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OTAR3088
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BioData-CellLine_annotated

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PMC11225860
1µM treated cells initially presented red and progressed to green at 8 hours.
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PMC10728200
The relative GSH/GSSG ratios were assayed.
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PMC9895440
Genomic DNA from these samples was extracted using the Qiagen Blood DNA mini kit, including a Proteinase K digestion step.
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PMC6901583
The BET family proteins (inclusive of BRD4 and others listed in the introduction) are targeted by small molecules targeting inflammation.
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PMC10588957
It must be emphasised that our focus was to explore the relevant mechanisms.
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PMC9509578
These nanoparticles are colloidal, biocompatible and biodegradable nanomaterials that entrap or encapsulate hydrophobic drugs such as cyclosporin, curcumin, paclitaxel and oxaliplatin in their matrices to improve their bioavailability in cells .
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PMC11759751
CD3+ T cells were then separated from the PBMCs using magnetic cell sorting (MACS) with CD3 microbeads (Miltenyi Biotec, Inc).
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PMC10547921
The microtubules, composed of α- and β-tubulin, are the main components of cytoskeleton.
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PMC9429973
Patient baseline characteristics are shown in the Table.
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PMC11499381
CGRP-responsive receptors comprise either CLR or CTR in complex with RAMP1.
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PMC10729469
For each of the immunohistochemical staining, six sections/slide were collected at eight intervals and were used for each of the experimental groups.
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PMC11703992
The colors indicate the sender of cell–cell communications, CD4+ T cells, and the edge thickness represents communication weight, and the arrow marked the communication direction Common characteristics of CD4+ Memory T cells in GCA and old samples.
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PMC11621493
Within the gastrointestinal tract, high expression was observed only in the stomach.
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PMC10743717
17β-HSD10 may also play a critical role in the control of mitochondrial structure, morphology and dynamics by acting as a member of the Parkin/PINK1 pathway, and by binding to cyclophilin D to open mitochondrial permeability pore.
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PMC9436459
Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants.
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PMC10999934
In addition, the IC50 of cisplatin in the control group was 2.060 μg/ml; however, the IC50 of cisplatin in the silenced FBXO2 group was 1.256 μg/ml for the SKOV3 human ovarian carcinoma cell line (Fig. 8C).
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PMC9429973
The most common treatment-emergent AEs (TEAEs) were nausea (60%), vomiting (52%), hypokalemia (48%), diarrhea (36%), and hypotension (36%).
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PMC10745221
The rightmost panel shows an anti-ADMA immunoblot with a 10 second exposure time.
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PMC9429973
Patients taking azoles, PPI’s, H2-receptor blocker, ATT etc.
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PMC11127909
F Degree of Ca2-mediated mitochondrial swelling in 143B-V, 143B-EFHD1, 143BR-shV and 143BR-shEFHD1 cells, N = 3.
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PMC9429973
At second serologic testing, at a median of 44 days after the booster, 80% patients tested positive, with a 67% rate of seroconversion, and 20% patients tested negative (Table 1).
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PMC11247842
NA means the variant is not significant in our analyses The SNPs near the lead SNPs of the QTL are potential causal variants.
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PMC8382973
The viability of the bacteria was determined by measuring the optical density (OD) absorbance at 450 nm, as described above.
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PMC11218145
Then, TB-treated cells were cultured in the presence or absence of the mevalonate compounds, GGOH and FOH.
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PMC11106977
These isoforms have 13.5, 9.5, and 2.5 (orange) TPRs, respectively.
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PMC11033180
Sema5A, Plexin A1 and Plexin A2 are expressed in enteric neurons in primary cultures of rat gut (A) Triple immunolabeling for Sema5A (green), Hu (red), and β3-tubulin (blue) at 12 days of culture. (
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PMC10854447
H NMR (400 MHz, δ ppm DMSO-d6): 8.81 (s, 1H, triazole-CH), 7.92–7.87 (m, 4H, Ar–H), 7.48 (d, J = 7.5 Hz, 2H, Ar–H), 7.40–7.35 (m, 3H, Ar–H), 6.28 (s, 2H, N–CH2), 2.38 (s, 3H, Ar–CH3).
