PMCID
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Sentences
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ner
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PMC10936243
because one of my limitations also is our clinic, we are not 24 hours” [D072]. “
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PMC9429973
However, no data are available regarding comparison to bendamustine and rituximab (BR), which has been one of the predominant first - line options for CLL patients ineligible for full – dose FCR.
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PMC11468365
It computes a binary vector for each atom in a molecule, capturing essential properties such as atom type, hydrogen bonding type (donor or acceptor), hybridization (‘sp’, ‘sp2’, ‘sp3’), aromaticity, degree of the atom (ranging from 0 to 5), formal charge, and the number of connected hydrogens (ranging from 0 to 4).
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PMC11745823
Furthermore, Chromatin immunoprecipitation (ChIP) assays demonstrated HIF‐1α binding to the RIT1 promoter (Figure 7C).
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PMC11055323
The structures were visualized using PyMOL (Version 2.5.5).
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PMC10957991
Mechanosensitive TRPV4 channel therefore act as critical player in the homeostasis of normal mammary epithelium through sensing the physical environment and guiding accordingly differentiation and structural organization of the bilayered mammary epithelium.
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PMC11792766
This study provides guidance on using these conditions to prepare samples compatible with in vitro biological testing.
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PMC9429973
Five out of 6 pts had post baseline tumor assessments and achieved complete response (4) or partial response (1).
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PMC8557138
Mounting pieces of evidence indicate intricate cellular and molecular interactions between the constituent cells of the blood vessel during angiogenesis.
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PMC9895440
Most current approaches to alleviate T cell exhaustion aim to increase co-stimulation or decrease co-inhibition.
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PMC9429973
Presented data as of January 2020.
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PMC11240052
Dot plot graphs were used to illustrate viable cells (lower left quadrant), early-phase apoptotic cells (lower right quadrant), late-phase apoptotic or dead cells (upper right quadrant), and necrotic cells (upper left quadrant).
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PMC11615828
Thus far, a versatile tool that can precisely perturb a wide spectrum of intracellular trafficking pathways with high spatiotemporal accuracy is still lacking.
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PMC11741906
Hsa-miR-133b, hsa-miR-203a-3p, hsa-miR-512-5p, hsa-miR-21-5p, hsa-miR-708-5p, hsa-miR-451a, hsa-miR-15b-5p, hsa-miR-200b-3p and hsa-miR-625-5p were used as input in DIANA-miRNAPath tool.
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PMC5810978
Bovine PBMCs were grown in E-RPMI (RPMI-1640 supplemented with 8% FBS, 2 mM L-glutamine, 0.1mM NEAA, 1mM sodium pyruvate, 20mM HEPES, 10 μg/mL ampicillin and 100 μg/mL Gentamicin).
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PMC9910796
Model for ASFV core assembly.
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PMC9429973
Results: A total 573 SCD patients were evaluated.
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PMC10142392
In addition, the cell-killing effect of DOX/S-PCLPDMAEMA was better than DOX/L-PCL-PDMAEMA against 293T, CRL-5802, MCF-7, and NCI-H358 cells.
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PMC11532793
These functions read the kallisto or Salmon output, including bootstrap samples, and estimate the RTA-dispersions.
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PMC11535726
J.C. Kang, sp. nov. A19BE87A-BA0F-5DD7-BF33-60B1C765E8A2 Fungal Names number: FN 572046 Facesoffungi number: FoF16486 Figs 4 , 5 The specific epithet “dendryphioides” is derived from the resemblance to the dendryphiopsis-like features.
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PMC11568601
Data are presented as the mean ± SD (n = 3). **
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PMC7802142
cel-miR-39 as the external reference.
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PMC10999934
Two benefits help to enhance the overall comprehension of chemoresistance in HGSOC.
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PMC10571053
Several small molecule ferroptosis inducers (FINs) have been reported, yet little information is available regarding their interaction with the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp, ABCB1) and ABCG2.
