OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11657695	Similar data were obtained for major players in the Hippo signalling pathway, such as ITGB2 and ITGB3 (Figs. 6B and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "data", "were", "obtained", "for", "major", "players", "in", "the", "Hippo", "signalling", "pathway", ",", "such", "as", "ITGB2", "and", "ITGB3", "(", "Figs.", "6B", "and", "D", ")", "." ] } ]
PMC10158546	WT – wild type; KO – PRNP knocked out; NPC – neural progenitor cell; PuroR – puromycin resistance; GFP – green fluorescence protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WT", "–", "wild", "type", ";", "KO", "–", "PRNP", "knocked", "out", ";", "NPC", "–", "neural", "progenitor", "cell", ";", "PuroR", "–", "puromycin", "resistance", ";", "GFP", "–", "green", "fluorescence", "protein", "." ] } ]
PMC11522251	PCR primers were purchased from Generay Biotechnology (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCR", "primers", "were", "purchased", "from", "Generay", "Biotechnology", "(", "Shanghai", ",", "China", ")", "." ] } ]
PMC8526701	Downregulation of BRD9 expression in AML (acute myeloid leukemia) may result in GI arrest .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Downregulation", "of", "BRD9", "expression", "in", "AML", "(", "acute", "myeloid", "leukemia", ")", "may", "result", "in", "GI", "arrest", "." ] } ]
PMC11200978	Understanding the MLT is crucial for optimizing cryoablation protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "MLT", "is", "crucial", "for", "optimizing", "cryoablation", "protocols", "." ] } ]
PMC11742290	Two ADCs targeting LGR5+ CRC cells had significantly increased survival in mice in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "ADCs", "targeting", "LGR5", "+", "CRC", "cells", "had", "significantly", "increased", "survival", "in", "mice", "in", "vivo", "." ] } ]
PMC5035325	Normal lung weight value is indicated (dashes lines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "lung", "weight", "value", "is", "indicated", "(", "dashes", "lines", ")", "." ] } ]
PMC11617590	Statistical significance was based on the difference compared with 0 μM SFN by one‐way ANOVA, followed by Dunnett's test (n = 3) (p < 0.01, *p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "based", "on", "the", "difference", "compared", "with", "0", "μM", "SFN", "by", "one‐way", "ANOVA", ",", "followed", "by", "Dunnett", "'s", "test", "(", "n", "=", "3", ")", "(", "", "", "p", "<", "0.01", ",", "", "", "*", "p", "<", "0.001", ")", "." ] } ]
PMC6650823	In experimental mouse models, it mediates protection from autoimmune pathologies, shows a potent histone deacetylase-inhibitory activity in CD4 T cells, inhibits the generation of small-intestinal Th17 cells, and ameliorates segmented filamentous bacteria (SFB)-promoted inflammation in the central nervous system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "experimental", "mouse", "models", ",", "it", "mediates", "protection", "from", "autoimmune", "pathologies", ",", "shows", "a", "potent", "histone", "deacetylase-inhibitory", "activity", "in", "CD4", "T", "cells", ",", "inhibits", "the", "generation", "of", "small-intestinal", "Th17", "cells", ",", "and", "ameliorates", "segmented", "filamentous", "bacteria", "(SFB)-promoted", "inflammation", "in", "the", "central", "nervous", "system", "." ] } ]
PMC5916734	In other words, the copy number of the gene encoding the selection marker separately from that of the target gene does not occur despite the amplification of the gene cassettes in the genome of producer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "other", "words", ",", "the", "copy", "number", "of", "the", "gene", "encoding", "the", "selection", "marker", "separately", "from", "that", "of", "the", "target", "gene", "does", "not", "occur", "despite", "the", "amplification", "of", "the", "gene", "cassettes", "in", "the", "genome", "of", "producer", "cells", "." ] } ]
PMC11518994	Furthermore, the gene expression classifier ALLCatchR was applied on RNA-SEQ data and both samples were assigned to “PAX5 P80R” sub-category with high-confidence score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "gene", "expression", "classifier", "ALLCatchR", "was", "applied", "on", "RNA-SEQ", "data", "and", "both", "samples", "were", "assigned", "to", "“", "PAX5", "P80R", "”", "sub-category", "with", "high-confidence", "score", "." ] } ]
PMC11748335	E Heatmap shows the average DNA methylation levels of the three groups of long LOCK regions in NE2 vs. KYSE450, across the whole genome and within common PMDs and HMDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Heatmap", "shows", "the", "average", "DNA", "methylation", "levels", "of", "the", "three", "groups", "of", "long", "LOCK", "regions", "in", "NE2", "vs.", "KYSE450", ",", "across", "the", "whole", "genome", "and", "within", "common", "PMDs", "and", "HMDs", "." ] } ]
PMC9429973	Hence, r/r PTCL patients urgently need better therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "r/r", "PTCL", "patients", "urgently", "need", "better", "therapies", "." ] } ]
PMC9219615	Furthermore, another recently published study revealed that Tpz-1 (compound MTPC) could target tumors in mice by encapsulating the compound in gold nanorod-loaded PLGA-PEG nanoparticles .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "another", "recently", "published", "study", "revealed", "that", "Tpz-1", "(", "compound", "MTPC", ")", "could", "target", "tumors", "in", "mice", "by", "encapsulating", "the", "compound", "in", "gold", "nanorod-loaded", "PLGA-PEG", "nanoparticles", "." ] } ]
PMC9065483	RNA was extracted from cell lysates 24 hpi and probed for MX2 mRNA expression by qPCR (n = 3, mean ± SD; ∗∗∗p < 0.001 by one-way ANOVA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "extracted", "from", "cell", "lysates", "24", "hpi", "and", "probed", "for", "MX2", "mRNA", "expression", "by", "qPCR", "(", "n", "=", "3", ",", "mean", "±", "SD", ";", "∗∗∗p", "<", "0.001", "by", "one-way", "ANOVA", ")", "." ] } ]
PMC10745221	al, 1983 .	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "al", ",", "1983", "." ] } ]
PMC10808409	The increase in the zeta potential accompanied by the incorporation of TPGS could be attributed to the ability of TPGS to increase in the solubility of FA, yielding more anionic FA in solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", "in", "the", "zeta", "potential", "accompanied", "by", "the", "incorporation", "of", "TPGS", "could", "be", "attributed", "to", "the", "ability", "of", "TPGS", "to", "increase", "in", "the", "solubility", "of", "FA", ",", "yielding", "more", "anionic", "FA", "in", "solution", "." ] } ]
PMC11657695	Current of each cells were analysed at + 60 mV. Lines indicate the median, each point represents the percentage of whole-cell currents sensitive to κ-Cono (Wilcoxon signed-rank test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Current", "of", "each", "cells", "were", "analysed", "at", "+", "60", "mV.", "Lines", "indicate", "the", "median", ",", "each", "point", "represents", "the", "percentage", "of", "whole-cell", "currents", "sensitive", "to", "κ-Cono", "(", "Wilcoxon", "signed-rank", "test", ")", "." ] } ]
PMC9436459	Among them, the enzymatic intermolecular [4 + 2] cycloaddition to produce natural MDAAs was the most efficient and applied strategy with an excellent enantioselectivity and yield.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "them", ",", "the", "enzymatic", "intermolecular", "[", "4", "+", "2", "]", "cycloaddition", "to", "produce", "natural", "MDAAs", "was", "the", "most", "efficient", "and", "applied", "strategy", "with", "an", "excellent", "enantioselectivity", "and", "yield", "." ] } ]
PMC11301242	Comparative analysis of gene expression levels involved in DNA repair pathways in lymphoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparative", "analysis", "of", "gene", "expression", "levels", "involved", "in", "DNA", "repair", "pathways", "in", "lymphoma", "cell", "lines", "." ] } ]
PMC11216402	Patients were stratified into Mes-like (n = 150) and Epi-like (n = 150) groups based on the median difference in the mean expression values of Mes and Epi DE TFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "stratified", "into", "Mes-like", "(", "n", "=", "150", ")", "and", "Epi-like", "(", "n", "=", "150", ")", "groups", "based", "on", "the", "median", "difference", "in", "the", "mean", "expression", "values", "of", "Mes", "and", "Epi", "DE", "TFs", "." ] } ]
PMC11754784	As illustrated in Fig. 1a, a DNP consists of two functional moieties, a head-like DNA cage and a tail fiber-like external DNA nano-claw.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "illustrated", "in", "Fig.", "1a", ",", "a", "DNP", "consists", "of", "two", "functional", "moieties", ",", "a", "head-like", "DNA", "cage", "and", "a", "tail", "fiber-like", "external", "DNA", "nano-claw", "." ] } ]
PMC9429973	All donors and patients signed informed consent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "donors", "and", "patients", "signed", "informed", "consent", "." ] } ]
