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OTAR3088
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BioData-CellLine_annotated

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PMC11802929
These results indicate that our original conclusions are not biased by specific dominant clones.
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PMC11628309
The advantage of using a model with endogenous dopamine synthesis such as BE (2)-M17 cell line, along with its regulatory and synthesis machinery, has allowed the study of additional aspects related to this important neurotransmitter.
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PMC11116779
The culture medium alone or the culture medium including PS-NPs at tested concentrations was used as a control to determine the background values.
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PMC11621493
Normal data distribution was confirmed with the Shapiro–Wilk normality test and significance was assessed with unpaired two-tailed Student’s t test combined with correction for multiple comparisons using the false discovery rate (FDR).
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PMC7553912
The kidney was quickly removed and postfixed in the same fixative at 4 °C for 3 h. All specimens were then immersed in 20% sucrose in 0.1 M PBS for 16 h. The specimens were embedded in an OCT medium, frozen rapidly in cold n-hexane in dry ice, and stored at -80 °C.
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PMC11040965
Flow cytometry was used to determine the percentage of cells staining positive for each proteasome subunit.
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PMC11401358
There are only six cysteines on both the heavy chain and the light chain in SF, which are connected by disulfide bonds to form a whole without a separate cysteine .
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PMC11680391
Handling antimicrobials was described by Gröndal et al. (2023) , where prescribing antimicrobials for dairy cattle needs to be understood as taking form in a relationship in which both veterinarians and farmers take an active part.
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PMC11767817
Furthermore, thioredoxin-1 levels can increase in multiple cancers, and an increase in Trx1 expression correlates with poor prognosis .
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PMC11741906
First, chemoresistance is a multifactorial process involving numerous pathways and interactions so we cannot rule out the possibility that other factors may influence the outcomes besides miRNA dysregulation.
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PMC9429973
Distinct features of der(1;7) were investigated by comparing the results with those from an additional 3,238 non-der(1;7) cases with different myeloid neoplasms comprising -7/del(7q), +1q, and other cases.
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PMC9429973
As targeted therapies have become available, there is a paradigm shift towards their use; however there is still much to learn about the optimal selection and sequencing of therapies in WM patients whose diseases are heterogenous by nature.
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PMC8316344
H Cell death was measured by staining with Sytox Green following flow cytometry in control cells and SK-Hep1 cells with or without TRIB2 knockout or overexpression following treating with DMSO, TSZ (1:1000, 4 h) or STS (100 nM, 24 h).
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PMC9429973
However, according to ELN 2017 there are greater differences between intermediate and unfavorable groups than in the other classifications.
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PMC9592219
The results of wound healing experiments showed that mi-22-5p inhibited the migration ability of MHCC97L and BEL-7404 cells, but this inhibition was reversed by the overexpression of TOP2A (Figure 7(c)).
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PMC9111184
The FTIR analysis were carried out as previously described (Ressaissi et al., 2020).
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PMC11718274
GraphPad Prism software was employed to determine the half-maximal inhibitory concentration (IC50) of the three treated replicates.
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PMC11721587
Furthermore, coexpression of WT but not a Ci-binding–deficient Sufu (D159R) blocked Ci phosphorylation by FuN in S2 cells (Fig. 1L).
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PMC10907726
Our investigation revealed that DATS could inhibit proliferation, migration and EMT, but induce autophagy and apoptosis in OS cells by downregulating EGFR, and its downstream PI3K/AKT/mTOR signaling pathway.
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PMC7802142
As well known, cell cycle control is important for cell proliferation.
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PMC11803918
C,D) Representative CLSM images and quantification results of HMGB1 release in the nucleus of A375 cells after different treatments with or without light irradiation (scale bar: 50 μm; blue: DAPI, green: HMGB1). (
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PMC9429973
D. Soliman, J. Altooq, S. Alkindi, H. Dewedar, A. Ibrahim, S. Elsawy Novartis Middle East, Dubai, United Arab Emirates; Salmaniyah Medical Complex, Manama, Bahrain; Sultan Qaboos University, Muscat, Oman; Dubai health Authority; Accsight, Dubai, United Arab Emirates; Accsight, Cairo, Egypt Background: Sickle cell disease SCD is the most predominant form of haemoglobinopathy worldwide.
