OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11470381	A pivotal investigation conducted by our team discovered the crucial role of Piezo1 in driving optimal human T-lymphocyte activation in response to T-cell receptor (TCR) triggering .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "pivotal", "investigation", "conducted", "by", "our", "team", "discovered", "the", "crucial", "role", "of", "Piezo1", "in", "driving", "optimal", "human", "T-lymphocyte", "activation", "in", "response", "to", "T-cell", "receptor", "(", "TCR", ")", "triggering", "." ] } ]
PMC11344246	The effect of this inhibitor in organoids was less striking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "this", "inhibitor", "in", "organoids", "was", "less", "striking", "." ] } ]
PMC11285179	However, the detailed molecular mechanism of this phenomenon is still obscure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "detailed", "molecular", "mechanism", "of", "this", "phenomenon", "is", "still", "obscure", "." ] } ]
PMC9927933	Given that DEPTOR plays an important role in regulation of various biological processes, including proliferation, autophagy, metabolism, and immunity (34, 44), it is very likely that DEPTOR levels could be regulated by additional E3 ligase(s).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "that", "DEPTOR", "plays", "an", "important", "role", "in", "regulation", "of", "various", "biological", "processes", ",", "including", "proliferation", ",", "autophagy", ",", "metabolism", ",", "and", "immunity", "(", "34", ",", "44", ")", ",", "it", "is", "very", "likely", "that", "DEPTOR", "levels", "could", "be", "regulated", "by", "additional", "E3", "ligase(s", ")", "." ] } ]
PMC11437637	Therefore, PBL levels could be used to monitor patient immune function and predict disease development, and this may also be a good entry point for therapeutic targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "PBL", "levels", "could", "be", "used", "to", "monitor", "patient", "immune", "function", "and", "predict", "disease", "development", ",", "and", "this", "may", "also", "be", "a", "good", "entry", "point", "for", "therapeutic", "targets", "." ] } ]
PMC7762347	Stock solutions of CYN (0.5 µg/mL) and MCLR (1 µg/mL) were prepared in 50% methanol and pure ethanol (99.8%), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stock", "solutions", "of", "CYN", "(", "0.5", "µg/mL", ")", "and", "MCLR", "(", "1", "µg/mL", ")", "were", "prepared", "in", "50", "%", "methanol", "and", "pure", "ethanol", "(", "99.8", "%", ")", ",", "respectively", "." ] } ]
PMC7841189	Experiments were performed in triplicate. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "performed", "in", "triplicate", ".", "*" ] } ]
PMC11365427	Through molecular docking simulations, we assessed the binding capacity of phenylalanine to VAPB (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "molecular", "docking", "simulations", ",", "we", "assessed", "the", "binding", "capacity", "of", "phenylalanine", "to", "VAPB", "(", "Fig.", "5E", ")", "." ] } ]
PMC11763111	G The left diagram shows the ratio of CAR-T cells number compared to the initial CAR-T cells number following a 48-h reaction period, as assessed by flow cytometry counting (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "The", "left", "diagram", "shows", "the", "ratio", "of", "CAR-T", "cells", "number", "compared", "to", "the", "initial", "CAR-T", "cells", "number", "following", "a", "48-h", "reaction", "period", ",", "as", "assessed", "by", "flow", "cytometry", "counting", "(", "n", "=", "3", ")", "." ] } ]
PMC6892818	Cells treated with DMSO alone (vehicle controls) were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "treated", "with", "DMSO", "alone", "(", "vehicle", "controls", ")", "were", "included", "." ] } ]
PMC10891340	The scale bar is 30 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "is", "30", "μm", ".", "(" ] } ]
PMC11441402	Figure 5 depicts the same data as Figure 4, however, only the endpoint data is considered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "5", "depicts", "the", "same", "data", "as", "Figure", "4", ",", "however", ",", "only", "the", "endpoint", "data", "is", "considered", "." ] } ]
PMC6190245	Fetal bovine serum (FBS) and penicillin/streptomycin were bought from Gibco (Grand Island, NY).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fetal", "bovine", "serum", "(", "FBS", ")", "and", "penicillin/streptomycin", "were", "bought", "from", "Gibco", "(", "Grand", "Island", ",", "NY", ")", "." ] } ]
PMC11049294	The GLA KO cell line was generated via CRISPR-Cas9-based transfection, validated with exome sequencing, gene expression and substrate accumulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GLA", "KO", "cell", "line", "was", "generated", "via", "CRISPR-Cas9-based", "transfection", ",", "validated", "with", "exome", "sequencing", ",", "gene", "expression", "and", "substrate", "accumulation", "." ] } ]
PMC10329074	The result was consistent with scratch assay experiments that the numbers of cells that traversed the Transwell were significantly reduced by YBX3 knockdown in the A498 cells (Fig. 6A-B, ***P < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "result", "was", "consistent", "with", "scratch", "assay", "experiments", "that", "the", "numbers", "of", "cells", "that", "traversed", "the", "Transwell", "were", "significantly", "reduced", "by", "YBX3", "knockdown", "in", "the", "A498", "cells", "(", "Fig.", "6A-B", ",", "", "", "*", "P", "<", "0.001", ")", "." ] } ]
PMC11489175	Deregulated USP28 expression is linked to the activation of β-catenin signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deregulated", "USP28", "expression", "is", "linked", "to", "the", "activation", "of", "β-catenin", "signaling", "pathway", "." ] } ]
PMC11538390	To prioritize these SNPs for possible regulatory variants, we examined their position relative to chromatin marks shown to correlate with active enhancer function including: (i) ATAC-seq peaks, which reveal open chromatin, from the HIOEC oral epithelial cells and the HEPM oral mesenchymal cells, (ii) H3K27Ac peaks, revealing active enhancers and promoters, from the HIOEC cells, and (iii) aggregate chromatin modification marks from 9 principal cell types from the ENCODE project and from human embryonic facial enhancers datasets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "prioritize", "these", "SNPs", "for", "possible", "regulatory", "variants", ",", "we", "examined", "their", "position", "relative", "to", "chromatin", "marks", "shown", "to", "correlate", "with", "active", "enhancer", "function", "including", ":", "(", "i", ")", "ATAC-seq", "peaks", ",", "which", "reveal", "open", "chromatin", ",", "from", "the", "HIOEC", "oral", "epithelial", "cells", "and", "the", "HEPM", "oral", "mesenchymal", "cells", ",", "(", "ii", ")", "H3K27Ac", "peaks", ",", "revealing", "active", "enhancers", "and", "promoters", ",", "from", "the", "HIOEC", "cells", ",", "and", "(", "iii", ")", "aggregate", "chromatin", "modification", "marks", "from", "9", "principal", "cell", "types", "from", "the", "ENCODE", "project", "and", "from", "human", "embryonic", "facial", "enhancers", "datasets", "." ] } ]
PMC8759873	A variety of molecular-targeted therapeutic drugs have come out in succession .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "variety", "of", "molecular-targeted", "therapeutic", "drugs", "have", "come", "out", "in", "succession", "." ] } ]
PMC10656496	Normalized read counts were obtained via calculating library size factors and scaling raw read counts using the Bioconductor R package DESeq2 v.1.6.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normalized", "read", "counts", "were", "obtained", "via", "calculating", "library", "size", "factors", "and", "scaling", "raw", "read", "counts", "using", "the", "Bioconductor", "R", "package", "DESeq2", "v.1.6.3", "." ] } ]
PMC11718274	Advances in therapies, including novel approaches like nano-therapy, are enhancing treatment outcomes and providing new options for patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Advances", "in", "therapies", ",", "including", "novel", "approaches", "like", "nano-therapy", ",", "are", "enhancing", "treatment", "outcomes", "and", "providing", "new", "options", "for", "patients", "." ] } ]
