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PMC9917080
In our experiments, the most pronounced increase in SELENOS expression occurred in cortical astrocytes and under the action of the SeSo nanocomplex, while in glioblastoma cells, this effect of increased expression was less pronounced after 48-h incubation with SeSo.
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PMC11615828
Transgenic animals were created by microinjecting plasmid DNA containing pHSP16/2::mCh‐CIBN‐Rab3‐SL2‐EMTB‐RFPnano‐Cry2 and pUNC‐104::GFP (a neuronal marker) into the gonads of wild‐type Bristol N2 animals using standard procedures.
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PMC11655498
BKRF4, a late lytic protein, has a limited impact on viral gene replication and protein expression, yet it is crucial for the production of infectious progeny viruses (Masud et al., 2017).
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PMC10093184
In COS3600 and COS3600B cells, distinct signs of 3D growth were observed after 24 h of cultivation: a dark central part corresponding to the bulky spherical cell structure in the middle was surrounded by a light-colored corona.
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PMC5811757
Couple of studies have indicated that several signal transduction pathways are involved in dysregulation of ABCB1 gene.
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PMC11534377
Figure 5 shows microscopy images of the A549 cell line, depicted both in bright-field (top row) and confocal microscopy (bottom row), under four different conditions: control, IR, 5-Aza, and a combination of two doses of 5-Aza plus 2 Gy of IR treatment.
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PMC11632064
As suggested in Figs 1A and B and S1A, targeting the expression of these kinases could affect the proliferation and pro-inflammatory response of melanoma cells and tumors.
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PMC11055443
In addition, MSC therapy has also achieved significant success in clinical trials of infectious disease such as sepsis (20).
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PMC10713411
The display of risk score, OS and OS status; Kaplan–Meier curves of the high- or low-PRPCDGs-risk group; prognostic performance of PRPCDGs risk signature presented in time-dependent ROC curves; heatmap of PRPCDGs expression in these two risk groups in KIRC training dataset. (
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PMC9429973
Although measuring mitochondrial metabolism has been identified as a major factor influencing response to treatments in several cancers, few studies have been documented in MM.
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PMC11674891
GRPR is widely expressed in various cancers, and its association with poor prognosis in cancer patients is well established.
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PMC9429973
S. Wang Department of hematology, Shandong University, Jinan, China Background: Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding.
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PMC11033180
Therefore, the 90–110 kDa forms detected in brain and colon might represent a secreted form of Sema5A.
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PMC10898159
Lysine (K)-specific demethylase 4D (KDM4D), as a histone demethylase, is overexpressed in GIST and promotes the progression of GIST via HIF1β/VEGFA signaling .
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PMC10142392
Linear PEG-b-PCL diblock copolymers, with a composition and overall molecular weight similar to that of miktoarm PEG-PCL2 copolymers, were also prepared to better understand the structure–property relationship between multi-arm copolymers and their linear counterparts (Figure 6).
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PMC11095939
Real-time PCR showing the mRNA levels of Mecp2 in 3T3 cells transfected with negative control siRNA (NC si) or Mecp2 siRNA (Mecp2 si) at the early stages of SR-induced cell cycle reentry.
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PMC3888431
All transcripts with significant BLASTp hit against the mouse reference protein set were classified into “correct” (red), “short” (green) and “false” (blue) assembled transcripts.
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PMC11025866
This analysis shows that global gene expression is dominated by effects of HDAC inhibition.
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PMC9429973
Prior to RM-001 DP infusion, patients received myeloablative conditioning with Busulfan from day-7 to day-3.
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PMC11543885
Treat the cells with tetracycline and Nigericin for distinct time-points as described in steps 2–3.
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PMC11618052
For more details, see Appendix A (ESI file).† The MTT assay was used to explore the antiproliferative efficacy of 8a–t against the four human cancer cell lines, using Erlotinib as a control.
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PMC11472639
indicates a significant difference from post-exercise at p < 0.001.
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PMC11779993
The antimicrobial properties of SPEE were determined against four bacterial strains of Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Bacillus cereus.
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PMC6889484
Averages of two independent infections per cell ratio are indicated.
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PMC10079526
Therefore, it would be interesting to test whether these types of HRD cancers are also sensitive to the combination therapy of TAK981 and 5-Aza-2’.