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PMC11767725
Commensal microorganisms interact with the host to perform critical functions, such as fortifying the skin barrier, modulating immune responses, and outcompeting potential pathogens.
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PMC11574271
The downregulation of RON expression resulted in decreased RON phosphorylation (Fig. 5C).
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PMC11745823
Representative pictures and histogram of tumour size and Ki‐67 staining between sh‐NC and sh‐RIT1#2, n = 5.
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PMC9341513
Here, we have simulated the breakpoint and rearrangement as mapped for the Z-138 cell line (about 60 kbp upstream of CCND1).
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PMC11413393
To further delineate relevant molecular pathways at play, we employed a proximity-labeling proteomics technique to describe the interacting partners of PRMT1 in ccRCC cells.
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PMC11320084
TNNT1 mRNA (Figure 1b) and protein (Figure 1c) expressions were also increased in LC cells versus BEAS‐2B cells.
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PMC10297204
At the ethanol concentrations above 30%, the number of cells passed through the invasion chamber was markedly reduced compared to that at the 0% concentration (Figure 4A).
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PMC9429973
Drowsiness, headache, and constipation were the most frequent AEs.
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PMC9964654
The complex [Au(cdc)2] (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively.
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PMC11092382
Meanwhile, the inhibitory effect of oxaliplatin on colorectal cancer liver metastasis could be further potentiated by the administration of sophocarpine.
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PMC11371747
L-LV enhances the antitumor activity of 5FU by increasing and prolonging the inhibition of thymidylate synthase (TS) (Peters et al., 2002; Danenberg et al., 2016).
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PMC9429973
Axi-cel intervention in 2L is supported by durable response rates not impacted by high TB, as seen in 3L axi-cel or 2L SOC.
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PMC11746948
Sample sizes: (f, h, j) n = 3 independent experiments.
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PMC11265931
According to 2012 data, men in the United States have a probability of one in seven of developing lifelong prostate cancer (Bilgili et al., 2019).
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PMC10940855
Loss of ephrin B2 reverse signaling abrogates multiple myeloma pathogenesis.
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PMC11742431
These analyses were performed using GraphPad Prism version 8.0 (GraphPad Software).
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PMC10759659
Liver cancer is the sixth most prevalent cancer and the fourth leading cause of cancer-related deaths worldwide .
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PMC9454178
We next assessed the effect of CDK7 knockdown on GIST cell cycle progression.
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PMC11334037
All animal experiments were approved by the Animal Ethics Committee of Beijing Viewsolid Biotechnology Co. LTD (Protocol No. VS2126A00170) and all methods followed the ARRIVE guidelines.
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PMC10988555
Caspase 8 is activated by apoptotic stimuli from the plasmatic membrane and, subsequently, will cleave several molecules, such as downstream caspases, nuclear proteins and plasma membrane, and mitochondrial proteins.
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PMC9512971
SARS-CoV-2 infection must have been tested using a standard method at the time the study was conducted (e.g., reverse transcriptase-polymerase chain reaction [RT-PCR] test, loop-mediated isothermal amplification [LAMP] test, or antigen test).
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PMC9429973
For Chinese patients with R/R SAA, there is no established standard of care other than transfusion support and treatment of infections.
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PMC11753949
Previous reports have shown that synaptopodin, a protein selectively concentrated in the spine apparatus and cisternal organelle in the brain, is required for the formation of these structures.
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PMC9509578
This acquired MDR phenomenon is mainly due to repetitive exposure to chemotherapeutic drugs .
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PMC11746942
Furthermore, we investigated the association between S1PR3 and SGPL1 in IMQ-induced mice.
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PMC11322866
Scale bar: 2 μm.
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PMC11257988
A multicenter retrospective cohort study of 216 Asian KRAS-mutant NSCLC patients analyzed by Lee et al. found that most patients were male (70.8%), Eastern Cooperative Oncology Group (ECOG) physical status scores were mostly 0–1 (92.1%), histological subtypes included adenocarcinoma (89.8%), squamous cell carcinoma (4.2%), and others (6.0%), and KRASG12D was the most common subtype (25.5%), mostly in never-smokers, suggesting that KRAS-mutant lung cancer in Asian patients may be driven by factors other than smoking .