PMC11525293	Means ± SE of three replicates of three cultures are shown ΔNp63α and ACE2 parallel modulation at both protein and mRNA levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Means", "±", "SE", "of", "three", "replicates", "of", "three", "cultures", "are", "shown", "ΔNp63α", "and", "ACE2", "parallel", "modulation", "at", "both", "protein", "and", "mRNA", "levels", "." ] } ]
PMC11457557	Genetic factors are important in CVD risk; current genome-wide association studies (GWASs) strongly support the notion that genetic predisposition to CVD is often caused by genetic mutations or variance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genetic", "factors", "are", "important", "in", "CVD", "risk", ";", "current", "genome-wide", "association", "studies", "(", "GWASs", ")", "strongly", "support", "the", "notion", "that", "genetic", "predisposition", "to", "CVD", "is", "often", "caused", "by", "genetic", "mutations", "or", "variance", "." ] } ]
PMC11040965	The lysis of miR-NC-transfected cells was low and similar to that of untransfected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lysis", "of", "miR-NC-transfected", "cells", "was", "low", "and", "similar", "to", "that", "of", "untransfected", "cells", "." ] } ]
PMC11247842	Compared to all reported QTL for CM and SCS in Animal QTLdb , the QTL on BTA3, BTA23, and BTA25 are new QTL.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "to", "all", "reported", "QTL", "for", "CM", "and", "SCS", "in", "Animal", "QTLdb", ",", "the", "QTL", "on", "BTA3", ",", "BTA23", ",", "and", "BTA25", "are", "new", "QTL.Fig", "." ] } ]
PMC11683240	α1AT, α1-antitrypsin; Gαi, α-subunit of inhibitory G protein; PT, pertussis toxin; WB, Western Blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "Gαi", ",", "α-subunit", "of", "inhibitory", "G", "protein", ";", "PT", ",", "pertussis", "toxin", ";", "WB", ",", "Western", "Blot", "." ] } ]
PMC11437637	Here, we discussed the PBLs from EC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "discussed", "the", "PBLs", "from", "EC", "patients", "." ] } ]
PMC10877303	MERS-CoV inhibitors (10 inhibitors) were also used for docking with the 3CL protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MERS-CoV", "inhibitors", "(", "10", "inhibitors", ")", "were", "also", "used", "for", "docking", "with", "the", "3CL", "protein", "." ] } ]
PMC11486946	Source data are provided as a Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "provided", "as", "a", "Source", "Data", "file", "." ] } ]
PMC9784246	It is worth noting that it is now widely accepted that pyruvate dehydrogenase kinase 3 (PDK3) and histone deacetylase 6 (HDAC6) inhibitors can be used to treat lung cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "worth", "noting", "that", "it", "is", "now", "widely", "accepted", "that", "pyruvate", "dehydrogenase", "kinase", "3", "(", "PDK3", ")", "and", "histone", "deacetylase", "6", "(", "HDAC6", ")", "inhibitors", "can", "be", "used", "to", "treat", "lung", "cancer", "." ] } ]
PMC10123657	Our results suggest that an in-depth examination of the sequence and fragmentation pattern of peptides detected in shotgun proteomics analyses of co-cultured cells from different species, may be a simple option to study the intercellular protein transfer phenomenon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "suggest", "that", "an", "in-depth", "examination", "of", "the", "sequence", "and", "fragmentation", "pattern", "of", "peptides", "detected", "in", "shotgun", "proteomics", "analyses", "of", "co-cultured", "cells", "from", "different", "species", ",", "may", "be", "a", "simple", "option", "to", "study", "the", "intercellular", "protein", "transfer", "phenomenon", "." ] } ]
PMC11543853	The CsCl gradient was established by ultracentrifugation at 220,000× g in an Optima X80 ultracentrifuge using a Beckman Coulter SW41 Ti rotor at 10 °C for 18 h. The opaque bands containing the virus were extracted with a 20-gauge needle mounted on a 5 mL disposable syringe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CsCl", "gradient", "was", "established", "by", "ultracentrifugation", "at", "220,000", "×", "g", "in", "an", "Optima", "X80", "ultracentrifuge", "using", "a", "Beckman", "Coulter", "SW41", "Ti", "rotor", "at", "10", "°", "C", "for", "18", "h.", "The", "opaque", "bands", "containing", "the", "virus", "were", "extracted", "with", "a", "20-gauge", "needle", "mounted", "on", "a", "5", "mL", "disposable", "syringe", "." ] } ]
PMC10380508	Cells were harvested by trypsinization and counted using a hemocytometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "harvested", "by", "trypsinization", "and", "counted", "using", "a", "hemocytometer", "." ] } ]
PMC11435360	However, biological responses to H2S demonstrate a bimodal effect, where negligible or high concentrations of H2S are toxic and attenuate pathophysiologic pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "biological", "responses", "to", "H2S", "demonstrate", "a", "bimodal", "effect", ",", "where", "negligible", "or", "high", "concentrations", "of", "H2S", "are", "toxic", "and", "attenuate", "pathophysiologic", "pathways", "." ] } ]
PMC11676674	In this set of experiments, micronuclei frequency was analyzed using ImagestreamX with the application of the IDEAS software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "set", "of", "experiments", ",", "micronuclei", "frequency", "was", "analyzed", "using", "ImagestreamX", "with", "the", "application", "of", "the", "IDEAS", "software", "." ] } ]
PMC11180402	5637 and UM-UC-3 cell lines, along with their respective transfectants, were plated in six-well plates and cultured in standard medium until achieving 70%-80% confluence.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5637", "and", "UM-UC-3", "cell", "lines", ",", "along", "with", "their", "respective", "transfectants", ",", "were", "plated", "in", "six-well", "plates", "and", "cultured", "in", "standard", "medium", "until", "achieving", "70%-80", "%", "confluence", "." ] } ]
PMC9592219	Furthermore, 75% of PLC patients have hepatocellular carcinoma (HCC) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "75", "%", "of", "PLC", "patients", "have", "hepatocellular", "carcinoma", "(", "HCC", ")", "." ] } ]
PMC11696576	Reliable clusters, defined by bootstrapping, are outlined in bold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reliable", "clusters", ",", "defined", "by", "bootstrapping", ",", "are", "outlined", "in", "bold", "." ] } ]
PMC11772449	After 14 days of culture, the colony formation assay was performed and the clone area was calculated using ImageJ software to detect the ability of cells to form clones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "14", "days", "of", "culture", ",", "the", "colony", "formation", "assay", "was", "performed", "and", "the", "clone", "area", "was", "calculated", "using", "ImageJ", "software", "to", "detect", "the", "ability", "of", "cells", "to", "form", "clones", "." ] } ]
PMC11474209	The compound cylindrospermopsin has a molecular weight of 415 Da and functions as a zwitterion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compound", "cylindrospermopsin", "has", "a", "molecular", "weight", "of", "415", "Da", "and", "functions", "as", "a", "zwitterion", "." ] } ]
PMC6835428	Blood vessels are abundantly scattered in the connective tissue layer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blood", "vessels", "are", "abundantly", "scattered", "in", "the", "connective", "tissue", "layer", "." ] } ]
PMC10812665	Our second goal was to unravel potential mechanistic commonalities of all seven hits, using unbiased approaches.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "second", "goal", "was", "to", "unravel", "potential", "mechanistic", "commonalities", "of", "all", "seven", "hits", ",", "using", "unbiased", "approaches", "." ] } ]
PMC9841531	MCT4 is a key protein in the metabolic reprogramming of hypoxic tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCT4", "is", "a", "key", "protein", "in", "the", "metabolic", "reprogramming", "of", "hypoxic", "tumor", "cells", "." ] } ]
PMC11759543	Szu-Wei Huang: Methodology.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Szu-Wei", "Huang", ":", "Methodology", "." ] } ]
