, located in the 5′-UTRs of Deide_10410, Deide_11090, Deide_19720, and Deide_23310, respectively (Table 1).

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PMC11085211

Moreover, given that secondary mutations in both KIT or PDGFRα have been found in imatinib-resistant GISTs, multi-target TKIs, such as sunitinib, regorafenib, and ripretinib, are administered as further treatment lines after the onset of resistance .

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PMC11350568

Reports suggest that the transport of iron ions is initiated by the endocytosis of the TfR1-transferrin complex, entering the endosome through receptor-mediated internalization pathways, then fusing with lysosomes to release iron ions in acidic conditions.

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PMC9813422

CFP1 binds to CGIs and recruits the methyltransferase SET1 responsible for H3K4me3 deposition.

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PMC11679033

From Figure 7 it can be seen that lymphocyte proliferation was highly disturbed in the positive control, where the most of cells were mononucleated and binucleated.

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PMC11675244

Peptides that target the Dvl-binding domain of Fzd-7 have also induced apoptosis selectively and promoted β-catenin degradation in HCC .

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PMC9429973

P. SESQUES, R. DI BLASI, S. LE GOUILL, G. CARTRON, G. MANSON, D. BEAUVAIS, F. LE BRAS, F. X. GROS, S. CHOQUET, P. BORIES, M. T. RUBIO, R. O. CASASNOVAS, L. BOUNAIX, M. MOHTY, M. JORIS, J. ABRAHAM, C. CASTILLA LLORENTE, M. LOSCHI, S. CARRAS, A. CHAUCHET, L. DRIEU LA ROCHELLE, J. ZERBIT, O. HERMINE, S. GUIDEZ, T. GASTINNE, J. J. TUDESQ, P. FOGARTY, F. BROUSSAIS, F. MORSCHHAUSER, R. HOUOT, C. THIEBLEMONT, E. BACHY CHU LYON SUD, LYON; Hematology, Assistance Publique Hôpitaux de Paris; Hematology, INSTITUT CURIE, PARIS; HEMATOLOGY, Département d’Hématologie clinique, CHU de Montpellier, MONTPELLIER; CHU de Rennes, RENNES; Hématologie clinique, CHU de Lille, LILLE; Lymphoid Malignancies, CRETEIL; Hématologie Clinique et Thérapie cellulaire, MERIGNAC; APHP la Pitié Salpêtriere, PARIS; Hematology Laboratory, Onco-occitanie Network, TOULOUSE; Service Hématologie, NANCY; Department of Hematology, DIJON; Department of Hematology, Clermont-Ferrand University Hospital, CLEMRONT FERRAND; Hôpital St Antoine, PARIS; Hematology department, CHU Amiens, AMIENS; CHU DE LIMOGES - HOPITAL DUPUYTREN, LIMOGES; GUSTAVE ROUSSY CANCER CAMPUS GRAND PARIS, VILLEJUIF; CHU NICE, NICE; CHU DE GRENOBLE, GRENOBLE; CHU JEAN MINJOZ, BESANCON; CHU BRETONNEAU, TOURS; APHP HOPITAL COCHIN; APHP HOPITAL NECKER, PARIS; CHU DE POITIERS - HOPITAL DE LA MILETRIE, POITIERS; Nantes University Hospital Clinical Hematology, NANTES; Hematology Department, Montpellier University Hospital, Univ Montpellier, MONTPELLIER; biostatistics; LYSARC, LYON; Maladies du Sang CHRU Lille, LILLE; CHU de Rennes, Université de Rennes, INSERM U1236, EFS, RENNES; Saint Louis Hospital, PARIS, France Background: Cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) are common immune-related toxicities associated with chimeric antigen receptor (CAR)–T-cell therapy.

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PMC11763126

Additionally, RIP assay confirmed that YTHDF2 binds to TRPM3 mRNA (Fig. 7H).

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PMC11750165

Transient transfections were performed using FuGENE6 transfection reagent (Roche, Basel, Switzerland).

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PMC11474209

It is widely recognized that mitochondria are MCs' most susceptible target organelles because the mitochondria regulate the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS), which is notably comprised of five multi-protein complexes and are responsible for energy production .

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PMC5916734

The membrane topology of VKORC1 was determined only by analogy to the bacterial protein from Synechococcus sp. The spatial electron transport chain to cysteine residues in the VKORC1 active site has not been described yet, as opposed to its homolog, VKORC1L1 .

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PMC11049548

Moreover, our method can be used to test other OV cell lines, in order to find the most appropriate in vitro model for metabolic studies of HGS tumours.

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PMC11739696

After incubation, the cell-dye mixture was placed on a clean slide and analyzed under an epi-fluorescent microscope at 200× magnification.

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PMC9895440

2SNX9 is a potential mediator of T cell exhaustion.a Schematic description of the targeted-pooled CRISPR-Cas9 KO screen.

