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PMC9111184
These cells are able to express membrane transporters; therefore, rendering them good models to study intestinal absorption and transport of natural products, as well as other processes that occur in the normal intestinal epithelium (Ming et al., 2011).
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PMC11366496
The second is K63 (Lys63)‐linked ubiquitination, which promotes the degradation of protein substrates and related cellular contents (such as damaged mitochondria and invading pathogens) via the autophagy pathway, or regulates the non‐degradation processes of substrate molecules, including protein trafficking, DNA repair, protein kinase activation, and molecular interactions.
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PMC11767793
The filtrate toxicity was tested with CHO K1 cells (Figure S12).
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PMC7057940
In the clinical samples, the FISH cytogenetic analysis showed the presence of the EWSR1 translocation nuc ish(EWSR1×2)(5′EWSR1 sep 3′EWSR1×1) in patient 1, indicated as separated signals in 10% of the interphase nuclei analyzed (Fig. 2C).
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PMC11765988
Specific immune responses to the bacterium in sarcoidosis patients have also been recognized .
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PMC10734950
These versatile compounds show promising activity, and here we will explore thiophene carboxylate F8 (Fig 1) anti-cancer activity in vitro.
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PMC11495567
These two proteins possess clusters of basic amino acid residues that bind to negatively charged phospholipid headgroups of specific membranes.
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PMC11665584
Together, PITX1 murine skin has structural and functional changes in the keratinocyte populations, such as increased proliferative and migratory capabilities.
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PMC11461833
Based on the above results, we speculate that the expression of STXBP5 in HA-progerin-expressing HEK293 cells is affected by progerin.
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PMC11593031
The karyotype differs from that of Neuro-2a by including two new derivative chromosomes and lacking one original derivative chromosome, while one derivative is duplicated.
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PMC11745600
GCG, glucagon; hSC, human stem cell-derived pancreatic; INS, insulin; NOG, NOD/Shi-scid IL2rγc.
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PMC11748335
B Comparative analysis of H3K27me3 intensity (n = 109), peak size (n = 109), DNA methylation (n = 20), and gene expression (n = 49) across different peak types.
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PMC10329074
After total RNA had been extracted from the cells, the expression of YBX3 was quantified using M-MLV-RTase (Promega Corporation, #M1701), and GAPDH was used as an internal control.
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PMC11742670
This type of data is commonly encountered in drug development due to the intricate nature of biological systems and the limitations of experimental information.
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PMC9352806
It summarizes the contribution of each variable to the model.
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PMC11098378
We were unable to obtain crystals suitable for X-ray crystallography with full-length Ceg10, possibly owing to flexible N- and C-terminal domains as determined by the AlphaFold prediction (Fig 3A).
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PMC11718817
However, to compare results to reports in the literature, standardized stimuli are helpful to induce characteristic macrophage phenotypes.
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PMC7917457
OV therapies can be further improved by arming OVs with immunostimulatory molecules, including various cytokines or chemokines.
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PMC9817179
Live- and fixed-cell images are compared. (
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PMC11766174
The Capricorn anti-HIV CA mAb binding domain is instead located at p24 amino acid position 188–197 (TLLVQNANPD), as determined by peptide mapping.
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PMC9429973
A. Beielstein, E. Izquierdo-Alvarez, N. Nickel, S. Blakemore, D. Vorholt, S. Chawan, H.-H. Bartel, J. Wiederstein, R. Linke, R. Brinker, M. Michalik, C. R. Costa Picossi, A. Villasenor, C. Barbas, M. Krüger, M. Hallek, C. Pallasch Department I of Internal medicine, University Hospital Cologne, Cologne, Germany; Universidad CEU San Pablo, Madrid, Spain; CECAD Research Center, University Hospital Cologne, Cologne, Germany Background: Treatment response in lymphoma depends on the interaction and functional status of macrophages as important effector cells for tumor cell clearance by antibody-dependent cellular phagocytosis (ADCP).
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PMC10588957
Data are represented as means ± SD; n = 3 per group (*P < 0.05, **P < 0.01, ***P < 0.001 versus respective control cells).
