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OTAR3088
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PMC9429973
The RP2D for the combination was defined as 800 mg Q3W + pembrolizumab 200 mg Q3W.
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PMC11401358
To further confirm the antioxidative properties of SF, we verified that different concentrations of SF could scavenge intracellular ROS.
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PMC11721096
As shown in Figure 2, the enzymatic activity slowly decreased, and it retained more than 80% of the initial recombinant cells of the 0 day, suggesting the good storage stability of the recombinant cells.
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PMC9919300
We observed that ROS levels were abated by curcumin and, in part, by andrographolide.
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PMC11525293
Nonetheless, this drug has found usage in clinical practice due to its anti-tumoral, immunomodulatory, and anti-inflammatory effects .
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PMC10748106
RN=∑j=1P−Mj; Mj<0 and −1≤RN≤0 where Mj is defined by Equation (13).
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PMC11506670
AutoDock Vina was then run in the command prompt, and the resulting docked configurations were visualized using PyMOL (The PyMOL Molecular Graphics System, Version 3.0, Schrödinger, LLC, Boston, MA, USA).
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PMC6163708
For Western blot analysis, cells were lysed in RIPA buffer (50 mM Tris-HCl pH 7.5, 150 mM NaCl, 5 mM EDTA, 1% NP-40, 0.5% sodium deoxycholate, 0.1% SDS), supplemented with aprotinin, leupeptin, pepstatin (Sigma), COMPLETE, and PhoStop (Roche, IN, USA).
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PMC11711871
G Determination of plasma concentrations of the glucocorticoids corticosterone, 11-dehydrocorticosterone and the corticosterone/11-dehydrocorticosterone ratio and H the mineralocorticoid aldosterone and its precursor 11-deoxycorticosterone in the morning (7–8 am) and afternoon (6–7 pm) of GR and GR. (
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PMC11343332
Morphology study We chose the best doses (IC-50: 80 ug/ml) for further research based on the MTT assay.
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PMC11656657
Specifically, the percentage of circulating CAR.GD2-T-cells increased in the first month from 46.32% ± 19.81% to 61.72% ± 23.78% (day + 33) and remained stable up to day 44 (62.80% ± 17.54%) (Supplemental Fig. 10C) mice treated with NT T-cells, a significant enrichment of the CD4 + subpopulation was observed (Supplemental Fig. 10D, while we observed a similar distribution between CD4 + CAR + T-cells (53.8% ± 17.2%) and CD8 + CAR T-cells (43.0% ± 15.4%) in mice treated with CAR.GD2 T-cells at day + 33 post treatment (Supplemental Fig. 10D–E).
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PMC11618052
The H NMR spectra of compound 8g, as an example, confirmed the presence of three characteristic singlet signals in the aliphatic range: first one at δ 2.36 (s, 3H, CH3), second one at δ 3.77 (s, 3H, O–CH3) and third one at δ 4.49 (s, 2H, S–CH2).
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PMC9739791
The first generation of photoactivated Pt(IV) complexes were diiodo Pt(IV) prodrugs, which showed elevated toxicity and an increase in DNA binding ability under white light irradiation.
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PMC11790971
Four single-origin recombinant CHO cell lines (referred to as A, B, C, and D) with varying production phenotypes were investigated in this study (Fig. 1a).
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PMC11247842
The map positions of the variants were based on the ARS-UCD1.2-assembly of the Bos taurus genome .
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PMC8170755
For protein extraction, the cells were suspended in RIPA lysis buffer (Santa Cruz Biotechnology, Inc., Dallas, TX) containing protease inhibitor (Sigma-Aldrich, St. Louis, MO).
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PMC8623816
Moreover, the phylogenetic analysis with RdRp sequences placed RsRV5 in a distinctive clade with members of Gammapartitivirus in the family Partitiviridae (Figure 3).
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PMC11342785
Following transduction, unsorted populations of cells spanned a wide range of expression levels that were useful for exploring synMAP behavior across different component concentrations.
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PMC11093197
Immunoblotting of indicated proteins in Scr, shRB1#1, and shRB1#2 MCF10A cells. (
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PMC11695623
DEGs was screened based on P.adj < 0.05, |log2FC| ≥ 1 and encoded protein gene.
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PMC6835428
It is comforting, however, that even a modest tumor accumulation seems to be sufficient to exert a functional effect.
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PMC11676674
For the assessment of cytotoxicity and genotoxicity, CHO-K1 cells were utilized.
