Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC10957991
Additionally, TRPV4 levels respond to the tension from the microenvironment and TRPV4-depletion-induced differentiation bias in the mammary epithelial cell populations takes place in a stiffness-dependent manner (Figs. 1, 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11321678
Previous literature has reported that macrophages are abundant in the brain tumor microenvironment, especially in the SHH subgroup.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "literature", "has", "...
PMC11092382
Moreover, conducting further in vivo experiments utilizing appropriate animal models such as mice or rats would be imperative for validating the antiarrhythmic resistance effect of sophocarpine.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315
HSF1 is an activation target for mTOR that activates HSF1 by phosphorylation of serine 326.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HSF1", "is", "an", "activation", "target", "for", "mTOR", ...
PMC11734514
The invasive ability of A549 cells treated with C. aerizusa extract was weakened compared to untreated cells (Figure 5A and B).
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10813895
ELF5 expression in luminal epithelial progenitor cells implicates a complex interplay between cellular phenotype and breast cancer progression, with implications for tumor heterogeneity and treatment resistance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726
In this study, no modification in SLC7A11 mRNA or protein expression was detected, despite a significant decrease in the GSH content.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC6771295
SIRT3 silencing led to inhibition of autophagy in U2OS cells treated with etoposide or resveratrol (Figure 8B, compare bars 3 and 4 to 11 and 12), whereas SIRT5 silencing resulted in inhibition of autophagy in resveratrol treated U2OS cells (Figure 8B, compare bar 4 to 16).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137
Acquired resistance to S63845 was accompanied by upregulation of MCL1 and BCL-XL in majority of the tested models.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acquired", "resistance", "to", "S63845", ...
PMC10887351
This study showed that β3-AR blockade led to the reactivation of the immune response, partly dependent on the involvement of the PD-1/PD-L1 signaling axis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11572213
Our results suggest that downregulation of TET2 expression in HL-60 cells is resistant to glutamine deficiency.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "suggest", "that", "downregulation...
PMC10705095
Typically, cancer cells exhibit higher basal levels of ROS compared to normal cells due to an imbalance between oxidants and antioxidants .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Typically", ...
PMC10747139
Furthermore, the diffusion across the cell membrane and the possibility to target organelles, such as mitochondria, or important biomolecules, such as DNA and proteins, should be studied in association with the charge or lipophilicity of the considered complexes in order to design and synthetize more nontoxic and selective drugs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892
Additionally, nintedanib may be effective in the imatinib‐resistant clones containing acquired mutations in KIT kinase and FGFR feedback activation that have emerged.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...
PMC11506670
Unlike KRAS mutations, which are very well characterized in CRC for their clinical consequences, as well as for their molecular and cellular effects on individual cancer hallmarks, there are fewer studies on NRAS mutants, most of which only report on their identification and their impact on lack of response to anti-EGFR therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8073654
Other constituents include curcuminoids, including a high content of curcumin as a yellow pigment in the rhizome , two quinones , phenolic compounds , and sesquiterpenoids such as (−)-β-sesquiphellandrene and zerumbone .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486
Striking similarities between the a.a sequences (e.g., VRFDSD and AYDGKDY) located on the independently expressed monomeric B2m-free HLA variants of HLA class I and class II (VRFDSD) prompted us to explore the literature on the phylogenetic relationship among the two major HLA classes, in the context of independent expression of B2m-free HLA variants.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10196713
Thus, upregulation of Fdx1 expression may play a critical role in acquiring cisplatin resistance, and Fdx1 may be a suitable diagnostic and/or prognostic marker for the treatment of platinum-resistant OC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10560648
Conclusion: Considering the growth inhibitory property of Cassiopea andromeda Venom, we recommend it as a part of combinational medication for treating ALL in animal trials and for other leukemias in vitro studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Teclistamab improved PFS (hazard ratio [HR] 0.43; 95% confidence interval [CI] 0.32–0.59; P<0.0001), TTNT (HR 0.42; 95% CI 0.31–0.58; P<0.0001), and OS (HR 0.73; 95% CI 0.48–1.09; P=0.13) compared with real-world treatments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The cumulative risk of SPM with death as competing risk was higher for patients compared to comparators with risks at 5, 10, and 15 years of 8.9% [95% confidence interval 6.9;11.0], 16.3% [13.3;19.3], and 20.1% [16.1;24.2] for patients compared to 4.8% [4.1;5.5], 10.5% [9.3;11.7], and 16.6% [14.6;18.5] for comparators (Fig. 1a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672617
This was followed by stirring the reaction mass at room temperature for 12 h, dilution with a new portion of methylene chloride, and the addition of DIPEA and α,ω-diol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3274243
The experiments using RSF and HepG2 cells reported here illustrate the advantages of real-time electrochemical analysis, whereby the effects of various ligands may be analysed over time without the need to define specific end-points.