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PMC11680049

The explants were cultivated on a nutrient medium containing mineral salts according to the Murashige and Skoog (MS) formulation or Woody Plant Medium (WPM), supplemented with growth regulators at various concentrations—2,4-dichlorophenoxyacetic acid (2,4-D) (Merck, Darmstadt, Germany) at a concentration of 2.5 mg/L combined with 6-benzylaminopurine (BAP) (Merck, Darmstadt, Germany) at 2.5 mg/L, 2% sucrose, and 0.7% agar.

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PMC11551844

A precipitate (JC-2) was isolated from one of the combined fractions.

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PMC7192625

Since ChAseR offers the possibility to calculate the combined correlation of two features, we decided to use the cross-ChAs and AND-ChAs options to evaluate ChAs of all the possible combinations of epigenomic marks included in this dataset.

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PMC11194678

The slices were washed three times in PBS for 10 min each and then incubated for 1 h at room temperature with fluorescein (FITC)-conjugated Affinipure goat anti-Rabbit secondary antibody (1:500, Cat# SA00003-2, RRID:AB_2890897; Proteintech).

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PMC11659734

In this study, the cytotoxicity and genotoxicity of BPA, BPE and BPP were assessed using the comet assay in HepG2 cell cultures.

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PMC11682525

Hence, in this study, we investigated the impact of hypoxic preconditioning on the survival and resilience of these two distinct human cell types.

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PMC10898159

This is followed by asymmetric arrangements of the cytoplasmic region of the KIT dimers associated to trans-autophosphorylation and final kinase activation .

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PMC9250505

However, the low response of platinum-resistant EOC, the emergence of resistance in BRCA-deficient cancer, and therapy-associated toxicities in patients limit the clinical utility of PARPis in recurrent EOC.

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PMC9429973

Interestingly, the proportion of FC+ patients in our cohort is comparable to (24% vs 25%), showing that although in our method we lose fewer cells, we identify the same proportion of FC+ patients.

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PMC11306019

Despite this, it’s debated whether BTZ therapy necessitates avoiding polyphenol-rich products, given the low bioavailability of polyphenols.

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PMC8345486

PI incorporation without annexin binding indicated rapid cell death due to acute cytotoxicity of the compounds.

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PMC11507371

Additionally, p65 is also able to directly interact with Keap1 to repress Nrf2 .

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PMC9429973

Methods: A retrospective study was carried out, in patients aged between 18 and 65 years old, with hematological onco diseases who went to the Blood Bank of the National Cancer Institute for the collection of HPCs from peripheral blood by apheresis for ASCT, between January 2017 and December 2020.

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PMC11678841

The quantification of bands was performed with a ChemiDoc Imaging System, Bio-Rad, and protein levels were normalized against housekeeping proteins.

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PMC11767793

For the DLS, ZP, and TEM measurements; stability test; and in vitro study, the final concentration of the AuNPs@NISTs in suspension, referred to here as the ‘test suspension’, should be around 50 µg/mL and diluted by appropriate media, such as DIW or physiological media.

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PMC11767817

For the preliminary combinatorial study, 5637 cells were seeded in 96-well plates at a density of 15 × 10.

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PMC9473868

In this study, we found that BAI enhanced the apoptosis of SW982 cells while inhibited the proliferation of SW982 cells, which might provide a new basis for the treatment of RA.

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PMC11703992

TNF Receptor Superfamily Member 1A (TNFRSF1A) activates the NF-κB, mitogen-activated protein kinase (MAPK), and other inflammation-related pathways to promote inflammation, while Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) and C–C Motif Chemokine Receptor 4 (CCR4) regulate the overstimulated T cells and inhibit the immune response during inflammation.

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PMC9429973

Summary/Conclusion: Even in the Rituximab era, patients continue to experience relapse and refractory disease.

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PMC10812665

Accordingly, our analysis clearly identified several important up-regulated ATF4 target genes (MTHFD2, PSAT1 and SLC7AC) and also transcripts known to be under a strong control by NRF2 (ABCC4, ME1 and NQO1).

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PMC11792740

Additionally, tumor cells can deplete tryptophan through the expression of IDO, affecting T-cell proliferation and differentiation .

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PMC5025404

Neutralizing activities of adalimumab against human TNF-α were measured on the mouse WEHI 164 cell line treated with actinomycin D according to the method described previously (Austgulen et al. 1986; Khabar et al. 1995).

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PMC9424261

Liver cancer cells that knockout HERPUD1 produced less lipid reactive oxygen species and cell death after treatment with the CA or ferroptosis inducers.

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PMC9429973

Methods: Following pilots with the Withings Steel HR and VitalPatch (Table 1.),

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PMC11473750

h–j Comparison of RNF121 mRNA expression levels for patients subdivided by either the age at diagnosis (<18 months or >18 months), disease stage (INSS stage 1,2,3,4s vs stage 4) or MYCN amplification status (MYCN non-amplified vs amplified) in the Kocak dataset (n = 649).

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PMC10237474

It is a robust cell line that can be grown in suspension culture, enabling large-scale production, and tolerates changes in environmental factors like pH and temperature.