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PMC10850553
Total RNA was then purified from treated cells subjected to quantitative RT-PCR analyses to examine the induction of TNF (a gene for TNF-α), IL1B or PTGS2 (a gene for COX-2; cyclooxygenase-2).
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PMC11607638
The effect of SK2 stimulation was also examined.
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PMC11718809
The rRNA-depleted reads were then mapped to the yak reference genome (BosGru_v2.0) using TopHat2 (v2.0.9) without fusion gene alignment.
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PMC8345486
For the experiments, the spheroid suspensions from 12 culture wells were pooled, the excess medium was removed, and 9 mL suspensions were distributed at 0.15 mL across the 96-well plate (Nunclon Sphera 96-well plates, Thermo Fisher Scientific, Waltham, MA, USA) and then treated with compounds, as described below.
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PMC11591038
Since HIF-1 is a major regulator of GLUT1 and GLUT3, these studies provide a piece of correlative evidence linking tau hyperphosphorylation to HIF-1α downregulation in AD.
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PMC11046454
All statistical data are presented as the mean value ± S.D., n = 3. *
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PMC11406030
LMTK3BPs induced apoptosis in ovarian cancer cells.
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PMC11345828
The reaction vessel was charged with toluene (0.4 M) and sparged with argon for 5 min.
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PMC10938377
To obtain structural data on adduct formation of the Au–peptide conjugates in the nucleosome core, native NCP crystals were subjected to incubation with magnesium buffer containing 0.5–2 mM of the conjugates.
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PMC8735881
Herein, we also utilized similar experimental protocols to characterize the antiviral mechanism of GPI-10E8.
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PMC11621565
The mixture was pipetted into microcentrifuge tubes and incubated for 1 h on ice.
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PMC9512971
Secondary efficacy endpoints were the time to the first two consecutive negative SARS-CoV-2 tests performed at the central laboratory, the proportion of patients testing negative for SARS-CoV-2, the ordinal scale for disease severity (Additional file 2: Table S2) , the proportion of patients requiring mechanical ventilation, and survival.
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PMC11742431
It is well known that the major degradation pathways of eukaryotic proteins include the ubiquitin‐proteasome system pathway and the lysosomal‐autophagic pathway.
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PMC9429973
Expansion of individual TRB clonotypes (>5% of all reads) at D0 was observed more frequently in HABMF patients (9 out of 22) compared to the nonHABMF patients (1 out of 10).
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PMC10243817
We found that the proinflammatory cytokine IL-1β, as well as type 2 cytokines IL-4 and IL-13, promoted MEX3B expression in nasal epithelial cells.
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PMC11684297
The peak at 834 cm demonstrates the presence of Zn and O in the synthesized nanoflower, which is further confirmed by the XRD analysis showing the ZnO crystalline structure.
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PMC11743316
In cancer cells, elevated FAO is linked to high ATP levels.
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PMC11474209
Mitochondrial dysfunctioning causes alterations in the biogenesis rate of mitochondria, mtDNA content, oxidative stress, and disturbed calcium homeostasis .
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PMC9429973
S. Geiger, R. Siegel, M. Essers Inflammatory Stress in Stem Cells, DKFZ Heidelberg, Heidelberg, Germany; Novartis, Basel, Switzerland Background: Disruption of circadian rhythm is associated with inflammatory diseases, metabolic syndrome and cancer.
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PMC6190245
We observed synergistic effects at non-toxic low doses of F. gummosa when co-administered with radiotherapy that suggest it a suitable radiosensitizer.
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PMC9786247
Cells were seeded into 24-well plates in numbers of 4–10 × 10 and cultured for 2 to 3 days to reach an 80% confluent cell monolayer.
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PMC7351993
The 6-parallel DA nodes with the 4-channel digitizers and FPGAs realize a constant and short latency of less than 0.12 ms for the image acquisition.
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PMC11394730
This phenomenon is known as aerobic glycolysis or the Warburg effect.
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PMC11265931
Despite the fact that Bcl-2 gene expression was increased up to 3.5-fold in HUVEC cells, the difference was statistically significant (Figure 3E).
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PMC11612315
After 15 min, the mice were challenged with glucose (2.0 g/kg body weight).
