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PMC11543885
This APEX2 PL-MS study has certain limitations, particularly in the use of HEK293 cells instead of appropriate immune cell types where the NLRP3 inflammasome assembly naturally occurs.
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PMC10976516
The use of MSCs in combination with different adenoviral designs has been widely investigated in (non)systemic therapy.
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PMC11607638
The control group was DEPC water.
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PMC11732628
Combined with above findings, we speculated that miR-490-3p might participate in the proliferation, migration, invasion, apoptosis, and cell cycle in osteosarcoma cells via the interaction with NUSAP1.
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PMC9429973
Methods: We retrospectively reviewed the histology of lymph node biopsy and clinical data, treatment and outcome of 21 adult patients consecutively diagnosed of a NLPHL between 1999 and 2021.
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PMC11467964
This study revealed BMRG's extensive regulatory mechanism affecting TME, clinicopathological characteristics, and prognosis in STS.
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PMC11078693
Timing: 1–2 h Timing: 1–2 h This step prepares cells for immunostaining and does not depend on the previous step for staining live cells.3.Fixing the cells.a.
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PMC9895440
n = 10 donors (Teff) and 8 (Tex).
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PMC10538569
GPI-GFP was detected on DiD dyed dendritic cells when imaged after 2 hours of coculture as indicated by white arrows. (
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PMC8010066
In other words, carbapenemase mediating resistance reduced considerably in combinations containing SA-1/PA-2 and SA-1/PA-3 (P-value 0.001).
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PMC9429973
Aims: The aim of this study was to analyze outcome of HSCT patients requiring ICU admission in our center.
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PMC9429973
Significant worsening was not observed for any domain.
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PMC6642070
ENO3-p53RRE3-WT-F:5′-CGGGGTGAGCTGACACTGTCCCAGCTGCCACCTAGACTCGGAGCTCCATC-3′, ENO3-p53RRE3-WT-R:5′-TCGAGGATGGAGCTCCGAGTCTAGGTGGCAGCTGGGACAGTGTCAGCTCACCCCGAGCT-3′, ENO3-p53RRE3-MUT-F:5′-CGGGGTGAGCTGACACTGTCCCAGCTGCCACCTAGATCCGGACCTCCATCC-3′, ENO3-p53RRE3-MUT-R:5′-TCGAGGATGGAGGTCCGGATCTAGGTGGCAGCTGGGACAGTGTCAGCTCACCCCGAGCT-3′. A-204 cells were co-transfected with the reporter plasmids and the transfection efficiency control plasmid (pGL4.54 [luc2/TK]) containing TK promoter and firefly luciferase.
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PMC9739791
It is also worth noting that for polymer Pt(IV) prodrug 30, photoinduced release is possible after two-photon absorption at 725 nm.
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PMC11682172
A two-tailed Student’s t-test was applied to find differences between the proteomes of the 3 cell lines prior to, and after incubation with activated T lymphocytes, or their CM.
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PMC9388315
This oncogene is a regulator of cell bioenergetic pathways such as ras, PI3K/AKT, and mTOR [15–17].
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PMC11541241
They constructed gain‐of‐function mutants of the Rheb GTPase protein, which maintained the high activity of the TORC1 pathway.
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PMC9429973
Summary/Conclusion: The origin of the second neoplastic cell, in patients with DLBCL with a previous history of cHL, remains controversial, although the different immunophenotypic characteristics suggest that it may mainly arise de novo in a subject with a possible individual predisposition to develop lymphoid neoplasms.
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PMC11248911
The authors used the wound-healing assay on MCF-7 cells to detect the effect of compound 8 on cell migration inhibition in breast cancer cells.
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PMC11695546
This aspect undoubtedly affects the ozonation kinetics as a sequence of the source of the green oils and the chemical structure of their fatty acids (De Almeida et al. 2016).
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PMC8009078
To check the behavior of each molecule in the dynamic state, an all-atom MD simulation was performed.
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PMC9429973
Nevertheless, some patients are refractory to this drug and do not attain a response when using the maximum eltrombopag approved dose of 75 mg per day after at least four weeks of treatment.