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PMC11587606
Likewise, PKCζ was able to co-IP simultaneously with both importin β1 and RHBDF1 under these experimental conditions (Fig. 4C).
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PMC5854676
It was also observed that the cell viability decreased with increasing MgO concentration.
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PMC11703992
JUN and FOS transcriptomic factors are significant components of Activator Protein-1, which promotes inflammation mediator release and cytokine secretion.
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PMC9429973
Results were generally similar in unadjusted analyses (Table).
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PMC11252033
It was previously demonstrated that ASA is a non-competitive inhibitor of CryZ quinone oxidoreductases activity through the interaction with a binding site closed to that of NADPH (Trabert et al., 2014; Huang et al., 2016).
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PMC11534377
The orthotopic in vivo models confirmed the effectiveness of the treatment, showing a decrease in both tumor size and metastasis.
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PMC9429973
Methods: MagnetisMM-9 (start date: October 2021; estimated completion date: April 2025) is an open-label, multicenter, non-randomized phase 1/2 study.
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PMC10203589
The carcinogenic activity of FGF18 is closely related to various GC pathways and plays a prominent driving role in the occurrence of GC, with functions such as gene amplification or somatic mutation (44).
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PMC11768927
They concluded that both the VSV WT or M51R mutant M protein could cause autophagy-induced cell death by increasing Beclin-1 expression.
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PMC11637276
Preliminary screening of MAPK inhibitors was performed in serum-free conditions to assess ECM-specific contribution and avoid MAPK activation by growth factors found in serum ; other assays were performed in 5% FBS.
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PMC11740207
The retained SC continues to divide and differentiate into germ cells, while the daughter cell begins differentiating into more mature forms of germ cells, such as oogonia in females or spermatogonia in males.
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PMC11351758
The activity of the mitochondrial reductase to convert soluble tetrazolium salt into an insoluble formazan precipitate was measured using an enzyme-linked immunoabsorbent assay (ELISA) reader (A-5082; TECAN, Grödig/Salzburg, Austria).
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PMC9884169
Regarding the inhibition of autophagy caused by siMCT4in 5637 cells, although no study has reported that siMCT4 can cause inhibition of autophagy, it has been reported that tumor hypoxia and acidosis are the main features of the bladder tumor microenvironment (TME) .
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PMC11701801
The number of cleaved PARP–positive cells within the total number of viable cells per slide was evaluated, and the mean number of positive tumor cells in three high-power fields (×400) within a hotspot of the tumor tissue was reported.
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PMC11583010
The DAR according to LC/MS analysis was 3.79 toxins per conjugated mAb.
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PMC11607321
Cai, Z. (2023) BioRender.com/m96b457.
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PMC9429973
Aims: Aim of the study is to evaluate efficacy and safety of MEK-inhibitor (cobimetinib) in eight pediatric BRAFV600e-negative refractory LCH patients.
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PMC10589262
Western blot analysis showed that BFA dramatically reduced phospho-KIT, phospho-AKT, and phospho-ERK levels, indicating that ER-retained MT-KIT was insufficient to activate downstream signaling (Fig. 2A).
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PMC10507284
The relative quantitative comparison of wound width of the wound healing assay (n = 3 for each group).
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PMC10823017
These data suggests that the combination of BYL and ICA-1 brings a notable alteration in the level of c-Myc by deactiovationg its upstream effector Akt1 and ERK1/2.
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PMC11757230
By contrast, when cADSCs and LL cells were separated using a Transwell system, apoptosis was only induced in CLC cells, and the pro-apoptotic or anti-apoptotic effects of cADSCs were lost in the other LL cell lines (Fig. 2a–f).
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PMC10713411
The limma R package was obtained for screening out the differentially expression genes (DEGs).
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PMC11593031
Since then, it has been applied in over 10,000 studies and is used by the World Organization for Animal Health for the routine diagnosis of rabies.
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PMC10958426
The scRNA-seq libraries were sequenced on Illumina NovaSeq6000, instrument with pair-end sequencing and dual indexing according to recommended Chromium platform protocol.
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PMC11705547
The targeted drug release induced DNA damage in the tumor cells, activated the cGAS-STING pathway, and increased the infiltration of DCs and CD8+ T cells in the TIME, resulting in enhanced anti-tumor immune response .
