Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11477621
Among the hydroxamic acid-based targeting products 3a–e, compound 3d exhibited the best inhibitory activity, indicating that a six-methylene linker is optimal for the activity.
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PMC7053076
The ability of U-332 to reduce the activity of NF-κB members was studied by ELISA test.
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PMC6642070
5p53 transcriptional represses ENO3. (
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PMC4443654
Genome-wide ChIP-seq datasets for 22 DNA binding proteins (ATF3, CEBPB, CHD1, CHD2, CMYC, CTCF, EGR1, EZH2, GABP, JUND, MAX, MXI1, NRSF, POL2, P300, RAD21, SIX5, SP1, TAF1, TBP, YY1 and ZNF143) and ten histone modifications (H3K27ac, H3K27me3, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me2, H3K9ac, H3K9me3 and H4K20me1) were produced by ENCODE (July 2012 data freeze, used in ), in addition to DNase I hypersensitivity data and H2A.Z occupancy (Additional file 1: Figure S5), for each of the Tier 1 ENCODE cell lines used in this work: H1 hESC, K562 and GM12878 .
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PMC11730320
Indeed, based on probe coverage reported by the DGV, this deletion cannot be detected by Affymetrix CytoScan HD, with 5 probes overlapping the deleted region, or other genotyping or genome hybridization arrays (Agilent 244k, Affymetrix SNP Array 5.0, Affymetrix SNP Array 6.0, Illumina HumanHap 300, Illumina HumanHap 550, Illumina Human 610 Quad, Illumina HumanHap 650Y, Illumina Human 660 W, Illumina HumanHap 1 M: 0-3 probes overlapping the deleted region) (Supplementary Fig. S6).
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PMC7812570
cell-cell transmission was monitored by quantifying the production of the luciferase reporter in the TZM-bl cells.
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PMC11337594
A375 and CASP3-KO cells were treated with TER (2.0 µg/ml) or DMSO for 24 h, and then labeled with Annexin V-FITC/PI for observation under a fluorescence microscope. (
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PMC11033180
To first examine whether Sema5A and its receptors Plexin A1/A2 were expressed in the gut, western blots were performed to assess their protein expression in the rat distal colon and brain lysates, the latter being used as a positive control.
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PMC10808409
The concentration where a sharp increase in absorbance was observed, corresponds to the CMC.
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PMC11748335
We also employed the LOLA R package to analyze the enrichment of peaks in the built-in datasets of LOLA, utilizing all peaks as the background .
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PMC9429973
Aims: HARBOR (NCT04910685) is a randomized, double-blind, placebo-controlled, phase 2/3 study assessing efficacy and safety of orally administered BLU-263 in patients with ISM whose symptoms are not adequately controlled by standard therapies.
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PMC10747160
Similarly, SARS-CoV-2 pseudovirions with additional structural proteins were produced at least twice to also account for batch-to-batch variation.
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PMC11127909
D WB analysis of c-Myc, cleaved caspase 3 (C–C3) and cleaved caspase 9 (C–C9) expression in 143B-V, 143B-EFHD1, 143BR-shV and 143BR-shEFHD1 cells after cisplatin treatment, N = 3.
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PMC9516447
In examining the effect of GRP78 deficiency on various RAS protein expression and cell viability, we noted that wild type KRAS protein levels and viability of a normal human lung epithelial cell line were not affected, consistent with the observations that at dosages exhibiting strong anti-cancer activity, YUM70 did not affect viability of normal pancreatic tissue-derived cells (HPNE) and HA15 did not show toxicity towards primary human melanocytes and fibroblasts, and no adverse effects were was observed in normal organs in vivo .
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PMC11575040
A, B Evaluation of the migration and invasion ability of A2058 cells after LINC00094 knockdown, followed by the quantification of their relative motility.
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PMC11799620
Therefore, OFAE protected HepG2 and HEK293 cells against Cd-induced injuries in cells.
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PMC10887351
Activation of β3-AR in the myometrium relaxed contractions , and its expression increased during gestation .
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PMC9479186
Lentiviral-infected BEL-7404 and SK-HEP-1 cells were seeded in six-well plates (2 × 10 cells per well) and cultured for 48 h. Then, the cells were subjected to Annexin V-APC/PI double staining following the instruction of Apoptosis Assays Kit (eBioscience, California, USA).