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PMC11711663
H.ratiose95% CIpvalueGradient ngtdm Contrast0.151.160.13[0.9, 1.49]0.26Logσ=3 3DFirstorder RootMeanSquared-0.100.900.17[0.64, 1.27]0.56Logσ=0.1-3D glszmSmallAreaLowGrayLevelEmphasis0.181.190.15[0.89, 1.6]0.24Exponential gldmLargeDependenceHighGrayLevelEmphasis0.061.060.19[0.74, 1.54]0.75Gradient ngtdm Strength-0.610.540.22[0.35, 0.83]0.01Concordance Index0.68Standard error0.04Likelihood ratio test11.650.04Wald Test9.60.09Score (logrank) test9.70.0995% CI is calculated by exp(coef ± 1.96×se).
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PMC6835428
Thus, it is feasible to assume that the therapeutic effects were exerted by the fraction of particles which escaped lymphatic lacunae drainage and made direct contact with tumor cells in the peritoneum.
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PMC7185206
Mean values and 95% confidence intervals (CI) are indicated in corresponding supplemental figures and tables.
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PMC11791264
Cell Counting Kit (CCK)-8 (A311–01) was purchased from Vazyme Biotech.
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PMC5035325
R3m or 7A7 mAbs followed by polyclonal rabbit anti-mouse immunoglobulins/FITC (Dako, F0232).
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PMC11240448
We exploited a cSTAR approach to analyze a mass cytometry dataset comprising 62 BC and five normal breast tissue cell lines, each subjected to five distinct kinase inhibitor perturbations .
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PMC5839394
An overnight pre inoculum of cells was prepared and inoculated both into this oxygen-free medium and that aerated medium with 10 ml of DSM 29614 culture (OD600nm = 1.0) and incubated at 30°C.
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PMC9429973
The key transcription factors of T cell differentiation were detected by real-time quantitative-PCR analysis.
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PMC11726183
Isatin is a heterocycle scaffold that is the foundation of many drugs.
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PMC9919300
Cells supplemented with media containing only BSA and DMSO served as the normal control (CTR), instead cells supplemented with media containing PA, OA, BSA, and DMSO were considered as the steatogenic control.
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PMC11088135
H qRT-PCR was conducted to analyze the mRNA expression of Bax.
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PMC10565698
I and J. qRT-PCR to validate TCF12 expression in liver cancer tissues and cells.
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PMC10440586
In summary, we believe that whether CD99 is down-regulated after bevacizumab treatment is related to the treatment response.
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PMC10847511
The National Cancer Institute has performed comprehensive molecular characterization of a large number of human tumors, their corresponding PDX models, and subsequent passages in various types of cancer using next-generation sequencing, and the results have been published in the Patient-Derived Models Repository (PDMR) database.
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PMC6487404
The growth medium was changed every other day, and the cells were trypsinized using Trypsin-EDTA every 4 days for passage.
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PMC11412721
In (F, G) scale bars = 50 μm.
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PMC8740518
Volcano plot with Log2(FC) and -Log10 (P-value) values was used to show the differential metabolites between xenograft and control groups.
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PMC7039683
150-bp-paired-end sequencing was performed using the HiSeq X Ten sequencer (Illumina, provided by Annoroad Genomics, China).
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PMC9926039
In the present study, methadone increased the migration rate in A549 cells after 4 h. Therefore, the effects of methadone may depend on its dosage and time.
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PMC11295144
Max intensity projection of the z-stack images was shown.
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PMC11583010
Clone HCT116-2G10 was selected for its high and homogenous human nectin-4 expression and further amplified and banked.
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PMC11635519
We introduced a 14-amino-acid overlap between neighboring peptides to guarantee full sequence coverage.
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PMC11063646
The 24 h In-vitro drug release was found to be 95.7 % following Higuchi kinetics.
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PMC9878562
Single cell suspensions were strained using a 70 µm cell strainer (Corning), centrifuged and resuspended in αMEM.
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PMC8973725
According to treatment guidelines, we usually perform partial nephrectomy for the T1 cases.
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PMC11481779
However, those are still used primarily for generating new images from text description - and not improving existing ones.
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PMC11718109
The extracted proteins were separated by SDS-PAGE in Mini-PROTEAN TGX precast polyacrylamide gels (Bio-Rad) and transferred to nitrocellulose membranes (Bio-Rad) at 100 V for 1 h or 75 V for 2 h (for high molecular weight proteins: >150 kDa).
