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OTAR3088
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BioData-CellLine_annotated

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PMC11591052
However, being unsure of this, we decided to proceed cautiously, as follows: we eliminated the dependence between LogFC and LogTL by subtracting the approximate straight line from the linear regression.
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PMC10055960
Yield: 0.046 g, 84%.
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PMC11301095
This shift represents the immune system's natural adaptation to prolonged infection, driven by: 1.
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PMC11536589
Each of these agents was prepared as a 5mM stock solution dissolved in dimethylsulfoxide (DMSO) for cell experiment.
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PMC11082662
Taken together, these results suggest that the transcription and translation levels of SMPDL3B are increased in ovarian carcinoma and are positively correlated with the culture time of primary cells derived from ovarian cancer.
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PMC11451829
A significant increase in conjunctival hyperemia was observed between grade 2 and grade 3 (P = 0.0023).
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PMC11721295
In this case, macrophages appeared to decrease upon KRAS inactivation, while neutrophils increased.
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PMC9429973
The study identified disparities in patient journey of people living with CML in different countries.
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PMC11486946
For verteporfin, which showed rapid photobleaching of EGFR-mEGFP as a photophysical effect induced by repetitive laser irradiation, the images were obtained at the same positions at only two-time points (0 min and 20, 40, 60, or 80 min) to minimize the effect.
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PMC9429973
In Table 1 baseline characteristics and results are presented.
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PMC9429973
Diagnosis of ATE was established using clinical, laboratory and radiological methods.
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PMC11548041
Statistical analysis.
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PMC11549612
Retrospective analyses of TCGA-KIRC cohort’s further support these observations, with BOLA1, BOLA2, and BOLA3 demonstrating substantial overexpression and hypomethylation in KIRC compared to normal tissues.
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PMC9429973
Interestingly, we identified an IGH::BCL3 translocation, displaying the breakpoints at the switch region IGHG2 and downstream of BCL3 in the diagnostic and transformation samples.
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PMC8358006
a H3K4me3, H3K4me1, H3K27ac, and DNA methylation density plots (left) and average density (right) across all modified regions in KYSE450 versus NE2 cell line.
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PMC11106977
Interleukin-17 A (IL-17 A) is the major cytokine that mediates the function of Th17 cells, and it plays a pivotal role in promoting inflammatory reactions .
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PMC11753435
The gating strategy is described in fig. S3.
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PMC9429973
All pts started on dasatinib 100mg QD, with Cmin taken at 7, 28, 56 & 90 days, then every 3 mos hence.
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PMC10854447
Again, compound 7l was the most potent derivative as a VEGFR-2 inhibitor, with an IC50 value of 2.40 ± 0.02 nM. These findings demonstrate that compounds 7j, 7k, and 7l are potent antiproliferative agents that may act as dual EGFR/VEGFR-2 inhibitors.
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PMC7961460
As for all the golgins, c10orf118 is a large protein of more than 500 residues (898 aa), interacts with a member of the Rab proteins (Rab2), localizes in the Trans Golgi Network (TGN) and contains coiled-coil motifs.
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PMC9429973
Methods: Patients who initiated a treatment for CLL between 01/01/2011 and 07/31/2021 were extracted from the Services Australia 10% Pharmaceuticals Benefits Scheme (PBS) dataset.
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PMC11538390
In conclusion, the MCS-9.7 regulatory region may represent a mutational hot spot for both rare and common genetic variation that can cause, or contribute risk for, different forms of OFCs potentially by disrupting IRF6 expression in periderm versus in basal layers of oral epithelium.
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PMC11518994
The germline variant in the two siblings was demonstrated to be inherited from the father (II.6) and the grandmother (I,4) both asymptomatic carriers with no history of cancer. *:
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PMC11754432
Secondary antibody IRDye® 680RD Goat anti-Rabbit IgG Secondary Antibody (LI-COR) was subsequently used.
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PMC11757230
Scale bar = 100 μm.
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PMC10907726
LC3B II is an indicator of autophagic induction, formed by the conversion of cytoplasmic LC3B I .