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PMC9429973
For inclusion, patients must be aged ≥18 years and must have R/R MM for which no established therapies are available or appropriate.
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PMC7185206
Apoptosis was measured by TMRE and Annexin-V staining on flow cytometry (c), percent TMRE-negative Annexin-V-positive apoptotic cells in treatment groups are reported (d).
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PMC11380329
Table 2 presents the CIs detected using CompuSyn software after treatment of OVCAR4 cells with different combinations of the different types of P and Vit D. CIs values at IC50 were 0.984, 0.866 and 0.891, for Ger P + Vit D, Egy P + Vit D and Fre P + Vit D, respectively.
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PMC11787355
Harmony (1.0.3) was subsequently used to integrate datasets.
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PMC9429973
Summary/Conclusion: The frequency of the FII mutation was more than double that of the FVL mutation, despite more than 80% of requests being for FVL alone.
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PMC11477621
C NMR (100 MHz, CDCl3) δ 188.7, 171.8, 130.7, 129.8, 121.0, 108.2, 49.7, 32.7, 31.1, 28.4, 27.3, 26.0, 25.2.
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PMC10965680
These animals play a crucial role in human society, providing not only meat and milk but also fiber, fertilizer, and even serve as a draft animal (Sinn and Rudenberg, 1992).
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PMC11700340
Furthermore, this result revealed that linagliptin exhibited robust activity, as evidenced by its high docking score and docking pattern, supported by its interaction capacity.
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PMC11297139
Fluorescence recovery after photobleaching (FRAP) experiments on the nuclear ARID1A condensates showed rapid molecular rearrangements, confirming that ARID1A condensates are indeed liquid-like (Fig. 1b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "recovery", "after", "photobleaching", "(", "FRAP", ")", "experiments", "on", "the", "nuclear", "ARID1A", "condensates", "showed", "rapid", "molecular", "rearrangements", ",", "confirming", "that", "ARID1A", "condensates", "are", "indeed", "liquid-like", "(", "Fig.", "1b", ")", "." ] } ]
PMC9429973
Newer strategies are warranted in this setting.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Newer", "strategies", "are", "warranted", "in", "this", "setting", "." ] } ]
PMC11770130
Therefore, we measured the expression of Gdf15 gene in the skeletal muscle of Ntsr2 AKO mice.
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PMC11783017
By reactivating T cells and promoting their ability to attack cancer cells, PD-1 blockade therapy may improve treatment outcomes and contribute to a more robust and durable anti-tumor immunity.
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PMC10606998
The application of magnetic nanoparticles opens up new opportunities in tumor theranostics: (i) it allows targeted delivery of drugs to affected areas ; (ii) it significantly expands the sensitivity of early diagnosis of tumors ; and (iii) it enables the use of non-invasive methods of treating tumors by local heating using the hyperthermia effect .
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PMC10706275
This is in agreement with Butler’s findings in 2005, where randomly integrated recombinant CHO cell lines lacked control over gene insertion sites and copy numbers, leading to notable discrepancies between the cell lines .
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PMC9429973
Outcomes in patients with previously untreated HR MDS treated with magrolimab + AZA a 9 patients had missing TP53 status.
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PMC9429973
PET scans were centrally and blindly reviewed by a panel of nuclear medicine physicians.
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PMC10926885
Our data show that NDE1 has a significant predictive value across many mouse immunotherapy groups.
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PMC11754094
The large-deletion frequency was normalized to that of the original PE3 system.
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PMC11442172
Subjecting cancer cells to physiologically relevant O2 levels might result in metabolic profiles that more accurately reflect tumor metabolism in vivo (48).
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PMC10452486
Expression of these molecules was completely inhibited by BFA and thus induction of B2m-free class-I heavy chains on activated T cells requires the transport of newly synthesized MHC class I molecules to the surface (p. 107, 11)”.
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PMC11696576
d Cell viability measured by CTG assay in cells preincubated with 2.5 mM glutathione (GSH) or 2.5 mM N-acetyl cysteine (NAC) for 30 min before addition of 0.5 or 1 µM AVX420, 0.06 µM RSL-3, or 0.06 µM ML-210 for 24 h. Data are the mean ± stdev of 3 biological replicates.
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PMC11696659
Abbreviations: COPD, chronic obstructive pulmonary disease; LC, lung cancer.