PMC9429973	In all cases the mutational status was unmutated, CD38 was positive in 6 patients and 3 patients were positive for TP53 mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "cases", "the", "mutational", "status", "was", "unmutated", ",", "CD38", "was", "positive", "in", "6", "patients", "and", "3", "patients", "were", "positive", "for", "TP53", "mutation", "." ] } ]
PMC11013014	This typically means that 55% of the administered substance is absorbed and becomes available to the body’s circulation and to target tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "typically", "means", "that", "55", "%", "of", "the", "administered", "substance", "is", "absorbed", "and", "becomes", "available", "to", "the", "body", "’s", "circulation", "and", "to", "target", "tissues", "." ] } ]
PMC9817179	Schematics of the protein constructs are shown on the left.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematics", "of", "the", "protein", "constructs", "are", "shown", "on", "the", "left", "." ] } ]
PMC10747139	The polypyridyl Ru(II) complexes also have physical and chemical advantages, such as high chemical stability and photostability, sensitive spectroscopic responses to HIV TAR RNA, and low toxicity to normal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "polypyridyl", "Ru(II", ")", "complexes", "also", "have", "physical", "and", "chemical", "advantages", ",", "such", "as", "high", "chemical", "stability", "and", "photostability", ",", "sensitive", "spectroscopic", "responses", "to", "HIV", "TAR", "RNA", ",", "and", "low", "toxicity", "to", "normal", "cells", "." ] } ]
PMC11594806	This work is a narrative literature review focusing on the role of the adenosine pathway in sarcomas and its relationship with chemotherapy resistance, immunotherapy, and innovative therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "is", "a", "narrative", "literature", "review", "focusing", "on", "the", "role", "of", "the", "adenosine", "pathway", "in", "sarcomas", "and", "its", "relationship", "with", "chemotherapy", "resistance", ",", "immunotherapy", ",", "and", "innovative", "therapeutic", "strategies", "." ] } ]
PMC9812014	The current anti-HSV-I medication acyclovir was also tested, and it exhibited similar inhibitory activity at 50 µM concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "current", "anti-HSV-I", "medication", "acyclovir", "was", "also", "tested", ",", "and", "it", "exhibited", "similar", "inhibitory", "activity", "at", "50", "µM", "concentration", "." ] } ]
PMC5673955	Significant changes of hTERT protein in Jurkat and CD4 cells cultivated with RrA were confirmed by western blotting (Fig. 6C–F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "changes", "of", "hTERT", "protein", "in", "Jurkat", "and", "CD4", "cells", "cultivated", "with", "RrA", "were", "confirmed", "by", "western", "blotting", "(", "Fig.", "6C", "–", "F", ")", "." ] } ]
PMC11763111	Crucially, compared to 1KO CAR-T cells, 4KO CAR-T and 4KO-LLT1 CAR-T cells generated noticeably more interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ) (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Crucially", ",", "compared", "to", "1KO", "CAR-T", "cells", ",", "4KO", "CAR-T", "and", "4KO-LLT1", "CAR-T", "cells", "generated", "noticeably", "more", "interleukin-2", "(", "IL-2", ")", ",", "tumor", "necrosis", "factor", "alpha", "(", "TNF-α", ")", ",", "and", "interferon-gamma", "(", "IFN-γ", ")", "(", "Fig.", "3B", ")", "." ] } ]
PMC11319300	Furthermore, our research revealed that in human and murine cells (which lack an ORF, yet bear the enhancer marks) the MYEOV-3′-putative enhancer and CCND1/Ccnd1 display interactions within the 3D genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "our", "research", "revealed", "that", "in", "human", "and", "murine", "cells", "(", "which", "lack", "an", "ORF", ",", "yet", "bear", "the", "enhancer", "marks", ")", "the", "MYEOV-3′-putative", "enhancer", "and", "CCND1/Ccnd1", "display", "interactions", "within", "the", "3D", "genome", "." ] } ]
PMC11388384	denotes not significant. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "denotes", "not", "significant", ".", "(" ] } ]
PMC9429973	This PET adapted approach reduces exposure to chemo andradiotherapy with no negative effect on long term outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "PET", "adapted", "approach", "reduces", "exposure", "to", "chemo", "andradiotherapy", "with", "no", "negative", "effect", "on", "long", "term", "outcome", "." ] } ]
PMC6600592	Cyclohexyl (E)-4-methoxyimino-4-(4-methoxyphenyl)butanoate (4B-2).	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyclohexyl", "(E)-4-methoxyimino-4-(4-methoxyphenyl)butanoate", "(", "4B-2", ")", "." ] } ]
PMC10976516	Zugazagoitia et al.; Yang et al.; Wang et al. Treatment modality for different stages of lung cancer These conditions may all be treated with chemotherapy:•as the primary treatment for those who are unable to undergo surgery•to relieve the pain of advanced cancer•to reduce the size of a tumor before surgery or radiation•to kill cancer cells that were not removed during surgery to lower the risk of recurrence•to relieve advanced cancer pain and as maintenance therapy in those with advanced cancer that is responsive to chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zugazagoitia", "et", "al.", ";", "Yang", "et", "al.", ";", "Wang", "et", "al.", "Treatment", "modality", "for", "different", "stages", "of", "lung", "cancer", "These", "conditions", "may", "all", "be", "treated", "with", "chemotherapy:•as", "the", "primary", "treatment", "for", "those", "who", "are", "unable", "to", "undergo", "surgery•to", "relieve", "the", "pain", "of", "advanced", "cancer•to", "reduce", "the", "size", "of", "a", "tumor", "before", "surgery", "or", "radiation•to", "kill", "cancer", "cells", "that", "were", "not", "removed", "during", "surgery", "to", "lower", "the", "risk", "of", "recurrence•to", "relieve", "advanced", "cancer", "pain", "and", "as", "maintenance", "therapy", "in", "those", "with", "advanced", "cancer", "that", "is", "responsive", "to", "chemotherapy", "." ] } ]
PMC11476222	Characterizing gangliosides using LC-MS is advantageous due to the high throughput and sensitivity of this analytical tool.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Characterizing", "gangliosides", "using", "LC-MS", "is", "advantageous", "due", "to", "the", "high", "throughput", "and", "sensitivity", "of", "this", "analytical", "tool", "." ] } ]
PMC9352806	The quality control (QC) sample was prepared by mixing an equal aliquot of the supernatants from all of the samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quality", "control", "(", "QC", ")", "sample", "was", "prepared", "by", "mixing", "an", "equal", "aliquot", "of", "the", "supernatants", "from", "all", "of", "the", "samples", "." ] } ]
PMC11544122	To test recruitment of SNX9 to mutant receptors, the cells were co-transfected with 500 ng of Rluc8-SNX9, and either 250 ng of FLAG-CXCR4-YFP, FLAG-CXCR4-YFP-5A or FLAG-CXCR4-YFP-4A and 2 µg of empty pcDNA3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "recruitment", "of", "SNX9", "to", "mutant", "receptors", ",", "the", "cells", "were", "co-transfected", "with", "500", "ng", "of", "Rluc8-SNX9", ",", "and", "either", "250", "ng", "of", "FLAG-CXCR4-YFP", ",", "FLAG-CXCR4-YFP-5A", "or", "FLAG-CXCR4-YFP-4A", "and", "2", "µg", "of", "empty", "pcDNA3", "." ] } ]
PMC7723249	Even if this observation doesn’t allow to discriminate the effect of cytokines from the effect of viral factors, this mechanism could be involved in the higher viremia and endothelial damage observed in the severe CCHF cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Even", "if", "this", "observation", "does", "n’t", "allow", "to", "discriminate", "the", "effect", "of", "cytokines", "from", "the", "effect", "of", "viral", "factors", ",", "this", "mechanism", "could", "be", "involved", "in", "the", "higher", "viremia", "and", "endothelial", "damage", "observed", "in", "the", "severe", "CCHF", "cases", "." ] } ]
PMC11742670	Adadi et al. explored the motivations and outcomes of XAI research to highlight the significance of XAI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adadi", "et", "al.", "explored", "the", "motivations", "and", "outcomes", "of", "XAI", "research", "to", "highlight", "the", "significance", "of", "XAI", "." ] } ]
PMC11252033	The mRNAs of both antiapoptotic genes are physiologically able to bind AUBPs by AU-rich sequence element in the 3′-UTR of their mRNAs, thus modulating the recruitment of the degradation machinery constituted by the exosome complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNAs", "of", "both", "antiapoptotic", "genes", "are", "physiologically", "able", "to", "bind", "AUBPs", "by", "AU-rich", "sequence", "element", "in", "the", "3′-UTR", "of", "their", "mRNAs", ",", "thus", "modulating", "the", "recruitment", "of", "the", "degradation", "machinery", "constituted", "by", "the", "exosome", "complex", "." ] } ]
