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OTAR3088
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PMC10852540
From this point of view, we thought that RA performs apoptosis through the mechanism of decrease in Bcl-2 gene expression.
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PMC11791203
NameMWH- bond acceptorsH-bond donorsMRConsensus Log PESOL Log SGI absorptionBBB permeantlog Kp (cm/s)Lipinski violationsBio-availability ScoreSulfurous acid hexyl octyl ester278.453079.864.5− 4.39HighYes− 3.7700.552,4-Ditert-Butylphenol206.321167.013.99− 4.55HighYes− 3.8700.55Cetene224.430078.556.46− 6.01LowNo− 1.3110.55Palmityl acrylate296.492094.266.24− 5.81HighNo− 2.1910.55Neodene224.430078.556.46− 6.01LowNo− 1.3110.55Cyclododecanol184.321158.853.24− 3.35HighYes− 4.7600.55Neophytadiene278.520097.317.07− 6.77LowNo− 1.1710.559-eicosene280.530097.787.7− 6.9LowNo− 0.8310.55N-pentadecane212.410074.226.06− 5.24LowNo− 2.110.55(E)-phytol296.531198.946.22− 5.98LowNo− 2.2910.551-Heneicosanol312.5711104.227.25− 6.71LowNo− 1.2310.55O o’-biphenol, 4,4’,6,6’-tetra-t-butyl-312.5711104.227.25− 6.71LowNo− 1.2310.55Tritetracontane605.1600208.8216.18− 15.39LowNo6.2720.171,2-benzenedicarboxylic acid166.134240.360.84− 1.57HighNo− 6.800.85Oleyl alcohol, trifluoroacetate268.481189.335.87− 5.21HighNo− 2.6510.55Tetratetracontane619.1900213.6216.54− 15.75LowNo6.5720.17Bis(2-ethylhexyl) terephthalate390.5640116.36.27− 6.06HighNo− 3.3910.55MW-Molecular weight (acceptable range: <500).HB-Hydrogen bond acceptor (acceptable range: ≤10).HB-Hydrogen bond donor (acceptable range: ≤5).Log Po/w - Lipophilicity (acceptable range: <5).Molar refractivity should be between 40 and 130.ESOLLogS- - solubility in water (acceptable range: <10).Bioavailability score-four classes of probabilities (11%, 17%, 56% or 85%).Rule of five: Number of violations of Lipinski’s rule of five; recommended range: 0–4.Negative values of logKpindicate low skin permeation.
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PMC11594641
The A375 human melanoma cell line and a patient-derived DMBC12 melanoma cell line isolated from a primary tumor (described in ref. )
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PMC10932641
lncRNA has a prominent regulatory role in the Wnt-β-catenin pathway: The increased expression of MSC-AS1, FAST, JPX, and LALR1 directly or indirectly enhances the stability of β-catenin, thereby activating the Wnt-β-catenin pathway (41,42); meanwhile, the decreased expression of OTUD6B-AS1 indirectly activates the Wnt-β-catenin pathway (43).
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PMC10530622
On univariate analysis, patients with OSA were older, with a higher BMI and higher likelihood of diabetes mellitus and HTN.
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PMC11548041
Data are reported as the average relative expression of β-catenin ± SD (n = 3 biological replicates).
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PMC11286266
The bar graph shows the mean ± SEM of the normalised median BiP::sfGFP reporter intensity from more than four independent experiments. (
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PMC9429973
Epstein-Barr virus (EBV) infection of B cells is responsible for about 50% of cases, either due to reactivation of the virus after transplantation or primary EBV infection.
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PMC9429973
Methods: Eligible patients were adults with R/R LBCL after first-line treatment who were not deemed candidates for HDCT and HSCT by their physician and met ≥ 1 frailty criteria as follows: age ≥ 70 years, Eastern Cooperative Oncology Group performance status (ECOG PS) of 2, diffusing capacity for carbon monoxide ≤ 60%, left ventricular ejection fraction < 50%, creatinine clearance < 60 mL/min, or alanine aminotransferase/aspartate aminotransferase > 2 × the upper limit of normal.
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PMC11726848
However, it should be noted that the release of phosphatidylserine does not mean the final start of apoptosis.
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PMC9429973
The cardiotoxicity was less common and neurotoxicity was more frequent in the R-DA-EPOCH group.
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PMC9429973
In the non-efficacy-related group, 85% and 71% of patients in eltrombopag and rh-TPO group maintained their response rates, respectively.
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PMC11055323
One well of a 6-well plate was seeded with 1,000 cells and cultured for 10 days.
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PMC3122064
This demonstrates that the release of the negative feedback on p53 by MDM2 is the important event for enhancing cisplatin-induced apoptosis in TC cells (Figures 6b–d and Supplementary Figures 5a–c).