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PMC11345828
NH4Cl, sat.
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PMC11592837
To minimize self-inhibiting of qPCR reactions by high sample concentrations, as had been observed at later time points (4–8 h), samples were diluted at least 1:2 with nuclease-free water with higher dilutions for later time points (4 h, 1:10; 6 h, 1:50; and 8 h, 1:100).
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PMC11394227
After administering puromycin and tunicamycin to cells for 48 h, the CHO-PAb and CHO-PAb-QS cells exhibited varying degrees of apoptosis (Figure 6A).
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PMC11049294
Fabry disease (MIM 301500) has an estimated incidence of 1:3000–7800, being the most prevalent LSD .
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PMC11411131
A luciferase assay was performed after transfecting Cos-7 cells with specific cDNA combinations. (
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PMC9429973
Data were collected from patients’ clinical histories.
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PMC9874064
The results showed that the red fluorescence in cells (mainly from the nanoparticles) was mainly distributed in the cells, and the red fluorescence intensity increased significantly with increasing drug incubation time, indicating that the uptake of NP-Pt-USP1i@Cy5.5 by cells was time-dependent (Fig. 2G).
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PMC11683130
Serpins play an complex role in regulation of the epidermal barrier and the development of psoriasis.
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PMC6889484
Recombination between the repeated regions during transfection of the virus-producing cells could potentially reconstitute A3G-D128K; therefore, viruses were prepared in the presence or absence of HIV-2 Vif (Vif2), which can induce degradation of A3G-D128K.
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PMC11721096
On the other hand, different modes of immobilization of the TYR may also lead to this result.
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PMC10882807
As reported in our previous study, plasma hsa_circ_0005397 represents a good value for HCC .
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PMC11290772
Quantification data were normalized to the control group.
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PMC11089031
Recent reports have shown that ZNF692 is linked to the recurrence of Wilms’ tumor the prognosis and proliferation of ccRCC , and the aggressiveness of lung adenocarcinoma (LUAD) and that it promotes the proliferation and invasion of cervical cancer cells .
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PMC9429973
Most relevant clinical variables as well as center-, demographic- and economic-related variables (generally named as socio-economic variables) were collected for all patients.
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PMC6222635
The connection of (1→4)-linked glucose and (1→4)-linked mannose constructs the skeleton of the DWDOP1 compound.
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PMC11291697
Targeted expression analysis by RT-qPCR in the proband’s LCL showed reduced expression of GTDC1 at about 50% as compared to the control LCL (#GM05380) (Supplementary Fig. S1a), suggesting that the intragenic deletion exerted a loss-of-function effect likely triggering nonsense-mediated mRNA decay (NMD).
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PMC11473843
Scale bar: 100 μm; n mice/group: 3, 3, 4, 4.
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PMC11731161
p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 To elucidate the role of USP7 in maintaining the stability of the XPO1 protein, we subsequently developed two doxycycline-inducible shRNA constructs (#1 and #2) targeting human USP7 for transduction into MM cells.
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PMC10988555
The fibroblast cell line was used as a control of the cytotoxicity of the complexes for healthy cells.
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PMC9429973
Results: Out of n=10,300 blood donations, n=210 bags (NP grouping, carried out at the level of the reception structure), the median age is 23 ±5.19 years, group O represents 41%, group A: 35 %, group B=16% and group AB:05%.
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PMC9960565
The metallodendrimers may even interact with DNA through other interactions (different from those used by free cisplatin), including electrostatic ones, leading to conformational changes and DNA helix disruption.
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PMC11684821
Across our study, TRAJ42 was paired with 10 different TRAV genes, giving an overall motif of CAXYGGSQGNLIF (where X represents 3–5 amino acids), with a near central tyrosine residue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Across", "our", "study", ",", "TRAJ42", "was", "paired", "with", "10", "different", "TRAV", "genes", ",", "giving", "an", "overall", "motif", "of", "CAXYGGSQGNLIF", "(", "where", "X", "represents", "3–5", "amino", "acids", ")", ",", "with", "a", "near", "central", "tyrosine", "residue", "." ] } ]
PMC5417661
In order to study if NOV202 is a substrate for the Pgp/MDR1 efflux pump, the compound was evaluated in a pair of OC cell lines consisting of a drug sensitive parental A2780 and its multidrug-resistant subline A2780/Adr.