PMC6461034	Prior to LC‐MS/MS, dry down the eluate (now in the autosampler vial) in a vacuum centrifuge to remove the acetonitrile originating from the elution solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "LC‐MS/MS", ",", "dry", "down", "the", "eluate", "(", "now", "in", "the", "autosampler", "vial", ")", "in", "a", "vacuum", "centrifuge", "to", "remove", "the", "acetonitrile", "originating", "from", "the", "elution", "solution", "." ] } ]
PMC11806182	In conclusion, this study, for the first time, provides valuable insights into the molecular link between PCOS and UCEC by identifying key miRNAs and their associated pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "this", "study", ",", "for", "the", "first", "time", ",", "provides", "valuable", "insights", "into", "the", "molecular", "link", "between", "PCOS", "and", "UCEC", "by", "identifying", "key", "miRNAs", "and", "their", "associated", "pathways", "." ] } ]
PMC10938336	Doxorubicin was selected as the standard anticancer medication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Doxorubicin", "was", "selected", "as", "the", "standard", "anticancer", "medication", "." ] } ]
PMC10938336	Additionally, 1,2-dimethoxy-12-methyl-13H-benzodioxolo[5,6-c]phenanthridin-5-ol displayed a binding affinity of −7.92 kcal/mol, with interactions centered around the Leu A97 residue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "1,2-dimethoxy-12-methyl-13H-benzodioxolo[5,6-c]phenanthridin-5-ol", "displayed", "a", "binding", "affinity", "of", "−7.92", "kcal/mol", ",", "with", "interactions", "centered", "around", "the", "Leu", "A97", "residue", "." ] } ]
PMC11320834	According to the data presented in Table 1S (please see the supplemental data), the experimental in vitro release data best fit the Peppas-Sahlin model, for which the highest r2 and the lowest Akaike information criterion (AIC) parameters were obtained (Table 1S).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "data", "presented", "in", "Table", "1S", "(", "please", "see", "the", "supplemental", "data", ")", ",", "the", "experimental", "in", "vitro", "release", "data", "best", "fit", "the", "Peppas-Sahlin", "model", ",", "for", "which", "the", "highest", "r2", "and", "the", "lowest", "Akaike", "information", "criterion", "(", "AIC", ")", "parameters", "were", "obtained", "(", "Table", "1S", ")", "." ] } ]
PMC9509578	The surfaces of these nanoformulations were modified to enable them to cross the BBB for accurate diagnosis and to deliver appropriate anticancer drugs to treat brain tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "surfaces", "of", "these", "nanoformulations", "were", "modified", "to", "enable", "them", "to", "cross", "the", "BBB", "for", "accurate", "diagnosis", "and", "to", "deliver", "appropriate", "anticancer", "drugs", "to", "treat", "brain", "tumors", "." ] } ]
PMC11674891	Furthermore, GRP treatment enhanced cellular invasion, which was significantly reduced to baseline levels when co-treated with LY294002, a potent PI3K/AKT inhibitor (Figure 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "GRP", "treatment", "enhanced", "cellular", "invasion", ",", "which", "was", "significantly", "reduced", "to", "baseline", "levels", "when", "co-treated", "with", "LY294002", ",", "a", "potent", "PI3K/AKT", "inhibitor", "(", "Figure", "5b", ")", "." ] } ]
PMC11727907	A likely hypothesis is that glucose is used in the PPP to provide building blocks for cellular proliferation and reduced coenzymes (NADPH) to enhance antioxidant defenses , as suggested by the G6PD activity increment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "likely", "hypothesis", "is", "that", "glucose", "is", "used", "in", "the", "PPP", "to", "provide", "building", "blocks", "for", "cellular", "proliferation", "and", "reduced", "coenzymes", "(", "NADPH", ")", "to", "enhance", "antioxidant", "defenses", ",", "as", "suggested", "by", "the", "G6PD", "activity", "increment", "." ] } ]
PMC9429973	Azacitidine was administered subcutaneously, five days per week in 3 cycles – 1 week on, 1 week off.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Azacitidine", "was", "administered", "subcutaneously", ",", "five", "days", "per", "week", "in", "3", "cycles", "–", "1", "week", "on", ",", "1", "week", "off", "." ] } ]
PMC9516447	MIA PaCa-2 xenograft tumor tissues were harvested from the mice at the end of the treatment and subjected to Western blot analysis for KRAS protein level with GAPDH serving as loading control.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MIA", "PaCa-2", "xenograft", "tumor", "tissues", "were", "harvested", "from", "the", "mice", "at", "the", "end", "of", "the", "treatment", "and", "subjected", "to", "Western", "blot", "analysis", "for", "KRAS", "protein", "level", "with", "GAPDH", "serving", "as", "loading", "control", "." ] } ]
PMC11435360	In conclusion, inhibition of endogenous H2S production reduced BC cell viability and tumor progression and enhanced GEM cytotoxicity, resulting in tumor regression and abrogating invasion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "inhibition", "of", "endogenous", "H2S", "production", "reduced", "BC", "cell", "viability", "and", "tumor", "progression", "and", "enhanced", "GEM", "cytotoxicity", ",", "resulting", "in", "tumor", "regression", "and", "abrogating", "invasion", "." ] } ]
PMC11750696	ATF6 is also activated under ER stress conditions leading to its translocation to the Golgi apparatus (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATF6", "is", "also", "activated", "under", "ER", "stress", "conditions", "leading", "to", "its", "translocation", "to", "the", "Golgi", "apparatus", "(", "17", ")", "." ] } ]
PMC11739484	MEXPRESS (https://mexpress.ugent.be/) is a valuable resource for researchers and clinicians in oncology, offering a comprehensive repository of cancer-related information, including promoter methylation data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MEXPRESS", "(", "https://mexpress.ugent.be/", ")", "is", "a", "valuable", "resource", "for", "researchers", "and", "clinicians", "in", "oncology", ",", "offering", "a", "comprehensive", "repository", "of", "cancer-related", "information", ",", "including", "promoter", "methylation", "data", "." ] } ]
PMC11354239	48-7349-41) for 30 min at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "48", "-", "7349", "-", "41", ")", "for", "30", "min", "at", "4", "°", "C", "." ] } ]
PMC11742670	These CSV files play as the input data for phase 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "CSV", "files", "play", "as", "the", "input", "data", "for", "phase", "3", "." ] } ]
PMC11541409	SDH couples the oxidation of succinate to fumarate in the citric acid cycle with the reduction of ubiquinone to ubiquinol in the electron transport chain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SDH", "couples", "the", "oxidation", "of", "succinate", "to", "fumarate", "in", "the", "citric", "acid", "cycle", "with", "the", "reduction", "of", "ubiquinone", "to", "ubiquinol", "in", "the", "electron", "transport", "chain", "." ] } ]
PMC9429973	Median relapse-free survival (RFS) was 3.5 months, with a 1-year RFS of 12%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "relapse-free", "survival", "(", "RFS", ")", "was", "3.5", "months", ",", "with", "a", "1-year", "RFS", "of", "12", "%", "." ] } ]
PMC11763111	And same dose NK cells were re-injected after 7 days of CAR-T inoculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "And", "same", "dose", "NK", "cells", "were", "re-injected", "after", "7", "days", "of", "CAR-T", "inoculation", "." ] } ]
PMC9429973	Median age was 62 years (range, 21-86), 178 patients (73%) presented in stage 3-4 and 97 patients (40%) had an IPI score of 3-5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "age", "was", "62", "years", "(", "range", ",", "21", "-", "86", ")", ",", "178", "patients", "(", "73", "%", ")", "presented", "in", "stage", "3", "-", "4", "and", "97", "patients", "(", "40", "%", ")", "had", "an", "IPI", "score", "of", "3", "-", "5", "." ] } ]
PMC10123657	Before the cells reached 80% confluency, the CCRF-CEM cells were washed 2× with PBS and diluted; the OP9 cells were trypsinized, washed, and reseeded for their expansion or use in subsequent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "the", "cells", "reached", "80", "%", "confluency", ",", "the", "CCRF-CEM", "cells", "were", "washed", "2", "×", "with", "PBS", "and", "diluted", ";", "the", "OP9", "cells", "were", "trypsinized", ",", "washed", ",", "and", "reseeded", "for", "their", "expansion", "or", "use", "in", "subsequent", "experiments", "." ] } ]