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PMC9436459
There are a few non-classic MDAAs (Fig. 11, 151 − 166) in moraceous plants, in which the dienophile moiety is the olefinic bond of other compounds rather than the α,β-unsaturated bond of a chalcone skeleton, or which might be derived from some classic MDAAs without the benzoyl at C-4" or the phenyl at C-8".
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PMC10940855
Data from the Total Therapy trials were gathered from Oncomine.
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PMC11543885
After incubation, the cells were fixed and stained with a streptavidin-Alexa Fluor 488 (AF488) conjugate to visualize biotinylated proteins and with an anti-NLRP3 antibody to determine the localization of NLRP3-APEX2.
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PMC8270637
We found that TGF-β1 promoted the expression of PD-1 and CTLA-4 in T cells in vitro and in vivo.
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PMC6222726
In 1980, Gillet changed the name of section Bullockia into Elaphrium due to the fact that some characteristics of this section resemble those of Elaphrium tomentosum Jacq. .
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PMC11269933
Root-mean-square fluctuation (RMSF) is an important parameter in protein molecular dynamics simulations that describes the deviation of each atom in a protein from its equilibrium position during the simulation.
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PMC11271278
Highlighted are the genes on the MYC-ERBB2 ecDNA that are significantly differentially expressed.
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PMC9429973
Blood counts were included as binary time–dependent covariates using the following thresholds: HCT >45%, WBC >11×10/L, PLT >400×10/L. Linear interpolation was used to determine lab values between observed lab values.
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PMC11026382
Color coding is identical to (a).
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PMC11544122
For rescue experiments in the ∆Q-GRK KO cell lines, cells were transfected as described and co-transfected with 100 ng of GRK2, 100 ng of GRK5, or 50 ng of both GRK2 and GRK5.
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PMC11590870
This phenomenon can also occurs in the cell membrane .
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PMC11064533
As the clump formation exhibited similarity to a biofilm-like 3D structure, we addressed the hypothesis that the clump structure protected the bacteria against external stresses.
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PMC11285179
We previously reported that high expression of CCL28 was induced in hypoxic lung adenocarcinoma cell lines, A549 and SPC-A1.
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PMC10538569
Fusion genes encoding the GPI-scFv X5 or AB65 were amplified by PCR using pRRL-GPI-scFv X5 or AB65 as templates with a pair of primers (Forward: 5’-CCATGGGCTTGCTGCTGACTGGCAGCGGCGCCACCAACTTCA-3’, Reverse: 5’-AGTCGCCGTGAACGTTCTTTT-3’).
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PMC11737091
Only 72 of the ccRCC patients had paired samples of tumor and normal tissue.
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PMC11604768
Indeed, each cell line responded to serum by activating subsets of promoters not activated in other cell lines.
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PMC9429973
So far, Tecartus was the first and only approved CAR-T-cell therapy for adult (r/r) B-ALL, which was based on results from ZUMA-3 study.
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PMC6160470
These properties were shown to be directly linked to lipophilicity and specific structural features of DAC-amide compounds.
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PMC11064533
The missing values were imputed using the MinDet method from imputeLCMD.
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PMC10502403
Mitochondria play an important role in the sustained killing of cytotoxic T cells.
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PMC9429973
The species richness and evenness were analyzed using Shannon and Chao1 indexes, respectively.
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PMC11401350
The CD8-LV coding for anti-CD4CAR resulted in a highly significant increased survival (80%) of the CAR group compared to the control group injected with CD8-LV coding for GFP (Fig. 5B).
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PMC11786600
NIH/3T3 cells were treated with different materials such as gauze, PED0, PED2, and PED4.
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PMC9250505
Points are mean of triplicate experiments; bars, ±SD.
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PMC11754784
Next, we investigated the specific recognition and Boolean operation-based molecular computation of DNP.
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PMC11732628
To further explore the reaction mechanism of miR-490-3p associated with NUSAP1 in malignant osteosarcoma cell phenotypes, miR-490-3p mimic and Over-NUSAP1 were co-transfected into 143B cells and above functional experiments were conducted again.