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PMC9429973
References were screened at title/abstract and then full text by two independent reviewers.
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PMC7338939
Tumor volume was assessed every day on the basis of the following formula: Mice tumors and lungs were harvested.
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PMC9429973
Image: Summary/Conclusion: Adults with R/R B-ALL benefitted from KTE-X19, with manageable safety, regardless of prior exposure to blinatumomab or prior alloSCT, though survival appeared better in patients without these prior therapies and in earlier lines of therapy, with limited patient numbers in some subgroups.
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PMC11543935
With accordance to ISO 10993-5 standards, the material can therefore be considered as non-cytotoxic.
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PMC9429973
R. Li, Z. Liu, X. Chen, Q. Long, Y. Yang, S. Lin, J. Jia, G. He, J. Li Hematology, the First Affiliated Hospital of Nanjing Medical University; Hematology, the Second People’s Hospital of Nanjing, Nanjing; Hematology, the First Bethune Hospital of Jilin University, Changchun; Hematology, Zhejiang Province Hospital of Traditional Chinese Medicine, Hangzhou; Hematology, Peking University People’s Hospital, Beijing, China Background: Eltrombopag (E-PAG) plus the immunosuppressive therapy (IST) consisted by antithymocyte immunoglobulin (ATG) and cyclosporin (CsA) has been reported with better efficacy in both refractory and naïve severe aplastic anemia (SAA) patients than IST alone.
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PMC10094992
In this context, it has been reported that the subfamily of aldehyde dehydrogenase 1A (ALDH1A), that belongs to the aldehyde dehydrogenase (ALDH) superfamily of 19 isoenzymes, play a key role in the progression, maintenance and drug resistance of various tumours .
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PMC6771295
Cells were maintained in 10% FBS DMEM 48 h after transfection.
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PMC10291556
The extracts were cleared with centrifugation (12,000g/5 min), and protein content was determined using Bradford assay.
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PMC7602170
It is well established that mTOR can assist the integration of nutrient and mitogen signals into intracellular, thereby regulating cell growth and cell division; meanwhile, rapamycin, an mTOR inhibitor, inhibits cell growth and cell cycle .
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PMC11413393
Tumors were excised at endpoint and tumor fragments were snap frozen in liquid nitrogen and stored at −80 °C for further analysis.
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PMC9429973
In neonatal cases spontaneus regression is frequently observed.
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PMC6222726
Maldini et al. studied the methanolic extract of Bursera simaruba bark and isolated 11 compounds, including lignans yatein (17), β-peltatin-O-β-d-glucopyranoside (34) (Figure 3), hinokinin (1), and bursehernin (18) .
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PMC11604768
Furthermore, as exemplified by our Gαi-coupled GPCR activation experiments, certain biological responses will not be reflected by changes in the output of our synthetic promoters.
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PMC11777207
As with B7 mice, we saw fewer KikRed DCs in the dLN regardless of the subset evaluated (fig. S3).
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PMC11711127
Immunosenescence is marked by a gradual decline in the efficiency of the adaptive immune system, particularly in B and T cells, might contribute to inflammaging.
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PMC9429973
Severe AEs were almost all (8 of 9) related to the conditioning regimen: anemia G3 (2x), leukopenia G4 (2x), neutropenia G3 (1x) and G4 (1x), thrombocytopenia G4 (1x), febrile neutropenia G3 (1x), lactic acidosis G3 (1x).
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PMC11802855
R, S Subcutaneous xenograft tumors of mice in CXCL7-OE group and NC group.
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PMC10874773
However, some sesquiterpenes were found not to be neurotoxic but to have neurotrophic activities.
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PMC11525028
NAT10 protein levels measured in 5 matched pairs of osteosarcoma and normal samples (top) and NAT10 expression in osteosarcoma cell lines (bottom) by immunoblotting. (
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PMC9429973
Events were defined as progression during or after TCD therapy or death from any cause.
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PMC11705862
The AD-related neuroinflammation is defined as a chronic activation of glial cells, primarily microglia and astrocytes, and subsequent release of pro-inflammatory cytokines and chemokines, surrounding senile plaques and affected neurons in the brain .
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PMC6742971
We used the model of immunodeficient NSG-HLA-A2 mice that express a human HLA-A2 transgene (further referred to as NSG-A2 mice) to perform adoptive T cell therapy using our clones with defined avidity.
