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PMC10125312
No statistical differences were observed between all conditions for Hek293 and 0–1 nM for THLE-3.
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PMC11476004
An Olympus BX53 microscope was used for microscopic analysis.
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PMC10719213
Two oligonucleotide probes for mtDNA (5ʹ-GGCTCCAGGGTGGGAGTAGTTCCCTGC; 5ʹ-CCTCCCGAATCAACCCTGACCCCTCTCC) and three for 18S rDNA (5ʹ-GGCCCGAGGTTATCTAGAGTCACC; 5ʹ-TATTCCTAGCTGCGGTATCCAGGC; 5ʹ-ACCATCCAATCGGTAGTAGCGACG) were 5ʹ end labeled with gamma P ATP by T4 Polynucleotide Kinase (NEB) and hybridized (50% formamide, 7% SDS, 0.25 M sodium phosphate pH 7.2, 10 mM EDTA pH 8.0, 0.24 M NaCl2) overnight at 37°C.
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PMC11060216
Other steps, including construction, production and concentration of lentivirus vector, pLVX-AcGFP1-N1-S100A6, cell infection, RNA extraction and qPCR, Western Blot, and animal experiments, have been described in our previously published paper.
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PMC10006224
c Quantification of salt-resistant vs. total chromatin-bound levels of STAG1 and STAG2 in G1 and G2 (n = 5 experiments).
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PMC11704135
Similarly, compounds 13 and 14 exhibited the least efficiency in inhibiting S. epidermidis, as their growth was inhibited at a concentration of 30 mg/mL. The principle behind this test is to use electron withdrawal potential from the examined compound to bleach the violet color of the DPPH radical.
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PMC5925824
Bio-Glo™ Reagent (Promega) was prepared according to manufacturer’s instructions and added to each well at 80 μl per well.
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PMC10024132
VAL cells were pre-treated with 2.5 μM zoledronic acid (ZA) for 24 h and then used as target cells at an E/T ratio of 3:1 (D); data are shown as mean ± SD from three different experiments. *
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PMC11388384
The receiver cells express a synthetic SHH reporter driven by a consensus Gli binding site (GBS) array.
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PMC11525293
As the control, cells were also transfected with a shRNA-SCRB vector.
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PMC6627640
Hence, cells were treated with 0.5 µM cisplatin for 3 h on 5 consecutive days and then allowed to recover for two to three weeks (Figure 1A).
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PMC4443654
In summary, we show that integrative modeling of large chromatin dataset collections using random forests can generate useful insights into chromosome structure and seed testable hypotheses for further experimental studies.
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PMC9509578
Another advantage of using nanomicelles is their hydrophilic outer shells.
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PMC7823217
Representative immunofluorescent staining for aSMA (red), LOX (green), and nuclei (blue) of 21PT and ADMSC within bioprinted constructs after 21-day culture and with the addition of different concentrations of DOX for another 3-day culture.
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PMC10976516
Remarkably, viral infection is a stressor as well and thereby enhances NKG2D ligand expression.
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PMC5173112
Cycling conditions followed the manufacturer's instructions, and CFX Manager was used for analyses (Bio-Rad).
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PMC10565698
A. Nucleocytoplasmic isolation assay of circUSP10 in HCCLM3 and BEL-7407 cells.
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PMC11489351
Cells were fixed and stained for pyruvate dehydrogenase kinase (PDHK), PDHK fluorescence is shown in green, and nuclei Hoescht stain in cyan (DAPI).
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PMC8540692
For instance in SW620 colon carcinoma cells, NaBu downregulated β-catenin-dependent expression of the Tcf-TK, matrilysin, and cyclin D1 promoters .
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PMC11623887
By age 15 ~50% of children are seropositive for the virus.
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PMC11545868
Usually, VEGF binds to VEGFR and promotes angiogenesis.
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PMC6450504
Anti-P-gp siRNA was chosen for this study for targeted gene therapy since it is both involved in MDR of various tumors and in view of the feasibility for evaluation of treatment response.