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PMC11615218
Product nameCommercial nameChimeric antigen receptor structureCell resourceTransfection methodApproved indications (date)Tisagenlecleucel (tisa-cel) KymriahAnti CD19-CD8α (hinge+tm)-41BB-CD3ζEnriched T cellsLentivirus-R/R B-ALL after ≥ 2 lines therapy with aged ≤ 25 years (Aug 2017)-R/R LBCL after ≥ 2 lines therapy (May 2018)-R/R FL after ≥ 2 lines therapy (May 2022)Axicabtagene ciloleucel (axi-cel) YescartaAnti CD19-CD28 (hinge+tm)-CD28-CD3ζPBMCsRetrovirus-R/R LBCL after≥2 lines of therapy (Oct 2017)-R/R FL after ≥2 lines of therapy (Apr 2021)-LBCL refractory to first-line therapy or relapsing within 12 months of first-line therapy (Apr 2022)Brexucabtagene autoleucel (brexu-cel) TecartusAnti CD19-CD28 (hinge+tm)-CD28-CD3ζCD19depleted and CD4/CD8 enriched T cellsRetrovirus-R/R MCL (Jul 2020)-R/R adult B-ALL (Oct 2021)Lisocabtagene maraleucel (liso-cel) BreyanziAnti CD19-IgG4 (hinge)-CD28 (tm)-41BB-CD3ζCD4 and CD8 T cells separatelyLentivirus-R/R LBCL after ≥2 lines of therapy (Feb 2021)-LBCL refractory to first-line therapy or relapsing within 12 months of first-line therapy and are not eligible for HSCT (Jun 2022)-R/R CLL/SLL after ≥2 lines of therapy (Mar 2024)-R/R FL after ≥2 lines of therapy (May 2024)Idecabtagene vicleucel (ide-cel) AbecmaAnti BCMA-CD8α (hinge+tm)-41BB-CD3ζPBMCsLentivirus-R/R MM after ≥4 lines of therapy (Mar 2021)-R/R MM after ≥2 lines of therapy (Apr 2024)Ciltacabtagene autoleucel (cilta-cel) CarvyktiDual anti BCMA-CD8α (hinge+tm)-41BB-CD3ζEnriched T cellsLentivirus-R/R MM after ≥4 lines of therapy (Feb 2022)-R/R MM after ≥1 lines of therapy (Apr 2024)tm transmembrane, R/R relapsed and/or refractory, B-ALL B-cell acute lymphoblastic leukemia, LBCL large B cell lymphoma, FL follicular lymphoma, PBMCs peripheral blood mononuclear cells, MCL mantle cell lymphoma, HSCT hematopoietic stem cell transplantation, CLL/SLL chronic lymphocytic leukemia/small lymphocytic lymphoma, BCMA B-cell maturation antigen, MM multiple myeloma.
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PMC9429973
Len-combo regimens were either doublets (Len with either dexamethasone [dex: n=10], elotuzumab [n=28] or ixazomib [n=14]) or triplets (Len with either bortezomib/dex [n=10], ixazomib/dex [n=10] or carfilzomib/dex [n=6]).
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PMC11767582
Yellow solid (84 mg, 0.26 mmol), yield 51%, mp 129–131 °C.
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PMC10297204
This tumor commonly affects adolescents and young adults and is classified into three types: monophasic type, biphasic type (spindle cells and glandular epithelial components), and poorly differentiated type .
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PMC9429973
Safety assessments include adverse event (AE, graded per National Cancer Institute Common Terminology Criteria for AEs v5.0) monitoring, physical examinations, vital signs, electrocardiograms, and laboratory tests.
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PMC10813895
As we describe in more detail later in this review, women who are carriers of BRCA1 show a decline of ELF5 expression.
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PMC8009078
Based on acceptable pharmacokinetic parameters and drug-likeness, finally, five molecules were found to be important for the TMPRSS2 inhibition.
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PMC11297139
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC10887351
The β3-AR subtype has been largely correlated with metabolic regulation, both in physiological and pathological conditions .
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PMC9479186
All experimental researches handling human cells were conducted in accordance with the Declaration of Helsinki and were approved by the Ethics Committee of the Zhejiang Cancer Hospital (Hangzhou, China).
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PMC11449273
We also observed a significant increase (54%) in the nuclear pool of NPM in H1299-p53-WT cells when plakoglobin was co-expressed in these cells (Fig 5B).
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PMC11659921
Gene enrichment analysis of TNFSF11 in OV. (
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PMC9895440
Afterward, 10’000 NY-ESO-1 specific T cells (measured by TCR Vβ13.1 staining as above) were co-cultured with 10’000 of these peptide-loaded T2 cells (1:1 E:T Ratio) for 5 h in the presence of 20 ng/ml anti-CD107a-PE antibody and 1x Monensin (Biolegend).
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PMC10996034
UNC5C affects FAK and FYN activity, and mediates cell migration by promoting integrin-dependent cell adhesion and increasing skeletal rearrangements.
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PMC9429973
Results: Combination treatment with magrolimab and AZA resulted in tolerable anemia that correlated with rapid, near-complete loss of CD47 in RBCs but not WBCs.
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PMC11092382
However, the role of sophocarpine in hypertension, a prevalent chronic disease, has not been fully elucidated.