PMC10936243	In fact, the newspapers that you see here, are purchased by the shelter as well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "the", "newspapers", "that", "you", "see", "here", ",", "are", "purchased", "by", "the", "shelter", "as", "well", "." ] } ]
PMC9429973	S. Liang, T. Dong, K. Yue, H. Gao, N. Wu, R. Liu, J. Liu, X.-J. Huang Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key laboratory of Hematopoietic Stem Cell Transplantation; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking university, Beijing, China Background: Description of immune landscapes that indulge or restrain survival and proliferation of malignant cells is critical to the improvement of therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S.", "Liang", ",", "T.", "Dong", ",", "K.", "Yue", ",", "H.", "Gao", ",", "N.", "Wu", ",", "R.", "Liu", ",", "J.", "Liu", ",", "X.-J.", "Huang", "Peking", "University", "People", "’s", "Hospital", ",", "Peking", "University", "Institute", "of", "Hematology", ",", "National", "Clinical", "Research", "Center", "for", "Hematologic", "Disease", ",", "Beijing", "Key", "laboratory", "of", "Hematopoietic", "Stem", "Cell", "Transplantation", ";", "Peking-Tsinghua", "Center", "for", "Life", "Sciences", ",", "Academy", "for", "Advanced", "Interdisciplinary", "Studies", ",", "Peking", "university", ",", "Beijing", ",", "China", "Background", ":", "Description", "of", "immune", "landscapes", "that", "indulge", "or", "restrain", "survival", "and", "proliferation", "of", "malignant", "cells", "is", "critical", "to", "the", "improvement", "of", "therapeutic", "strategies", "." ] } ]
PMC11519583	Therefore, we examined the expression profiles of the respective Wnt family genes in TA muscles treated with Ctx or glycerol to identify a candidate Wnt ligand(s) of Ror2 that may induce IMAT accumulation (Fig. 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "examined", "the", "expression", "profiles", "of", "the", "respective", "Wnt", "family", "genes", "in", "TA", "muscles", "treated", "with", "Ctx", "or", "glycerol", "to", "identify", "a", "candidate", "Wnt", "ligand(s", ")", "of", "Ror2", "that", "may", "induce", "IMAT", "accumulation", "(", "Fig.", "3a", ")", "." ] } ]
PMC11701801	Data are presented as the mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SEM", "." ] } ]
PMC11525028	The sgRNA were inserted into the lentiCRISPRv2 vector (#52961, Addgene) to generate the knockout plasmids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sgRNA", "were", "inserted", "into", "the", "lentiCRISPRv2", "vector", "(", "#", "52961", ",", "Addgene", ")", "to", "generate", "the", "knockout", "plasmids", "." ] } ]
PMC8740518	The color scale indicates the relative expression levels of the amino acids, blue represents an expression level less than the mean, while red represents an expression level greater than the mean. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "color", "scale", "indicates", "the", "relative", "expression", "levels", "of", "the", "amino", "acids", ",", "blue", "represents", "an", "expression", "level", "less", "than", "the", "mean", ",", "while", "red", "represents", "an", "expression", "level", "greater", "than", "the", "mean", ".", "(" ] } ]
PMC9219615	All compounds described herein were commercially purchased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "compounds", "described", "herein", "were", "commercially", "purchased", "." ] } ]
PMC11593084	We also cloned the VL cDNA of PMab-117 and combined it with the CL cDNA of the mouse kappa light chain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "cloned", "the", "VL", "cDNA", "of", "PMab-117", "and", "combined", "it", "with", "the", "CL", "cDNA", "of", "the", "mouse", "kappa", "light", "chain", "." ] } ]
PMC9429973	The 12-month progression-free survival rate was 75% and the 12-month event-free rate was 79%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "12-month", "progression-free", "survival", "rate", "was", "75", "%", "and", "the", "12-month", "event-free", "rate", "was", "79", "%", "." ] } ]
PMC6948907	It has been reported that low physiological concentrations of genistein have an anticancer effect in HCT116 colon cancer cells (Mure et al., 2006) and can alter DNA methylation consistent with altered gene expression in breast cancer cell lines (King-Batoon et al., 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "low", "physiological", "concentrations", "of", "genistein", "have", "an", "anticancer", "effect", "in", "HCT116", "colon", "cancer", "cells", "(", "Mure", "et", "al.", ",", "2006", ")", "and", "can", "alter", "DNA", "methylation", "consistent", "with", "altered", "gene", "expression", "in", "breast", "cancer", "cell", "lines", "(", "King-Batoon", "et", "al.", ",", "2008", ")", "." ] } ]
PMC11247842	Fig. 1Study workflow.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Fig.", "1Study", "workflow", "." ] } ]
PMC5833712	of three independent experiments. *	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "of", "three", "independent", "experiments", ".", "*" ] } ]
PMC5173112	In contrast, only 4.1% ALDH cells were detected in the 786-O USP21 siRNA knockdown cells (Figure 2G and 2H), suggesting the loss of a specific subpopulation of CSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "only", "4.1", "%", "ALDH", "cells", "were", "detected", "in", "the", "786-O", "USP21", "siRNA", "knockdown", "cells", "(", "Figure", "2", "G", "and", "2H", ")", ",", "suggesting", "the", "loss", "of", "a", "specific", "subpopulation", "of", "CSCs", "." ] } ]
PMC9436459	Dimoracin (153) was isolated from M. alba , and its formation process is similar to that of 151 and 152, except that its dienophile and diene are derived from the same prenylated-2-arylbenzofuran, moracin C .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dimoracin", "(", "153", ")", "was", "isolated", "from", "M.", "alba", ",", "and", "its", "formation", "process", "is", "similar", "to", "that", "of", "151", "and", "152", ",", "except", "that", "its", "dienophile", "and", "diene", "are", "derived", "from", "the", "same", "prenylated-2-arylbenzofuran", ",", "moracin", "C", "." ] } ]
PMC9429973	Interestingly, genes involved in transport of mature transcripts to cytoplasm and nuclear RNAs metabolism were also upregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "genes", "involved", "in", "transport", "of", "mature", "transcripts", "to", "cytoplasm", "and", "nuclear", "RNAs", "metabolism", "were", "also", "upregulated", "." ] } ]
PMC11588085	Furthermore, it was found that OVCAR3-KRAB cells with XIST KD were larger and spindle-like than control cells, while SKOV3-KRAB cells with XIST KD were more elongated than control cells, exhibiting more fibroblast-like morphology (Fig. 2E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "it", "was", "found", "that", "OVCAR3-KRAB", "cells", "with", "XIST", "KD", "were", "larger", "and", "spindle-like", "than", "control", "cells", ",", "while", "SKOV3-KRAB", "cells", "with", "XIST", "KD", "were", "more", "elongated", "than", "control", "cells", ",", "exhibiting", "more", "fibroblast-like", "morphology", "(", "Fig.", "2E", ")", "." ] } ]
PMC9429973	The arms were well-balanced for all variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "arms", "were", "well-balanced", "for", "all", "variables", "." ] } ]
PMC9872547	After gently removing the supernatant, Formazan crystals were dissolved in 200 μL of dimethyl sulfoxide (DMSO from Sigma Aldrich Company), and the optical density (OD) of the samples was measured at 540 nm by a plate Reader (BioTek Company, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "gently", "removing", "the", "supernatant", ",", "Formazan", "crystals", "were", "dissolved", "in", "200", "μL", "of", "dimethyl", "sulfoxide", "(", "DMSO", "from", "Sigma", "Aldrich", "Company", ")", ",", "and", "the", "optical", "density", "(", "OD", ")", "of", "the", "samples", "was", "measured", "at", "540", "nm", "by", "a", "plate", "Reader", "(", "BioTek", "Company", ",", "USA", ")", "." ] } ]
PMC4485648	Secondly, the vast majority of studies was performed in normoxia, although almost all solid tumors contain hypoxic areas, which are known to affect cell behavior and reduce response to therapies (8–10,22,26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondly", ",", "the", "vast", "majority", "of", "studies", "was", "performed", "in", "normoxia", ",", "although", "almost", "all", "solid", "tumors", "contain", "hypoxic", "areas", ",", "which", "are", "known", "to", "affect", "cell", "behavior", "and", "reduce", "response", "to", "therapies", "(", "8–10,22,26", ")", "." ] } ]
