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PMC11576293
The findings indicated that compounds 22 and 29 are potential apoptotic antiproliferative agents that inhibit EGFR and VEGFR-2.
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PMC11783017
Fig. S9).
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PMC9429973
PFA-100 ® in whole citrated blood with collagen +ADP and collagen+Epinephrine cartridges.
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PMC6642070
The point mutations introduced into p53RRE3 are shown in underscore characters.
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PMC9429973
Furthermore, WU-NK-101 exhibited enhanced glycolytic and mitochondrial oxidative phosphorylation capacity (i.e., metabolic fitness) compared with cNK cells.
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PMC11803918
Next, we explored the interaction of hybrid exosomes with melanoma tumor cells and normal skin fibroblasts.
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PMC10719213
Immunoblotting was carried out as described .
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PMC11759543
Cytotoxicity of doxorubicin for 24 h treatment. (
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PMC11534377
Total RNA extraction was executed using TriReagent (Thermo Fisher), followed by purification using the RNeasy Mini kit (Qiagen) according to the manufacturer’s protocol.
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PMC10728200
All mice were euthanized 18 days later.
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PMC11476666
The following two modalities were used in parallel: one where the treatments were added immediately after cell seeding (preformation) and another where the molecules were added only after spheroid formation on day 3 (postformation).
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PMC7987994
DesignationInput materialChemical treatment of powderProcessingMg_HF_SPSMg powderHF (24 h)Cold pressing and SPS (500 °C)Zn_SPSZn powder–Cold pressing and SPS (300 °C)Zn0.8 MgZn, Mg ingots–Casting (on air) + extrusion (300 °C and extrusion ratio 10) Materials used for testing.
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PMC11718109
Finally, blots were imaged using the Gel Doc imaging system (Bio-Rad) using manufacturer’s protocols.
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PMC10158546
However, we did not characterize the composition of PrP’s GPI-anchor in the differentiated ReN cultures, which might have yielded additional insights into the lack of prion replication observed.
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PMC11638255
It was not possible to accurately assign a cell type to 2/15 identified immune clusters due to the minimal number of cells present (n < 50) and were therefore excluded from analysis.
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PMC7757104
However, these effects were less pronounced following 96-h CDDP exposure (Fig. S5A and B).
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PMC6160470
Increase in MAC activity can be observed in compounds with longer side chains and higher lipophilicity, as shown in Table 1.
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PMC11075223
Maxim.
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PMC9429973
In the HDT group, the major risk factors for CHF were older age at the time of HDT (HR 1.20 per decade), and male sex (HR 2.15).
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PMC10932641
Specifically, we observed the proliferation, invasion, and migration of RCC lines after silencing and overexpressing lncRNA GPRC5D-AS1 and measured the size of tumor volumes in nude mice.
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PMC11194678
These data further confirm the role of STAU1 in regulating autophagy.
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PMC11045125
As shown in Fig 8A (upper left panel), we confirmed that P493-6 cells express the EBV EBNA1 protein but not the LMP1 or EBNA2 proteins, allowing us to examine the effect of Myc expression on various cellular proteins without the confounding effect of altered LMP1 expression.
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PMC10212663
This study has some inherent limitations.
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PMC11711871
sEH activity was measured using the soluble epoxide hydrolase assay (ab240999; Abcam, Cambridge, UK) following the manufacturer’s instructions as described previously .
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PMC6268318
Furthermore, this data survey was supplemented with searches in the PubMed and ScienceDirect sites.
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PMC8358176
Expression of TNFRSF10A was similar to that of TNF.
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PMC10969097
Thus, the combination of GAD with cisplatin triggers a series of events, including an increase in intracellular ROS and the inhibition of ERK1/2, which results in greater sensitivity of tumour cells to cisplatin.
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PMC11659734
Therefore, BPA and BPE were found to be non‐cytotoxic under our experimental conditions.
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PMC11725127
Although two DUBs, USP18 and OUTB1, are associated with the stability of KRAS, the DUBs that directly remove ubiquitin(s) from and stabilize KRAS remain unknown.
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PMC11806106
Each n indicates one transfection measured as triplicate.
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PMC11587606
Typical images of RHBDF1 (Left) and PKCζ (Right) immunofluorescence-staining of human breast cancer and para-cancerous tissues; scale bar 50 μm (number of patients n = 6). (
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PMC11300085
Western blot analysis showed that chemerin addition evidently increased the expression of CMKLR1 in SK-OV-3 cells (Figures 3(b) and 3(c)).