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PMC10831439
Major mismatched mo-DCs (stimulators) were plated together with allogeneic T cells (responders) at a 1:1 ratio and 5-fold third-party donor CD19-CAR-iNKT cells or untransduced iNKT cells.
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PMC11285179
Written informed consent was obtained from all subjects before collecting the samples.
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PMC3203927
So in vitro, the cells growing in 3D relate to any of those two models depending upon their type – malignant or primary, respectively, and therefore upregulation of their cytokine levels was physiologically relevant.
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PMC9024365
In addition, the mean size of GluA2 clusters is significantly greater when co-localized with SD4, while non-colocalized clusters are not significantly different compared with GluA2 alone (Figure 1D).
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PMC11759751
We observed a negligible inhibitory effect of chidamide on CD19 CAR T cells at 0.5 μM for 3 days (Fig. 3A, B).
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PMC9596868
Protein bands were detected using SuperSignal™ West Femto Maximum Sensitivity Substrate (Cat.
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PMC9143157
In vivo studies using xenograft tumor models revealed that P-THP significantly suppressed the MES-SA C9 high, A2780, and A2780cis tumor growth at the dose of 15 mg/kg (THP equivalent), which is three times above the maximal tolerance dose of native THP, while no body weight loss or acute death occurred.
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PMC8345486
This procedure guaranteed clear solutions of the compounds.
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PMC11767725
SD’s pathogenesis involves a multifaceted interaction of sebaceous gland activity, microbial dysbiosis—particularly involving Malassezia species—and immune system dysregulation.
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PMC10454535
The combination PIN/BTZ showed an even further increase in these proteins’ expression.
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PMC11754094
We evaluated four cancer or transformed cell lines (HeLa, HEK293T, U2OS, K562), human fibroblasts and a human embryonic stem cell line (H9) (Fig. 2a–f).
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PMC9429973
Aims: To validate the prognostic precision and discriminative power of the Stellae-123 gene expression signature in external cohorts and to compare its performance with standard prognostic scores: ELN-2017 in adult patients and clinical risk score in pediatric patients.
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PMC9429973
Aims: In this study, we aimed to explore the clinical significance and prognostic implication of sAML-type mutations in non-M3 AML patients.
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PMC11420784
The 5637 cells were pretreated with the autophagy inhibitor 3-MA or vehicle, and the invasion and exocytosis of 5637 cells infected with WT, ΔpldA, or ΔpldA+ were assayed at 4 hpi, which is the time point when the majority of UPEC undergo autophagy .
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PMC9325715
The effect may be connected to the interaction between the CH group with a metal cation.
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PMC11347429
ICOSLG (Inducible T Cell Costimulator Ligand) codes for a cell co-stimulator.
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PMC11792090
Conversely, the level of the inhibitory cytokine IL-6 was lower in the SAP UCAR-T group ( Figure 6H ).
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PMC7305184
Electric field for no (0%) and maximum/full permeabilization (100%) and cell death stays the same even after 30 generations.
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PMC11519583
Furthermore, anti-Ki-67 immunostaining and EdU incorporation analyses revealed that stimulation with recombinant Wnt5b, but not Wnt5a, promoted MP proliferation in a Ror2-dependent manner (Fig. 3d).
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PMC9429973
And SPSS software was used for statistical analyses.
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PMC3122064
However, involvement of other genes in this pathway cannot be excluded, because p53 has been shown to transcriptionally activate several other genes involved in apoptosis via the Fas/FasL system after cisplatin treatment.
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PMC9429973
Serology tests were performed at least 2 weeks after the 2nd vaccination.
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PMC11770199
Cancer cell fusion induced by p14 protein expression.
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PMC11518702
HGAL’s lipidation sites each have been defined (via [H]-myristic and palmitic acid labeling and mutation) to mediate HGAL’s plasma membrane localization (3, 7, 28, 31).
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PMC11658074
During the standard preparation process of AT-EVs and ADSC-EVs, AT-EVs can be harvested by continuous collection in vitro within 48 h of obtaining AT.
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PMC11240571
On immunostaining analysis, PD-L1 (green) was observed in each HT1080 cell (left) and each 143B (right) cell.
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