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PMC11201245
The calculated sensitivity of the OC-FISH test is 0.94 (Figure 4).
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PMC11680982
The triple combination treatment group administered neratinib, CDK4/6 inhibitor, and endocrine therapy after actinomycin D intervention revealed significantly reduced HER2 mRNA stability at 5 and 10 h (Fig. 6E) compared with the CDK4/6 inhibitor + endocrine therapy group.
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PMC11544122
For experiments with Rluc8-SNX9, the cells were co-transfected with 500 ng of Rluc8-SNX9, 250 ng of HA-CXCR4-YFP, and 2.25 µg of empty pcDNA3.
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PMC10758402
, CD3-AlexaFluor 700 (1:100, BD Biosciences, Cat. #
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PMC6461034
Centrifuge at 550 × g for 5 min at 4°C and remove supernatant.
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PMC10887351
Altogether, targeting β3-AR in the TME could represent a promising approach for the multiple non-redundant pro-tumoral signaling pathways.
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PMC11723210
The figures clearly demonstrate the BPR method accurately reconstructed large phase changes during cell division, providing detailed morphological and quantitative phase data that conventional methods failed to resolve.
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PMC11301242
Top: Ideogram depicting the chromothripsis region.
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PMC11792888
Annexin V FITC Early Apoptosis Detection Assay Kit was obtained from Cell Signaling Technology.
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PMC11583010
, (ii) PVRL4_ OMb23568D–Macaca mulatta cDNA nectin-4/PVRL4 (vector pcDNA3.1), (iii) PVRL4_ ORa08956–Rattus norvegicus cDNA nectin-4/PVRL4 (vector pcDNA3.1), and (iv) PVRL4_ Omu23587–Mus musculus cDNA nectin-4/PVRL4 (vector pcDNA3.1; GenScript).
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PMC11770746
Pt NMR chemical shifts were reported with respect to the chemical shift of standard K2PtCl4 in water at −1624 ppm.
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PMC10317042
However, the knockdown of EWSR1::ATF1 did not reduce SOX10 expression (Supplementary Fig. S4E).
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PMC10840195
Before taking photos, the cells were washed with PBS and replaced in fresh serum-free medium.
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PMC6379402
Importantly, we validated 57.1% of our predictions by gene silencing coupled with cell viability experiments.
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PMC11585565
Kato et al. identified that a pathogenic missense variant at the end of exon 5 of LMNA, encoded lamin A/C, in severe dilated cardiomyopathy.
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PMC11679892
Materials and Methods: For the cell culture, SH-SY5Y human neuroblastoma cells were thawed, cultured, and maintained under appropriate conditions for experiments.
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PMC10317042
In addition, motif analysis revealed that vorinostat treatment suppressed the transcriptional factor SOX10, which directly regulates EWSR1::ATF1 expression and is involved in CCS proliferation.
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PMC10380508
Since PAX6 was expressed at very low levels in the A498 cell line, PAX6 knockdown was not performed.
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PMC11792766
Summary of no‐observed‐adverse‐effect‐concentrations (NOAECs) for exposed HepG2 and Caco‐2 cell lines to acetic acid as determined via the MTT, lactate dehydrogenase (LDH), and neutral red uptake (NRU) assays.
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PMC9429973
Moreover, survival after 2L chemotherapy was significantly decreased in pts with low LN TL % with a median of 7.3 vs 101.6 m in those with normal-high values, p: 0.004.
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PMC11025866
This result indicates that VPM does not regulate cellular gene expression in HH514-16 cells through metabolic conversion to the HDACi VPA.
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PMC6642070
To confirm the specificity of the elevated lactate production with the inhibition of HMGCR by statins, we carried out lentivirus-mediated knockdown of the enzyme and found increased lactate productions by two distinct lentiviral hairpins (Fig. 2d).
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PMC9429973
Main Outcome and Measure Change of liver iron content measured by MRI.
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PMC11321678
The cells of the cerebellum are derived from two distinct germinal zones.
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PMC11683240
ADP-ribosylated and thus biotin-labeled Gαi was detected by Western blotting (Fig. 4).