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PMC9429973
Comparisons were assessed using Student t-test or Fisher’s exact test, considering a p-value <0.05 statistically significant.
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PMC11739504
According to a previous study, the acetylation of α-tubulin increases the flexibility of microtubules, contributing to better resistance against mechanical stress and consequently making them long-lived.
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PMC11574271
To establish stable RON-overexpressing cell lines, the bladder cancer J82 cells at 50% confluence in a 6-well plate were infected with the lentiviral package according to the manufacturer’s instruction (https://www.genechem.com.cn/proinfo/16.html).
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PMC11804588
As proof of principle, the authors demonstrated that scFOODIE was able to resolve TF binding patterns in a mix of four human cell lines (GM12878, K562, HEK293, and HeLa), where cell-type-specific open chromatin signals can be used to classify the cells.
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PMC6267596
Cell cycle analysis showed that with time 8n polyploid cells can shift back to 2n-near aneuploid cells. (
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PMC11045125
B. Extracts harvested from Myc expressing tumors derived from Donor 1 or Donor 2 as indicated or Donor 1 derived tumors without Myc were examined by immunoblot for expression of Myc, Myb and BACH2 as indicated.
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PMC11731161
By analyzing mRNA expression data from the Human Protein Atlas (HPA) database, we found that USP7 expression was much lower in cells exhibiting greater sensitivity to SEL (Fig. 5A).
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PMC6442998
Cilostazol is already approved by the FDA for clinical use in indications such as intermittent claudication or platelet aggregation .
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PMC10490530
Compared to untreated cells, expression and stabilization of p53-NLuc fusion protein were evident in immunoblot experiments performed after 24 h treatment of the A2780 cell line with two different concentrations of doxorubicin and TNFα (Figure 4b).
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PMC9398137
Venetoclax was given on days 1, 2, 3, 6, and 7.
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PMC10854447
On the other hand, compounds 4a–o were prepared according to a reported procedure in THF via an iodine-catalyzed transformation of the formyl group in 3a–o to a cyano group utilising ammonia as a nitrogen source.
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PMC11342785
Scale bars represent 20 μm (TIRF images) and 200 nm (EM images).
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PMC11644761
In this work, for DNA methylation evaluation, the MeSAP-PCR reaction was used.
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PMC11737091
The gene expression data and grouping information for all samples were then used as inputs for analysis based on the database of hallmark gene sets (h.all.v2023.1.Hs.symbols.gmt).
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PMC11682224
However, due to the disordered blood vessel structure and uneven blood supply, the ability to supply oxygen and nutrients cannot meet the demands of tumor cells, resulting in the formation of hypoxic regions.
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PMC3035438
Concentration of chicken IgM in culture supernatants determined by quantitative ELISA.
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PMC10818573
We also determined the minimum reaction time and found that a positive test could still be detected when the total time of the two-step reaction was shortened to 10 min.
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PMC3888431
Nevertheless, very few assembled cDNA sequences of CHO cells were publicly released until recently, which puts a severe limitation on biotechnological research.
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PMC11718274
From enhancing LED lighting to serving as contrast agents in imaging technologies, Y2O3NPs demonstrate superior performance in comparison to their bulk counterparts, thanks to their unique size and surface characteristics.
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PMC11591052
In accordance with this finding, the present study demonstrates that 20E induces the activation of both AKT (S473) and mTOR (S2448).
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PMC11583690
The release process increased gradually and maximized at 120 h. However, the BPMO@DTX sample exhibited superior release kinetics, and when compared with MSN@DTX and free DTX, its release was higher as early as after 3 h, and remained consistently higher at all time points, peaking at 51.6 % at 120 h when compared with 42.55 % and 40.95 % for MSN@DTX and free DTX, respectively.
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PMC11798926
Representative dendrites with wild-type SynDIG4 and SynDIG4 AVPA, and quantification of PSD95 puncta size and colocalization of surface SynDIG4 with PSD95 in wild type and AVPA transfected neurons.