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PMC11519583
Cells were collected, resuspended in PBS containing 2% (v/v) FBS, and incubated with the respective antibodies on ice for 1 h. Flow cytometric analysis was performed using a BD LSRFortessaTM X-20 instrument (BD Biosciences).
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PMC11413393
To summarize, our findings reveal the central role of PRMT1 as a regulator of RNA metabolism, including splicing, and add to the growing body of knowledge linking splicing disruptions to the DNA damage response.
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PMC9429973
Consistently, cell cycle assays showed that depletion of LINC01547 slowed cell cycle progression and led to accumulation of cells in G0/G1 phase.
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PMC9429973
D. Antic, D. Djikic, V. Otasevic, O. Mitrovic-Ajtic, V. Vukovic, T. Suboticki, V. Djurasinovic, K. Tomic, B. Mihaljevic, V. Cokic Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia; Faculty of Medicine, University of Belgrade; Department of molecular oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia Background: Oxidative stress is caused by imbalance between excessive production of reactive oxygen species and decreased capabilities of antioxidant system, and it is recognized as a feature in cancerogenesis, as well in hematologic malignancies.
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PMC11001582
All data are presented as mean ± s.e.m.
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PMC11757230
The mice were divided into four groups according to the number of cADSCs co-injected with CLC/fLuc cells as follows (n = 6/group):•Control group: injected with 100 μL of PBS without cADSCs•Low-dose group: injected with 2 × 10 cADSCs (CLC/fLuc:cADSC = 1:0.2)•Equal-dose group: injected with 1 × 10 cADSCs (CLC/fLuc:cADSC = 1:1)•High-dose group: injected with 1 × 10 cADSCs (CLC/fLuc:cADSC = 1:10) Control group: injected with 100 μL of PBS without cADSCs Low-dose group: injected with 2 × 10 cADSCs (CLC/fLuc:cADSC = 1:0.2) Equal-dose group: injected with 1 × 10 cADSCs (CLC/fLuc:cADSC = 1:1) High-dose group: injected with 1 × 10 cADSCs (CLC/fLuc:cADSC = 1:10) Injections of cADSCs without CLC/fLuc cells were repeated on days 7 and 14 at the indicated doses.
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PMC11461833
Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the upregulated DEGs in the STXBP5 OE cells exhibited enrichment in the terms mitogen-activated protein kinase (MAPK) signalling pathway, the Hippo signalling pathway and restricted SMAD protein phosphorylation (Fig. 6A), whereas the cAMP signalling pathway and ECM-receptor interaction were enriched in the downregulated DEGs (Figure 6B).
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PMC9429973
MSCs were isolated from BM samples and cocultured with human naive conventional T (Tconv) cells in Transwell culture dishes.
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PMC9577200
Its anticancer activity may be through apoptosis, and the cell cycle stops at the G0/G1 phase by lowering the cell viability and activating caspase-3 (Prasad et al., 2019; Chang et al., 2021).
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PMC9429973
Deposition of C3b and generation of downstream inactivation fragments such as iC3b and C3dg is controlled by binding of complement receptor type 1 (CR1) to C3b with factor I (FI), forming a trimolecular complex (TMC).
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PMC11476837
Next, we demonstrated differences in apoptosis level after incubation with doxorubicin between HL-60 and HL-60/DR cells (Figure 2B).
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PMC9250505
Histopathological assays were replicated at least three times, with each orthogonal method confirming the same result.
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PMC11672881
The results are expressed as the mean ± SEM or SD, with a p-value ≤ 0.05 considered statistically significant.
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PMC9429973
Moreover, LAPTM4B-mediated activation was able to induce MAPK signalling in the leukemic cell context.
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PMC11591038
The altered expression of HIF-1α has been noted in AD patients as well as in transgenic AD mouse models.
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PMC11594806
As previously noted, AMPK may play a role in chemotherapy resistance.
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PMC11806613
Top, luminescence images taken on days 9, 18, and 27 after treatment.
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PMC11794847
Single-cell data of lung cancer were obtained from Tumor Immune Single-cell Hub (TISCH) project (http://tisch.comp-genomics.org/home/) , including GSE131907 and GSE176021 cohorts .
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PMC11782508
A pre-stained 10–170 kDa protein marker (Maestrogen, China) was used as a reference for molecular weight estimation.
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PMC11541409
The median time to progression (mTTP) was 26.6 weeks in the sunitinib group (95% CI, 16.0–32.1) versus 6.4 weeks in the placebo group (95% CI: 4.4–10.0) .