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PMC11201989
RCTE (ATCC, Cat# PCS-400-010) and RPE (ATCC, Cat# CRL-4000) cells were maintained at 37 °C in 5% CO2 in DMEM/F-12, GlutaMAX™ (Gibco, Grand Island, NY, USA) supplemented with 10% FBS and 1% Pen Strep.
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PMC11392912
SW982 and RA primary cells (RAFLS) were grown in a 6-well plate (Nunc, U.S.A.) in complete DMEM and various assay groups (n=4) were made; G1-untreated Control (UT), G2- treated with transfection reagent, G3-Negative control (NC) + recombinant TNF-α, G4- 10 nM Clo-miR-14 mimic with transfection reagent+ recombinant TNF-α.
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PMC11790971
The generalizability of our findings to other CHO cell lines or biopharmaceutical production systems requires further investigations.
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PMC11757230
Therefore, similar studies using primary canine LL cells are needed to ensure the safety of MSC-based therapies in veterinary medicine.
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PMC11306019
In conclusion, while C3-OH plays a definitive role, aromaticity primarily dictates flavonoids’ antagonistic effects against BTZ.
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PMC4369959
Ginger (Zingiber officinale), a member of the Zingiberaceae family, is a popular spice used globally especially in most of the Asian countries .
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PMC8540692
These compounds upregulated RASSF1A not only in T98G cells, but also in A-172, and downregulated its expression in U-138 MG cells.
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PMC10154881
The proportion and number of GrBCD8 (G, H) and IFN‐γCD8 T cells (I, J). *
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PMC6487404
Kajosaari et al. reported that coadministration of REG with cyclosporine A, significantly increased the plasma concentrations of REG in healthy volunteers.
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PMC11723947
The fate of immune cells exposed to suppressive signals has also been largely documented.
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PMC9341513
In this new arrangement, the promoters of CCND1 and LTO1 readily interact with each other and with the proximate Eµ and Eδ super-enhancers, whereas weaker interactions were observed with the more distant Eα1 and Eα2.
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PMC5963610
Under compassionate basis, at 18 months after the initial diagnosis, he received the anti-EGFR mAb (Nimotuzumab, Nimo) weekly (i.v.)
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PMC9516447
Despite the recent breakthrough advance of KRAS specific inhibitors, for downregulation of KRAS and its oncogenic effects, it has been suggested that physical loss or degradation may provide a more robust and durable anti-tumor effect.
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PMC11593031
Background: The Neuro-2a cell line, derived from a murine neuroblastoma (NB), was established as early as 1969 and originates from a transplantable tumor that arose spontaneously in an A/Jax male mouse in 1940.
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PMC11423992
Notably, TFAB002-1 displayed an enhanced binding affinity with CD3.
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PMC11739696
Table 2Integrity of genomic DNA in the melanoma A-375 cells following exposure to IC50 concentration of Co3O4NPs for 72 h.CellTreatment (µg/ml)tail length (px)%DNA in tailTail momentA375 cellsCo3O4NPs 0.006.82 ± 1.5126.38 ± 1.831.83 ± 0.51Co3O4NPs (303.80)15.01 ± 0.84**40.83 ± 3.18**6.36 ± 0.62**Results are expressed as mean ± SD.**, ***:
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PMC10734950
The membrane was then washed in the same manner as previously mentioned, and 2 ml of 1X HRP-Anti-Rabbit IgG was pipetted into each well and incubated for 2 hours.
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PMC11572213
In glutamine-deficient medium, the mRNA expression of glutamine synthetase is increased, which could be related to glutamine addiction in cells.
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PMC11633763
All media were prepared in complete culture medium containing 10% FBS (fetal bovine serum), 1% streptomycin and penicillin.
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PMC9776316
XRCC4, a gene in the NHEJ pathway, is involved in the cellular response to DNA damage.
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PMC5600151
The balance between positive charges and nucleic acids affinity determines the therapeutic efficiency and toxicity of PAMAM dendrimers.
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PMC11546117
Several models have been developed to predict the milk-to-plasma ratio (M/P ratio) based on physicochemical properties , but these models often face over- or underprediction for specific physicochemical classes of medicines.