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10882807
After depletion of EIF4A3, expression of hsa_circ_0005397 decreased significantly in HCCLM3 cells (Fig. 5I).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "depletion", "of", "EIF4A3", ","...
PMC11462673
Statistical significance was ascribed to P values less than 0.05 as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504
These results provide strong evidence for the ciliary role of Kat2b.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "provide", "strong", "evidence", "for", "the", "ciliary", "role", ...
PMC8389560
This work is devoted to the study of the molecular and cellular mechanisms of action of selenium nanoparticles on glioblastoma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "i...
PMC9509578
Their findings indicated that the nanosystem disrupts EGFR-mediated downstream signaling cascades and eventually inhibits tumor growth and invasion.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "findings", "indicated", "that", ...
PMC9429973
All patients included performed at least one PET CT with a total of 20 test median age was 50 (range 34-84) and 7 were males (14%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Our data also highlight the combination therapy in clinical application in T-ALL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "also", "highlight", "the", "combination", "therapy", "in", "clini...
PMC11650848
Environmental stimuli such as exercise, smoking and nutrition can alter the distribution of DNA methylation throughout the genome, modifying gene transcription and expression [1–3].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936
A Wnt pathway real-time-PCR array was used to evaluate changes in gene expression as cells differentiated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Wnt", "pathway", "real-time-PCR", "array", "was",...
PMC9780037
Other cyt c modifications have also shown antiapoptotic effects.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "cyt", "c", "modifications", "have", "also", "shown", "antiapoptotic", "effects", "." ] } ]
PMC11543885
Wash the cells with 200 μL DPBS for three times, each wash lasting 5 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wash", "the", "cells", "with", "200", "μL", "DPB...
PMC5415764
PTX would then be released into the cytoplasm via the breakage of disulfide bonds (10 mM glutathione)32.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTX", "would", "then", "be", "released...
PMC11365983
Resulting membranes were scanned with Odyssey Imaging System (Li-Cor).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resulting", "membranes", "were", "scanned", "with", "Odyssey", "Imaging", "System", "(", ...
PMC11228511
A description is provided in SI Appendix.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "description", "is", "provided", "in", "SI", "Appendix", "." ] } ]
PMC8916024
For β-diversity analysis, principal coordinates analysis (PCoA) of the Bray–Curtis distances was generated in the R project Vegan package (Neogi et al., 2011).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11321678
First, ArchR (0.9.5) was used to create arrow files (filterTSS < = 4, filterFrags < = 1000), and then, barcode list in each sample was extracted.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263
Correspondingly, we found a significant inverse correlation between methylation (beta value) and log2 fold change (log2FC) in HERV expression across all investigated cell lines (D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5386478
Every 24 h, 50% of supernatant was replaced with fresh medium±1–155 or R281 TG2 inhibitors (at final concentration of 25 μM).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9000591
Then, the sample was rewashed several times using distilled water to remove sodium hypochlorite.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "sample", "was", "rewashed", "several", ...
PMC11506827
These results suggest that the combination of GEF and TRAIL promotes apoptosis by facilitating the binding of TRAIL to DR4/5, leading to the recruitment of FADD and caspase-8, which are key components of the extrinsic apoptosis pathway in RCC cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8348645
as anticancer agents .
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "as", "anticancer", "agents", "." ] } ]
PMC11307990
Taken together, this study provides a promising candidate platform for the efficient delivery of cell membrane receptor inhibitors in anticancer therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "tog...
PMC10470467
A pan-cancer study shows that CHMP7 is low expressed in most tumor tissues, and patients with low expression have a poor prognosis (42).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11319300
The myeloma overexpressed gene (MYEOV) has been proposed to be a proto-oncogene due to high RNA transcript levels found in multiple cancers, including myeloma, breast, lung, pancreas and esophageal cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199
Some loops, in particular in the C-terminal domain, could not be unambiguously traced.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "loops", ",", "in", "particular", "in", "the", ...
PMC10170482
Labeled cells were subjected to 649 nm high-fluence, low-power (HFLP) laser irradiation for 90 min and imaged by confocal microscopy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Labeled...