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PMC10530622
SLC26A6 is abundant in the small intestine, secreting oxalate into the lumen, while SLC26A3 in the colon facilitates oxalate absorption .
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PMC10734950
Here we discuss the effects of thiophenecarboxylate compound, F8, and its ability to induce cell death in multiple cancer cell lines.
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PMC11746948
Before trypsinization, the cells were incubated with C11-BODIPY (581/591) (1 μM) for 30 min at 37 °C.
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PMC9429973
All patients were in advanced stage (stage III-IV), and received a median of 7 lines of prior treatment.
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PMC11481779
To validate the model thoroughly, we have performed 22-fold cross-validation - creating 22 models, each with one chromosome excluded for testing purposes (see Methods).
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PMC11740399
The schematic diagram of 3025@ML is shown in Fig. 2A.
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PMC8701144
The observed increased potency of WNT/β-catenin signaling activation in HEK293 cells with native E1B-55k protein levels would be compatible with a scenario where the aggregation of central components of the β-catenin destruction complex in the E1B-55k clusters interferes with the destruction complex activity resulting in altered WNT/β-catenin signaling activation.
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PMC9429973
We determined that MYCT1 is a membrane-associated protein localized in endosomes, where it interacts with vesicle trafficking components and signaling receptors with critical functions in HSC biology.
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PMC6901583
Individually, BRD4, CD31, and CD68 antibody staining was performed with selected slides that were then analyzed by two experienced pathologists.
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PMC3164356
Care was taken to ensure that the cells were in a single-cell suspension.
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PMC11759751
The mechanism of enhancing CD19 CAR T cells after pretreatment with B-NHL by chidamide needs further investigation.
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PMC5839394
It is well established that cancer is a multifactorial disease caused by a complex mixture of genetic and environmental factors.
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PMC10808409
Our results revealed that IC50 of FA and TPGS mixed micelles formula significantly increased the expression level of CASP-3, with a more prominent effect of TPGS mixed micelles formula as compared to FA treatment.
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PMC6487404
In order to evaluate the viability of gut sac and any possible damage due to the sac preparation, the release of the cytosolic enzyme LDH was examined.
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PMC10743717
which underlies the conversion of ABAD from ERAB .
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PMC5925824
One-way ANOVA was used for statistical analysis.
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PMC8996378
Regardless natural or designed, some taxoids may be good regulators of MDR in cancer chemotherapy (Kobayashi et al., 1998).
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PMC11337594
The membrane was blocked in 5% BSA for one hour and then incubated with the target primary antibody (Table S1) overnight.
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PMC10759659
The expression data were downloaded from https://www.biosion.org .
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PMC11387401
To conclude, we constructed a new extensive HIV-1 protein–host RNA interactome across all HIV-1 proteins with several variants of the nRIPseq platform in two cell lines and HIV-1 infection states.
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PMC7987994
i.e., 50% and 25% extracts were used) and for ICP-MS measurement.
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PMC11792766
The solvents involved in the preparation should be miscible with water in order to be capable of forming a homogeneous solution involved in the exposure of the biological system and should not pose background adverse effect to the system during the investigation of the migrant chemicals toxicity.
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PMC11155445
Intramolecular hydrogen bond formation occurred between NH and carbonyl group oxygen and thus made the carbonyl group less reactive as compared to the thiocarbonyl group.
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PMC9960565
When comparing with pristine anionic PAMAM dendrimers (Figure S24), cisplatin-metallodendrimers showed a shift in the characteristic carbonyl stretching band from 1639 to 1631 cm¹ in the G0.5(COOPt(NH3)2Cl)8, 1633 to 1658 cm in the G1.5(COOPt(NH3)2Cl)16, and 1638 to 1647 cm¹ in the G2.5(COOPt(NH3)2Cl)32 (Figure S25).
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PMC9429973
Interestingly, NOTCH1 mutated PDX samples also showed higher BCAT1 expression compared to un-mutated cases.
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PMC9429973
Summary/Conclusion: In conclusion, our results suggest that SLIT2 has tumor suppressive functions in AML in vitro and in vivo highlighting the therapeutic potential with low cytotoxicity of SLIT2 in AML.
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