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PMC11585254
Cells were maintained in Dulbecco’s minimum essential medium (DMEM; Corning, 10-013-CV) supplemented with 10% fetal bovine serum (FBS; Omega Scientific, FB-11) at 37°C with 5% CO2.
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PMC9545474
Cancer is the second leading cause of death worldwide, accounting for 9.6 million deaths in 2018.
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PMC11190062
Each dot represents cells from one individual patient.
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PMC11766309
However, these HPV-associated tumors have evolved to escape immune detection.
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PMC9792775
Differences were considered significant only when the p-value < 0.05.
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PMC11792740
For example, DNA demethylation of the promoter regions of immunosuppressive receptor genes, such as PD-1 and TIM-3, in depleted T cells results in the upregulation of their expression .
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PMC11201989
However, whether regulators of the immune synapse participate in ciliogenesis is unknown.
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PMC11496491
Cluster analysis results.
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PMC11741577
HMC-1 cells cultured in FBS-containing IMDM were also treated for 24 h with human TLR 1–9 agonists (InvivoGen, San Diego, CA, USA).
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PMC10507284
The above cells were all cultured in Dulbecco's Modified Eagle Mproedium (DMEM; Procell) containing 10% fetal bovine serum (FBS; Procell) and 1% penicillin–streptomycin solution (Bioss), the culture temperature was 37°C, and the environment and humidity were 95% oxygen, 5% carbon dioxide, and 95% relative humidity, respectively.
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PMC9429973
In 90% cases of death patients had no remission of their underlying disease.
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PMC10529414
These findings are consistent with RUNX2 gene expression levels measured in primary tissues from patients, where the expression levels were higher in metastatic cancer samples (Figure 1D).
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PMC11036064
It has been shown that the transfection of negative control miR has no significant cytotoxic effect on A172 cells (Figure 7C(Fig.
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PMC10745221
Overall, similarities in ADMA and SDMA on histones were observed between the HCT116 and 143B cells, while H460 cells seemed to lack ADMA on histones and non-histone proteins.
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PMC11742231
A multi-channel graph attention module that uses multi-head attention mechanisms with 8 heads in the first layer and 1 head in the second layer, leveraging LeakyReLU activation with a negative slope of 0.2; attention coefficients are computed using shared weight matrices and attention vectors .
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PMC11366496
The quantities of migrants and invading cells are displayed.
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PMC11453018
Similarly to the EWS::FLI1 cell lines, both CADO-ES1 and COGE352 lines underwent senescence following iP300w treatment.
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PMC11683130
SerpinB2 plays a role in maintaining epidermal barrier integrity and inhibiting keratinocyte proliferation.
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PMC11711345
In addition, the potential of cuminic acid was investigated extensively.
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PMC9436459
Sanggenon D (128) was found to inhibit the growth of transplanted tumor and the proliferation of tumor cells in mice .
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PMC9872547
Quantitation of extracted protein was determined by Bradford staining and flow cytometry.
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PMC11248911
Within the thiazole-pyrazoline hybrids, it was observed that the halo substituted derivatives 11, 13, 16 and 18 were the most potent (IC50 = 6.9, 6.7, 6.6 and 6.9 μM, respectively).
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PMC11186948
To date, three neurodevelopmental disorders caused by mutations in genes encoding for HDACs (HDAC4, HDAC6 and HDAC8) and thus belonging to the group of chromatinopathies, have been described.
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PMC11751675
Notable examples include guaianolides and germacranolides, which have demonstrated promising activity against viruses such as hepatitis C, influenza, and herpes simplex.
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PMC6642070
R, purine; W, A, or T base. (
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PMC8592717
DHI protects patients from cerebral injury during coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) through antioxidation, antiinflammation, and immune factors regulation mechanisms .
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PMC11730305
Fig. 7TGA analysis of Co3O4@Glu-Ellagic acid; suggests good thermal stability of the.
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PMC10988555
Cells were harvested with a cell scraper and solutions with 1 × 10 cells/mL in PBS were prepared.