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PMC11365427
The area under the curve (AUC) for BM supernatant samples (AUC = 0.753) was lower than that for PB plasma samples (AUC = 0.98), indicating that phenylalanine can serve as a potential biomarker for MM (Fig. S2B).
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PMC11599565
Interestingly, the type II intermediate filament Keratin 80 (KRT80) (O) was expressed in these nested cells, indicating that this filament is involved in early stages of tumor cell differentiation.
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PMC8751435
Meanwhile, adenosine, cordycepin, and cordycepic acid, which are bioactive components in C. militaris extract (CME), have been identified as proapoptotic constituents.
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PMC11409031
These findings indicate that hub genes could potentially serve varying functions in inducing the differentiation of T cells.
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PMC11468365
So, it focuses on the important features and minimizes the noise.
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PMC6627640
In the present study, we used de novo approaches that unexpectedly uncovered an important role for polycomb in TGCT sensitivity and resistance to cisplatin, and we are the first to implicate histone methylation in the chemosensitivity of TGCTs.
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PMC11144200
The fluorescence level of the tumor site within the free IR-780 category decays throughout a 24-h period, while a significant fluorescent signal is retained in those groups containing liposomal formulations (Fig. 4A–G, I).
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PMC11766174
The sensitivity of CA-ICC was further assayed by spiking MOLT IIIB cells into uninfected Jurkat cells in limiting dilutions.
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PMC6617630
VAL MYC 3R1G2F, BCL-2 3R1G1F, and BCL-6 1R1G1F (g-i).
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PMC9964654
Overall, the results obtained evidenced the potential of BCM-[Au(cdc)2] as a novel drug-delivery system with promising anticancer and antimicrobial activities that deserve to be further evaluated.
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PMC11361748
To examine whether TAR represents a systemic response after the initial stress, we performed studies in which sequential TPA Tx, 24 h apart, are applied on the same versus contralateral ears (S1C Fig).
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PMC11659921
This interaction is particularly evident in the context of hypoxia, a common feature of solid tumors, which can induce the expression of hypoxia‐inducible factors (HIFs) that promote both angiogenesis and the maintenance of stemness in CSCs.
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PMC3995603
The contents of six compounds (chlorogenic acid, caffeic acid, isochlorogenic acid A, hyperoside, isoquercitrin and scoparone) in AC were simultaneously assayed using HPLC system.
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PMC3813807
The overexpression of miR-373 caused the suppression of a luciferase reporter containing the TNFAIP1 3′UTR in the HEK293 cells and reduced the levels of TNFAIP1 protein in the AGS cells.
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PMC11371747
In the present CRC cell line panel, modulation is also about 2-fold which is obviously related to the efficient uptake of reduced folates by these CRC cells (Van Triest et al., 1999); uptake will not be affected by d-LV since this compound has a poor affinity for RFC compared to l-LV (Figure 3).
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PMC11597291
This allowed PCT to create strong π–π stacking and hydrophobic interactions with the graphite lattice.
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PMC9429973
Peripheral blood (PB) and bone marrow (BM) were analyzed pre-Ven for somatic mutations via targeted next-generation sequencing (NGS).
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PMC8922418
The combination antiretroviral therapy (cART), although able to suppress HIV-1 replication, cannot eliminate the proviral DNA integrated into the human genome and thus requires lifelong treatment that may lead to various side effects.
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PMC6600253
As expected, some anticancer natural products are also G-quadruplex stabilizers.
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PMC10988555
Statistical analysis was performed by the two-way ANOVA method.
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PMC11473750
After a 2-week resting period, mice were treated with 3 i.p.
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PMC11730320
Both αβ and γδ lineages express CD3 at later differentiation stages, but the γδ lineage cells lack expression of CD4 alongside absent or low CD8.Fig.
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PMC11395280
CCR7-CEM cells were pre-incubated in cRPMI ± 200 nM CCL198-83, and 7.5 × 10 CCRF-CEM cells were added to the top of each intact cerebral microvascular endothelial cell monolayer.