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PMC11650848

A pyroassay was designed using the PyroMark Q48 Autoprep software (Qiagen) to analyse the DNA methylation percentage for each CpG site covered by the primers and an in-assay bisulfite conversion technical control was incorporated according to the manufacturer’s recommendations to ensure efficient conversion of all CpG sites.

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PMC5916734

The reaction takes place in the lumen of the endoplasmic reticulum and precedes proprotein translocation to the Golgi compartment.

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PMC11240448

For each cell line-specific model, this was achieved by minimizing the sum of squares of the differences between the experimental and simulated data points using the Differential Evolution algorithm provided by SciPy .

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PMC7961460

8701-BC epithelial cells derive from a primary ductal infiltrating carcinoma (DIC) of human breast.

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PMC2944824

The protein concentration was determined by Bradford assay.

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PMC11707577

A 96‐multiwell plate was loaded with 96 µL of each solution and mixed with 4 µL of ABMDMA stock solution (5 mM in DMSO).

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PMC10772747

During the analysis of potential target genes, we identified 156 pathways related to cancer, immune system, inflammation, and metabolism.

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PMC11588085

Our study showed that ovarian cancer cells with XIST KD were more plastic and adapted to hypoxic conditions more easily.

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PMC10998613

This is due in part to the inherent challenges of demonstrating the presence of those receptor complexes in physiologically relevant cellular context.

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PMC11240571

Furthermore, irradiation to control mice increased exosomal PD-L1 derived from normal cells, and irradiation to tumor-bearing mice enhanced exosomal PD-L1 release derived from normal cells of mice and implanted tumor cells.

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PMC9429973

Management strategies include von Willebrand factor concentrates either as on-demand treatment (ODT) of bleeds or long-term prophylaxis (LTP) to prevent bleeds.

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PMC9503669

Combining Nef inhibitors with latency reversal agents and therapeutic vaccines may provide a path to clearance of viral reservoirs.

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PMC10243817

The iRIP clusters represent predicted binding sites in all potential target RNAs.

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PMC11064533

yggT has been implicated in antibiotic resistance in Salmonella enterica, where yggT-deleted D14 mutant showed a decrease in streptomycin resistance (fourfold).

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PMC11767793

Only one type of Au-PEG-COOH was obtained from C1 for this study.

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PMC11252553

Flow cytometry analysis can identify different cell populations, such as live, early-apoptotic, late-apoptotic, and necrotic lymphocytes, by analyzing the staining patterns and their location in the quadrants of Annexin V and PI.

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PMC5035325

Here, we described for the first time, a positive staining of NeuGcGM3 expression in lung metastasis induced by 4T1-cells, as second model.

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PMC11519567

Meanwhile, SS18-SSX (AR Mut) no longer promotes cell proliferation compared to wild-type SS18-SSX.

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PMC11806613

Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment.

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PMC10443665

CCRF-CEM and CCRF-CEM/MTX were maintained in RPMI-1640 medium supplemented with 10% FBS.

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PMC10849234

To determine which promyelocytic cell line could differentiate into NLCs with greater degranulation activity, we differentiated HL-60 and PLB-985 cells into NLCs using traditional methods .

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PMC11530949

The present study demonstrated that the biosynthesized Ag-doped CuO NPs using Ephedra intermedia extract exhibit significant anticancer effects on the HepG2 liver cancer cells.

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PMC11544771

Cells treated with vehicle alone were used as a control.

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PMC11543935

B: Temperature curve measured in the center of a hydrogel with a fiber optic temperature sensor during treatment with the IGEA GeneDrive at E = 1000 V/cm with 25 cycles of 8 pulses.

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PMC10291556

ND = not determined.

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PMC11429241

Similarly, the A2780 cell line migrated towards the printed scaffolds, though these cells formed looser 3D structures.

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PMC5311252

Fixed modifications were TMT-10plex on lysines and N-termini, and carbamidomethylation on cysteine residues, a variable modification was used for oxidation on methionine residues.

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PMC6901583

For the activation of M1 macrophages in vitro, 2 × 10 cells/l of the isolated cells (as described above) were treated for 1 day with 25 μg/ml LPS (lipopolysaccharide; Sigma) to the above-isolated cells, while for the activation of M2-polarized macrophages, 45 ng/ml recombinant human interleukin-4 (IL-4, R&D) was used.

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PMC11758416

Collect the remaining cells in the culture plate by adding 100 μL of 1X PBS to each well of the culture plate, mix thoroughly, and transferring to the staining plate or FACS tubes.

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PMC10291556

Representative membranes.

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PMC9429973

Aims: We aimed to assess the risk of thrombotic and bleeding events in patients with ALL treated with PEG-Asp and compare the treatment modalities with either AT3 + fibrinogen repletion vs the addition of prophylactic anticoagulation (AC) with either subcutaneous heparin 5000 TID or subcutaneous lovenox 30-40mg/day.

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PMC10873328

The univariate Cox regression was performed to assess the prognostic value of hub HRGs.

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