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PMC9436459
Ha et al. found that all the PTP1B inhibitors albasin B (8), macrourin G (26), morusalbin A (27), mulberrofuran G (31), mulberrofuran K (40), morusalbin B (42), yunanensin A (44), albanol B (46), morusalbin C (49), and morusalbin D (67) exhibited strong inhibitory activities against α-glucosidase with IC50 ranging from 2.29 to 5.91 μM. The type of α-glucosidase inhibition of the active MDAAs 8, 26, 44, and 67 with Ki values of 0.42, 2.42, 1.19, and 0.64 μM, respectively, were determined to be competitive-type by enzyme kinetic studies .
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PMC11347429
To advance the diagnosis and better predict the probability of progression to severe influenza and risk of ICU admission, it is pivotal to characterize host responses in-depth.
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PMC7723249
During the infection, the other side of the transwell was treated with 100μl (apically) or 600μl (basolaterally) of complete DMEM medium.
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PMC8984067
The anti-EpCAM monoclonal antibody was used to label the BEL-7404 cell line.
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PMC8193046
For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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PMC4659567
The complex [Ru(η -p-cym)(L4)Cl2] with 3-aza-5H-phenanthridin-6-one (L4) acting as monodentate N-donor ligand was moderately in vitro cytotoxic against human A549 lung, HCT116 colon, A2780 ovarian and Hcc1937 breast carcinoma cell lines, as well as against MRC5 normal lung fibroblast cell line with the IC50 values equalled 85.1, 38.8, 46.0, 93.3 and 143.0 μM, respectively .
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PMC9844987
Densities of the lowest Pearson correlation between all pairs of decomposed promoters originating from the same promoter across all CAGE-inferred promoters with at least two decomposed promoters.
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PMC11739696
Different letters indicate significant difference at p < 0.001.
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PMC11687167
The role of E proteins (transcriptional activators or repressors with the ability to bind specific DNA sequences termed E-box sites) during the differentiation of mature CD4 + T cells has been emphasized, especially in the maintenance of Treg and Th17 cells .
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PMC11682172
Co-culture of breast cancer cell lines with activated T lymphocytes stimulated passage of the cancer cells through the artificial BBB.
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PMC11621565
The protein was detected with rabbit anti- α-synuclein primary monoclonal antibody (Recombinant anti-α-synuclein antibody [EPR20535], ab212184, Abcam), overnight at 4°C , followed by incubation with goat anti-rabbit secondary antibody (sc-2004, Santa Cruz), for 1 h at room temperature.
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PMC11794588
After every four hours, the tubes were put in a sonicator bath for one hour.
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PMC11337594
The results demonstrated that cytochrome c was released from the mitochondria into the cytoplasm and partially into the nucleus in TER-treated A375 cells (Fig. 3D and E), a finding that was further corroborated by the transcriptome data (Fig. 3F).
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PMC11551844
A saturation of 90% was necessary for sub-culturing.
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PMC6468656
The sequences were confirmed via DNA sequencing by Sequencing Core Facility, SIC, Academia Sinica.
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PMC11748363
Three different procedures were used to prepare the title compounds: 1,1′‐carbonyldiimidazole (CDI) coupling (procedure A), activation of acid by oxalyl chloride (procedure B, when synthesis using CDI did not produce final compounds in reasonable yields) and direct reaction of commercially obtained phenylacetyl chloride with the corresponding amine (procedure C).
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PMC9429973
Results: The median age of the patients was 33 years (16-60), 139 (62%) were females, 40% had B-symptoms, 32% extranodal involvement (E or stage IV), 18% PS≥2, 84% elevated LDH (35% highly elevated≥2xnormal).
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PMC10938336
These comprehensive docking results underscore the high binding affinities and specific interactions between the active compounds and key cancer-related proteins, PARP1 and CASP3.
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PMC4659567
Calcd.
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PMC10440586
The correlation between CD99 expression and the predicted IC50 of PI3K-AKT pathway inhibitors of the TCGA glioma samples.
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PMC10777969
This would presumably create the diverse biological activity of FCP23 and FCP26.
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PMC7305184
Two experiments (upper and lower panels) both for 15 generations, are shown.