PMC11429241	On day 7, the 3D cell cultures were collected for gene expression analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "day", "7", ",", "the", "3D", "cell", "cultures", "were", "collected", "for", "gene", "expression", "analysis", "." ] } ]
PMC11697703	Brains for neuron reconstruction were vibratome sectioned coronally at 250 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brains", "for", "neuron", "reconstruction", "were", "vibratome", "sectioned", "coronally", "at", "250", "μm", "." ] } ]
PMC11248911	HNMR (DMSO-d6, δ ppm): 2.09 (s, 3H, CH3), 2.88–2.94 (dd, 1H, pyrazoline, J = 6.80, 18.00 Hz), 3.59–3.67 (dd, 1H, pyrazoline, J = 11.76, 18.20 Hz), 5.41–5.46 (dd, 1H, pyrazoline, J = 6.96, 11.68 Hz), 7.23–7.69 (m, 11H, Ar–H and CH-thiazole).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HNMR", "(", "DMSO-d6", ",", "δ", "ppm", "):", "2.09", "(", "s", ",", "3H", ",", "CH3", ")", ",", "2.88–2.94", "(", "dd", ",", "1H", ",", "pyrazoline", ",", "J", "=", "6.80", ",", "18.00", "Hz", ")", ",", "3.59–3.67", "(", "dd", ",", "1H", ",", "pyrazoline", ",", "J", "=", "11.76", ",", "18.20", "Hz", ")", ",", "5.41–5.46", "(", "dd", ",", "1H", ",", "pyrazoline", ",", "J", "=", "6.96", ",", "11.68", "Hz", ")", ",", "7.23–7.69", "(", "m", ",", "11H", ",", "Ar", "–", "H", "and", "CH-thiazole", ")", "." ] } ]
PMC11764090	Beijing 24) during cold storage may be attributed to its ability to induce antioxidant systems and heat shock proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beijing", "24", ")", "during", "cold", "storage", "may", "be", "attributed", "to", "its", "ability", "to", "induce", "antioxidant", "systems", "and", "heat", "shock", "proteins", "." ] } ]
PMC11541241	The highly conserved structural organization of the TOR protein and the feature of the inhibitor‐sensitive TOR pathway in regulating the growth and virulence of the majority of pathogens enable the development of TOR inhibitor‐based strategies for antifungal therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highly", "conserved", "structural", "organization", "of", "the", "TOR", "protein", "and", "the", "feature", "of", "the", "inhibitor‐sensitive", "TOR", "pathway", "in", "regulating", "the", "growth", "and", "virulence", "of", "the", "majority", "of", "pathogens", "enable", "the", "development", "of", "TOR", "inhibitor‐based", "strategies", "for", "antifungal", "therapies", "." ] } ]
PMC11742047	On the other hand, CL appear to be intimately involved in the mechanism of programmed cell death, also because they provide a mechanism underlying the activation of caspase 8, a protein crucial in apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "CL", "appear", "to", "be", "intimately", "involved", "in", "the", "mechanism", "of", "programmed", "cell", "death", ",", "also", "because", "they", "provide", "a", "mechanism", "underlying", "the", "activation", "of", "caspase", "8", ",", "a", "protein", "crucial", "in", "apoptosis", "." ] } ]
PMC11128598	To measure homologous recombination efficiency the HR-GFP reporter was used, which allows flow cytometry-based detection of HR stimulated by I-SceI endonuclease-induced DSBs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "measure", "homologous", "recombination", "efficiency", "the", "HR-GFP", "reporter", "was", "used", ",", "which", "allows", "flow", "cytometry-based", "detection", "of", "HR", "stimulated", "by", "I-SceI", "endonuclease-induced", "DSBs", "." ] } ]
PMC10452486	Due et al. minimized the binding of insulin receptor to the cell surface HLA-I using HC-specific monoclonal antibodies (mAbs) (PA 2.6 and BB 7.5, -6, and -7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "et", "al.", "minimized", "the", "binding", "of", "insulin", "receptor", "to", "the", "cell", "surface", "HLA-I", "using", "HC-specific", "monoclonal", "antibodies", "(", "mAbs", ")", "(", "PA", "2.6", "and", "BB", "7.5", ",", "-6", ",", "and", "-7", ")", "." ] } ]
PMC8584319	In this study, we screened an anticancer drug library to select compounds with translational repression functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "screened", "an", "anticancer", "drug", "library", "to", "select", "compounds", "with", "translational", "repression", "functions", "." ] } ]
PMC11656657	Residual GFP + RD cells B and CD3 positive cells C were quantified during the “stressed” co-culture with tumor addition every 5 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Residual", "GFP", "+", "RD", "cells", "B", "and", "CD3", "positive", "cells", "C", "were", "quantified", "during", "the", "“", "stressed", "”", "co-culture", "with", "tumor", "addition", "every", "5", "days", "." ] } ]
PMC11021472	In our previous work, we hypothesized that the ZDHHC11 transcripts ensure high levels of MYB by binding to miR-150, thereby stimulating growth of BL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "previous", "work", ",", "we", "hypothesized", "that", "the", "ZDHHC11", "transcripts", "ensure", "high", "levels", "of", "MYB", "by", "binding", "to", "miR-150", ",", "thereby", "stimulating", "growth", "of", "BL", "cells", "." ] } ]
PMC10965315	An annexin V‐FITC assay kit was purchased from Cayman Chemical (#Item No. 600300, Michigan, MI, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "annexin", "V‐FITC", "assay", "kit", "was", "purchased", "from", "Cayman", "Chemical", "(", "#", "Item", "No.", "600300", ",", "Michigan", ",", "MI", ",", "USA", ")", "." ] } ]
PMC9428827	Mutein has shown lower toxicity than wtIL-2; consequently, it is possible to use 30 μg or higher doses without inducing severe toxic effects on treated mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutein", "has", "shown", "lower", "toxicity", "than", "wtIL-2", ";", "consequently", ",", "it", "is", "possible", "to", "use", "30", "μg", "or", "higher", "doses", "without", "inducing", "severe", "toxic", "effects", "on", "treated", "mice", "." ] } ]
PMC9046263	HML-6 is considered part of the beta retrovirus-like viruses (Class II) and contains at least one open reading frame (ERVK3-1) and several pro-viral loci.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HML-6", "is", "considered", "part", "of", "the", "beta", "retrovirus-like", "viruses", "(", "Class", "II", ")", "and", "contains", "at", "least", "one", "open", "reading", "frame", "(", "ERVK3", "-", "1", ")", "and", "several", "pro-viral", "loci", "." ] } ]
PMC9436459	not measured MDAAs isolated from moraceous plants Type A: Dehydroprenyl-2-arylbenzofuran type MDAAs 57 compounds (1 − 57) distributed in 14 species: C. regia, M. alba (including M. alba var.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "not", "measured", "MDAAs", "isolated", "from", "moraceous", "plants", "Type", "A", ":", "Dehydroprenyl-2-arylbenzofuran", "type", "MDAAs", "57", "compounds", "(", "1", "−", "57", ")", "distributed", "in", "14", "species", ":", "C.", "regia", ",", "M.", "alba", "(", "including", "M.", "alba", "var", "." ] } ]
PMC9429973	Emerging data support that T cell subpopulations, expression of transcription factors and immune checkpoint molecules are critical to regulate pathophysiology of AA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emerging", "data", "support", "that", "T", "cell", "subpopulations", ",", "expression", "of", "transcription", "factors", "and", "immune", "checkpoint", "molecules", "are", "critical", "to", "regulate", "pathophysiology", "of", "AA", "." ] } ]
PMC10747160	Briefly, HEK-293FT cells were maintained in 293 media and seeded at a density of approximately 2.5 × 10 cells in 8–10 mL of 293 media into a 100 mm tissue culture Petri dish or approximately 0.2 × 10 cells in 2–3 mL of 293 media into a 6-well tissue culture plate (batches of virus were made in either of the two plate types).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "HEK-293FT", "cells", "were", "maintained", "in", "293", "media", "and", "seeded", "at", "a", "density", "of", "approximately", "2.5", "×", "10", "cells", "in", "8–10", "mL", "of", "293", "media", "into", "a", "100", "mm", "tissue", "culture", "Petri", "dish", "or", "approximately", "0.2", "×", "10", "cells", "in", "2–3", "mL", "of", "293", "media", "into", "a", "6-well", "tissue", "culture", "plate", "(", "batches", "of", "virus", "were", "made", "in", "either", "of", "the", "two", "plate", "types", ")", "." ] } ]
PMC9587298	The glucose residue in position C5 of A-ring might explain this lack of reactivity of anthocyanins (Shao, Bai, He, Ho, Yang, & Sang, 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "glucose", "residue", "in", "position", "C5", "of", "A-ring", "might", "explain", "this", "lack", "of", "reactivity", "of", "anthocyanins", "(", "Shao", ",", "Bai", ",", "He", ",", "Ho", ",", "Yang", ",", "&", "Sang", ",", "2008", ")", "." ] } ]
PMC11733919	Briefly, the nanoplatform developed for targeting and killing senescent cells consisted of cubic iron oxide nanoparticles (MNPs) coated with a polymer poly(maleic anhydride-alt-1-octadecene) (PMAO) that was previously modified with a dye to track MNPs inside cells (TAMRA, T).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "the", "nanoplatform", "developed", "for", "targeting", "and", "killing", "senescent", "cells", "consisted", "of", "cubic", "iron", "oxide", "nanoparticles", "(", "MNPs", ")", "coated", "with", "a", "polymer", "poly(maleic", "anhydride-alt-1-octadecene", ")", "(", "PMAO", ")", "that", "was", "previously", "modified", "with", "a", "dye", "to", "track", "MNPs", "inside", "cells", "(", "TAMRA", ",", "T", ")", "." ] } ]