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PMC11317131
The donor plasmids each contain the DsRed fluorescent protein and hygromycin resistance genes.
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PMC11794568
Fig. 8CRIP1 inhibits proliferation and invasion of cutaneous melanoma cells by suppressing TFAM-mediated mitochondrial biogenesis. (
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PMC9429973
OS was not reached.
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PMC9111184
Permeability of cholesterol through Caco-2 ​cells in the absence and presence of hydroxycinnamic acid derivatives and Ezetimibe (%).
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PMC9429973
When stratified for response, it appeared that patients achieving CMR after DA-EPOCH-R had significantly higher CD3 T cells (p=0.04) at enroll than patients not achieving CMR.
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PMC9429973
C. Yang, C. Song, Z. Ge Department of Hematology, Zhongda Hospital，Medical School of Southeast University, Institute of Hematology Southeast University, Nanjing, China; Hershey Medical Center, Pennsylvania State University Medical College, Hershey; Division of Hematology, The Ohio State University Wexner Medical Center, the James Cancer Hospital, Columbus, United States of America Background: Acute Myeloid Leukemia(AML) is a highly heterogeneous blood cancer with poor outcomes.
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PMC5854676
In this experimental scheme, PEG-coated MgO conjugated with efficient photosensitizers were employed for cancer tissue island necrosis via ROS.
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PMC10170482
Insert visualizes the fiber cross-section.
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PMC11011020
Ovarian cancer, frequently diagnosed at advanced stages with existing metastasis, offers a distinctive and valuable opportunity for studying the tumour microenvironment.
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PMC10142392
The multi-armed polymers developed in this study exhibited a single transition temperature similar to that of the PMMA or PtBA homopolymers, likely due to the relatively short length of the PCL chains compared to those of PMMA and PtBA.
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PMC9429973
Eighty-three patients (70.9%) remain on treatment, while treatment was discontinued in thirty-four cases (29.1%).
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PMC10882807
Hsa_circ_0005397 might also be involved in other pathogeneses with various binding sites.
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PMC11723947
This observation suggested that the HP1γ-dependent epigenetic mechanisms that negatively regulate this gene network are already at work in activated T cells.
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PMC11726848
After LDR irradiation at a dose close to LD50, the fluorescence intensity of the probe increased four times (Figure 6C).
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PMC11666785
Reconstructed images along with enlarged 3D surface plots and intensity plots suggests a better background rejection for corrSMLM as compared to SMLM.
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PMC11040965
Tests included the Mann–Whitney U test for comparisons of groups, the Wilcoxon signed-rank test for comparisons of matched samples, Spearman’s rank test for correlations, and log-rank test for survival analysis.
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PMC11754436
The results demonstrated that FBXL17 (Fig. 4B) and NPEPPS (Fig. 4C) were expressed at low levels in OS tissues and had a high risk.
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PMC11534035
When the Hippo signaling pathway is switched on, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are phosphorylated and degraded.
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PMC9429973
Median duration from MM initial diagnosis was 5.2 years.
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PMC5535901
Cells were treated with I3C or DIM at different doses for 48 h and cell viability was assessed using CCK8 kit following manufacturer’s instructions.
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PMC11267036
MM is a plasma cell hematologic malignancy of bone marrow, which commonly triggers end-organ injury, including anemia, renal impairment, lytic bony impairment, as well as hypercalcemia .
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PMC11750696
However, if ER stress is excessive or persistent, these adaptive responses may fail, leading to cell death through apoptosis (24).
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PMC11674834
2,6-DMA is a very poor substrate for both NAT1 and NAT2, and 3,5-DMA is a preferential substrate for NAT2 versus NAT1 .
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PMC11589157
1Genomescope profile based on the HiFi reads (K = 21).
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PMC11300639
Since the mTOR signaling pathway is reported to regulate VEGFA expression and promote ccRCC angiogenesis and progression, we tested whether the mTOR signaling pathway is one of the key pathways mediating the cancer-related function of RNF26.
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PMC11806818
As shown in Fig. 5D, the prepared CuS/ZnIn2S4 is first fixed on the fluorine-doped tin oxide (FTO) electrode, which helps to generate a strong and stable photocurrent.