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PMC11548041
HuCCT1 cholangiocarcinoma cells were obtained and cultured as previously described on collagen-coated plates and maintained in DMEM-HG with 10% FBS and 1% P/S .
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PMC11806106
The measurement was controlled using the software SparkControl.
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PMC11661024
In this regard, any increase in postbiotic concentrations showed no decrease in cell viability.
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PMC11476837
However, pre-incubation of A549 with ML-385 and then incubation with hydrogen peroxide significantly increased KEAP1 expression compared to hydrogen peroxide alone .
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PMC9261184
Methane is the second most prevalent greenhouse gas (GHG), contributing a quarter of today’s manmade warming, and methane mitigation is vital in meeting a 1.5 or 2 °C global temperature limit.
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PMC8751435
CCK‐8 solution was added to each well and incubated for another 1 h. The absorbance was measured using a microplate reader (Varioskan Flash, Thermo) at 450 nm.
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PMC11216402
Similar results were found using peaks within 100,000, 150,000, 200,000, or 250,000 bp from the TSS.
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PMC9621239
Compared with HBx-WT, HBx-TM significantly elevated the mRNA and protein levels of MYC in Huh7 and Bel-7404 (Figure 3B-E).
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PMC9024365
The full-length AMPAR subunits GluA1 and GluA2, as well as the kainate receptor subunit (GluK2), were expressed in heterologous COS cells either alone or co-expressed with full-length HA-tagged SD4.
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PMC11679892
In addition, the increased expression of caspase-3 and caspase-9 indicates that apoptosis progresses via the mitochondrial pathway .
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PMC11737091
Kaplan-Meier analysis revealed that high DBF4 expression was associated with a significantly lower five-year overall survival rate.
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PMC11704834
Since EMT is a known mechanism for EGFR-TKI resistance in the human LUAD A459 cells (14) which were previously shown to develop EMT phenotype upon exogenous TLE1 expression (8,9), stable exogenous GFP-TLE1-expressing and control GFP A549 clonal pool of cells (Fig. 2A) were treated with the EGFR-TKI gefitinib and their proliferation (Fig. 2B) and basal apoptosis (Fig. 2C) were assessed.
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PMC11708541
Tuberculosis (TB) is an infection that affects lungs.
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PMC11476004
Isolated lymphocytes mixed with 0.5% LMP (low melting point) agarose gel were spotted on microscope slides covered with 0.5% NMP (normal melting point) agarose and incubated at 4 °C.
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PMC11705547
Therefore, CSF1R inhibitors can overcome resistance to cisplatin by modulating the polarization of TAMs .
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PMC11499955
As shown in Fig. 5C, LC-MS/MS analysis confirmed that TMPP-H24 is the most abundant representing more than 85% of all released tags.
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PMC9429973
However, the influence of ZnO NPs on MM cells is still unclear.
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PMC11718109
The representative EM images (B, D) are depicted on the right of each panel.
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PMC11740207
These cells are quiescent, entering dormancy to protect against environmental stresses, including oxidative damage.
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PMC9429973
Interleukin-18 values demonstrated a positive correlation with the weight loss among the patients with PV.
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PMC11635087
Super-resolution fluorescence microscopy image and orthogonal view of the z-stack of CHO-K1 cells that incorporated chloroplasts at 0 day after the co-cultivation.
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PMC11592837
Interestingly, we also detected a delayed formation of 53BP1 foci between both cell types, supporting our analysis on γH2AX.
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PMC11045125
Whether IL7-induced signaling or surrogate light chain expression plays any role in supporting the growth of human BLs in patients is an interesting area for future study.
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PMC11687167
It can not only be used as a therapeutic target but can also be used as a prognostic predictor of the degree of inflammation or activation.
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PMC11736898
Keratinocytes were used for experiments at passage 2 or 3.
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PMC11297139
The PrLD of early B-cell factor 1 (EBF1) is indispensable for B-cell lineage commitment.
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PMC11531744
We additionally screened the immune DEGs related to prognosis through Univariate Cox Regression analysis.