PMC10874773	jiadifengpiLiu et al., 2016611,2,3,4-TetradehydroneomajucinAnti-HBVI.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "jiadifengpiLiu", "et", "al.", ",", "2016611,2,3,4-TetradehydroneomajucinAnti-HBVI", "." ] } ]
PMC11679033	There was no significant increase in MNi, NBPs or NBUDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "increase", "in", "MNi", ",", "NBPs", "or", "NBUDs", "." ] } ]
PMC10761218	This impact may lead to morphological changes in HepG2 cancer cells, ultimately resulting in their death or hindering their ability to multiply and spread.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "impact", "may", "lead", "to", "morphological", "changes", "in", "HepG2", "cancer", "cells", ",", "ultimately", "resulting", "in", "their", "death", "or", "hindering", "their", "ability", "to", "multiply", "and", "spread", "." ] } ]
PMC8557138	Bioprinting offers a paradigm shift in the field of organoid development by offering prospects for simulating the early phases of in vivo organogenesis (Chawla et al. 2018a, b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bioprinting", "offers", "a", "paradigm", "shift", "in", "the", "field", "of", "organoid", "development", "by", "offering", "prospects", "for", "simulating", "the", "early", "phases", "of", "in", "vivo", "organogenesis", "(", "Chawla", "et", "al.", "2018a", ",", "b", ")", "." ] } ]
PMC11513571	PBMCs from four healthy subjects were stimulated with or without rhTSLP (100 ng/mL) and rSP (5 μg/mL) in 96-well culture plates (Thermo Fisher Scientific) for 10 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PBMCs", "from", "four", "healthy", "subjects", "were", "stimulated", "with", "or", "without", "rhTSLP", "(", "100", "ng/mL", ")", "and", "rSP", "(", "5", "μg/mL", ")", "in", "96-well", "culture", "plates", "(", "Thermo", "Fisher", "Scientific", ")", "for", "10", "days", "." ] } ]
PMC10955424	Methanol was used as blank.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methanol", "was", "used", "as", "blank", "." ] } ]
PMC7229095	Media have been developed during the past decades, which have led to changes in process aspects of cell line development (CLD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Media", "have", "been", "developed", "during", "the", "past", "decades", ",", "which", "have", "led", "to", "changes", "in", "process", "aspects", "of", "cell", "line", "development", "(", "CLD", ")", "." ] } ]
PMC9429973	The obesity was correlated with higher levels of cEPCs in the ST and LYM compared to the ALL group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obesity", "was", "correlated", "with", "higher", "levels", "of", "cEPCs", "in", "the", "ST", "and", "LYM", "compared", "to", "the", "ALL", "group", "." ] } ]
PMC9429973	Around 75% of T-LBCL are of ABC subtype and display frequent genetic alterations of BCR signaling (CARD11, MYD88 and CD79B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Around", "75", "%", "of", "T-LBCL", "are", "of", "ABC", "subtype", "and", "display", "frequent", "genetic", "alterations", "of", "BCR", "signaling", "(", "CARD11", ",", "MYD88", "and", "CD79B", ")", "." ] } ]
PMC11609529	RK3E cells were plated at 10 cells/dish in 10 cm culture dishes and incubated overnight.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RK3E", "cells", "were", "plated", "at", "10", "cells/dish", "in", "10", "cm", "culture", "dishes", "and", "incubated", "overnight", "." ] } ]
PMC9429973	HCT trends showed growth in transplant activity, a rapid increase in the number of autologous HCT, remarkable growth in older (>60-year-old) patients receiving HCT, an increase in haploidentical donors (HID), and an expansion of harvesting stem cells from both the peripheral blood (PB) and the bone marrow (BM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCT", "trends", "showed", "growth", "in", "transplant", "activity", ",", "a", "rapid", "increase", "in", "the", "number", "of", "autologous", "HCT", ",", "remarkable", "growth", "in", "older", "(", ">", "60-year-old", ")", "patients", "receiving", "HCT", ",", "an", "increase", "in", "haploidentical", "donors", "(", "HID", ")", ",", "and", "an", "expansion", "of", "harvesting", "stem", "cells", "from", "both", "the", "peripheral", "blood", "(", "PB", ")", "and", "the", "bone", "marrow", "(", "BM", ")", "." ] } ]
PMC9429973	Methods: In CASTOR and POLLUX, patients with RRMM and ≥1 prior line of therapy were randomized to D-Vd/Vd or D-Rd/Rd, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "In", "CASTOR", "and", "POLLUX", ",", "patients", "with", "RRMM", "and", "≥1", "prior", "line", "of", "therapy", "were", "randomized", "to", "D-Vd/Vd", "or", "D-Rd/Rd", ",", "respectively", "." ] } ]
PMC11471157	As shown in Table 1, the content per 100 g of DFP was: 317 kcal of energy, 70.1 g of protein, 4.1 g of lipid, 0.0 g of carbohydrate, 1.4 g of salt equivalent, 540 mg of sodium, 12.0 g of water, and 13.8 g of ash.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Table", "1", ",", "the", "content", "per", "100", "g", "of", "DFP", "was", ":", "317", "kcal", "of", "energy", ",", "70.1", "g", "of", "protein", ",", "4.1", "g", "of", "lipid", ",", "0.0", "g", "of", "carbohydrate", ",", "1.4", "g", "of", "salt", "equivalent", ",", "540", "mg", "of", "sodium", ",", "12.0", "g", "of", "water", ",", "and", "13.8", "g", "of", "ash", "." ] } ]
PMC11470999	Statistical significance is indicated as p < 0.05, p < 0.01, p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "is", "indicated", "as", "p", "<", "0.05", ",", "p", "<", "0.01", ",", "p", "<", "0.001", "." ] } ]
PMC9014716	Equal amounts of proteins were separated by 6% or 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis (10% gel for glyceraldehyde 3-phosphate dehydrogenase) and then transferred onto polyvinylidene fluoride membranes (250 mA, 3 hours), which were blocked for 1 hour, and then incubated overnight with primary rabbit monoclonal antibodies against MDR1/ABCB1 or glyceraldehyde 3-phosphate dehydrogenase (dilution, 1:1000; Cell Signaling, USA) at 4°C, followed by horseradish-conjugated secondary goat anti-rabbit antibodies against immunoglobulin G (dilution, 1:10000; Nanjing Jiancheng Bioengineering Institute, Nanjing, China) for 1 hour at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "amounts", "of", "proteins", "were", "separated", "by", "6", "%", "or", "10", "%", "sodium", "dodecyl", "sulfate", "polyacrylamide", "gel", "electrophoresis", "(", "10", "%", "gel", "for", "glyceraldehyde", "3-phosphate", "dehydrogenase", ")", "and", "then", "transferred", "onto", "polyvinylidene", "fluoride", "membranes", "(", "250", "mA", ",", "3", "hours", ")", ",", "which", "were", "blocked", "for", "1", "hour", ",", "and", "then", "incubated", "overnight", "with", "primary", "rabbit", "monoclonal", "antibodies", "against", "MDR1/ABCB1", "or", "glyceraldehyde", "3-phosphate", "dehydrogenase", "(", "dilution", ",", "1:1000", ";", "Cell", "Signaling", ",", "USA", ")", "at", "4", "°", "C", ",", "followed", "by", "horseradish-conjugated", "secondary", "goat", "anti-rabbit", "antibodies", "against", "immunoglobulin", "G", "(", "dilution", ",", "1:10000", ";", "Nanjing", "Jiancheng", "Bioengineering", "Institute", ",", "Nanjing", ",", "China", ")", "for", "1", "hour", "at", "room", "temperature", "." ] } ]
PMC8345486	The resolution of the acquired digital images was 2560 × 1920 pixels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resolution", "of", "the", "acquired", "digital", "images", "was", "2560", "×", "1920", "pixels", "." ] } ]
PMC11401350	Created with Biorender.com.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "with", "Biorender.com", "." ] } ]
PMC11448304	Furthermore, 2-hydroxyisobutyrylome identified 30,089 Khib modified sites on 4635 proteins, indicating that Khib modifications play vital role in regulating NSCLC radioresistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "2-hydroxyisobutyrylome", "identified", "30,089", "Khib", "modified", "sites", "on", "4635", "proteins", ",", "indicating", "that", "Khib", "modifications", "play", "vital", "role", "in", "regulating", "NSCLC", "radioresistance", "." ] } ]