PMC11271278
HAPI analysis identified these three genes as enhancer hijacking genes (Fig. 4F), which have 34%-42% of enhancer activity contributed from enhancers near MYC on chromosome 8 that are now on the same ecDNA (Fig. 4G–I).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8592717
PAL suppressed cisplatin-induced acute kidney injury (AKI) by inhibiting NOX-mediated renal inflammation and oxidative stress, making PAL and its derivatives potential chemoprotective agents .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10237474
After loading, column was washed with the equilibration buffer for 15 CV.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "loading", ",", "column", "was", "washed", "with", "the", "eq...
PMC11737091
All the cells were maintained at 37 °C, in a 5% CO2 incubator.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "cells", "were", "maintained", "at", ...
PMC11788920
The gRNA strands used in cellular studies (gRNA-1, gRNA-2, and gRNA-3) were utilized in the beacon studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gRNA", "st...
PMC11737091
For the Transwell invasion assay, 100 µL of serum-free medium containing 5 × 10 starved ccRCC cells was cultured in the upper chamber (Corning, USA) with Matrigel (BD Biosciences, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
C. De Ramón, E. A. Rojas, I. J. Cardona-Benavides, M. V. Mateos, L. A. Corchete, N. C. Gutiérrez Hematology, University Hospital of Salamanca, IBSAL, Cancer Research Center-IBMCC (USAL-CSIC), Salamanca, Spain Background: Cytogenetic abnormalities remain the most relevant prognostic factors, especially those related to TP53 gene.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416
Many oxidoreductase enzyme assays incorporate spectroscopic absorbance and polarography .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "oxidoreductase", "enzyme", "assays", "incorporate", "spectroscopic", "absorbance", "and", "polarography",...
PMC11472639
However, it has been previously reported that blocking CD16 receptors alone induces greater ADCC inhibition compared to blocking CD32 receptors alone (Yeap et al., 2016), and HLA-DRCD14CD16 effector cells were preferentially mobilised when compared to CD32 effector cells herein.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Methods: The in vitro system included 5 cHL cell lines (MDA-V, L-1236, HDLM-2, L-428 and KM-H2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ...
PMC11388384
Live, singlet cells were identified by gating for the modal population on forward scatter and side scatter, and identical gates were used for each experimental condition.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794
Through a comprehensive series of experiments, including cell viability assays, molecular analyses, and functional assays, we aim to elucidate the molecular mechanisms underlying the anti-apoptotic effects of GA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868
Long-term treatment with MST-312 leads to resistance development in cancer cells by adapting alternative telomere lengthening mechanisms like selecting cells with long telomeres .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long-te...
PMC5941560
The latest dbSNP annotations for the hg19 reference genome were downloaded as a VCF file from the NCBI ftp repository (ftp://ftp.ncbi.nih.gov/snp/organisms/human_9606_b151_GRCh37p13/VCF/All_20180423.vcf.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lates...
PMC11755624
Early studies demonstrated an important role of PRINS in keratinocyte functionality.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "studies", "demonstrated", "an", "important", "role", "of", "PRINS", "in", "k...
PMC11683240
Docking analysis.
[ { "tags": [ "O", "O", "O" ], "tokens": [ "Docking", "analysis", "." ] } ]
PMC9581083
In addition, glycyrrhizin and isoliquiritigenin suppress LPS-induced activation of signaling cascades and cytokine production (Honda et al., 2012).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC9429973
The data presented here augur well for R/R AML patients who will be treated in the upcoming clinical study, WUN101-01.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973
We came across the cases where mutation load calculated for DNA isolated from the buccal epithelium did not correspond to either the heterozygous or homozygous variant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11738017
Subsequently, healthy donor PBMCs and anti-BCMA TCE were added to the cultures at an E:T ratio of 1:1 or 3:1 for 48 hours (Figure 3G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154881
p < 0.05, n.s.,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "n.s", ".", "," ] } ]
PMC7351993
The FSC signal is digitized and sent to the TM node to record the arrival time at the event detection point with a unique identification (ID) number for the event.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794
Luminescence signal was measured using a GloMax Discover System Microplate Reader (Promega).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luminescence", "signal", "was", "measured", "using", "a", "GloMax", ...