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PMC9817179
Adding 0.2% GA to 4% PFA does not reduce the fixation artifact.
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PMC9429973
Summary/Conclusion: In this updated analysis of LEPUS, D-Vd continued to demonstrate substantial efficacy benefits versus Vd in terms of PFS, ORR, and depth of response.
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PMC10366908
In many carcinomas, EGFR overexpression and its mutation are involved in sustaining proliferative signaling, which is an important hallmark of cancer .
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PMC11129910
Data of in vitro assays were obtained from three repeats of independent experiments, and statistical analysis was performed using Student's t-test (two-tailed).
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PMC11752767
CAR-T cells exhibit anti-tumor activity through various mechanisms, such as releasing granzymes and perforins to directly kill tumor cells or secreting pro-inflammatory cytokines like IL-2 and IFN-γ, which alter the tumor microenvironment and promote apoptosis and necrosis of tumor cells .
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PMC10926885
The top layer received media without serum, while the bottom layer received media containing 10% serum.
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PMC11604768
Across the population of TRE units, we observed a pronounced effect of the paired minimal promoter on baseline transcription rates, whereas the spacer sequences between TF binding motifs and the distance between the TRE unit and minimal promoter did not globally alter transcription (Supplementary Fig. 3).
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PMC10840195
Determination of the proliferation ability of SR-A498 cells overexpressing Twist by CCK-8 assay (A).
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PMC11742047
These effects are due to a multi-target mechanism mediated by different receptors and the modulation of signaling pathways involved in the hallmarks of cancer pathology.
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PMC9429973
Furthermore, we inhibited mitochondrial pyruvate carrier (MPC) to examine the metabolic compensation for mitochondrial pyruvate deficiency via Seahorse Substrate Oxidation Stress Test.
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PMC11322866
The abnormality of Lamin B1 in MM senescent cells (A) Lamin B1 protein level was measured by western blot analysis in RRM2 OE- or GSK126 (1.5 μM for 24 h)-treated MM cells. (
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PMC9429973
Combination therapy was continued until a complete response, defined as three consecutive PET-CT-negative and MRD-negative results 3 months apart.
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PMC10899471
These data revealed that miR-939-3p was significantly upregulated in sarcoma and was inversely associated with the prognosis of sarcoma patients.
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PMC10203589
In summary, FGF18 promotes EC cell progression.
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PMC9874064
Ubiquitin-specific protease 1 (USP1) is one of the most classical DUB proteins.
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PMC11740508
Other significant genetic variants in TM00091 and TM00089 are included in Supplemental Table 1, and it is possible that they may ultimately contribute to the definition of a more exact susceptibility signature.
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PMC11457557
The Smad-dependent pathway has been shown to regulate the expression of many miRNAs, such as miR-21, miR-29, miR-192, and miR-214.
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PMC10840195
The fluorescence area of the zebrafish tumour was photographed by capture software with a body fluorescence microscope; all figures were completed on GraphPad; and the tumour fluorescence area was measured by ImageJ software.
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PMC6627640
Despite high cure rates, a portion of metastatic TCGTs are resistant or develop resistance to standard chemotherapy regimens .
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PMC11656657
Notably, the Osteosarcoma and Alveolar Rhabdomyosarcomas subtypes exhibited the highest GD2 expression levels, while Ewing sarcoma showed the lowest.
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PMC11411004
ns, not significant vs. DMSO To investigate how I-4 affects the mRNA expression of recombinant ADM monoclonal antibody, we collected sample cells treated with 2 μM I-4 on day 7 of cell culture, as shown in Fig. 3.
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PMC11727000
This prompted us to take an unbiased approach to identify novel binding partners.
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PMC11742047
The high lipid clearance rate, when filtering by the coefficient of variation (CV > 20%) in HL-60 cells, shows high variability in biological replicates.
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PMC9429973
In the ASCEMBL primary analysis, asciminib had superior efficacy and better safety/tolerability vs bosutinib (BOS) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) after ≥2 prior tyrosine kinase inhibitors (TKIs).
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PMC6450504
Moreover, as supported by the cytotoxicity results, the PEIPOS do not interfere with the PTX mechanism of action.
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PMC11592008
After 24 h of incubation, the cell pellets and supernatants were collected for analysis.
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