PMC11470381

A pivotal investigation conducted by our team discovered the crucial role of Piezo1 in driving optimal human T-lymphocyte activation in response to T-cell receptor (TCR) triggering .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "pivotal", "investigation", "conducted", "by", "our", "team", "discovered", "the", "crucial", "role", "of", "Piezo1", "in", "driving", "optimal", "human", "T-lymphocyte", "activation", "in", "response", "to", "T-cell", "receptor", "(", "TCR", ")", "triggering", "." ] } ]

PMC11344246

The effect of this inhibitor in organoids was less striking.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "this", "inhibitor", "in", "organoids", "was", "less", "striking", "." ] } ]

PMC11285179

However, the detailed molecular mechanism of this phenomenon is still obscure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "detailed", "molecular", "mechanism", "of", "this", "phenomenon", "is", "still", "obscure", "." ] } ]

PMC9927933

Given that DEPTOR plays an important role in regulation of various biological processes, including proliferation, autophagy, metabolism, and immunity (34, 44), it is very likely that DEPTOR levels could be regulated by additional E3 ligase(s).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "that", "DEPTOR", "plays", "an", "important", "role", "in", "regulation", "of", "various", "biological", "processes", ",", "including", "proliferation", ",", "autophagy", ",", "metabolism", ",", "and", "immunity", "(", "34", ",", "44", ")", ",", "it", "is", "very", "likely", "that", "DEPTOR", "levels", "could", "be", "regulated", "by", "additional", "E3", "ligase(s", ")", "." ] } ]

PMC11437637

Therefore, PBL levels could be used to monitor patient immune function and predict disease development, and this may also be a good entry point for therapeutic targets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "PBL", "levels", "could", "be", "used", "to", "monitor", "patient", "immune", "function", "and", "predict", "disease", "development", ",", "and", "this", "may", "also", "be", "a", "good", "entry", "point", "for", "therapeutic", "targets", "." ] } ]

PMC7762347

Stock solutions of CYN (0.5 µg/mL) and MCLR (1 µg/mL) were prepared in 50% methanol and pure ethanol (99.8%), respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stock", "solutions", "of", "CYN", "(", "0.5", "µg/mL", ")", "and", "MCLR", "(", "1", "µg/mL", ")", "were", "prepared", "in", "50", "%", "methanol", "and", "pure", "ethanol", "(", "99.8", "%", ")", ",", "respectively", "." ] } ]

PMC7841189

Experiments were performed in triplicate. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "performed", "in", "triplicate", ".", "*" ] } ]

PMC11365427

Through molecular docking simulations, we assessed the binding capacity of phenylalanine to VAPB (Fig. 5E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "molecular", "docking", "simulations", ",", "we", "assessed", "the", "binding", "capacity", "of", "phenylalanine", "to", "VAPB", "(", "Fig.", "5E", ")", "." ] } ]

PMC11763111

G The left diagram shows the ratio of CAR-T cells number compared to the initial CAR-T cells number following a 48-h reaction period, as assessed by flow cytometry counting (n = 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "The", "left", "diagram", "shows", "the", "ratio", "of", "CAR-T", "cells", "number", "compared", "to", "the", "initial", "CAR-T", "cells", "number", "following", "a", "48-h", "reaction", "period", ",", "as", "assessed", "by", "flow", "cytometry", "counting", "(", "n", "=", "3", ")", "." ] } ]

PMC6892818

Cells treated with DMSO alone (vehicle controls) were included.