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PMC10582049
Venn diagram shows intersection of differentially expressed genes in identified CAF subpopulations.
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PMC7057940
Results are expressed as % input ± SEM using normal IgG as a specificity control.
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PMC11789597
For co‐culture assays, MM cells were added to BMSCs for 2 h and treated with bortezomib at the indicated concentrations for another 48 h. Finally, the cell viability was measured using the Cell Titer glo Luminescent Viability assay.
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PMC9429973
Methods: Following established guidelines for registries, Saudi MOH implemented multiple steps in building the registry which include establishing registry team, defining the scope, objectives, and data sets, establishing a governance and oversight plan, and developing a project plan and timelines.
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PMC7351993
Specifically, Supplementary Fig. 9a shows a detailed schematic of our experimental procedure for Raman image-activated sorting of Euglena gracilis cells.
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PMC9429973
Methods: Manufacturing: CAR-T products were generated using a semi-automated, closed process from non-mobilised patient leukapheresate.
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PMC9817179
Figure 1, Video 1, and Figure 1—figure supplement 1 compare the same cells before and after treatment of 4% PFA for 10 min unless otherwise noted, a typical condition utilized for fixed-cell imaging techniques such as immunofluorescence.
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PMC11387401
Ratios of the biotypes of the detected RNA interactors for all HIV-1 proteins for each of the performed nRIPseq assays (A–D).
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PMC8193813
Aerial measurement of plume concentrations is a new field made possible by advances in unmanned aircraft systems (UASs, or “drones”), miniature sensors, computers, and small batteries.
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PMC7762347
Cylindrospermopsin (CYN), another very important cyanotoxin, has been recently considered as an emerging toxin.
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PMC6835428
Thus, the system has the great advantage of significantly reducing the experimental load, as it can easily simulate/predict the effects of many variables of the system via mathematical simulation .
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PMC7053076
The Rel homology domain is characteristic for all memb ers the NF-κB family, while the ankyrin repeats only for the NF-κB inhibitors and the NF-κB precursors of p50 and p52 subunits (p100, p105).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Rel", "homology", "domain", "is", "characteristic", "for", "all", "memb", "ers", "the", "NF-κB", "family", ",", "while", "the", "ankyrin", "repeats", "only", "for", "the", "NF-κB", "inhibitors", "and", "the", "NF-κB", "precursors", "of", "p50", "and", "p52", "subunits", "(", "p100", ",", "p105", ")", "." ] } ]
PMC11423992
Jurkat-NFAT cells were cultured in RPMI-1640 media (cat. #
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PMC7570809
A total of 1 × 10 cells/150 μL were seeded in the upper chamber.
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PMC8524093
The complete budding mechanism is still not completely understood, but some interesting studies have reported the dependence of optimal temperature and pH conditions, as well as the presence of host cell membrane cholesterol to occur (Marquardt et al., 1993; Lu and Kielian, 2000; Lu et al., 2001).
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PMC11555465
Although the culture supernatant of T. gondii tachyzoites was found to inhibit the proliferation, migration and invasion and promote the apoptosis of bladder cancer 5637 cells, the exact mechanism is not known and the present study lacked in vivo experiments.
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PMC11789597
Apoptosis analysis was performed as previously described.
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PMC11476837
An important aspect of the potential clinical use of the NRF2 inhibitors, including ML-385, is their interactions with anticancer drugs.
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PMC11049294
The transfection efficiency was validated also at RNA level, with undetectable GLA expression in GLA KO cell line (Figure 2C).
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PMC11095939
Representative liver morphology and liver index of Mecp2 and Mecp2 cKO mice at 7 d post-PHx.
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PMC11013014
HRMS (+ESI) m/z: [M + H] calculated for C18H17Cl2N2O3: 379.0610, found, 379.0609.