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PMC9429973
Further analysis of the cytokine profile of the E/R parents compared with an age- and gender-matched healthy control group revealed an overall significantly elevated cytokine response (p < 0.05) after stimulation, but the different sub-features, such as the fungal, bacterial and viral immune responses were not different.
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PMC11743414
In addition, high expression of FHL1 in AML was found to reduce the sensitivity of conventional chemotherapy drugs such as cytarabine and daunorubicin in subsequent tests.
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PMC9429973
Finally, it should be noticed that during the year 2020 mean factor VIII values were much increased in all children in comparison to the years 2018, 2019 and 2021 (137 vs 129, 123 and 127, %, respectively), probably reflecting the effects of unknown pandemic COVID-19 which initiated in 2020, and showing that factor VIII could be an evidence of stress condition.
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PMC11672142
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was purchased from EMD Biosciences Inc. Tris was purchased from Amresco.
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PMC10919056
These proteins are involved in multiple biological processes, such as apoptosis, proliferation, immune response, and digestion (14, 15).
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PMC10631132
In contrast to the EB differentiation approach, MB differentiation showed similar, yet not as spatially organized expression patterns of markers for the three germ layers.
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PMC11139449
Using a fluorescent microscope as a guide, we harvested various clones and transferred them to a 96-well plate.
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PMC11674891
Cells were suspended in serum-free medium and seeded into the upper chamber at a density of 2.0–5.0 × 10 cells per well, while serum-containing medium was added to the lower chamber.
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PMC9599726
Verteporfin and cumene hydroperoxide were purchased from Sigma, St. Louis, MO, USA (Cat# C0737, SML0534, and 247502, respectively).
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PMC3813807
The present study demonstrated that miR-373 is upregulated in gastric adenocarcinoma tissue and gastric carcinoma cell lines when compared to normal gastric tissues.
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PMC11767793
The demand for reference materials in the hazard screening of nanomaterials is well documented.
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PMC11730320
I Profiling of the T cell receptor β variable (TRBV) genes by sequencing analysis at age 28 months revealed similar gene usage in the patient and control.
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PMC11637820
A self-developed plasma reactor along with a high-frequency power supply was used in the present study.
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PMC10092581
A. H157 cells were treated for 24 h with IC50 concentrations of the tested complexes or CCCP (3 μM).
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PMC11564322
Therefore, we can assume that PPARγ is involved in the mechanism of action of the VGVAPG and VVGPGA peptides in all the studied cell lines.
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PMC11786704
TUNEL staining images indicating apoptosis levels in NIH3T3 cells under various treatments. (
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PMC11640115
The TMB measurement incurs considerable expense for next-generation sequencing.
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PMC11774112
p <0.05, **p <0.01.
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PMC11055323
n = 30 pixels, from 3 nuclei. *
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PMC11075223
Cimigenoside (0, 1, 2 and 5 μmol/L) suppressed the activation of NF-κB signaling and inducing apoptosis in A549 cells .
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PMC7723249
After infection, cells were washed 3 times with PBS on both sides and complete culture medium was added as described above.
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PMC10698968
In this experiment we used spheroids as a 3D model to have a more controlled system with respect to myxospheres in terms of cell number, shape, and dimension of the 3D structure.
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PMC10976516
OV-mediated oncolysis then further promotes immune activation by TAAs spreading, which results in the proliferation of CTLs targeting other TAAs presented by MHC in addition to CAR T cells.
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PMC11694109
In contrast, in TCL, the microenvironment contains not only physiological reactive T cells but also neoplastic T cells which show functional and partial phenotypic overlaps with their benign counterparts.
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PMC6461034
The final network object is printed.
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PMC11655536
F Cell viability of RPMI-8226 cells.
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PMC10878518
This method would support the selection of patients with bone and soft-tissue tumors eligible for treatment with OBP-301, providing valuable insights for the clinical application of OBP-301 against bone and soft-tissue tumors.
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PMC11457557
This paradigm demonstrates that investigating the genetics of disorders associated with glucose dysregulation and the relationship between genetics and therapy may give insight into the clinical effectiveness of innovative treatments.
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PMC9429973
Results: At the clinical cut-off date, March 15, 2021, 12 pts received M retreatment; 6 pts completed retreatment and 6 pts discontinued retreatment (PD, n=5; start of another anti-lymphoma therapy, n=1).