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PMC11650848
However, the G/G group did show significant differences when split by intervention groups (p = 0.035), with the placebo group here scoring lower than the FA group, similar to the same investigation in symbol search.
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PMC11711127
Though therapy with tolDCs is promising, the methodology to administrate tolDCs generated ex vivo raises significant challenges regarding their stability and migratory capacity (see T cell resistance as a target for immunotherapy section).
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PMC11672602
Positive control of liver section was used, magnification X100. (
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PMC8751435
Effect of Cordyceps militaris extract (CME) on cell cycle and cycle regulative proteins. (
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PMC11264242
Data represent mean ± SD of 3-4 independent experiments. *
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PMC11188874
Fluorescence was determined at excitation of 490 nmol/L and emission of 525 nmol/L. Assay of multiple myeloma culture supernatants indicated no hydrolysis of LLVY-R110 under the same conditions.
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PMC7348793
This suggests that COS-7 mtDNA is at variance with published sequences, which prompted us to determine the full nucleotide sequence of the mitochondrial genome in this cell line.
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PMC7961460
Differently from MCF-7 and MDA-MB-231 that derive from a pleural effusion, 8701-BC originate from an infiltrating ductal carcinoma before its metastatic effusion, and showed the highest expression of c10orf118 mRNA, suggesting a possible connection with cell metastasis and c10orf118 expression.
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PMC11240571
were added along with exosomes, a blocking effect as with the anti-human PD-L1 antibody was not observed, and the release of IFN-γ was suppressed.
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PMC9325715
Similar results were obtained for iron chloride on BALB/c and HepG2 cells.
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PMC9503541
The more similar the sample data, the closer the points in the PCA score plot .
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PMC9429973
Incidence of grade ≥ 3 (G3) treatment-emergent adverse events (TEAEs) was higher with PVd vs Vd in NF (88.1 vs 61.3%) and F (96.8 vs 87.9%) subgroups; peripheral neuropathy, acute renal failure, and hypertension were the most common.
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PMC11711871
The values are presented as the mean ± SEMs, and the data were evaluated via two-way ANOVA and subsequently compared with an unpaired two-tailed t test with Welch’s correction.
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PMC11204465
Aflatoxicol M1 (82) was a reduced metabolite of AFB1, AFR0, or AFM1 catalysed by soluble NADPH-dependent reductases in the liver .
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PMC11335267
The antibody had been incubated in the presence of GST. (
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PMC9429973
Presence of a TP53 mutation did not significantly impact OS (P=0.22).
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PMC10734950
In mitochondria where the membrane is intact, the JC-1 dye will aggregate and emit red fluorescent complexes.
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PMC11543885
Here, we present a protocol to profile spatially resolved NLRP3 inflammasome complexes using ascorbic peroxidase 2 (APEX2)-based proximity labeling combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS).
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PMC11754291
Importantly, the photomicrographs were obtained without fixation techniques, such as formalin, thereby eliminating the possibility of pigment artifacts and ensuring that the observed pigmentation is attributable to melanin production.
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PMC11741906
To determine the clinical significance of the identified miRNAs in patients with ovarian cancer, Kaplan-Meier survival curves for ovarian cancer patients was generated using the KM plotter database.
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PMC9874064
In BEL-7404DPP cells, the anti-tumor activity of NP-Pt-USP1i was also found to be significantly higher than that of other drugs.
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PMC9681981
The difference between the contact group and without cell group was only significant at 0 h. As the pathogenesis of bacteria relies on toxin production, studies on the expression regulation of clostridial toxin genes in the presence of host cells and on the evaluation of toxin production by Clostridium spp.
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PMC11021472
In this study, we investigated the relevance of circZDHHC11 and the miR-150 binding site region in regulating growth of BL.
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PMC11731614
The microfluidic chambers were visualized after 16 h by confocal microscopy.
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PMC11803149
Flow cytometry analysis confirmed the transduction efficiency of Epas1-expressing vector indicated by expression of Thy1.1 marker was about 15% of GFP cells transduced with OT-I TCR ( Figure 8A ).
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