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PMC9429973
The incidence of moderate thrombocytopenia (platelet count <100 x 10/L) is about 25% in newly diagnosed MF pts; however, the prevalence is about 67% in all MF pts.
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PMC10454535
In this study, we observed RES, PIN, and PIC cytotoxicity in MM cells and identified the combination of 5 μM PIN and 5 nM BTZ as synergistic in reducing the viability of MM cells.
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PMC9895440
Statistics are pairwise 2-way ANOVAs followed by Bonferroni correction.
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PMC7090062
P < 0.05 vs. non-specific control; P < 0.05 vs. miR-30a inhibitor.
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PMC11267830
The plot was generated with IGV.
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PMC9429973
In 29 patients (14.9%) with pre-sternum diagnosis of ICUS, a post-sternum diagnosis of ICUS and hypo-MDS were identified in 75.9% (22/29) and 24.1% (7/29) patients, respectively.
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PMC10958426
We found cancer cells highly expressed genes associated with protein folding, neutrophil degranulation, cellular responses to stress, cytokine signaling, VEGF pathway and MYC pathway, indicating cancer cells have increased cell activity and enhanced of immune cell infiltration/maturation compared with their normal counterpart.
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PMC11244823
Each horse serum was tested in three independent assays with each three replicates against four different gD1 antigens.
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PMC11469524
In agreement with the findings from the analysis of the Burkitt lymphoma cell line BL-2, we also note a central role of PI3K in the studied DLBCLs indicated by the network central position of the PI3K node even after the individual network adjustment (Fig 5C, bottom), i.e., every network node can be reached by PI3K.
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PMC9429973
X. chen, R. zhang, W. zhai, Q. ma, A. pang, D. yang, Y. he, J. wei, S. feng, M. han, E. Jiang State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tian Jin, China Background: To investigate the preventive effect of low-dose porcine antithymocyte globulin (P-ATG) on graft versus host disease (GVHD) in HLA matched sibling donor transplantation.
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PMC11190538
These results are in agreement with Hamouda and El-Naggar who stated that C-phycocyanin possesses a molecular weight ranging from 70 to 110 kDa.
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PMC11409031
Following this, principal component analysis was conducted on the top 2000 most variable genes, with the selection of 10 principal components for reducing dimensionality and clustering.
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PMC11774747
In addition to an optimal memory phenotype, the expression of exhaustion markers is being evaluated to generate less exhausted cells, for a better long-term survival.
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PMC9351137
Most notably, BAF53a and Tip60 interacted at telophase with each other and with a number of cytokinesis regulators, positively controlling their recruitment to the midbody (Fig. 6 and Table 3).
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PMC11015054
The above results indicate that METTL5 expression is upregulated in HCC and suggest that this poor prognosis may be related to increased NETs release.
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PMC11560255
Some plant active components, such as alkaloids, flavonoids, and phenolic compounds, have been proven to possess cytotoxic activity against cancer cells (Ganadhal et al., 2021).
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PMC11394227
Data from each group were compared by t-test or one-way analysis of variance test; p < 0.05 was a significant difference.
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PMC11612626
Effect of compound A on allogenic and autologous T-cell anti-myeloma cytotoxicity.
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PMC9545714
Trans‐epidermal water loss was measured under standard conditions at the clinic visits.
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PMC11371747
The relative affinity of folic acid was set at 1.
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PMC11632064
For the assessment of viability, cells were seeded in 96-well plates at 1,250 cells/100 μl (A-375), 7,500 cells/100 μl (MeWo), 10,000 cells/100 μl (Rho-0) to which 100 μl of 2X concentrated inhibitor dilutions (BI-D1870, LJH685, and BI 6727) were added.
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PMC9621239
Briefly, 100 ug/mL colchicine was added to the culture medium, and the cells were incubated at 37°C for 70 min.
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PMC9429973
2 patients complaint minor rash & itchy skin.
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PMC11285179
K Representative immunofluorescence images of PAN-CK, NG2, CCL28 with DHRS11 or RDH13 or Angiopoietin-1 on biopsy tissues from lung cancer patients (left panel).
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PMC10197932
In 9 the frequency resonance hypothesis is illustrated even in terms of possible effects on subcellular structures and enzymatic activity.
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PMC11489175
Thus, USP48 may represent a prognostic biomarker and may be exploitable for therapeutic targeting.
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PMC10135767
After the screening, the cells were verified by flow cytometry combined with Western blotting to evaluate the effects of knockdown.
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PMC4369959
Zerumbone was also reported to induce phase II detoxification enzymes in cultured rat normal liver epithelial cell line.
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PMC11743975
ATP production in COS-7 cells treated with different concentrations of niclosamide and different incubation time.
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PMC9429973
This data suggests the RARA biomarker selects for patients who may respond to tamibarotene and may be less likely to respond to ven/aza.