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PMC9429973
Aims: Our aims were to provide biological insight into the contribution of ncRNAs to AZA mechanisms of action and to propose novel disease biomarkers that would be able to predict future response to AZA treatment.
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PMC11597291
The CGO was functionalized with PEG-amine and thiol-terminated FA for the conjugation of GNP.
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PMC10955424
Development of ascites is a major indication of disease recurrence .
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PMC11798926
On day one, 170,000 cells/well were seeded into 6 well plates.
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PMC11499381
Briefly, on the day of the experiment, transfection media was aspirated and replaced with 4% paraformaldehyde (PFA) in phosphate-buffered saline (PBS) and left to incubate for 20 min at room temperature with shaking, after which the cells were washed twice with PBS.
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PMC10932641
Although targeted therapy can provide superior treatment outcomes, it is prone to drug resistance, and individual responses to immunotherapy vary greatly.
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PMC11518702
For C1ORF150 (p)Y69 and corresponding HGAL-pY86 sites, interacting partners are undefined, but each are consensus ITIM’s (S/I/V/LxYxxI/V/L) with PTPs recruitment potentials (65, 66).
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PMC11342785
To this end, we replaced the FKBP/FRB heterodimerization module with an FHA/PKAsub interaction pair, in which the FHA domain only binds to PKAsub when it is phosphorylated by PKA (55, 56).
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PMC9727330
Cell morphology was assessed using an inverted microscope.
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PMC10729469
This results in increased reduction of reactive microglia numbers and composition concomitant with increased amyloid plaque clearance and improved cognitive outcomes.
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PMC9429973
Methods: Both patients were treated according to the high risk arm of the AIEOP-BFM ALL 2017 protocol as front-line therapy.
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PMC11697703
Spine density only increased with miR-193b-miR-365 expression with respect to miR-Cnt-double.
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PMC10170482
JC-1 selectively enters mitochondria and, in healthy cells with high mitochondrial membrane potential, forms complexes (J-aggregates) with intense red fluorescence.
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PMC10589262
C, D Confocal microscopic analysis of GM130, BLZF1, and KIT in GIST cells with or without BLZF1 shRNA treatment.
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PMC11534035
E-F: Cell proliferation in vulvar squamous cell carcinoma (VSCC) cell lines is impacted by treatment with GPER agonist G1.
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PMC11095939
Serum restimulation (SR)-induced (A–D, I–L) or contact inhibition loss (CIL)-induced (E–H, M–P) quiescence exits in mouse hippocampal neuronal HT22 cells (A–H) or in HUVECs (I–P) was analyzed by propidium iodide (PI) staining (A, B, E, F, I, J, M, N), real-time PCR (C, G, K, O), and western blotting (WB) (D, H, L, P) in a time course of quiescence exit. (
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PMC11740508
The second BRCA1 PDX, TM00091, expresses the common pathogenic C61G missense mutation, with 100% variant allele frequency.
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PMC11474209
Pradyumna Kumar Mishra: Writing – original draft, Validation, Supervision, Project administration, Formal analysis, Data curation, Conceptualization.
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PMC9429973
P. M. Kolijn, K. Boer, O. C. Manintveld, C. C. Baan, P. L. van Daele, M. A. Versnel, R. C. Vermeulen, A. W. Langerak Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam; Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht; Department of Internal Medicine, Division of Nephrology and Transplantation; Department of Cardiology, Thorax Center, Erasmus MC Transplant Institute; Department of Internal Medicine, Division of Clinical Immunology; Department of Immunology; Department of Immunology, Erasmus MC, Rotterdam, Netherlands Background: Since chronic lymphocytic leukemia development can be detected up to 16 years prior to diagnosis through immunogenetic sequencing, we aim to evaluate whether early detection through immunogenetic sequencing translates to other types of non-Hodgkin lymphoma (NHL).
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PMC11754436
Combined with the aforementioned key modules and lncRNA network, a DHRS4-AS1-dependent lncRNA subnetwork was constructed.
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PMC11650848
Those that were confirmed as heterozygous for rs365052 (C/G) also had a heterozygous rs2747429 genotype (C/T).
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PMC10729469
Treg–mediated % inhibition was calculated, and statistical differences were determined by one-way ANOVA followed by Turkey’s post hoc test. ***
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PMC11342785
The synMAP circuits we present generate new cytoskeletal structures inside cells, but these structures do not yet encode new biological functions.
