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OTAR3088
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PMC11412752
CCK-8 Cell Counting Kit (A311; Vazyme) was used to perform cell proliferation assays.
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PMC11365427
Figure 3Phenylalanine deprivation inhibits MM in vitro. (
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PMC9429973
Finally, we found a consistent enrichment of cholesterol metabolism related-pathways in cases with high 4- PI in all the cohorts.
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PMC10849234
HL-60 or PLB-985 cells were differentiated into Neutrophil-like cells (NLCs) with DMSO, plus either G-CSF or Nutridoma and then left unstimulated (unstim) or stimulated with cytochalasin B and fMLP (fMLP).
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PMC9429973
According to the Ann-Arbor classification, the stage of the disease was I in 5 patients (20%) and IV in 20 patients (80%).
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PMC11474209
Due to the PP1 and PP2A inhibitory effects of MCs, PPIA can effectively detect MCs.
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PMC5673955
C,D) Results of telomerase activity measured by TRAP.
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PMC10170482
Blocking of membranes was achieved with 5% (w/v) nonfat dried milk or alternatively with 5% (w/v) BSA for 1 h. Then, PVDF membranes were incubated with various specific primary antibodies summarized in Table S3 at 4 °C overnight, washed in TBST, and incubated with the respective HRP-conjugated secondary antibody (Table S3) for 1 h. Finally, the chemiluminescence signal was revealed utilizing the imaging system G:BOX CHEMI XRQ (Syngene, Synoptics Group, Cambridge, UK).
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PMC11279397
In patients with long-term COVID-19 disease, luteolin could enhance GABAB-ergic activity and cortical plasticity while also showing potential for treating COVID-19/asthma comorbidity .
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PMC11604830
Following size characterization, the high‐resolution NMR spectra were acquired at 14T for the three nanosystems, showing a single well‐defined peak at 3.7 ppm for DSPE‐PEG2000 and Kolliphor® P188, with smaller peaks in the 1–3.5 ppm range.
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PMC11574029
After cell lysis, chromatin was fragmented by sonication.
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PMC11599565
Panel A: ΔΔCt values for transcription factors and neuronal markers (RT-qPCR TaqMan system).
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PMC9429973
Aims: Evaluating the colony-forming ability of the bone marrow using a culture method as part of the differential diagnosis of neutropenia of unknown origin.
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PMC10568263
The different BSA incubation times of 15, 30, 45, 60, and 75 min were used to detect 100 ng mL HSP70; in the results, the ΔRct-value tended to be stable with BSA incubation time greater than 30 min.
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PMC11788920
UV shadowing was used to identify the full-length product band.
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PMC11615218
On the basis of these cytokine functions, many CAR-T cell preclinical studies and clinical trials have been conducted to search for favorable CAR-T memory subsets [44, 59–61].
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PMC11087055
Given that PS morphogenesis is required for maintenance of the polonaise movements, we next examined the converse of the relationship, that the polonaise movements may be required for PS formation.
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PMC11753435
The entries are organized in accordance with the ipTM scores attributed to the test set peptides.
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PMC9429973
I. Mayer, E. Doma, M. Prchal-Murphy, T. Klampfl, K. Kollmann, V. Sexl Department of Biomedical Sciences, Univeristy of Veterinary Medicine, Institute of Pharmacology and Toxicology, Vienna, Austria Background: Cell cycle kinase CDK6 acts as a transcriptional regulator and links cell cycle progression to differentiation and cellular homeostasis.
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PMC11769522
In addition, single treatments with IFN-γ and IL-4 did not induce IL-6 production in a previous study using canine buccal epithelium .
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PMC10976516
injected causing tumor regression and growth arrest, followed by an increase of IFN-γ secretion.
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PMC2193049
∼150 ml blood was washed five times with cold PBS, and the cells were pelleted at 2,000 g for 10 min.
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PMC11679892
The observation that this ratio was disrupted in our study is strong evidence of the apoptosis-promoting effect of P. sidoides.
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PMC9429973
We think, this treatment should be considered in patients with refractory immune cytopenias secondary to CLL and assessed with prospective clinical trials.
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PMC11531735
Tumor free survival with multiple groups were calculated by employing Kaplan-Meier analysis using the log-rank test with the Bonferroni correction.