PMC11155445	Novel oxadiazole derivatives (23a and 23b) were synthesized by Abdelhamid et al. from thiosemicarbazides (22a and 22b) via cyclization reaction by refluxing thiosemicarbazides in acetic acid and in trimethylamine, respectively to give oxadiazole (Scheme 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "oxadiazole", "derivatives", "(", "23a", "and", "23b", ")", "were", "synthesized", "by", "Abdelhamid", "et", "al.", "from", "thiosemicarbazides", "(", "22a", "and", "22b", ")", "via", "cyclization", "reaction", "by", "refluxing", "thiosemicarbazides", "in", "acetic", "acid", "and", "in", "trimethylamine", ",", "respectively", "to", "give", "oxadiazole", "(", "Scheme", "6", ")", "." ] } ]
PMC3995603	All experimental procedures were carried out in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals and were approved by Korea Institute of Oriental Medicine Institutional Animal Care and Use Committee.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experimental", "procedures", "were", "carried", "out", "in", "accordance", "with", "the", "NIH", "Guidelines", "for", "the", "Care", "and", "Use", "of", "Laboratory", "Animals", "and", "were", "approved", "by", "Korea", "Institute", "of", "Oriental", "Medicine", "Institutional", "Animal", "Care", "and", "Use", "Committee", "." ] } ]
PMC9646302	The 786-0 cells were cultured in RPMI-1640 medium (cat.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "786", "-", "0", "cells", "were", "cultured", "in", "RPMI-1640", "medium", "(", "cat", "." ] } ]
PMC11506670	While many of them are likely to be infrequent, the American Society for Clinical Oncology posits that rare mutations, including those in KRAS, may represent new mechanisms of resistance, and therefore argued for expanded KRAS and NRAS mutational analysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "many", "of", "them", "are", "likely", "to", "be", "infrequent", ",", "the", "American", "Society", "for", "Clinical", "Oncology", "posits", "that", "rare", "mutations", ",", "including", "those", "in", "KRAS", ",", "may", "represent", "new", "mechanisms", "of", "resistance", ",", "and", "therefore", "argued", "for", "expanded", "KRAS", "and", "NRAS", "mutational", "analysis", "." ] } ]
PMC9429973	Most promising drugs with highest and lowest dDSS were selected for further analysis with single-cell RNA sequencing to determine their mechanism of action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "promising", "drugs", "with", "highest", "and", "lowest", "dDSS", "were", "selected", "for", "further", "analysis", "with", "single-cell", "RNA", "sequencing", "to", "determine", "their", "mechanism", "of", "action", "." ] } ]
PMC10243817	Library construction and sequencing were performed by Seqhealth Technology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Library", "construction", "and", "sequencing", "were", "performed", "by", "Seqhealth", "Technology", "." ] } ]
PMC10571053	Transfected HEK293 cells were grown in MEM with 10% fetal calf serum, glutamine and Pen/Strep along with 2 mg/mL G418 to maintain expression of the transporters.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfected", "HEK293", "cells", "were", "grown", "in", "MEM", "with", "10", "%", "fetal", "calf", "serum", ",", "glutamine", "and", "Pen/Strep", "along", "with", "2", "mg/mL", "G418", "to", "maintain", "expression", "of", "the", "transporters", "." ] } ]
PMC6267596	To further check experimental data quality, clustering was performed after calculation of the Z-score (Figure 4b and 4g) respectively, for U2932 and VAL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "further", "check", "experimental", "data", "quality", ",", "clustering", "was", "performed", "after", "calculation", "of", "the", "Z-score", "(", "Figure", "4b", "and", "4", "g", ")", "respectively", ",", "for", "U2932", "and", "VAL", "cells", "." ] } ]
PMC11704834	While key survival signaling pathways impacted by EGFR-TKIs are yet to be identified, very little information is currently available on the effects of EGFR-TKIs on gene transcription and epigenetic machineries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "key", "survival", "signaling", "pathways", "impacted", "by", "EGFR-TKIs", "are", "yet", "to", "be", "identified", ",", "very", "little", "information", "is", "currently", "available", "on", "the", "effects", "of", "EGFR-TKIs", "on", "gene", "transcription", "and", "epigenetic", "machineries", "." ] } ]
PMC11513571	Additional studies are required to evaluate the correlation between increased TSLP protein expression and IgG response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "studies", "are", "required", "to", "evaluate", "the", "correlation", "between", "increased", "TSLP", "protein", "expression", "and", "IgG", "response", "." ] } ]
PMC10976516	Except for apoptosis, the remaining modes of cell death mentioned above are very immunogenic and trigger both non-specific and specific immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Except", "for", "apoptosis", ",", "the", "remaining", "modes", "of", "cell", "death", "mentioned", "above", "are", "very", "immunogenic", "and", "trigger", "both", "non-specific", "and", "specific", "immune", "responses", "." ] } ]
PMC11727062	Mechanism diagram of the main actions of cold-natured Chinese medicinal monomers in melanoma (by Figdraw).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanism", "diagram", "of", "the", "main", "actions", "of", "cold-natured", "Chinese", "medicinal", "monomers", "in", "melanoma", "(", "by", "Figdraw", ")", "." ] } ]
PMC11529598	F&G. U251 miR-3154 sponge or control cells (1 × 10) were subcutaneously injected into nude mice (n = 6) for xenograft assay.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F&G.", "U251", "miR-3154", "sponge", "or", "control", "cells", "(", "1", "×", "10", ")", "were", "subcutaneously", "injected", "into", "nude", "mice", "(", "n", "=", "6", ")", "for", "xenograft", "assay", "." ] } ]
PMC11407042	A549 cell line culture mediumReagentFinal concentrationAmountGibco Dulbecco’s Modified Eagle Medium-500 mLGibco Fetal Bovine Serum10%50 mL Alternatives: 1% antibiotics (50 U/mL of penicillin-streptomycin) can be added to prevent contamination.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A549", "cell", "line", "culture", "mediumReagentFinal", "concentrationAmountGibco", "Dulbecco", "’s", "Modified", "Eagle", "Medium-500", "mLGibco", "Fetal", "Bovine", "Serum10%50", "mL", "Alternatives", ":", "1", "%", "antibiotics", "(", "50", "U/mL", "of", "penicillin-streptomycin", ")", "can", "be", "added", "to", "prevent", "contamination", "." ] } ]
PMC9454852	Several authors showed how a calcium homeostasis disorder can lead to various types of cell death in cancer cells and how this modified Ca homeostasis weaves together with the ER redox state alteration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "authors", "showed", "how", "a", "calcium", "homeostasis", "disorder", "can", "lead", "to", "various", "types", "of", "cell", "death", "in", "cancer", "cells", "and", "how", "this", "modified", "Ca", "homeostasis", "weaves", "together", "with", "the", "ER", "redox", "state", "alteration", "." ] } ]
PMC11791432	Subsequently, we identified 24 cell clusters (Fig. 5A), suggesting that gliomas are heterogeneous at the cellular level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "identified", "24", "cell", "clusters", "(", "Fig.", "5A", ")", ",", "suggesting", "that", "gliomas", "are", "heterogeneous", "at", "the", "cellular", "level", "." ] } ]
PMC11632064	See also Fig S5. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "also", "Fig", "S5", ".", "(" ] } ]
PMC11011837	In fact, the first component (that explains 25.8% of variance) divides the Jurkat and Molt-16 cell lines from the CCRF-CEM and Molt-4 cell lines, while the second component (15%) was able to separate between the CCRF-CEM and Molt-4 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "the", "first", "component", "(", "that", "explains", "25.8", "%", "of", "variance", ")", "divides", "the", "Jurkat", "and", "Molt-16", "cell", "lines", "from", "the", "CCRF-CEM", "and", "Molt-4", "cell", "lines", ",", "while", "the", "second", "component", "(", "15", "%", ")", "was", "able", "to", "separate", "between", "the", "CCRF-CEM", "and", "Molt-4", "cell", "lines", "." ] } ]
PMC11075223	Natural products with low toxicity and high efficiency had become the main source of drugs targeted to breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "products", "with", "low", "toxicity", "and", "high", "efficiency", "had", "become", "the", "main", "source", "of", "drugs", "targeted", "to", "breast", "cancer", "." ] } ]