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PMC10891340

The scale bar is 30 μm. (

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PMC11441402

Figure 5 depicts the same data as Figure 4, however, only the endpoint data is considered.

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PMC6190245

Fetal bovine serum (FBS) and penicillin/streptomycin were bought from Gibco (Grand Island, NY).

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PMC11049294

The GLA KO cell line was generated via CRISPR-Cas9-based transfection, validated with exome sequencing, gene expression and substrate accumulation.

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PMC10329074

The result was consistent with scratch assay experiments that the numbers of cells that traversed the Transwell were significantly reduced by YBX3 knockdown in the A498 cells (Fig. 6A-B, ***P < 0.001).

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PMC11489175

Deregulated USP28 expression is linked to the activation of β-catenin signaling pathway.

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PMC11538390

To prioritize these SNPs for possible regulatory variants, we examined their position relative to chromatin marks shown to correlate with active enhancer function including: (i) ATAC-seq peaks, which reveal open chromatin, from the HIOEC oral epithelial cells and the HEPM oral mesenchymal cells, (ii) H3K27Ac peaks, revealing active enhancers and promoters, from the HIOEC cells, and (iii) aggregate chromatin modification marks from 9 principal cell types from the ENCODE project and from human embryonic facial enhancers datasets.

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PMC8759873

A variety of molecular-targeted therapeutic drugs have come out in succession .

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PMC10656496

Normalized read counts were obtained via calculating library size factors and scaling raw read counts using the Bioconductor R package DESeq2 v.1.6.3.

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PMC11718274

Advances in therapies, including novel approaches like nano-therapy, are enhancing treatment outcomes and providing new options for patients.

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PMC11525293

Means ± SE of three replicates of three cultures are shown ΔNp63α and ACE2 parallel modulation at both protein and mRNA levels.

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PMC11457557

Genetic factors are important in CVD risk; current genome-wide association studies (GWASs) strongly support the notion that genetic predisposition to CVD is often caused by genetic mutations or variance.

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PMC11040965

The lysis of miR-NC-transfected cells was low and similar to that of untransfected cells.

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PMC11247842

Compared to all reported QTL for CM and SCS in Animal QTLdb , the QTL on BTA3, BTA23, and BTA25 are new QTL.Fig.

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PMC11683240

α1AT, α1-antitrypsin; Gαi, α-subunit of inhibitory G protein; PT, pertussis toxin; WB, Western Blot.

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PMC11437637

Here, we discussed the PBLs from EC patients.

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PMC10877303

MERS-CoV inhibitors (10 inhibitors) were also used for docking with the 3CL protein.

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PMC11486946

Source data are provided as a Source Data file.

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PMC9784246

It is worth noting that it is now widely accepted that pyruvate dehydrogenase kinase 3 (PDK3) and histone deacetylase 6 (HDAC6) inhibitors can be used to treat lung cancer .

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PMC10123657

Our results suggest that an in-depth examination of the sequence and fragmentation pattern of peptides detected in shotgun proteomics analyses of co-cultured cells from different species, may be a simple option to study the intercellular protein transfer phenomenon.

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PMC11543853

The CsCl gradient was established by ultracentrifugation at 220,000× g in an Optima X80 ultracentrifuge using a Beckman Coulter SW41 Ti rotor at 10 °C for 18 h. The opaque bands containing the virus were extracted with a 20-gauge needle mounted on a 5 mL disposable syringe.

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PMC10380508

Cells were harvested by trypsinization and counted using a hemocytometer.

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PMC11435360

However, biological responses to H2S demonstrate a bimodal effect, where negligible or high concentrations of H2S are toxic and attenuate pathophysiologic pathways .

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PMC11676674

In this set of experiments, micronuclei frequency was analyzed using ImagestreamX with the application of the IDEAS software.

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PMC11180402

5637 and UM-UC-3 cell lines, along with their respective transfectants, were plated in six-well plates and cultured in standard medium until achieving 70%-80% confluence.

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PMC9592219

Furthermore, 75% of PLC patients have hepatocellular carcinoma (HCC) .

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PMC11696576

Reliable clusters, defined by bootstrapping, are outlined in bold.

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PMC11772449

After 14 days of culture, the colony formation assay was performed and the clone area was calculated using ImageJ software to detect the ability of cells to form clones.

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PMC11474209

The compound cylindrospermopsin has a molecular weight of 415 Da and functions as a zwitterion.

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PMC6835428

Blood vessels are abundantly scattered in the connective tissue layer .

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PMC10812665

Our second goal was to unravel potential mechanistic commonalities of all seven hits, using unbiased approaches.

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PMC9841531

MCT4 is a key protein in the metabolic reprogramming of hypoxic tumor cells.

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PMC11759543

Szu-Wei Huang: Methodology.

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PMC6461034

Prior to LC‐MS/MS, dry down the eluate (now in the autosampler vial) in a vacuum centrifuge to remove the acetonitrile originating from the elution solution.

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PMC11806182

In conclusion, this study, for the first time, provides valuable insights into the molecular link between PCOS and UCEC by identifying key miRNAs and their associated pathways.

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PMC10938336

Doxorubicin was selected as the standard anticancer medication.

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PMC10938336

Additionally, 1,2-dimethoxy-12-methyl-13H-benzodioxolo[5,6-c]phenanthridin-5-ol displayed a binding affinity of −7.92 kcal/mol, with interactions centered around the Leu A97 residue.

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PMC11320834

According to the data presented in Table 1S (please see the supplemental data), the experimental in vitro release data best fit the Peppas-Sahlin model, for which the highest r2 and the lowest Akaike information criterion (AIC) parameters were obtained (Table 1S).

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PMC9509578

The surfaces of these nanoformulations were modified to enable them to cross the BBB for accurate diagnosis and to deliver appropriate anticancer drugs to treat brain tumors .

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PMC11674891

Furthermore, GRP treatment enhanced cellular invasion, which was significantly reduced to baseline levels when co-treated with LY294002, a potent PI3K/AKT inhibitor (Figure 5b).

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PMC11727907

A likely hypothesis is that glucose is used in the PPP to provide building blocks for cellular proliferation and reduced coenzymes (NADPH) to enhance antioxidant defenses , as suggested by the G6PD activity increment.

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PMC9429973

Azacitidine was administered subcutaneously, five days per week in 3 cycles – 1 week on, 1 week off.

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PMC9516447

MIA PaCa-2 xenograft tumor tissues were harvested from the mice at the end of the treatment and subjected to Western blot analysis for KRAS protein level with GAPDH serving as loading control.

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PMC11435360

In conclusion, inhibition of endogenous H2S production reduced BC cell viability and tumor progression and enhanced GEM cytotoxicity, resulting in tumor regression and abrogating invasion.

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PMC11750696

ATF6 is also activated under ER stress conditions leading to its translocation to the Golgi apparatus (17).