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PMC11530949
The observed NO concentration in the extract-treated group was approximately one-third of the concentration in the nanoparticle-treated cells. *
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PMC10870498
Additionally, the number of migrated cells and wound healing area were also decreased by KIF23 knockdown (Fig. 2C and D).
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PMC11469524
A bead-based multiplex ELISA platform (MagPix) was then used to measure the phosphorylation of fourteen key signaling and effector proteins: SYK, ZAP70, Btk, AKT, RPS6, BAD, ERK2, MEK1, p90RSK, GSK-3a/b, NF-κB-p65, HSP27, JNK and cJun.
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PMC11470999
Recent studies have shown that it exhibits promising anticancer potentials.
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PMC9910796
Precursor pp220, in turn, interacts with polyprotein pp62 to form the core shell, whose membrane anchoring would be further sustained by N-myristoylation of pp220 and a positively charged aa patch present in the p35 region of pp62.
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PMC11629461
The dose–response relationship for UVA irradiation‐induced calcium spikes (area under the curve above baseline, per 10 min), the N numbers are indicated in brackets above each column.
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PMC11696576
Created in BioRender.
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PMC11591794
In our studies, we also demonstrated the expression of proapoptotic genes P53 and Bax, which are involved in the apoptosis process induced by GA in HeLa cells.
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PMC11314247
The genomic response to estrogens is associated with ligand-activated transcription factors via ERs, whereas non-genomic signaling involves events for stimulating intracellular pathways that indirectly modulate gene expression via small GPER agonists .
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PMC11228511
Bar graph showing the frequency of a nuclear bleb forming at a NM rupture (NMR) site.
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PMC11228511
Irregular lamin A meshworks with large gaps were identified in both Lmnb1 and Zmpste24 SMCs (Fig. 7C).
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PMC10777969
We also found that normal cells are more resistant to the studied compounds compared to cancer cells (Supplementary Materials).
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PMC7294030
The balance between the levels of pro- and anti-apoptotic proteins is important for cell survival or programmed cell death (Peng et al., 2016).
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PMC10079526
P-value ** ≤ 0.01, *** ≤ 0.005.
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PMC11767582
HRMS (ESI/Q-TOF): m/z [M+H] calcd.
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PMC11422150
In the mice intracerebral hemorrhage model, a lesion similar to SCI, hAMSC treatment had suppressed TNFα expression in the damaged site (Kuramoto et al., 2022a).
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PMC11596967
Antioxidant peptides (AOPs) are active biochemicals that counteract reactive oxygen species (ROS) and protect cells from oxidative damage .
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PMC9429973
Hematopoietic stem and progenitor cells (HSPC), monocytes, monocytic myeloid-derived suppressor cells (M-MDSC), polymorphonuclear MDSC (PMN-MDSC), B lymphocytes, T lymphocytes and CD45 cells (control) were sorted from thawed BM-MNC on a BD FACS Jazz.
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PMC9545714
Both β‐1,3‐galactosyltransferases transfer a galactosyl residue from UDP‐galactose to a terminal N‐acetylglucosamine of a glycoprotein or ganglioside. ,
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PMC9429973
One participant in the 30 mg/kg nipocalimab cohort discontinued study drug infusion after 22 minutes due to a moderate infusion-related reaction, which was considered to be related to study treatment.
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PMC9429973
004-1,016]; p=0.001), LDH level (OR:1.004; 95%[1.001-1.019]; p<0.001) and NLR ratio (OR: 1.18; 95%[1.07-1.3]; p<0.001), including these four parameters in multivariate analysis, we find that LDH level (OR: 1.007;95%[1.002-1.011];p=0.005), and NLR ratio (OR:1.47;95%[1.16-1.87];p=0.001) at admission are predictive of mortality.
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PMC11269792
Similar to a previous report, this study also presented that circAPP was overexpressed in GIST.
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PMC11739670
Reported solution affinities of CD8 for MHCI alleles are weak and differ for different MHCI alleles, with most reported KD’s between 100 and 220 µM for the human MHCI:CD8αα interaction, and even KD’s in the millimolar range have been measured for certain alleles such as HLA‐A*6801 .
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PMC9429973
The lifetime cost of chronic complications, including pulmonary hypertension, chronic kidney disease, retinopathy, and neurocognitive impairment, was estimated as $760,000.
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PMC9429973
We subsequently conducted univariate and MVA and assessed the impact of bariatric surgery and covariates such as sex, BMI, Sokal risk, TKI used, age and use of proton pump inhibitors.
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PMC11686380
In stark contrast, we could not detect any signals of myc-GAP43-E111K (Fig. 2D).
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PMC11267830
e Pattern diagram.
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PMC10578720
Abbreviations: DCA, dichloroacetate; MFI, median fluorescence intensity; MHCII, major histocompatibility complex class II; rAAV, recombinant adeno-associated virus.