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PMC11532793
We further showed that the RTA-induced dispersion can be (literally) divided out of the transcript counts, after which the divided counts can be input into standard edgeR analysis pipelines that were originally developed for gene-level counts.
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PMC9429973
Cost of chelation therapy and frequency of transfusions are the main drivers of modelled lifetime cost estimates.
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PMC9429973
Cox proportional-hazards regression models were used for univariate and multivariate analysis.
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PMC7519871
Among them are recognized drugs (e.g., nonsteroidal anti-inflammatory drugs abbreviated as NSAIDs) and phytochemicals.
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PMC10810426
The infection percentage was determined by analyzing the integrated copy numbers relative to the number of initially seeded cells.
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PMC11247842
Then we extracted the SVs of the 123 Nordic Holstein from the joint calls of various breeds.
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PMC11335267
Data represent the mean ± SEM. *
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PMC11453018
The sample sizes were determined based on previous experience with similar assays to achieve sufficient statistical power.
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PMC10079526
E, F Respectively show Ni-NTA pulldown of His10-SUMO2- and His10-ubiquitin.
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PMC9872547
Horseradish peroxidase-conjugated secondary antibody (HRP Rabbit Anti-Mouse (IgG) secondary antibody purchased from Abcam Company) was employed to attach to primary antibodies with 1: 1000 v: v concentration.
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PMC9429973
According to immunophenotyping data, statistically significant differences were obtained on the Zap70 marker: in the 1st group the median was 10.1%, in the 2nd group - 21.6%.
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PMC10965680
The individuals of each breed are distributed in clusters, and they are basically clustered on a branch without crossing each other.
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PMC11741906
While our findings provide insights into the molecular changes in cisplatin resistant ovarian cells, several limitations should be addressed in the future studies.
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PMC11767817
5637 cells were seeded in a black 96-well plate at a density of 15 × 10 cells per well and incubated overnight.
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PMC11569208
Cells were transfected with PP-targeting siRNA for 48 h, then infected with VSV∆51 tagged with green fluorescent protein (VSV∆51-GFP) at a multiplicity of infection of 0.05.
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PMC10470467
Finally, the PCR experiment of 3 key genes could be considered an external validation in a sense, but we only used one ES cell line, which is also a limitation of our study.
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PMC9219615
After washing cells twice more, the liquid was removed from each well and 200 μL of 5% w/v bovine serum albumin (BSA) dissolved in Tris-buffered saline with 0.5% v/v Tween 20 (TBS-T) was added for blocking purposes.
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PMC9429973
Methods: In our observational clinical study, image-based ex vivo drug screening (Pharmacoscopy; PCY) measured the single-cell level responses to drug and immunotherapy combinations for 138 patient samples from 98 patients covering all stages of the disease.
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PMC10748106
However, in this study, Geniposide did not exert any cytotoxic effects in any of the cell lines tested.
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PMC8469018
The cells with collapsed mitochondrial potential exhibit a decrease in their red/green fluorescence intensity ratio.
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PMC9429973
The 8 remaining patients who received prophylactic DLI are still disease free at last follow up.
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PMC11678841
α-Tocopherol (α-TOH) and garcinoic acid (GA), a vitamin E metabolite, with immunomodulatory properties, were investigated for the first time in vaginal epithelial cells exposed to C. albicans infection to assess their effects on inflammatory signaling parameters important to restore cellular homeostasis.
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PMC11098378
Images in G-I were created with BioRender.com.
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PMC9429973
A longer treatment period may strengthen this effect.
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PMC9895440
Tumor cell killing was evaluated using an MTT assay.
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PMC11574029
Overall, these findings indicate that targeting NOTCH3 can inhibit tumor growth and metastasis, suggesting that NOTCH3 is a potential therapeutic target for BLCA.Fig.
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PMC11676674
As shown in Figure 8, treating CHO-K1 cells with the positive control MMC for 24 h resulted in an increase in micronuclei frequency compared to NC control cells by 2.2 fold.
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PMC11381192
The screening criteria for statistically significant functions were defined as both p value and false discovery rate (FDR) below 0.01.