PMC9429973	Disease awareness is low and diagnostic delays are common.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disease", "awareness", "is", "low", "and", "diagnostic", "delays", "are", "common", "." ] } ]
PMC10490530	As expected, the bacterial colonies expressing Luz-deficient control plasmid did not yield any BL signal for any of the four substrates tested, whereas the colonies expressing Luz plasmid showed the BL signal only in the column added with 3-OH hispidin substrate (Figure 2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "the", "bacterial", "colonies", "expressing", "Luz-deficient", "control", "plasmid", "did", "not", "yield", "any", "BL", "signal", "for", "any", "of", "the", "four", "substrates", "tested", ",", "whereas", "the", "colonies", "expressing", "Luz", "plasmid", "showed", "the", "BL", "signal", "only", "in", "the", "column", "added", "with", "3-OH", "hispidin", "substrate", "(", "Figure", "2a", ")", "." ] } ]
PMC11478724	PMX also up-regulated the expression of hsa-MiR-320a by about 12-fold change.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMX", "also", "up-regulated", "the", "expression", "of", "hsa-MiR-320a", "by", "about", "12-fold", "change", "." ] } ]
PMC11775197	The results of this study illustrate the potential function and influence of PPAR in CRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "this", "study", "illustrate", "the", "potential", "function", "and", "influence", "of", "PPAR", "in", "CRC", "." ] } ]
PMC10198699	It should be noted, however, that although South African courts may have regard for foreign judgments, such judgments are of course not binding authority in South Africa, and would only be relevant to the extent that the legal principles informing the judgment are applicable in South African law.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "should", "be", "noted", ",", "however", ",", "that", "although", "South", "African", "courts", "may", "have", "regard", "for", "foreign", "judgments", ",", "such", "judgments", "are", "of", "course", "not", "binding", "authority", "in", "South", "Africa", ",", "and", "would", "only", "be", "relevant", "to", "the", "extent", "that", "the", "legal", "principles", "informing", "the", "judgment", "are", "applicable", "in", "South", "African", "law", "." ] } ]
PMC5363531	In MPM cell lines, SRC inhibitors led to apoptosis, cell cycle arrest and decreased migration and invasion In NSCLC cell lines, the synergistic effect of PEM in combination with dasatinib, an oral dual Bcr/Abl and SFKs competitive ATP inhibitor, has already been reported .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "MPM", "cell", "lines", ",", "SRC", "inhibitors", "led", "to", "apoptosis", ",", "cell", "cycle", "arrest", "and", "decreased", "migration", "and", "invasion", "In", "NSCLC", "cell", "lines", ",", "the", "synergistic", "effect", "of", "PEM", "in", "combination", "with", "dasatinib", ",", "an", "oral", "dual", "Bcr/Abl", "and", "SFKs", "competitive", "ATP", "inhibitor", ",", "has", "already", "been", "reported", "." ] } ]
PMC10975211	Insects, amphibians, and animals contribute unique AMPs like cecropins, temporins, and cathelicidins, showcasing broad-spectrum activities against bacteria, fungi, and viruses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Insects", ",", "amphibians", ",", "and", "animals", "contribute", "unique", "AMPs", "like", "cecropins", ",", "temporins", ",", "and", "cathelicidins", ",", "showcasing", "broad-spectrum", "activities", "against", "bacteria", ",", "fungi", ",", "and", "viruses", "." ] } ]
PMC10197932	The KTAC-4000.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "The", "KTAC-4000", "." ] } ]
PMC11592837	Phosphorylation of H2AX is widely considered as a useful clinical biomarker for induction of DSBs caused by genotoxic stress such as exposure to radiation or cytotoxic drugs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phosphorylation", "of", "H2AX", "is", "widely", "considered", "as", "a", "useful", "clinical", "biomarker", "for", "induction", "of", "DSBs", "caused", "by", "genotoxic", "stress", "such", "as", "exposure", "to", "radiation", "or", "cytotoxic", "drugs", "." ] } ]
PMC11387401	The normalized relative quantities (NRQs) of each gene were calculated using the (primer efficiency) ΔCt method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "normalized", "relative", "quantities", "(", "NRQs", ")", "of", "each", "gene", "were", "calculated", "using", "the", "(", "primer", "efficiency", ")", "ΔCt", "method", "." ] } ]
PMC10940855	These data also suggest a dominant-negative effect caused by the competition of overexpressed dEFNB2 with endogenously expressed EFNB2 for binding to EPHB receptors, resulting in inhibition of endogenous EFNB2 reverse signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "also", "suggest", "a", "dominant-negative", "effect", "caused", "by", "the", "competition", "of", "overexpressed", "dEFNB2", "with", "endogenously", "expressed", "EFNB2", "for", "binding", "to", "EPHB", "receptors", ",", "resulting", "in", "inhibition", "of", "endogenous", "EFNB2", "reverse", "signaling", "." ] } ]
PMC10729469	Both age-matched untreated APP/PS1 mice and non-transgenic mice served as controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "age-matched", "untreated", "APP/PS1", "mice", "and", "non-transgenic", "mice", "served", "as", "controls", "." ] } ]
PMC11453018	These adaptations prevent the activation of P53-mediated apoptotic pathways, even in the presence of typical apoptotic stimuli like actinomycin D, low-dose cisplatin, and staurosporine .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "adaptations", "prevent", "the", "activation", "of", "P53-mediated", "apoptotic", "pathways", ",", "even", "in", "the", "presence", "of", "typical", "apoptotic", "stimuli", "like", "actinomycin", "D", ",", "low-dose", "cisplatin", ",", "and", "staurosporine", "." ] } ]
PMC10667689	Increased mRNA expression of GLUT-1, HK-2, PFKFB-3, and G6PD in a time-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "mRNA", "expression", "of", "GLUT-1", ",", "HK-2", ",", "PFKFB-3", ",", "and", "G6PD", "in", "a", "time-dependent", "manner", "." ] } ]
PMC4355729	The epithelial-mesenchymal transition (EMT) is considered to be crucial to tumor progression and metastasis, in which NCAD is the hallmark of EMT1920.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "epithelial-mesenchymal", "transition", "(", "EMT", ")", "is", "considered", "to", "be", "crucial", "to", "tumor", "progression", "and", "metastasis", ",", "in", "which", "NCAD", "is", "the", "hallmark", "of", "EMT1920", "." ] } ]
PMC11269933	In this study, we firstly reported a conserved PK Ser11 phosphorylation site in mollusks, which enhanced enzyme activity by promoting substrate binding, thereby regulating divergent thermal metabolism of two allopatric congeneric oyster species with differential habitat temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "firstly", "reported", "a", "conserved", "PK", "Ser11", "phosphorylation", "site", "in", "mollusks", ",", "which", "enhanced", "enzyme", "activity", "by", "promoting", "substrate", "binding", ",", "thereby", "regulating", "divergent", "thermal", "metabolism", "of", "two", "allopatric", "congeneric", "oyster", "species", "with", "differential", "habitat", "temperature", "." ] } ]
PMC10297204	Next, HS-SY-II was digested with 0.25% trypsin and 0.02% EDTA and centrifuged at 1200 rpm for 3 min and was plated at a density of 6.4 × 10 cells per well in 96-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "HS-SY-II", "was", "digested", "with", "0.25", "%", "trypsin", "and", "0.02", "%", "EDTA", "and", "centrifuged", "at", "1200", "rpm", "for", "3", "min", "and", "was", "plated", "at", "a", "density", "of", "6.4", "×", "10", "cells", "per", "well", "in", "96-well", "plates", "." ] } ]
PMC10197932	D6883 was from Sigma Aldrich.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "D6883", "was", "from", "Sigma", "Aldrich", "." ] } ]
PMC11765678	In addition to exhibiting high antitumor activity as a single agent at reasonably low concentrations, ER enhances the sensitivity of both NCI/ADR-RES and MCF-7/MXR cells to Adriamycin and Topotecan, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "exhibiting", "high", "antitumor", "activity", "as", "a", "single", "agent", "at", "reasonably", "low", "concentrations", ",", "ER", "enhances", "the", "sensitivity", "of", "both", "NCI/ADR-RES", "and", "MCF-7/MXR", "cells", "to", "Adriamycin", "and", "Topotecan", ",", "respectively", "." ] } ]
PMC7553912	a–c) Gene expressions of crystal-binding molecules, OPN (a), ANXA1 (b), and ANXA2 (c), in the kidney of WT and OSMRβ mice on days 0 (without GOx injection), 3, or 6. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "–", "c", ")", "Gene", "expressions", "of", "crystal-binding", "molecules", ",", "OPN", "(", "a", ")", ",", "ANXA1", "(", "b", ")", ",", "and", "ANXA2", "(", "c", ")", ",", "in", "the", "kidney", "of", "WT", "and", "OSMRβ", "mice", "on", "days", "0", "(", "without", "GOx", "injection", ")", ",", "3", ",", "or", "6", ".", "(" ] } ]