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PMC9429973
Aims: In the dose-escalation part of the study, we aim to assess the safety and tolerability of BGB-16673 in selected relapsed or refractory (R/R) B-cell malignancies, to characterize its pharmacokinetic (PK) and pharmacodynamic (PD) profiles, to determine a recommended phase 2 dose (RP2D) and to evaluate anti-tumor activity.
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PMC11585994
Incorporating the sgc8 aptamer significantly enhanced the delivery efficiency and cell specificity of siBCL11B, leading to reduced proliferation and increased apoptosis in T-ALL cells.
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PMC11767725
Sebaceous lipids are not only a nutrient source for C. acnes but also modulate the immune response.
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PMC11306331
Box plots show median, hinges represent 25th and 75th percentiles; whiskers represent 1.5x inter-quartile range (IQR).
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PMC10495912
Then, the CAT enzyme metabolizes hydrogen peroxide into water molecules and molecular oxygen (Nandi et al., 2019).
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PMC8170755
The secondary HRP-conjugated anti-mouse antibody (Santa Cruz Biotechnology, Inc.) diluted in TBST buffer (1:10000) was then added to the membrane and incubated for 1 h at 37 °C.
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PMC11777207
Our data highlight the need to evaluate differences in patients treated with PD-1 and PD-L1 antibodies regarding irAEs since signaling of PD-L1 within DCs promotes migration from the tissue to the draining LN.
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PMC5535901
Elevated levels of these inflammatory cytokines are associated in the pathophysiology of many chronic inflammatory diseases, including cancer .
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PMC9516447
Preparation of cell lysates and immunoblot analysis procedure have been described in detailed previously .
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PMC9429973
More pts receiving luspatercept vs placebo had ≥33% or ≥50% response during any rolling 12- or 24-wk interval up to the cutoff date (all P<0.0001); the number of responders receiving luspatercept was higher compared with previous data cuts (Table).
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PMC9429973
Median overall survival after occurrence of CNS relapse was two (95% CI: 0-4.9) months.
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PMC10854447
C20H19N5O4: C, 61.06; H, 4.87; N, 17.80.
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PMC9429973
After 26 weeks of PEG-treatment, patients displayed clinically meaningful improvements in most of the functional scales and the global health status/QoL at Week 26 as indicated by a ≥10-point score increase from baseline (Table B).
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PMC10729469
Further, we looked at the cytokine profile of the engineered TCRAβ-Tregs stimulated with PMA and ionomycin using a mouse cytokine array kit.
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PMC11435360
It is currently unknown whether BC cells can develop resistance to PAG treatment, and this knowledge is vital for the development of PAG as a BC therapeutic.
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PMC11588085
Cell fates can change based on developmental signaling as pluripotent SCs differentiate into a variety of different cell types during development.
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PMC11434983
Cell cycle analysis was performed using flow cytometry.
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PMC11655498
In addition to the transcription activity, the host proteins interact with Zta or Rta and modulate their capabilities in EBV reactivation (Figure 1B and Table 1).
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PMC8389560
It was shown that, in response to the application of 5 µg/mL SeNP, Gap26 suppressed Ca signals in 87 ± 11% of cells after 30 min of exposure to the cells (Figure 7A).
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PMC11082662
SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B; TCGA-OV, The Cancer Genome Atlas-Ovarian Cancer; PTGS1, prostaglandin-endoperoxide synthase 1; IL4I1, interleukin-4-induced-1; OS, overall survival; PFS, progression-free survival; OV, ovarian cancer; TPM, transcripts per million; CI, confidence interval.
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PMC10578720
Abbreviations: CS, citrate synthase; NR, nicotinamide riboside; PDHC, pyruvate dehydrogenase complex; PBMC, peripheral blood mononuclear cell; SIRT3, Sirtuin 3.
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PMC9429973
Chromatin Immunoprecipitation sequencing (CHIP-seq) and CHIP-qPCR were previously accomplished (the results have not yet been published).
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PMC11023271
BSA is a major component in FBS and, as shown above, stayed a dominant protein component in the fraction that down-regulated RIPK4 mRNA.
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PMC11209164
Building on previous studies demonstrating that DMF inhibits the nuclear translocation of the p65 subunit of NF-κB , we aimed to evaluate whether TPF exhibits a similar inhibitory effect.
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PMC11680578
< 0.001 as compared to that of the PTX alone.
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PMC9429973
, highlighting the need for more therapeutic strategies.