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PMC10747160
The protein solution was then dialyzed four times against 4 Liters of 50 mM NaCl, 10 mM Tris, and pH 8 at 4 °C for 6–12 h each.
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PMC11509224
A review critically analyzed drugs/drug candidates inspired by natural sponge products .
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PMC9429973
The hematological reassessment after 2 cures has shown a partial response on the monoclonal gammopathy.
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PMC11321678
However, the development of targeted therapy methods and the advancement of genomic knowledge have facilitated the identification of specific and efficient therapeutic targets.
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PMC11756514
Hartshorn et al. (47) showed that SP-D induced aggregation of an acapsular S. aureus strain.
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PMC9429973
Only a few studies are available on NLR in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
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PMC9429973
Hazard ratios (HRs) and 95% CIs were computed using a weighted Cox proportional hazards model for time-to-event endpoints (PFS, OS, and TTNT).
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PMC9429973
The transcription factors peroxisome proliferator-activated receptors (PPAR) α and γ are important regulators of FA metabolism.
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PMC8041314
Data analysis was performed as described before.
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PMC11599565
PAX9 was highly expressed by nested cells and to a lesser extent in surrounding cells.
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PMC9429973
Hypomethylating agents (HMAs) have also shown clinical responses in some subsets of PTCL (Lemonnier et al., Blood, 2019).
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PMC7887261
Knockdown efficiency was quantified by RT-qPCR and shown in Supplementary Fig. 6.
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PMC6835428
Indeed, this model, relaying on 12 ordinary differential equations, is organized into four modules that can be changed independently to modify model complexity as desired.
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PMC10605143
The spheroid perimeter was measured using ImageJ software (v. 1.51k).
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PMC10938336
Energy-minimized ligands were converted to pdbqt format for docking.
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PMC11040965
In contrast, DNMT3B levels correlated positively with plasma cell number in both MGUS (r = 0.64; P = 0.0019) and MM (r = 0.91; P < 0.0001).
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PMC11409031
Next, we investigated the copy number changes of these 10 T cells related genes.
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PMC7724160
N-glycans from collected antibodies were enzymatically removed and then labelled using the Agilent AdvanceBio GlyX Glycan labeling kit.
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PMC11568601
Endogenous catalase was inactivated in 3% H2O2.
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PMC11012012
Currently, very little data are available on the expression of SLAMF8/CD353 in B-CLPD.
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PMC10243817
We demonstrated that the collagen production was positively correlated with TGF-βR3 levels, but inversely correlated with MEX3B levels in nasal epithelial cells collected from patients with eosinophilic CRSwNP.
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PMC11435360
However, a deeper investigation into other side effects, such as damage to surrounding tissue, fatigue, nausea, etc.,
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PMC11265931
When the expression levels of proapoptotic genes were examined in PC-3, it was observed that there was approximately a 1.5-fold increase detected in the expressions of the Bax and Cas9 genes.
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PMC11201245
In nearly 60% of the OCs we examined, we can also confirm losses in the chromosomal region 17p12, as also reported by Kim et al. (2007) and Lambros et al. (2005) .
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PMC9429973
Although the ORR to first line (corticosteroid therapy) was 68.6%, 34pts (50.8%) were treated with 2 line therapies, whom 20pts (30%) with anti-thymocyte globulin (ATG), 9 pts (13.4%) with infliximab and 5pts (7.5%) with ruxolitinib.
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PMC10079526
Sample size calculation: two-tailed, alpha = 0.05, Power 0.80; standard deviation (in the control group) = 20%, effect size (difference control and treatment group) = 40%, shows that a group size of 7 animals per condition is sufficient.
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PMC11119602
In a separate study, TG2 bound to the p62-LC3 heterodimer protein complex was shown to associate with the tumour protein 53 (p53) in the autophagosome, thus suggesting that TG2 may function as a molecular chaperone and facilitate the translocation of ‘client’ proteins to the autophagosome .