PMC11657695

Similar data were obtained for major players in the Hippo signalling pathway, such as ITGB2 and ITGB3 (Figs. 6B and D).

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PMC10158546

WT – wild type; KO – PRNP knocked out; NPC – neural progenitor cell; PuroR – puromycin resistance; GFP – green fluorescence protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WT", "–", "wild", "type", ";", "KO", "–", "PRNP", "knocked", "out", ";", "NPC", "–", "neural", "progenitor", "cell", ";", "PuroR", "–", "puromycin", "resistance", ";", "GFP", "–", "green", "fluorescence", "protein", "." ] } ]

PMC11522251

PCR primers were purchased from Generay Biotechnology (Shanghai, China).

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PMC8526701

Downregulation of BRD9 expression in AML (acute myeloid leukemia) may result in GI arrest .

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PMC11200978

Understanding the MLT is crucial for optimizing cryoablation protocols.

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PMC11742290

Two ADCs targeting LGR5+ CRC cells had significantly increased survival in mice in vivo .

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PMC5035325

Normal lung weight value is indicated (dashes lines).

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PMC11617590

Statistical significance was based on the difference compared with 0 μM SFN by one‐way ANOVA, followed by Dunnett's test (n = 3) (**p < 0.01, ***p < 0.001).

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PMC6650823

In experimental mouse models, it mediates protection from autoimmune pathologies, shows a potent histone deacetylase-inhibitory activity in CD4 T cells, inhibits the generation of small-intestinal Th17 cells, and ameliorates segmented filamentous bacteria (SFB)-promoted inflammation in the central nervous system.

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PMC5916734

In other words, the copy number of the gene encoding the selection marker separately from that of the target gene does not occur despite the amplification of the gene cassettes in the genome of producer cells.