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PMC11739484

MEXPRESS (https://mexpress.ugent.be/) is a valuable resource for researchers and clinicians in oncology, offering a comprehensive repository of cancer-related information, including promoter methylation data.

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PMC11354239

48-7349-41) for 30 min at 4 °C.

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PMC11742670

These CSV files play as the input data for phase 3.

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PMC11541409

SDH couples the oxidation of succinate to fumarate in the citric acid cycle with the reduction of ubiquinone to ubiquinol in the electron transport chain.

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PMC9429973

Median relapse-free survival (RFS) was 3.5 months, with a 1-year RFS of 12%.

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PMC11763111

And same dose NK cells were re-injected after 7 days of CAR-T inoculation.

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PMC9429973

Median age was 62 years (range, 21-86), 178 patients (73%) presented in stage 3-4 and 97 patients (40%) had an IPI score of 3-5.

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PMC10123657

Before the cells reached 80% confluency, the CCRF-CEM cells were washed 2× with PBS and diluted; the OP9 cells were trypsinized, washed, and reseeded for their expansion or use in subsequent experiments.

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PMC10936243

In fact, the newspapers that you see here, are purchased by the shelter as well.

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PMC9429973

S. Liang, T. Dong, K. Yue, H. Gao, N. Wu, R. Liu, J. Liu, X.-J. Huang Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key laboratory of Hematopoietic Stem Cell Transplantation; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking university, Beijing, China Background: Description of immune landscapes that indulge or restrain survival and proliferation of malignant cells is critical to the improvement of therapeutic strategies.

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PMC11519583

Therefore, we examined the expression profiles of the respective Wnt family genes in TA muscles treated with Ctx or glycerol to identify a candidate Wnt ligand(s) of Ror2 that may induce IMAT accumulation (Fig. 3a).

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PMC11701801

Data are presented as the mean ± SEM.

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PMC11525028

The sgRNA were inserted into the lentiCRISPRv2 vector (#52961, Addgene) to generate the knockout plasmids.

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PMC8740518

The color scale indicates the relative expression levels of the amino acids, blue represents an expression level less than the mean, while red represents an expression level greater than the mean. (

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PMC9219615

All compounds described herein were commercially purchased.

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PMC11593084

We also cloned the VL cDNA of PMab-117 and combined it with the CL cDNA of the mouse kappa light chain.

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PMC9429973

The 12-month progression-free survival rate was 75% and the 12-month event-free rate was 79%.

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PMC6948907

It has been reported that low physiological concentrations of genistein have an anticancer effect in HCT116 colon cancer cells (Mure et al., 2006) and can alter DNA methylation consistent with altered gene expression in breast cancer cell lines (King-Batoon et al., 2008).

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PMC11247842

Fig. 1Study workflow.

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PMC5833712

of three independent experiments. *

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PMC5173112

In contrast, only 4.1% ALDH cells were detected in the 786-O USP21 siRNA knockdown cells (Figure 2G and 2H), suggesting the loss of a specific subpopulation of CSCs.

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PMC9436459

Dimoracin (153) was isolated from M. alba , and its formation process is similar to that of 151 and 152, except that its dienophile and diene are derived from the same prenylated-2-arylbenzofuran, moracin C .

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PMC9429973

Interestingly, genes involved in transport of mature transcripts to cytoplasm and nuclear RNAs metabolism were also upregulated.

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PMC11588085

Furthermore, it was found that OVCAR3-KRAB cells with XIST KD were larger and spindle-like than control cells, while SKOV3-KRAB cells with XIST KD were more elongated than control cells, exhibiting more fibroblast-like morphology (Fig. 2E).

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PMC9429973

The arms were well-balanced for all variables.

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PMC9872547

After gently removing the supernatant, Formazan crystals were dissolved in 200 μL of dimethyl sulfoxide (DMSO from Sigma Aldrich Company), and the optical density (OD) of the samples was measured at 540 nm by a plate Reader (BioTek Company, USA).

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PMC4485648

Secondly, the vast majority of studies was performed in normoxia, although almost all solid tumors contain hypoxic areas, which are known to affect cell behavior and reduce response to therapies (8–10,22,26).

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PMC10874773

jiadifengpiLiu et al., 2016611,2,3,4-TetradehydroneomajucinAnti-HBVI.

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PMC11679033

There was no significant increase in MNi, NBPs or NBUDs.

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PMC10761218

This impact may lead to morphological changes in HepG2 cancer cells, ultimately resulting in their death or hindering their ability to multiply and spread.

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PMC8557138

Bioprinting offers a paradigm shift in the field of organoid development by offering prospects for simulating the early phases of in vivo organogenesis (Chawla et al. 2018a, b).

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PMC11513571

PBMCs from four healthy subjects were stimulated with or without rhTSLP (100 ng/mL) and rSP (5 μg/mL) in 96-well culture plates (Thermo Fisher Scientific) for 10 days.

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PMC10955424

Methanol was used as blank.

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PMC7229095

Media have been developed during the past decades, which have led to changes in process aspects of cell line development (CLD).

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PMC9429973

The obesity was correlated with higher levels of cEPCs in the ST and LYM compared to the ALL group.

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PMC9429973

Around 75% of T-LBCL are of ABC subtype and display frequent genetic alterations of BCR signaling (CARD11, MYD88 and CD79B).

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PMC11609529

RK3E cells were plated at 10 cells/dish in 10 cm culture dishes and incubated overnight.

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PMC9429973

HCT trends showed growth in transplant activity, a rapid increase in the number of autologous HCT, remarkable growth in older (>60-year-old) patients receiving HCT, an increase in haploidentical donors (HID), and an expansion of harvesting stem cells from both the peripheral blood (PB) and the bone marrow (BM).

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PMC9429973

Methods: In CASTOR and POLLUX, patients with RRMM and ≥1 prior line of therapy were randomized to D-Vd/Vd or D-Rd/Rd, respectively.

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PMC11471157

As shown in Table 1, the content per 100 g of DFP was: 317 kcal of energy, 70.1 g of protein, 4.1 g of lipid, 0.0 g of carbohydrate, 1.4 g of salt equivalent, 540 mg of sodium, 12.0 g of water, and 13.8 g of ash.

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PMC11470999

Statistical significance is indicated as p < 0.05, p < 0.01, p < 0.001.

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PMC9014716

Equal amounts of proteins were separated by 6% or 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis (10% gel for glyceraldehyde 3-phosphate dehydrogenase) and then transferred onto polyvinylidene fluoride membranes (250 mA, 3 hours), which were blocked for 1 hour, and then incubated overnight with primary rabbit monoclonal antibodies against MDR1/ABCB1 or glyceraldehyde 3-phosphate dehydrogenase (dilution, 1:1000; Cell Signaling, USA) at 4°C, followed by horseradish-conjugated secondary goat anti-rabbit antibodies against immunoglobulin G (dilution, 1:10000; Nanjing Jiancheng Bioengineering Institute, Nanjing, China) for 1 hour at room temperature.

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PMC8345486

The resolution of the acquired digital images was 2560 × 1920 pixels.

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PMC11401350

Created with Biorender.com.

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PMC11448304

Furthermore, 2-hydroxyisobutyrylome identified 30,089 Khib modified sites on 4635 proteins, indicating that Khib modifications play vital role in regulating NSCLC radioresistance.

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