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PMC10565698
G. Survival curve analysis to investigate the link between circUSP10 expression and prognosis of liver cancer. *:
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PMC11755624
Keratinocytes demonstrate high expression of IL-36 receptors.
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PMC11612315
Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management.
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PMC9429973
Results: CD123 CAR constructs with four different novel scFvs differed in CAR protein expression ratio.
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PMC11441402
For the MTT assay, differences in cellular metabolic activity mean that formazan is not directly proportionate to cell number, but rather to the activity of cells which can be influenced by altered mitochondrial activity.
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PMC11621565
The cell medium used was DMEM with 4500 mg/L glucose, L-glutamine, and 1% antibiotic–antimycotic, supplemented with 10% FBS, and cells were incubated in a dark humidified atmosphere of 5% CO2 at 37 °C.
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PMC11467964
To find optimum prognostic signature, multivariate Cox regression on above 14 OS‐related DEGs was performed on the basis of the Akaike information criterion value, and ultimately, eight genes remained (Supporting Information S1: Figure S3).
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PMC10831439
The retroviral supernatants were produced as described previously.32 iNKT cells were isolated upfront from peripheral blood mononuclear cells (PBMCs) using anti-iNKT MicroBeads (Miltenyi Biotech, Bergisch Gladbach, Germany) according to the manufacturer’s instructions.
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PMC9429973
The incidence is higher in men.
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PMC11467964
Ultimately, we carried out RT‐qPCR to verify the eight genes expressions in STS cell lines.
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PMC10440586
The UMAP plot of hypoxia score in HF3016 GSCs from the Johnson et al. dataset. (
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PMC11733919
Imaging cytometry-based analysis of lipid peroxidation using dedicated kit. (
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PMC11739504
DZIP1L is another ciliopathic gene that encodes the ciliary transition zone protein and is associated with autosomal recessive polycystic kidney disease (ARPKD).
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PMC11799620
As presented, cactus is an important source of these components.
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PMC11088135
E, F Flow cytometry was used to quantify the apoptosis of U251 cells.
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PMC11474209
Selective targeting utilizing designed nano-vectors is an intriguing approach that could offer a new tool for mitochondria engineering and open the door to treating these catastrophic MC-LR-related mitochondrial illnesses in humans.
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PMC11397654
The 2-(trifluoromethyl)aniline diamide derivative 30a displayed the highest antiproliferative activity against MCF-7 and A549 cell lines, activity higher than that of 5-fluorouracil against those particular cell lines (IC50 = 19.47 μM against A549 and 8.33 μM against MCF-7, compared to 5-FU’s 38.42 μM and 20.61 μM, respectively).
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PMC11544122
The pEC50 was 9.904.
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PMC11786704
E–F) The levels of pro-inflammatory factor IL-6 and TNF-α in RAW 264.7 cells treated with LPS and PC capsules. (
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PMC4270159
KHM-3S:p-EGFR Y1068.EGFR.p-AKT S473.AKT.p-ERK T202/Y204.ERK.p-MET Y1234/5.MET.β-tubulin [additional control].A. Loading control.v.
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PMC10582049
Tissue images were obtained using the Keyence BZ-X710 microscope (KEYENCE, USA) using a 10× objective with a Texas Red filter (excitation wavelength 560/55 nm, emission wavelength 645/75 nm), a GFP filter (excitation wavelength 480/30 nm, emission wavelength 535/40 nm), and a DAPI filter (excitation wavelength 350/50 nm, emission wavelength 460/50 nm).
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PMC11794568
The oxygen consumption rate (OCR) of cells is measured using the Extracellular OCR Plate Assay Kit (Dojindo) according to the manufacturer’s protocol.
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PMC10329074
Immunotherapy has become a powerful clinical strategy for treating cancer patients, particularly those with metastatic spread (Kennedy and Salama 2020; Yu et al. 2022; Zheng et al. 2023).
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