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PMC10810426
Shown to the right is the MTT assay, demonstrating that serum starvation decreased cell division.
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PMC9429973
Methods: Migration assays were performed using primary CLL cells stimulated -/+ 1μM ODN 2006 (TLR9 agonist), -/+ 1μM ibrutinib (BTK-inhibitor), 2μM ODN INH-18 (TLR9 antagonist) or -/+ 2.5-10μM CW15337 (NIK inhibitor).
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PMC8140214
After 3.5 hr incubation, 100 μl DMSO was added to dissolve the formazan crystals, and then, absorbance was determined at 570/650 nm wavelength using an ELISA reader (Bio Rad, USA).
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PMC11257988
Shepherd et al. summarized the prognostic and predictive roles of KRAS mutation status and subtype in early-stage resected NSCLC in four adjuvant chemotherapy trials and found that KRAS mutation status was not a significant independent prognostic factor, especially for amino acid substitution mutations in the 12th codon .
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PMC9429973
The median age of the patients was 40 years (range: 16-66 years).
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PMC11802929
i Construction of the large SCT-pMHC library representing HLA-A*02:01 peptide-MHC complexes covering antigens from across the full SARS-CoV-2 proteome.
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PMC8345486
However, generating these structures requires the adjustment of culture conditions to the individual requirements of a given cell line or the cells of a given type of cancer.
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PMC7759933
The expression of drug-metabolising enzymes including CYP1A1, CYP1A2, and ALDH3A1 is regulated by the activation of nuclear factors such as aryl hydrocarbon receptors (AhR) .
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PMC9429973
Key PRO endpoints included global health status (GHS), physical and role functions, and fatigue, pain, diarrhea, and nausea/vomiting.
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PMC11461874
Further, we have shown that D-box functions are critical not only for the circadian output but also for the circadian input of the cellular clock.
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PMC11290772
This tumor tissue was fixed in 4% paraformaldehyde, dehydrated, and embedded in paraffin.
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PMC11391695
Conversely, the number of SMMC-7721 and BEL-7404 cells that underwent apoptosis decreased drastically when treated with si-ACYP2 + si-KCNN4 (Fig. 3F and Fig. S4C).
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PMC10470467
First, although we used different datasets to verify the accuracy of the signature, it is still a retrospective study in nature and is susceptible to the inherent biases of this research paradigm.
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PMC11756514
Using a langerin-expressing cell line and recombinant langerin, MBL, and SP-D, we demonstrated that langerin, MBL, and SP-D all recognize nonencapsulated S. aureus.
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PMC11001582
n = 3 mice per genotype, one-tailed one-way ANOVA, Fisher’s least significant difference procedure following Levene test for equal variances and test for normality.
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PMC9250505
B Kaplan–Meier analysis: relapse and survival times were compared by Kaplan–Meier analysis and overall survival (OS) or progression-free survival (PFS) were tested for significance by using the log-rank test.
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PMC11435360
The BBN cohort (n = 6) received saline.
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PMC5308810
We designed and synthesized CXCR4-KLA to investigate the therapeutic merits of targeting CXCR4.
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PMC11095939
Data were then normalized to the input and expressed as fold changes (relative enrichment) compared with the control group.
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PMC11285179
The balance between pro-angiogenesis and anti-angiogenesis factors was postulated as the key molecular base of vascular normalization .
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PMC11394730
Globally, millions of individuals consume green tea daily, and its polyphenol compounds have been widely studied for their anticancer properties.
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PMC11541241
Genetic modification technology and biopesticide mentioned here are based on the literature survey conducted on the papers published recently.
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PMC11394227
The higher protein folding and antibody production efficiency of CHO-PAb-QS cells inevitably results in an increased load on intracellular energy metabolism, producing more reactive oxygen species.
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PMC9429973
Recently, using high-throughput technologies, the search for new biomarkers has pointed towards non-coding RNAs, especially long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs).
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PMC11763126
F Changes in TRPM3 mRNA degradation rate in A498 cells after manipulating YTHDF2 expression.
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PMC11578343
Given that mz‐visco‐NPS enables single‐cell viscoelastic studies at multiple frequencies, performing similar experiments could elucidate the cell cycle‐dependent mechanical changes at the single‐cell level, particularly the dynamic interactions between cytoskeletal, nuclear, and organelle structures.
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PMC11047729
Crocin is a water-soluble carotenoid pigment that can be found in the stigma of crocuses (Crocus sativus) or gardenias.
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PMC10723784
The increase in G0/G1 phase from the control, 70.8 ± 1.4% to 77.4 ± 1.3% and 85.1 ± 1.1% when CBD was used at 10 and 30 μM, respectively, was followed by a decrease in the S phase.
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