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PMC11286266
The XBP1 band represents DNA species containing one strand of XBP1u and one strand of XBPs (Shang and Lehrman, 2004).
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PMC11046454
Flow cytometry of CEM cells after incubation with 200 nM Lib, AptPTK7-T0, AptPTK7-T5, AptPTK7-T15, or AptPTK7-T20 in binding buffer at 4 °C for 30 min. (
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PMC10123657
Indeed, OP9 cells were superior to human MSC, grown from primary human bone marrows, in promoting proliferation and providing protection against vincristine to human ALL cells .
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PMC10823017
The data represent N=3 independent experiments, mean ±SEM. (**
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PMC11762280
Importantly, by western blotting assay, we found that the expressions of N-GSDMD, cleaved PARP, cleaved caspase-3, and p-MLKL were all elevated in mice epidermis at 72 h after UVB irradiation (Fig. 1F).
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PMC10933092
In summary, differentially mA methylated transcripts in BLCA cells were enriched in pathways involved in cellular processes, biological regulation, and cancer.
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PMC11739504
Primary cilia are sensory organelles that regulate various signaling pathways.
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PMC8557138
The presently available scaffolds makes it cumbersome to obtain a controlled matrix that can sustain both cellular physiological growth as well as interaction similar to that observed in vivo (Cunha et al. 2011; Jaganathan et al. 2014).
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PMC11638288
It is uniformly expressed in both resting and activated NK cells and plays a vital role in regulating the clearance of viruses and rejection of tumors by NK cells .
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PMC9000591
column (Waters Cooperation, Milford, MA, USA).
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PMC11306331
D Experimental setup, doxycycline was added at time zero to induce expression of FUS-CHOP, after 24 h, blue light was applied to the cells to recruit MBP to FUS-CHOP droplets.
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PMC11721587
In the absence of Hh, HA-Fu could only be detected in the soluble fraction (S100); however, after Hh treatment, HA-Fu was detected in both the soluble fraction and condensates (P100) (Fig. 4C).
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PMC10858941
Viability staining shows in green alive cells and in red dead cells.
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PMC11768927
Following intravascular inoculation, VSVrp30 demonstrated selective and simultaneous lysis of multifocal brain tumors as well as subcutaneous tumors located in the flank region .
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PMC11266100
Conversely, buffer No. Five exhibits a negative impact on cell viability during GET, potentially decreasing to approximately 30%.
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PMC11411131
Two days after transfection, the neurons were treated with 0, 6, or 20 µM MeHg for 24 h. The results showed that cells exposed to 6 µM MeHg exhibited increased luciferase activity compared with that in untreated cells.
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PMC8633974
Forty-eight hours post treatment, the Fluc LNP treated cells were analysed using Luciferase Assay System (Promega # E1500).
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PMC11569208
The objective of this study was to identify PP targets that could mimic the OV-enhancing effects of vanadium and its respective mechanism of action in regulating the innate antiviral response.
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PMC9325715
70%.
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PMC10391797
Then, 1 week later, mice were infused with CD123 CAR-T cells and untreated T cells (CON) with or without VPA treatment (n=6 for each group). (
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PMC7081114
Kinesins are a superfamily of motor proteins that participate in mitosis, intracellular transportation, and cytoskeletal reorganization.
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PMC9429973
In contrast, there is an increase in IGF1 expression at the onset, which can lead to stem cell activation.
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PMC11684269
FABP1 orchestrates FA uptake, facilitating the accumulation of TRM in liver (75).
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PMC11786156
Generally, the DLBCL cases showed homogeneous crowded and medullary structures in microscopy.
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PMC9429973
Of these, 57 had AML (AML Not Otherwise Specified (NOS) (n=45), AML with myelodysplasia-related changes (n=12).
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PMC11621493
Statistical comparisons were performed with multiple unpaired two-tailed Student’s t test with correction for multiple comparisons using the false discovery rate (FDR).
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PMC11791432
The results showed that the proliferation ability of glioma cells U87 and A172 was attenuated after knockdown of ANXA1, indicating that ANXA1 could promote the proliferation of glioma cells.
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PMC9599726
Although the link between CA3 (CIL-56) and ferroptosis has been controversial , our study provides evidence that CA3 (CIL-56) induces ferroptosis with a significant depletion in GPX4 protein levels in GIST cells.
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PMC9429973
With regards to platelet aggregation, JAK2 V617F platelets presented similar or lower levels when compared to HD platelets, in line with their proteomic profiles.
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PMC10813895
Oxidative stress may play a crucial role in carcinogenesis, including BC .
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PMC10047551
The methylation status of CpG sites in the PD-L1 CpG island shores is inversely correlated with PD-L1 expression in acute myeloid leukemia and colorectal, melanoma, bladder, and prostate cancer .