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PMC11772585
NumberSexAge (year)Pathological typePathological gradingTumor siteDegree of infiltration1Male71SCCITempusN/A2Male77SCCILeft auricleN/A3Male35SCCILeft foot rootN/A4Male54SCCIScalpN/A5Male70SCCIRight cheekDermis6Male63SCCIBottom of left footN/A7Male67SCCILeft tempusN/A8Male58SCCIScalpDermis9Female50SCCIScalpN/A10Female75SCCILeft TempusN/A11Female91SCCILeft frontal faceStriated muscle12Female76SCCILeft TempusN/A13Male73SCCILeft TempusSubcutaneous tissue14Male74SCCIAuricleN/A15Male78SCCIVulvaSubcutaneous tissue16Female83SCCIIRight cheekSuperficial muscular layer17Female86SCCIILeft forearmN/A18Male82SCCIIRight eyeN/A19Male74SCCIISkinN/A20Female39SCCIIScalpSubcutaneous tissue21Male70SCCIILeft cheekDermal reticular layer22Male76SCCIIOccipital posteriorN/A23Female81SCCIIBack of the right handN/A24Male82SCCIIRight tempusDermal papilla layer25Male83SCCIILeft cheekDermis26Female84SCCIILeft wristN/A27Female74SCCIIRight cheekSubcutaneous adipose tissue28Female89SCCIILeft cheekDermal reticular layer29Male95SCCIILeft frontal faceN/A30Female68SCCIIEternal auditory canalN/A31Female86SCCIIIRight thighDermis and Subcutaneous adipose tissue32Female95SCCIIILeft tmpusN/A33Female43SCCIIIPosterior wallFull layer34Male79SCCIIIRight auricleN/A35Female36SCCIIILeft noseN/A36Female74SCCIIIRight cheekN/A37MaleadultN/AN/AN/AN/A38MaleadultN/AN/AN/AN/A39FemaleadultN/AN/AN/AN/A40FemaleadultN/AN/AN/AN/A41FemaleadultN/AN/AN/AN/A42MaleadultN/AN/AN/AN/A43MaleadultN/AN/AN/AN/A Basic information for healthy people and cSCC patients.
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PMC11519567
The blue dotted line represents the nuclear boundary.
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PMC5025404
Worldwide, adalimumab has largely been successful in the treatment of inflammatory rheumatic diseases, including in multiple random clinical trials (Scott and Kingsley 2006).
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PMC11543853
c–f Sections from cryo-tomograms of cos-7 cells sixty minutes after the addition of OsO4-stained VLDL complexes.
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PMC10933092
Both the input sample (without immunoprecipitation) and the mA antibody-immunoprecipitated samples were subjected to 150 bp paired-end sequencing on an Illumina HiSeq sequencer.
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PMC11395280
It comes as no surprise that more than 475 drugs that are currently on the market target GPCRs given their targetability.
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PMC8701144
SIM imaging of E1B-55k and TNKS proteins in HEK293 cells treated with control siRNA revealed that the cytoplasmic TNKS aggregates were assembled in spheroid structures composed of a central TNKS core encapsulated by a narrow layer of E1B-55k protein (Figure 3a) (hereafter referred to E1B-55k aggregates).
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PMC11119602
Cisplatin-resistant HepG2 cells were developed following a single dose treatment, according to the conditions previously described , with minor modifications (described below).
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PMC7840816
RT-qPCR was performed in a final volume of 10 μl, which contained 5 μl of SsoFast™ EvaGreen Supermix (Bio-Rad Laboratories), 1 μl of cDNA (1:50 dilution), and 2 μl each of the forward and reverse primers (1 mM).
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PMC11786767
Next, we added RO-3306 into COS-7 cell culture that had been arrested at prometaphase by means of nocodazole (Fig. 8A).
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PMC11621565
Specifically, our findings suggest that dopaminergic-differentiated SH-SY5Y neurons serve as a viable model for both enteric and central nervous system neurons, reflecting the dual pathways through which these toxins can exert their effects.
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PMC11190238
Among a selected panel of EMT signature genes showing the switch from the active state to the poised/bivalent or repressed states at the promoter in the Chung study, three genes (ESRP1, GRHL2, LAD1) are concordant with those switching from H3K4me3 to H3K27me3 at the promoter in the Malouf study.
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PMC11342785
Symbols denote experiments performed qualitatively.
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PMC11323699
This may help explain, at least in part, how these two compounds complement each other to yield an improved therapeutic effect.
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PMC9429973
Other cause of treatment discontinuation is hyperglycemia, bowel obstruction by disease.
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PMC11799620
Then, 85 µl and 22µl of NBT (1 mM) and riboflavin were added to the reaction mixture, respectively.
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PMC9895440
For the DGO condition, DG was added first for 10 min and then O was added for the last 5 min, according to the manufacturer’s instruction.