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PMC11496728
The results indicated that the expression level of the protein could be remarkably increased with the addition of regulatory sequences compared with the control, whether it was transient or stably expressed.
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PMC9429973
Patients who had previously undergone chemotherapy were treated until the moment of discharge statistically significantly longer than patients who had not undergone antitumor therapy.
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PMC11604768
Projections for PAR1, GPR91, and MRGPRX2 conditions were closely related to that of 5-HT2A, again suggesting these GPCRs activate similar downstream signaling pathways.
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PMC11704135
The outcomes of biological assays conducted on the synthesized derivatives of 4,6-dimethylpyrimidine-2-thiol hydrochloride offer valuable insights into the Structure–Activity Relationship (SAR) of these compounds.
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PMC10589262
Error bars in G and H represent the standard deviation (SD) of the mean of three independent western blots.
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PMC5261804
We used mutations and copy number alterations from CCLE datasets to remove lost nodes and build 206 cell line context specific networks.
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PMC11774112
Preincubated A375 cells were cotreated with DTIC (0.1–3 μg/mL) and miRNA 34a (0.5–2 μg/mL) for 72 h (A and B) (n=6).
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PMC11695546
The Equilibration time 0.5 min.
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PMC3730428
Z-VAD-fmk and nec-1 were purchased from Calbiochem (Gibbstown, NJ, USA).
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PMC11310713
Sp (Fig. 6F and G).
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PMC11269933
However, their phosphorylation levels (CgERK1/2 (corresponding to HmERK1) and CgMAP2K1/2 (corresponding to HmMAP2K1)) showed a divergent pattern, with higher levels observed in the southern habitat than the northern habitat and in C. angulata than in C. gigas (Figure 6A).
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PMC11707832
Deficiency of αM-II has been linked to the development of a systemic lupus erythematosus (SLE)-like autoimmune disease in mice .
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PMC11724582
We used the GEPIA2 website to determine a weakly significant association between YAP1, TAZ, and the CAF marker α-SMA (ACTA2), which was subsequently verified by qPCR.
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PMC9429973
Our results suggest that one of the most important unmet medical need in CML management is availability of better tolerated drugs G. Montalban-Bravo, F. Ma, I. Ganan-Gomez, R. Kanagal-Shamana, V. Adema, N. Thongon, H. Yang, K. A. Soltysiak, C. Bueso-Ramos, H. Kantarjian, G. Garcia-Manero, S. Colla Leukemia, The University of Texas MD Anderson Cancer Center, Houston; Molecular Biology Institute, University of California, Los Angeles; Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, United States of America Background: Most patients (pts) with chronic myelomonocytic leukemia (CMML) have incomplete or transient responses to hypomethylating agent (HMA) therapy.
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PMC7759933
Compared to the 2D monolayer cultures, HepG2 spheroids showed a time-dependent reduction in cell proliferation with cell division arrested in the G0/G1 phase of the cell cycle.
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PMC11754436
The results demonstrated that overexpression of miR-362-5p could promote the proliferation of OS cells and inhibit the apoptosis of OS cells.
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PMC11269933
The background colors of sequence name represent different phyla.
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PMC11525293
Indeed, modulation of ACE2 levels with Thal may prevent or effectively contrast SARS-CoV-2 infection if properly given in early phases of the virus attack.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "modulation", "of", "ACE2", "levels", "with", "Thal", "may", "prevent", "or", "effectively", "contrast", "SARS-CoV-2", "infection", "if", "properly", "given", "in", "early", "phases", "of", "the", "virus", "attack", "." ] } ]
PMC11173119
One cell line was selected for detailed characterization and was registered in the Human Pluripotent Stem Cell Registry (hPSCreg, https://hpscreg.eu, accessed on 14 March 2024) under the name RAUi002-A. We carried out quantitative (RT-qPCR) and qualitative (immunofluorescence) analyses of this line for markers of pluripotent cells.
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PMC9024365
Intriguingly, the bi-directional clustering requires incubation at 37C, suggesting that an endocytosis of surface labeled AMPARs is most likely necessary for clustering with SD4.
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PMC8633974
Escherichia Coli (E.Coli, STBL3, Stellar) was used for transformation and streak plated on selective antibiotic-containing (ampicillin, 100μg/mL, or kanamycin, 25μg/mL) on Luria Bertani (LB)-agar plates then incubated for 16 hours at 37C.
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PMC11718274
14.94 and 28.89 µg/ml) for 72 h .