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PMC11708541
Oliveira et al., examined the effects of novel aminopyridine derivatives complexed with Cu against T. cruzi trypomastigote forms: cis-aquadichloro pyridinemethanamino copper (39a) and its glycosylated ligand, cis-dichloro (glucopyranosyloxy)phenyl methyl pyridinemethamino copper (39b).
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PMC10568263
It is anticipated that this testing model can be extrapolated to other cancer cell lines, thereby providing a universal approach for potential applications across different types of cancer (as most cancer cell apoptosis results in the production of HSP70 and other apoptosis-related proteins).
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PMC8633974
Having demonstrated the ability of TatDE CRISPR to suppress plasmid-encoded viral transcription, we next investigated whether latent HIV-1 could be excised in leukocytes.
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PMC11680578
Mitochondria were stained by JC-1 fluorescent dye.
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PMC11519567
It shows that 20% 1,6-hex can make the SS18-SSX1-mCherry condensates diffused, meanwhile, the SS18-EGFP condensates also become diffuse (Fig. 4E).
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PMC11026382
The heatmap shows the fraction of DHFR mutations with relative growth rates of 0.9 or better as TYMS kcat and Km are discretely varied.
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PMC9275501
The researches of nanoparticles used to co-deliver chemotherapy drugs and natural active ingredients.
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PMC11487720
Proapoptotic tumor suppressors WWOX and p53 are known partners in causing apoptosis and BCD [6, 13, 14, 53–56].
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PMC11551844
The presence of sterols increased the ability of transforming Au(iii) into Au(0) to form AuNPs and further enhancing cellular uptake and, thus, anti-cancer activity.
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PMC11468365
This approach also reduces the risk of side effects by decreasing the required dosage of each drug.
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PMC11757230
Mice inoculated with CLC/fLuc cells, with or without cADSC treatment, were anesthetized using a three-anesthetic mixture of medetomidine, midazolam, and butorphanol followed by an intraperitoneal injection of 150 mg/kg D-luciferin.
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PMC11805741
Xanthophylls, which are oxygenated carotenoids like zeaxanthin, cryptoxanthin, and lutein; and (ii) Carotenes, which are pure hydrocarbons without functional groups like α-carotene, β-carotene or lycopene (Maoka 2020).
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PMC11610461
The incidence of KC has remained high (Sung et al., 2021).
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PMC11575040
Urbonas et al. reported that diabetic patients (type 2 DM) with melanoma who received metformin exhibited a lower risk of melanoma-specific mortality compared with nondiabetic patients; however, a previous clinical trial indicated that metformin monotherapy had no benefit for patients with melanoma of an advanced stage .
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PMC11593713
Infections in immunocompromised, chronically ill, elderly, or pediatric patients generally have a more severe course and are characterized by a higher number of deaths.
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PMC8735881
To this end, cell culture supernatants containing equal amounts of the p24 antigen were applied to infect TZM-bl cells, and the relative virus infectivity was measured by quantifying luciferase activity in cell lysates.
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PMC5854676
Figure 2 shows the XRD pattern of the MgO NPs sintered at 900 °C for 6 h. The seven prominent peaks that appear in the XRD pattern show a single phase crystalline structure.
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PMC5963610
All incubations were done for 60 min at 4°C.
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PMC11429241
However, not all the cells were attached, and some remained in close proximity to the scaffold.
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PMC11409031
Data analysis was conducted using information from the cancer genome atlas (TCGA) database (TCGA-OV) and GEO database (GSE140082).
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PMC9429973
PD-1CD4 T cells were higher in LIM cHL than in controls (median 31.75 vs. 23.05 %, respectively, p=0.0030), while PD-1CD8 T cells were higher in both LIM and ADV cHL (median 32.05 (p=0.0041) and 32.20 (p=0.0135) vs. 21.15 %, respectively).
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PMC9219615
Approximately 20,000 events (cells) were analyzed per sample, with data analysis achieved as previously mentioned.
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PMC9429973
Randomization: 2:1 to MMB 200 mg QD plus DAN placebo or DAN 600 mg QD plus MMB placebo for 24 wks.
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PMC8751435
The data represent the mean ± SD of three replicates and three independent experiments. *
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PMC11546117
The linearity of the cumulative amount transported curve was assessed, and the initial points were removed until the linearity threshold was reached (R ≥ 0.970).
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PMC9429973
Multiple preventive measures, including low microbial diet, have been adopted to reduce these complications.
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PMC11335267
Mice were decapitated and epididymal visceral white adipose tissue (vWAT) and the gastrocnemius muscles were rapidly removed and frozen in liquid nitrogen.
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