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PMC6835428
An alternative to the use of neutral lipids is the employment of positively charged lipids, such as 3β[N-(N’,N’-dimethylaminoethane)-carbamoyl]DC-cholesterol, 1,2-dioleoyl-3-trimethylammonium propane (DOTMA) .
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PMC11388384
SCUBE1 catalyzes exchange between discrete diffusive populations of SHH. (
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PMC11628904
For experiments including photoconverted larvae and larvae exposed to C. albicans, imaging was performed using a spinning disc microscope (CSU‐X, Yokogawa) with a confocal scanhead on a Zeiss Observer Z.1 inverted microscope, either a Plan‐Apochromat NA 0.8/20× objective or a Plan‐Apochromat NA 1.4/63× objective, and a Photometrics Evolve EMCCD camera.
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PMC11594588
The literature data have shown a high incidence of platelet apoptosis in patients with CF-LVADs .
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PMC10890055
Four replicates were used for each sample for each medium.
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PMC9429973
Reliability of the diagnosis of COVID-19 is confirmed by a positive PCR test result and/or the presence of class G antibodies to the SARS-Cov2 virus.
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PMC11638255
Principal Component (PC) Analysis was used to reduce the dimensionality of the integrated dataset.
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PMC11697703
Our work shows that the miR-193b–365 miRNA cluster is regulated by Fezf2 and promotes dendritic branching in deep-layer neurons via regulation of MAPK8.
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PMC11286266
Targeted integration was performed by co-transfection with the circular landing pad donor vector (UK2846) and a single sgRNA/Cas9 targeting cgROSA26 locus (UK2847).
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PMC11658074
h, i Immunofluorescence staining of γ-H2AX in the cell nucleus in the five groups.
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PMC11678130
After excluding the potential toxicity of this treatment on the CAM blood vessels, the work continued by exploring the potential impact of QUE+5-FU on angiogenesis—a key process involved in tumor development and metastasis formation .
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PMC8592717
XBJ prevented the release of serum proinflammatory cytokines, thereby alleviating hepatic I/R injury and promoting the recovery of intestinal function, but it did not demonstrate a protective effect on coagulopathy .
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PMC9622879
From these local prices, the daily energy cost of each home inside the community is determined.
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PMC9429973
Patients must be aged ≥18 years, have an Eastern Cooperative Oncology Group Performance Status of 0 or 1 and a life expectancy of >12 weeks.
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PMC11591794
Indeed, our findings supported this.
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PMC11656657
Previous studies have reported that 143B tumor cells induce the expansion of murine MDSC populations, potentially contributing to resistance to immunotherapy .
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PMC11787355
e Cellular states of generated IPTOs with PTPRZ1 expression.
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PMC8345486
Solutions of CuSO4 × 5H2O (100 mM) and sodium ascorbate (100 mM) were added to the reaction mixture.
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PMC11782780
The combination of drugs targeting CSCs and paclitaxel, a drug targeting cancer cells, synergistically enhances cytotoxic effects in BC cells.
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PMC10840195
To verify this hypothesis, we constructed Sunitinib-resistant RCC cell lines to clarify the effects of Wnt/β-catenin signaling pathway and EMT pathway crossinuation on the mechanism of Sunitinib resistance in vitro and vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "verify", "this", "hypothesis", ",", "we", "constructed", "Sunitinib-resistant", "RCC", "cell", "lines", "to", "clarify", "the", "effects", "of", "Wnt/β-catenin", "signaling", "pathway", "and", "EMT", "pathway", "crossinuation", "on", "the", "mechanism", "of", "Sunitinib", "resistance", "in", "vitro", "and", "vivo", "." ] } ]
PMC8751435
Cell bubbling is found to be associated with GSDME activation in previous research (Yu et al., 2019).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "bubbling", "is", "found", "to", "be", "associated", "with", "GSDME", "activation", "in", "previous", "research", "(", "Yu", "et", "al.", ",", "2019", ")", "." ] } ]
PMC11659921
To investigate the potential roles of angiogenesis and stemness‐related genes in OV, we utilized GSCALite to analyze the associated pathways, single nucleotide variations (SNVs), and copy number variations (CNVs) of these 14 genes in OV.
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PMC11049548
Samples were held inside the NMR probe head for five minutes before the measurements in order to equilibrate the temperature at 300 K. In the case of cell lysates- to avoid sample degradation during the analysis-frozen samples were thawed and analyzed one at a time.