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PMC9430052
All pts presented with rapidly progressive disease especially pt 3 had a bulky nodal lesion with 12.2 cm in the long axis before lymphodepletion (8.6 cm at screening stage).
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PMC11190062
Heterogeneous response to TLR agonists in MM patients.
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PMC11552389
Western blotting analyzed the amount of LC3I/II protein in melanoma cell lines A357 and A375R. (
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PMC11546117
Negative controls were obtained by omitting primary antibodies.
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PMC11719944
Thus, there is a need to propose new analytical approaches that could lead to innovative strategies for monitoring T1D.
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PMC11795610
Isolated epidermis was digested with 0.25% trypsin/EDTA for 10 min and strained through a 200-mesh sieve.
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PMC11791264
Each bar represents the mean ± SD (n = 3).
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PMC4485648
A chemotactic signal for the cell movement was provided by supplying 10% FCS into the lower chamber.
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PMC11591794
After, the MTT procedure was applied.
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PMC11509309
Aplyzanzine C (7) and psammaplysene D (11) were tested at concentrations below 5 µM since they were cytotoxic at concentrations higher than or equal to 5 µM (Figure S2).
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PMC9611901
The results suggest that vegetable and synthetic tanning, perhaps due to their complex composition, cause higher overall primary DNA damage than “normal” chrome tanning.
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PMC11618052
As recently discovered, hybrid molecules have addressed several challenges associated with traditional drugs, including side effects and multidrug resistance (MDR).
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PMC8922418
The combination of viral antigens by ABACAS can suppress virus entry into cells.
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PMC9429973
Influence of KitM on ICM/ligand expressions on T-cells/blasts - ICM/ligand expressions on uncultured T-cells/blasts: In contrast to H, PTs presented high co-expressions of CTLA-4 and PD-1 on PB T-cells (Figure 1).
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PMC11394386
Enrichment analyses focusing on cancer signaling pathways and transcription factors demonstrated a significant association of HOTAIR with the transcriptional regulation of both pathways (Figure 1A,B).
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PMC9429973
At the molecular level, the patient’s BCR-ABL fusion gene was confirmed as e1a2 transcript.
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PMC11453018
Hence, for our testing, we opted for Dasatinib and Fisetin, established senolytics targeting the PI3K pathways, while Navitoclax and Quercetin, known BCL-2 targets, served as negative controls [25–27].
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PMC11543885
= 10 mM) and incubate for 30 min at 25°C.30.Alkylate the samples by adding 20.4 μL of 0.5 M iodoacetamide (IAA) per sample (final conc.
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PMC11794568
Mitochondria were labeled using Mitotracker (Red).
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PMC11661040
Results from three experiments are summarized in a histogram format. (
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PMC10813895
The similarity of the accumulation of KRT14 and KRT8 or KRT19 double-positive progenitors during pregnancy in the conditional ELF5 knockout mice and during aging in human breasts suggests that the loss of ELF5 expression during aging might cause increased proportions of luminal progenitor cells.
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PMC11679892
After the incubation was completed, 50 μL of stop solution was added and readings were performed using a microplate reader (Epoch 2) at 450 nm within 10 min.
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PMC11380329
Comparaison between several kinds of ovarian cance cell line will be envisageable in future investigation, (ii) There are difficulties in simulating the consequences of long term treatment in vitro, and finally (iii) We cannot accurately replicate neither the inherent complexity of organ cells in living organisms nor the internal environment of human body.
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PMC11401350
This can be attributed to the fact that CD4 + PD-1 AITL cells mainly use mitochondrial respiration (Oxidative phosphorylation) as metabolic pathway to fuel their energy requirements .
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PMC10899471
P < 0.05, **P < 0.01, ***P < 0.001.
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PMC9119314
Dose–response curves of test and control compounds are shown in Supplementary Figure S7.
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PMC5673060
The lack of significantly upregulated pTyr-containing proteins raises the possibility that the major alterations associated with drug resistance in the A204 cells may instead be driven by phosphoserine (pSer) and phosphothreonine (pThr) signalling events.
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PMC11487720
Calcium chelator EGTA retarded the bubble formation.
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