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PMC9429973
The primary objectives were to evaluate the safety and efficacy of cilta-cel.
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PMC11552389
The CCK8 test and colony formation assay showed that over-expressing FOXN3 significantly reduced the proliferation of A375 cells whereas knocking down FOXN3 dramatically increased the proliferation of A875 cells (Figure 2C and D).
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PMC9847912
For the CEMss cells, the cultures were mixed by pipetting, and 50-μl samples (cells and medium) from each well were transferred to a new 96-well plate; 50 μl of CellTiter-Glo Solution was then added to each sample.
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PMC11726183
In several ground-breaking compounds and research, isatin has demonstrated efficacious potential against breast cancer cells.
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PMC11365427
DR5 co-localized with caspase-8 on the cytomembrane of NCI-H929 cells.
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PMC11745823
Additionally, our experimental results demonstrated that RIT1 facilitates glioma aggressiveness by activating PI3K/AKT/c‐Myc signalling (Figures 2, 3, 4, 5).
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PMC10810426
Levels of integrated MLV were determined by LINE1-gag nested qPCR, based on the Alu-gag qPCR for HIV.
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PMC9429973
Methods: The workflow of the B-cell MRD Assay consists of two parts, sample preparation and sequencing.
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PMC9429973
Methods: This is a prospective study of pts with N/D CBF-AML treated at our center on FLAG based regimens.
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PMC11506827
However, further research should aim to understand the molecular mechanisms underlying the GEF-mediated DR4/5 expression modulation and their impact on MuD function.
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PMC9429973
Thirty-six pts were still on BOS at the last contact: 6% on 400 mg, 50% on 300 mg, 44% on 200 mg.
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PMC11588008
Precooling centrifuge for a marriage proposal at 4°C.
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PMC11532793
Datasets were generated for two groups with n = 3, n = 5 or n = 10 samples per group.
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PMC9065483
Cells were seeded on 12-mm glass round coverslips (Thomas Scientific, cat.
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PMC11803918
The solution was evaporated to form a thin film on the bottom of the round-bottomed flask.
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PMC11791478
Both conjugates exhibited translocation from the cell surface to the intracellular space, with XB002-AF647 showing a punctate endosomal distribution (Supplementary Fig. S6).
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PMC6835428
The folic acid (FA) receptor (FR) is a 38 kDa glycosyl-phosphatidylinositol membrane-anchored glycoprotein .
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PMC9684669
All imaging data are presented as the mean ± SEM and represent data from cells in at least 10 fields from three or more independent experiments.
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PMC9080589
Most importantly, a study has recently shown that PCDH8 significantly decreased the level of β-catenin in glioma cells.
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PMC10344560
Therefore we switched fluconazole IP to oral voriconazole, without any antibiotic treatment.
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PMC11725127
Kaplan–Meier curves indicating overall survival (OS) of MM patients with low or high levels of USP2.
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PMC11626627
10.13039/501100003787Hebei Province Natural Science Foundation under Grant (H2020206146).
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PMC11269792
Taken together, circAPP targets the regulation of miR-6838-5p levels.
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PMC9429973
Rare genetic disorders, such as SCN, require prioritising bone marrow failure diagnosis and therapy tailored to individual patients.
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PMC9429973
25% patients relapsed once and 12.5% ​​twice.
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PMC10079526
5-Aza-2’ has a dual role of action, in short hypomethylation and thus reactivation of tumor suppressor genes as described and inducing cytotoxic stress via DNA-protein crosslinks (DPC) due to the entrapment of DNMT1 to the DNA .
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PMC10940855
Median value for U266 was used as a basis for relative expression.
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PMC11736898
Although the levels of staining were variable among samples in each group, as illustrated in Figure 4, overall, the pattern indicated higher levels of staining in keloid samples compared with normal skin.
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PMC11721277
The hydrophilic complexes 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (Ga-TFPP) and [Ga]-TFPP demonstrated high tumor uptake in fibrosarcoma, along with favorable tumor-to-blood and tumor-to-muscle ratios in preclinical studies.
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PMC6684588
Individual skeletal muscles display remarkable diversity, leading to important clinical consequences.
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PMC11531744
In summary, we utilized comprehensive bioinformatics analysis to build an effective prognostic gene model for OC patients.
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