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PMC11666785
It relies on the fact that fortunate molecules (molecules with long blinking periods) fluoresce for a longer time (than standard SMLM).
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PMC9429973
All 9 patients increased significantly CAC (p=0.004) and MESA (p=0.003) scores at 6 months, while 5/9 patients also increased the number of AVB.
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PMC9926039
An RT-PCR assay was developed based on SYBR Green I and in a total reaction volume of 10 μL using a Corbett Rotor-Gene 6000 system (Life Science, Australia).
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PMC8382973
Our study provides a detailed characterization of the rectal and vaginal microbiota of male and female NZW rabbits and opens up new prospects for establishing this animal model.
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PMC11434983
Several metals have been investigated in combination with EGFR TKIs, such as Ruthenium, Cobalt, Platinum, Rhodium, Iron, and Gallium .
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PMC9841531
Reagents and conditions: (a) compound 12, POCl3, N,N-dimethylformamide (DMF), 0 °C, overnight; (b) compound 13, ethyl bromoacetate, Cs2CO3, DMF, 0 °C, 1 h; (c) compound 14, NaOH, ethanol, reflux, 1 h; (d) compound 15, methyl cyanoacetate, piperidine, ethanol, room temperature, overnight; (e) compound 16 with either (i) respective amine, pyridine, POCl3, dichloromethane (DCM), 0 °C–room temperature; 6–8 h or (ii) respective amine, EDC·HCl, HOBt, N,N-diisopropylethylamine (DIPEA), DMF, 0 °C–room temperature, 6–8 h. The inhibitory activity of indole derivatives against MCT1 was determined by applying a functional 3-bromopyruvate (3-BP) cell viability assay, as described in the literature with minor modifications.
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PMC11470999
We confirmed that CIP2A is the direct binding protein of PF and elucidated the mechanism by which PF reduces CIP2A levels in melanoma.
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PMC11352666
Higher concentrations of 400 nM MRX-2843 or 4 µM ventoclax reduced cell densities by 68.0% ± 3.6% and 51.8% ± 6.4%, respectively, while the combination provided an 81.6% ± 2.7% reduction in tumor cells.
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PMC11240448
In sharp contrast, the inferred connection circuitries of core networks among 28 distinct basal BC cells exhibit significant qualitative differences, partitioning into mainly four different classes with different driver pathways.
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PMC10988555
For each sample, the concentration was determined by using a calibration curve in n-octanol.
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PMC11767725
These immune-regulating functions of the microbiota are crucial for maintaining a balanced immune tone in the skin, reducing the likelihood of inflammatory and autoimmune conditions .
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PMC11738017
Scatter plot representing levels of sBCMA measured from the culture media of OPM2 or OPM2_BCMA cells after 48 and 96 hours.
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PMC10362265
Dysregulation of its activity has been implicated in many immune-related diseases in humans , , .
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PMC9844987
The high performance of predicting promoter variability from local DNA sequence and the distinct TF binding profiles of low and highly variable promoters imply that attenuation and amplification of variability are driven by distinct regulatory mechanisms.
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PMC11661040
Results from three experiments are summarized in a histogram format. (
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PMC8633974
These results also suggest that cleavage at other multiexon locations along the HIV-1 genome, such as gag/pol and nef/LTR, or tat/rev/gp41 by other Cas nucleases may afford broader antiviral coverage.
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PMC11489275
Lymphocytes of the patients who died within 1 month were significantly lower than survivors by different lymphocyte grouping methods, and the total lymphocytes showed a gradually decreasing trend in non-survivors.
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PMC5810978
DMEM containing 20% FBS, NEAA, sodium pyruvate, and the antibiotics was also used to maintain calf tissues (duodenum and jejunum) in a petri dish.
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PMC10411253
The Arg312Cys-mutant AMH was significantly reduced in the major band and was undetectable in the minor fragment.
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PMC9352806
Since the relevance between PE and the aging, follow-up studies should be conducted to expand our findings.
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PMC9919300
For this purpose, we evaluated the effects on lipid accumulation and ROS production by cotreatment with andrographolide, focusing our attention on its ability to prevent curcumin toxicity.
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PMC11657695
While previously KCNA3 and KCNA5 expression have been shown to correlate with survival in lung squamous cell carcinoma and stomach adenocarcinoma patients, respectively , this study demonstrates that KCNA2 expression correlates with the overall and event-free survival of ES patients.
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