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PMC11518994

Furthermore, the gene expression classifier ALLCatchR was applied on RNA-SEQ data and both samples were assigned to “PAX5 P80R” sub-category with high-confidence score.

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PMC11748335

E Heatmap shows the average DNA methylation levels of the three groups of long LOCK regions in NE2 vs. KYSE450, across the whole genome and within common PMDs and HMDs.

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PMC9429973

Hence, r/r PTCL patients urgently need better therapies.

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PMC9219615

Furthermore, another recently published study revealed that Tpz-1 (compound MTPC) could target tumors in mice by encapsulating the compound in gold nanorod-loaded PLGA-PEG nanoparticles .

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PMC9065483

RNA was extracted from cell lysates 24 hpi and probed for MX2 mRNA expression by qPCR (n = 3, mean ± SD; ∗∗∗p < 0.001 by one-way ANOVA).

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PMC10745221

al, 1983 .

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PMC10808409

The increase in the zeta potential accompanied by the incorporation of TPGS could be attributed to the ability of TPGS to increase in the solubility of FA, yielding more anionic FA in solution.

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PMC11657695

Current of each cells were analysed at + 60 mV. Lines indicate the median, each point represents the percentage of whole-cell currents sensitive to κ-Cono (Wilcoxon signed-rank test).

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PMC9436459

Among them, the enzymatic intermolecular [4 + 2] cycloaddition to produce natural MDAAs was the most efficient and applied strategy with an excellent enantioselectivity and yield.

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PMC11301242

Comparative analysis of gene expression levels involved in DNA repair pathways in lymphoma cell lines.

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PMC11216402

Patients were stratified into Mes-like (n = 150) and Epi-like (n = 150) groups based on the median difference in the mean expression values of Mes and Epi DE TFs.

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PMC11754784

As illustrated in Fig. 1a, a DNP consists of two functional moieties, a head-like DNA cage and a tail fiber-like external DNA nano-claw.

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PMC9429973

All donors and patients signed informed consent.

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PMC9429973

In all cases the mutational status was unmutated, CD38 was positive in 6 patients and 3 patients were positive for TP53 mutation.

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PMC11013014

This typically means that 55% of the administered substance is absorbed and becomes available to the body’s circulation and to target tissues.

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PMC9817179

Schematics of the protein constructs are shown on the left.

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PMC10747139

The polypyridyl Ru(II) complexes also have physical and chemical advantages, such as high chemical stability and photostability, sensitive spectroscopic responses to HIV TAR RNA, and low toxicity to normal cells.

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PMC11594806

This work is a narrative literature review focusing on the role of the adenosine pathway in sarcomas and its relationship with chemotherapy resistance, immunotherapy, and innovative therapeutic strategies.

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PMC9812014

The current anti-HSV-I medication acyclovir was also tested, and it exhibited similar inhibitory activity at 50 µM concentration.

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PMC5673955

Significant changes of hTERT protein in Jurkat and CD4 cells cultivated with RrA were confirmed by western blotting (Fig. 6C–F).

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PMC11763111

Crucially, compared to 1KO CAR-T cells, 4KO CAR-T and 4KO-LLT1 CAR-T cells generated noticeably more interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ) (Fig. 3B).

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PMC11319300

Furthermore, our research revealed that in human and murine cells (which lack an ORF, yet bear the enhancer marks) the MYEOV-3′-putative enhancer and CCND1/Ccnd1 display interactions within the 3D genome.

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PMC11388384

denotes not significant. (

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PMC9429973

This PET adapted approach reduces exposure to chemo andradiotherapy with no negative effect on long term outcome.

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PMC6600592

Cyclohexyl (E)-4-methoxyimino-4-(4-methoxyphenyl)butanoate (4B-2).

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PMC10976516

Zugazagoitia et al.; Yang et al.; Wang et al. Treatment modality for different stages of lung cancer These conditions may all be treated with chemotherapy:•as the primary treatment for those who are unable to undergo surgery•to relieve the pain of advanced cancer•to reduce the size of a tumor before surgery or radiation•to kill cancer cells that were not removed during surgery to lower the risk of recurrence•to relieve advanced cancer pain and as maintenance therapy in those with advanced cancer that is responsive to chemotherapy.

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PMC11476222

Characterizing gangliosides using LC-MS is advantageous due to the high throughput and sensitivity of this analytical tool.

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PMC9352806

The quality control (QC) sample was prepared by mixing an equal aliquot of the supernatants from all of the samples.

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PMC11544122

To test recruitment of SNX9 to mutant receptors, the cells were co-transfected with 500 ng of Rluc8-SNX9, and either 250 ng of FLAG-CXCR4-YFP, FLAG-CXCR4-YFP-5A or FLAG-CXCR4-YFP-4A and 2 µg of empty pcDNA3.

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PMC7723249

Even if this observation doesn’t allow to discriminate the effect of cytokines from the effect of viral factors, this mechanism could be involved in the higher viremia and endothelial damage observed in the severe CCHF cases .

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PMC11742670

Adadi et al. explored the motivations and outcomes of XAI research to highlight the significance of XAI.

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PMC11252033

The mRNAs of both antiapoptotic genes are physiologically able to bind AUBPs by AU-rich sequence element in the 3′-UTR of their mRNAs, thus modulating the recruitment of the degradation machinery constituted by the exosome complex.

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PMC11429241

On day 7, the 3D cell cultures were collected for gene expression analysis.

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PMC11697703

Brains for neuron reconstruction were vibratome sectioned coronally at 250 μm.

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PMC11248911

HNMR (DMSO-d6, δ ppm): 2.09 (s, 3H, CH3), 2.88–2.94 (dd, 1H, pyrazoline, J = 6.80, 18.00 Hz), 3.59–3.67 (dd, 1H, pyrazoline, J = 11.76, 18.20 Hz), 5.41–5.46 (dd, 1H, pyrazoline, J = 6.96, 11.68 Hz), 7.23–7.69 (m, 11H, Ar–H and CH-thiazole).

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PMC11764090

Beijing 24) during cold storage may be attributed to its ability to induce antioxidant systems and heat shock proteins.

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PMC11541241

The highly conserved structural organization of the TOR protein and the feature of the inhibitor‐sensitive TOR pathway in regulating the growth and virulence of the majority of pathogens enable the development of TOR inhibitor‐based strategies for antifungal therapies.

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PMC11742047

On the other hand, CL appear to be intimately involved in the mechanism of programmed cell death, also because they provide a mechanism underlying the activation of caspase 8, a protein crucial in apoptosis.

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PMC11128598

To measure homologous recombination efficiency the HR-GFP reporter was used, which allows flow cytometry-based detection of HR stimulated by I-SceI endonuclease-induced DSBs.

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PMC10452486

Due et al. minimized the binding of insulin receptor to the cell surface HLA-I using HC-specific monoclonal antibodies (mAbs) (PA 2.6 and BB 7.5, -6, and -7).

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PMC8584319

In this study, we screened an anticancer drug library to select compounds with translational repression functions.

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PMC11656657

Residual GFP + RD cells B and CD3 positive cells C were quantified during the “stressed” co-culture with tumor addition every 5 days.

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PMC11021472

In our previous work, we hypothesized that the ZDHHC11 transcripts ensure high levels of MYB by binding to miR-150, thereby stimulating growth of BL cells.

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PMC10965315

An annexin V‐FITC assay kit was purchased from Cayman Chemical (#Item No. 600300, Michigan, MI, USA).

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PMC9428827

Mutein has shown lower toxicity than wtIL-2; consequently, it is possible to use 30 μg or higher doses without inducing severe toxic effects on treated mice.

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PMC9046263

HML-6 is considered part of the beta retrovirus-like viruses (Class II) and contains at least one open reading frame (ERVK3-1) and several pro-viral loci.