PMC11411004
This finding was consistent with the trend in the pre-suspension assay; thus, in combination with Fig. 1, the most potent 2-μM concentration was selected for subsequent studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508
In the benzamide series the most potent compounds possessing a urea linker were 78 and 79 with fold resistances of 1.51 and 1.62 respectively, at 10 M concentration, proving to be more potent than the lead compound 60 (fold resistance of 2.76).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9027909
P value < 0.05; ** P value < 0.01; *** P value < 0.001; **** P value < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9325715
Both, iron complexed with bLTF and citrate did not increase the level of released LDH what means that did not adversely affect the integrity of the membranes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
All remaining IRR-estimates were not statistically significant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "remaining", "IRR-estimates", "were", "not", "statistically", "significant", "." ] } ]
PMC8633974
As comparators, two CRISPR-Cas9 reference systems were adopted.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "comparators", ",", "two", "CRISPR-Cas9", "reference", "systems", "were", "adopted", "." ] } ]
PMC8409415
Although CD70 was not found to be associated with proliferation, previous studies involving murine fibrosarcoma, melanoma, and colon cancer models have shown that CD70‐CD27 signaling increases the number of CD4‐CD25‐Treg cells and promotes tumor growth and metastasis in vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331
This construct is compatible with both optogenetic and chemogenetic dimerization systems through the interactions between iLID-SspB and FRB-FKBP, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "construct", "is", ...
PMC9429973
Results: We discovered 83 novel BCL2L12 circRNAs, 9 of which were common between MDS-L cells and at least one AML cell line.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9847912
Our findings for the CA/SP1 mutant of HIV-2ROD9 are also concordant with other studies showing that specific amino acid changes in CA/SP1 of HIV-1 can confer resistance to bevirimat [15, 16, 19–21, 43, 44, 49] and to the bevirimat analogs GSK254 and GSK795 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10317042
In this study, we performed a high-throughput drug screening, finding that the histone deacetylase inhibitor vorinostat exerted an antiproliferation effect with the reduced expression of EWSR1::ATF1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
At d28, 21/24 assessable patients were MRD negative (81.5%), 4/28 pts could not get d28 MRD assessment f/u due to COVID-19 restrictions however were assessed at a later timepoint.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806
Head thrashes(E) and body bends (F) were counted under a microscope for 30 s (n > 30 worms per group). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973
Our treatment schedule at the dose of 1 mg/kg/3 times a week showed 87.5% resolution with no major hematological or renal toxicities requiring dose adjustment for concomitant potentially nephrotoxic agents or treatment discontinuation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084
Paclitaxel resistance phenotype is frequently associated with alteration of the class III β-tubulin isotype expression .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paclitaxel", "resistance", "phenotype", "is", "frequently", "asso...
PMC11739696
During this time, the dye entered the cells and specifically reacted with ROS forming dichlorofluorescein (DCF), a fluorescent compound.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During"...
PMC11695623
We used qRT-PCR technique to detect the expression of DCUN1D5 in normal bronchial epithelial cell line HBE and lung adenocarcinoma cell line H1299.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-Cell...
PMC11699042
The methylated and unmethylated signals were corrected individually.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "methylated", "and", "unmethylated", "signals", "were", "corrected", "individually", "." ] } ]
PMC11267830
b Fluorescence images of mice captured at four distinct time points.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Fluorescence", "images", "of", "mice", "captured", "at", "four", "distinct", "ti...
PMC10887351
The available public database data have shown that ADRB2 expression in primary NB tumors is correlated with prognosis or known biological risk factors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11626627
Interestingly, circATP2B1 acts as a "reservoir" by stabilizing the expression of miR-204–3p.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "circATP2B1", "acts", "as", "a", "\"",...
PMC7504302
Even though the number of functional genomics studies in MPM is limited, the available literature successfully validates the functional aspects of numerous genetic alterations that are significantly associated with biological processes including transcription, signal transduction, cell division, and migration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The frequency and severity of GI AEs were substantially lower in FREEDOM than in previous FEDR clinical trials, likely due to early implementation of GI prophylaxis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
In patients diagnosed with early stage HL and in patients diagnosed with early stage NHL, bone mineral density in PET/CT 3 increased significantly compared to PET/CT2 (respectively; p = 0.001, p = 0.017).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
DNA was extracted from formalin-fixed paraffin-embedded (FFPE) tissue (n=45), frozen tissue biopsies (n=10), or PB (n=6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5963610
Representative photomicrographs of 3LL-metastases showing the NK 1.1cells infiltration by the immunofluorescence staining.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "photomicrographs", "of", "3LL-metastases", "showing", "the", "N...
PMC9370419
Intermolecular docking between the HBx and estradiol benzoate may block the H-box from reaching out to bind with DDB-1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intermolecular", "docking", "between", ...
PMC10391797
The RNA sequencing data of patients with AML and healthy donors were obtained from the The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expressio (GTEx) databases.16 The different gene expressions and the proportion of immune cells between AML and healthy donors were performed on the online tool Gene Expression Profiling Interactive Analysis (GEPIA) (http://gepia.cancer-pku.cn) using Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) calculation method.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...