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PMC11046454
Schematic illustration of constructing FITC-DNA-conjugated CEM (FITC-CEM) cells and their interaction with CAR-J. (E) Flow cytometry analysis of Ac4ManNAz-pretreated CEM cells after incubation with FITC-DNA-DBCO with different concentrations in binding buffer at 37 °C for 1 h. The cell surface density of FITC moiety was calculated according to the FITC fluorescence of the cell lysates. (
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PMC11674834
Survival was determined by a colony-forming assay and expressed as a percent of vehicle control.
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PMC10999934
It has been reported that endoplasmic reticulum stress has an important pathological influence on many diseases, including cancer, metabolic disorders, and neurological disorders [, , ].
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PMC9105697
Surveillance of other anatomical sites is usually not necessary, as metastases to extrapulmonary sites are an exception in SS.
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PMC11740207
The structural similarities between these EV types and ABs suggest that they could be classified as forms of ABs; conversely, ABs might also be classified as EVs (Table 2).
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PMC11633763
Therefore, this study aimed to investigate the expression, role and potential mechanism of USP22 in osteosarcoma.
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PMC11786767
These results demonstrate that we had successfully knocked down Ki-67 and impaired the spatial arrangement of mitotic chromosomes in COS-7 cells.
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PMC11588085
The Gene Set Enrichment Analysis (GSEA) of mean XIST KD counts, using the Hallmarks gene set from Msigdb, showed an enrichment of pathways up-regulated in CSCs, such as the MTORC1 signaling pathway (NES 2.86) and the MYC target pathway (NES 2.60) (Fig. 3C) (49–51).
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PMC2193049
The final concentration of lactacystin was 50 μM. Peptides were synthesized using standard solid-phase F-moc chemistry on an Applied Biosystems synthesizer.
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PMC6684588
ACE-083 differs from native FST315 by nearly complete removal of the C-terminal domain (CD) and by attachment to an immunoglobulin Fc domain, which results in dimerization of the follistatin polypeptide.
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PMC11247842
Then, we defined all annotation as genomic features to perform the enrichment analysis and prioritize the possible candidate variants by estimation of the key variants that drive the enrichment features.
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PMC7841189
However, little is known regarding the functional role of LTBP2 in thyroid carcinoma.
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PMC11694625
Tris-HCl-NaCl buffer solution (0.05 M Tris-HCl/0.1 M NaCl, pH 7.4) was prepared by using ultrapure water.
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PMC9429973
Adverse events (AEs) of special interest were analyzed by selecting prespecified MedDRA terms to generate TEAE clusters.
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PMC11803149
Conversely, retroviral expression of Epas1 enhances anti-tumor activity of aged CD8 TCR-T cells.
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PMC9429973
Results: Figure 1 shows the differential melting plots of the DNA fragments.
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PMC11474209
Kashish Gupta: Writing – original draft.
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PMC8526701
The primary primers are list as follows: BRD9, forward: 5′-ATGTTCCATGAAGCCTCCAG-3′, reverse: 5′-AGCTCCTTCTTCACCTTCCC-3′; PUMA, forward: 5′-ACGACCTCAACGCACAGTACG-3′, reverse: 5′-TCCCATGATGAGATTGTACAGGAC-3′; GAPDH forward: 5′-GCACCGTCAAGGCTGAGAAC-3′, reverse: 5′-TGGTGAAGACGCCAGTGGA-3′. The animal experiments were approved by the local animal ethics committee of The Second Hospital of Jilin University.
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PMC5600151
In summary, low generation PAMAM has fewer surface primary amines and looser surface structure, while high generation PAMAM has much more surface primary amines that form a surface with high density .
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PMC11367146
Previous findings indicates a connection between estrogen deficiency and the onset and advancement of osteoarthritis (OA), impacting different tissues within joints, such as articular cartilage.
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PMC9429973
A once-weekly dosing schedule has been widely adopted, but to date, no clinical trials have been conducted to compare the efficacy and side effect profile of this dosing frequency in transplant-eligible myeloma.
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PMC11461874
Statistical analysis of the data was performed with one-way ANOVA with Tukey’s correction.
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PMC11552389
P < 0.01.
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PMC11638255
Source data are provided as a Source Data file.
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PMC7724160
Integrated peak areas for metabolites detected by NMRTable 4.
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PMC10203589
After knockdown of FGF18, the proliferation and invasion of EC cell lines ishikawa and Hec-1A were significantly reduced (143).
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