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PMC11791478
PDX studies were performed by Champions Oncology, Inc. (bladder, gastric, HNSCC, and NSCLC PDX) and Crown Bioscience Inc. (cervical PDX) in compliance with Institutional Animal Care and Use Committee procedures.
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PMC11640419
Subsequently, all cell samples were subjected to analysis on a NovoCyte Penteon flow cytometer (Agilent, Santa Clara, CA, USA).
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PMC11024707
Table 1 shows previous studies explored the mi-RNAs that are associated with ASD and several related neurodevelop-mental disorders.
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PMC9429973
Fewer physicians reported cost (4.8%), patient acceptability of lag time between leukapheresis and CAR-T infusion (7.2%), patient acceptability of frequency of administration (8.0%), less monitoring needed (8.8%) and fewer outpatient / inpatient consultations needed (5.6% and 7.6% respectively) as their top 7 3L tx attributes considered.
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PMC10568263
Finally, MoO3 nanosheets were dispersed in DI water for further use.
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PMC9727330
The absorbance of each well was measured at 450 nm (Khalil H et al., 2017; Khalil et al., 2020a).
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PMC11665555
Metabolically, among the OVOL1 targets, PPARG mediates FAO.
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PMC11721587
For lentivirus production, HEK293T-17 (ATCC) cells were seeded and transfected with psPAX2 and vesicular stomatitis virus glycoprotein, along with pLKO.1-puro [for short hairpin RNA (shRNA) lentivirus] or FUXW (for protein-expressing lentivirus).
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PMC11730320
All stages of raw sequence processing was performed by pRESTO (v.0.7.1), including quality control, primer masking, annotation of reads with sequence embedded barcodes, generation of unique molecule identifier (UMI) consensus sequences, assembly of paired-end reads, and identification of duplicate sequences.
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PMC9583612
Using current CEMS technology will require operator insight (e.g., operation logs or SCADA data) to translate the list of events into a list of likely sources.
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PMC11488203
Taxol substance between 0.1 nM and 10 nM was used again as a cytotoxicity control (Fig. 6E).
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PMC11092382
Pharmacokinetic parameters of sophocarpine Although sophocarpine can be absorbed in various forms to exert its pharmacological effects, current pharmacokinetic studies are predominantly conducted via intravenous administration, and the pharmacokinetic parameters for oral administration are still lacking and warrant further exploration.
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PMC9429973
Here we report the initial findings of the phase I component.
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PMC11297139
The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.
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PMC9878562
VAL and DOHH2 cells were cultured in RPMI-1640 supplemented with 10% heat-inactivated Fetal Bovine Serum (FBS), 1% Penicillin/Streptomycin (P/S), 1% GlutaMAX.
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PMC11742231
The concatenation operation involves simply concatenating the features from different modalities into a single feature vector.
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PMC11422150
The significance level was set at P < .05 (two-tailed).
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PMC10734950
In an effort to identify novel anti-cancer agents, we employed a well-established High Throughput Screening (HTS) assay to assess the cytotoxic effect of compounds within the ChemBridge DIVERSet Library on a lymphoma cell line.
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PMC8303372
After this step, the cells were seeded in the wells of the array 24 h prior to the treatment , and continuously monitored with ECIS in an incubator (37 °C, 95% humidity, 5% CO2).
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PMC11352746
The central nervous system (CNS), which comprises the brain and spinal cord, is undoubtedly the most delicate system in the human body, owing to its susceptibility to damage and injury.
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PMC11240052
To determine the functional roles of hsa_circ_0008285 in ovarian cancer, cell proliferation, apoptosis, and cell invasion assays were performed.
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PMC11607764
PTBP1 deletion in DCs has been shown to perturb T-cell homeostasis and enhance antitumour immunity.
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PMC11290772
Supplementary Figure 1).
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PMC9856122
Similarly, another category such as aporphine alkaloids also exerted anti-HIV action.
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PMC9739791
This indicates the quenching of fluorescence due to photoinduced electron transfer.
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PMC9429973
Methods: We prospectively characterized snoRNA and sdRNA expression in 96 AML patient samples, as well as in healthy hematopoietic stem and progenitor cells and differentiated white blood cells by small RNA sequencing.
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PMC11350568
However, existing TMPD methodologies face challenges such as complex molecular architectures, scarce availability, and cumbersome construction requirements.
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