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PMC7081114
A multivariate Cox proportional-hazards regression model was used to identify independent prognostic factors.
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PMC6222726
The leaves are compound, bright, and mostly glabrous when mature.
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PMC11790971
For SVMs, the estimates of class probabilities were generated using 5-fold cross-validation during prediction.
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PMC10253973
The results of tumor cell exposure to 48 and 3-methyl adenine (47) or curcumin (present as a ligand in complex 49) indicate the critical role of autophagy in inducing cell death by compound 49.
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PMC10958426
These success stories of identification of cancer cells and tumor subclones using scRNA-seq inferred-CNV are promising .
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PMC10713411
Then mRNA expression data and the gene sets were utilized for calculation of activity scores among various terms based on the Gene Set Variation Analysis (GSVA) R package.
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PMC8469018
The IC50 value for teriflunomide was not achieved.
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PMC9429973
Bleeding occurs in most patients and may result in death in 4–10%.
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PMC11714165
To evaluate the effect of DN‐F nanoparticles on osteolysis, the tumor bearing tibias were quantitatively analyzed by micro‐computed tomography (micro‐CT) after treatment (Figure 6A).
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PMC11656657
In this preclinical study, we investigated the potential use of iCasp9.2A.GD2.CAR-CD28.4–1BBζ (CAR.GD2) T-cells as a treatment option for patients who have GD2-positive sarcomas and we sought to identify factors shaping hostile tumor microenvironment in this setting.
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PMC11720808
Quantification and normalization of p-p65 protein levels were performed relative to α-tubulin. (
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PMC9429973
Among 15 MRD-evaluable pts, 14 (93%) achieved MRD 10 negativity.
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PMC2777936
Thus, repression of FZD5 and FZD7 expression in human NT2/D1 EC cells inhibited growth, but did not impact expression of several key pluripotency factors.
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PMC7039683
They were enriched for a set of binding sites, such as TEAD, JUN, C/EBP, GRHL and TFAP2; among these several were shared with zGPAEs and mPEAEs (Figure 5—figure supplement 3).
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PMC11643361
The inclusion of molecules with established biological activity has also been demonstrated beyond functionalization of the tpm ligand via direct coordination of the metal.
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PMC4839679
Caki2+PBRM1 with respect to Caki2+Vector and 2.
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PMC11680391
However, there is a difference in how the data were collected in the cited studies; they were based on interviews, whereas the present study is based on closed-end questions in a questionnaire.
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PMC10958426
Then, we divided genes that expressed in ≥5% cancer cells or normal epithelial cells into noCNV, deletion and duplication regions in each patient, and calculated average relative expression level of those genes in each category.
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PMC9592219
A gene coexpression network was developed to investigate the modules that were significantly relevant to the sample characteristics.
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PMC9841531
Chloroform/methane (95%/5%) was used as an eluent, and the results were viewed under a UV cabinet (Desaga, Biostep, Burkhardtsdorf, Germany) at a wavelength of 254 nm.
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PMC9429973
Data was acquired from the WMUK Rory Morrison Registry.
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PMC11047729
the promyelocytic leukemia protein (PML) nuclear bodies are created.
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PMC2196094
With respect to their RMCP-7 content, CTMCs of ears and peritoneum may therefore be regarded as two distinct subpopulations of MCs.
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PMC8409415
Significant P values are given in bold font.
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PMC11295144
However, the TM 3–4 ICL may not be sufficient for binding to occur, given that no binding to NL2 was detected when the purified GST-fusion of the γ2 TM3-4 intracellular loop was tested in binding assays in vitro.
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PMC11591038
In contrast, HIF-1α is overexpressed in brain microvessels derived from AD patients .
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PMC9429973
No differences in genotype frequencies of cytokine SNPs were observed regarding the number of relapses.
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PMC11588085
This finding suggests that XIST expression is associated with more differentiated cell states in ovarian cancer and exhibits an anticorrelation with CD44 expression, a pattern consistent with our in vitro observations (Fig. 4E).
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