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PMC9436459

not measured MDAAs isolated from moraceous plants Type A: Dehydroprenyl-2-arylbenzofuran type MDAAs 57 compounds (1 − 57) distributed in 14 species: C. regia, M. alba (including M. alba var.

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PMC9429973

Emerging data support that T cell subpopulations, expression of transcription factors and immune checkpoint molecules are critical to regulate pathophysiology of AA.

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PMC10747160

Briefly, HEK-293FT cells were maintained in 293 media and seeded at a density of approximately 2.5 × 10 cells in 8–10 mL of 293 media into a 100 mm tissue culture Petri dish or approximately 0.2 × 10 cells in 2–3 mL of 293 media into a 6-well tissue culture plate (batches of virus were made in either of the two plate types).

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PMC9587298

The glucose residue in position C5 of A-ring might explain this lack of reactivity of anthocyanins (Shao, Bai, He, Ho, Yang, & Sang, 2008).

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PMC11733919

Briefly, the nanoplatform developed for targeting and killing senescent cells consisted of cubic iron oxide nanoparticles (MNPs) coated with a polymer poly(maleic anhydride-alt-1-octadecene) (PMAO) that was previously modified with a dye to track MNPs inside cells (TAMRA, T).

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PMC11155445

Novel oxadiazole derivatives (23a and 23b) were synthesized by Abdelhamid et al. from thiosemicarbazides (22a and 22b) via cyclization reaction by refluxing thiosemicarbazides in acetic acid and in trimethylamine, respectively to give oxadiazole (Scheme 6).

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PMC3995603

All experimental procedures were carried out in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals and were approved by Korea Institute of Oriental Medicine Institutional Animal Care and Use Committee.

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PMC9646302

The 786-0 cells were cultured in RPMI-1640 medium (cat.

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PMC11506670

While many of them are likely to be infrequent, the American Society for Clinical Oncology posits that rare mutations, including those in KRAS, may represent new mechanisms of resistance, and therefore argued for expanded KRAS and NRAS mutational analysis .

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PMC9429973

Most promising drugs with highest and lowest dDSS were selected for further analysis with single-cell RNA sequencing to determine their mechanism of action.

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PMC10243817

Library construction and sequencing were performed by Seqhealth Technology.

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PMC10571053

Transfected HEK293 cells were grown in MEM with 10% fetal calf serum, glutamine and Pen/Strep along with 2 mg/mL G418 to maintain expression of the transporters.

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PMC6267596

To further check experimental data quality, clustering was performed after calculation of the Z-score (Figure 4b and 4g) respectively, for U2932 and VAL cells.

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PMC11704834

While key survival signaling pathways impacted by EGFR-TKIs are yet to be identified, very little information is currently available on the effects of EGFR-TKIs on gene transcription and epigenetic machineries.

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PMC11513571

Additional studies are required to evaluate the correlation between increased TSLP protein expression and IgG response.

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PMC10976516

Except for apoptosis, the remaining modes of cell death mentioned above are very immunogenic and trigger both non-specific and specific immune responses.

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PMC11727062

Mechanism diagram of the main actions of cold-natured Chinese medicinal monomers in melanoma (by Figdraw).

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PMC11529598

F&G. U251 miR-3154 sponge or control cells (1 × 10) were subcutaneously injected into nude mice (n = 6) for xenograft assay.

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PMC11407042

A549 cell line culture mediumReagentFinal concentrationAmountGibco Dulbecco’s Modified Eagle Medium-500 mLGibco Fetal Bovine Serum10%50 mL Alternatives: 1% antibiotics (50 U/mL of penicillin-streptomycin) can be added to prevent contamination.

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PMC9454852

Several authors showed how a calcium homeostasis disorder can lead to various types of cell death in cancer cells and how this modified Ca homeostasis weaves together with the ER redox state alteration .

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PMC11791432

Subsequently, we identified 24 cell clusters (Fig. 5A), suggesting that gliomas are heterogeneous at the cellular level.

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PMC11632064

See also Fig S5. (

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PMC11011837

In fact, the first component (that explains 25.8% of variance) divides the Jurkat and Molt-16 cell lines from the CCRF-CEM and Molt-4 cell lines, while the second component (15%) was able to separate between the CCRF-CEM and Molt-4 cell lines.

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PMC11075223

Natural products with low toxicity and high efficiency had become the main source of drugs targeted to breast cancer.

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PMC9429973

Disease awareness is low and diagnostic delays are common.

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PMC10490530

As expected, the bacterial colonies expressing Luz-deficient control plasmid did not yield any BL signal for any of the four substrates tested, whereas the colonies expressing Luz plasmid showed the BL signal only in the column added with 3-OH hispidin substrate (Figure 2a).

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PMC11478724

PMX also up-regulated the expression of hsa-MiR-320a by about 12-fold change.

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PMC11775197

The results of this study illustrate the potential function and influence of PPAR in CRC.

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PMC10198699

It should be noted, however, that although South African courts may have regard for foreign judgments, such judgments are of course not binding authority in South Africa, and would only be relevant to the extent that the legal principles informing the judgment are applicable in South African law.

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PMC5363531

In MPM cell lines, SRC inhibitors led to apoptosis, cell cycle arrest and decreased migration and invasion In NSCLC cell lines, the synergistic effect of PEM in combination with dasatinib, an oral dual Bcr/Abl and SFKs competitive ATP inhibitor, has already been reported .

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PMC10975211

Insects, amphibians, and animals contribute unique AMPs like cecropins, temporins, and cathelicidins, showcasing broad-spectrum activities against bacteria, fungi, and viruses.

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PMC10197932

The KTAC-4000.

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PMC11592837

Phosphorylation of H2AX is widely considered as a useful clinical biomarker for induction of DSBs caused by genotoxic stress such as exposure to radiation or cytotoxic drugs .

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PMC11387401

The normalized relative quantities (NRQs) of each gene were calculated using the (primer efficiency) ΔCt method.

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PMC10940855

These data also suggest a dominant-negative effect caused by the competition of overexpressed dEFNB2 with endogenously expressed EFNB2 for binding to EPHB receptors, resulting in inhibition of endogenous EFNB2 reverse signaling.

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PMC10729469

Both age-matched untreated APP/PS1 mice and non-transgenic mice served as controls.

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PMC11453018

These adaptations prevent the activation of P53-mediated apoptotic pathways, even in the presence of typical apoptotic stimuli like actinomycin D, low-dose cisplatin, and staurosporine .

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PMC10667689

Increased mRNA expression of GLUT-1, HK-2, PFKFB-3, and G6PD in a time-dependent manner.

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PMC4355729

The epithelial-mesenchymal transition (EMT) is considered to be crucial to tumor progression and metastasis, in which NCAD is the hallmark of EMT1920.

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PMC11269933

In this study, we firstly reported a conserved PK Ser11 phosphorylation site in mollusks, which enhanced enzyme activity by promoting substrate binding, thereby regulating divergent thermal metabolism of two allopatric congeneric oyster species with differential habitat temperature.

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PMC10297204

Next, HS-SY-II was digested with 0.25% trypsin and 0.02% EDTA and centrifuged at 1200 rpm for 3 min and was plated at a density of 6.4 × 10 cells per well in 96-well plates.

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PMC10197932

D6883 was from Sigma Aldrich.

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PMC11765678

In addition to exhibiting high antitumor activity as a single agent at reasonably low concentrations, ER enhances the sensitivity of both NCI/ADR-RES and MCF-7/MXR cells to Adriamycin and Topotecan, respectively.

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PMC7553912

a–c) Gene expressions of crystal-binding molecules, OPN (a), ANXA1 (b), and ANXA2 (c), in the kidney of WT and OSMRβ mice on days 0 (without GOx injection), 3, or 6. (

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