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PMC11687663
The secondary metabolites were identified through the use of LC retention time, molecular mass and high-resolution mass spectra analysis in the extracts (Fig 2).
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PMC10588957
HepG2 cells were treated with different concentrations of DATS (0, 10, 20, 40, 80, 160 μM) for 24 and 48 h, and cell viability was measured using a CCK-8 assay.
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PMC10253973
Attempts are also being made to evaluate ruthenium complexes as potential photosensitizers with polypyridine ligands for use in cancer chemotherapy.
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PMC9429973
Oral-AZA (CC-486) is approved for pts with AML in first remission (CR1) after IC who are ineligible for transplant or other curative therapies.
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PMC11756907
The plates were then incubated at 37°C for 4 hours and the supernatant was removed after prior centrifugation (700 × g for 10 min).
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PMC11656657
In all the analyses, the population of interest was gated based on forward vs side scatter characteristics followed by singlet gating, and live cells were gated using 7-Amino-Actinomycin D (7-AAD) (BD Biosciences, Italy).
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PMC11188874
Generation of HeLa HDAC6-KO cells overexpressing pcDNA-HDAC6-FLAG, pcDNA-HDAC6.DC-FLAG, or pcDNA-HDAC6.ΔBuz-FLAG was achieved using lipofectamine 3000 (Thermo Fisher Scientific, catalog no. L3000001).
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PMC11767793
Likewise, based on the UV–Vis measurements over time, the Au-PEG-COOH@NIST showed an adequate shelf-life up to 6 months (Figure 1d,f).
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PMC11766309
Among these differentially enriched pathways, the 3 pathways most closely related to the 33 tumor types were the mRORC1 signaling pathway, the PI3K/AKT/mTOR pathway, and the unfolded protein response pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "these", "differentially", "enriched", "pathways", ",", "the", "3", "pathways", "most", "closely", "related", "to", "the", "33", "tumor", "types", "were", "the", "mRORC1", "signaling", "pathway", ",", "the", "PI3K/AKT/mTOR", "pathway", ",", "and", "the", "unfolded", "protein", "response", "pathway", "." ] } ]
PMC9587298
The reaction products obtained by reaction of selected phenolic compounds and S. nigra extracts with MGO were further analysed by UHPLC-MS to confirm the results obtained by direct injection ESI-MS (Fig. 5), as it can decrease eventual matrix suppression effects and detect possible isomeric structures (Pitt, 2009).Fig.
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PMC11365427
AutoDock Vina was used for molecular docking.
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PMC11463018
Besides, the introduction of electron-withdrawing groups such as chlorine (16i and 16k) or trifluoromethyl (16 l and 16 m) seemed to be detrimental to JAK1 activity but with no obvious influence on their HDAC6 activity.
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PMC11394227
ER stress markers PERK, BiP, and CHOP levels were also quantified.
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PMC11760643
P2X7 expression was significantly greater on CD56CD16 NK cells (462.3 ± 45.6) compared with both CD56CD16 (272.0 ± 26.2; p = 0.008) and CD56CD16 NK cells (273.8 ± 28.2; p = 0.009), which had similar expression (Figure 3H).
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PMC9429973
As pathogenic germline RUNX1 variants are causative for RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies it is crucial to distinguish between somatic and germline variants.
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PMC11683240
However, this minimal effect is unlikely to account for the substantial inhibition of cell intoxication by α1AT.
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PMC11711127
T cell progenitors migrate from the bone marrow to the thymus, where they are subjected to a complex process of maturation and selection for weak recognition of self pMHC, before being released to the periphery as naive T cells.
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PMC11719944
In terms of the hormonal profile, we found a direct relationship between serum levels of PRL and HbA1c.
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PMC11552389
Immunofluorescent staining revealed a significant increase in cytoplasmic autophagosome numbers in Vemurafenib-resistant melanoma cells (A375R) relative to drug-sensitive parental cells (A375) (Figure 4A).
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PMC8903741
Scale bar = 200 μm.
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PMC9429973
Rituximab (if CD20+), prophylactic ITs and imatinib (if Ph+) were standard.
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PMC9429973
Aims: The aim of this study is to identify genetic differences between E/R cases stratified by MRD and to identify potential mediators of poor therapy response.
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PMC10507284
Differences in the expression of TROAP between metastatic (n = 59) and nonmetastatic (n = 120) STS patients.
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