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PMC10858941
The efficacy of anti-tumoral treatments is not homogeneous throughout the tumour, and it is therefore essential to study their effects on the tumour mass, including all its niches.
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PMC11541409
Final overall survival (OS) analysis from the same trial (NCT03673501) showed that similar efficacy of mOS existed in the ripretinib group (35.5 months) and the sunitinib groups (31.5 months) for all patients.
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PMC11697703
See also Figures S1 and S2.
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PMC11271278
In LNCaP cells, WGS-identified breakpoints support translocations underlying the enhancer-hijacking events.
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PMC6163708
GLI2 has been identified as a target for the treatment of osteosarcoma and the HH pathway has been reported to be important for osteosarcoma progression and metastasis .
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PMC9429973
Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance.
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PMC11661040
CCK8 experiments following siRNA transfection demonstrated a reduction in osteosarcoma cell proliferation at lower levels of CGREF1 knockdown, directly proportional to the extent of knockdown (Supplementary Fig. 1 C, F).
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PMC11321678
After 35 days, the mice were harvested for subsequent tumor staining.
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PMC10114490
Such limitations can be overcome with proliferation-induced primary hepatocytes or iPSC-derived hepatocyte-like cells generated from such patients; still, it requires isolation and culture of patient hepatocytes which is ethically and economically challenging .
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PMC11696576
cPLA2α inhibitors are shown in red.
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PMC7570809
Determination of caspase-3 activity was performed by a fluorometric assay based on the proteolytic cleavage of the carbobenzoxy-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin (Acetyl-DEVD-AFC Alexis Biochemicals, San Diego, CA, USA) as described elsewhere .
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PMC11707577
The phage‐templated 1D‐TNP showed photocytotoxicity at picomolar concentrations, and the ability to deeply penetrate 3D spheroids and Hydra tissues.
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PMC10362265
Akin to the YLDV tetramer, the interfaces in the human tetramer were stabilized by other contacts than disulfide bonds.
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PMC11394730
Regarding the in vitro tests, the precise mechanism of action remains to be determined.
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PMC11129910
RAB25 was successfully downregulated in HMEC 5.6 and 2.6 cell lines compared to the parental HMEC 5.6 and 2.6 cell lines (Figures 1(a) and 1(b)).
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PMC8009078
Hence, optimization and/or different conformation analyses can form potential interactions with the catalytic triads.
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PMC10568263
Finally, the as-obtained precipitates were dried at 60 °C for 12 h for later use.
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PMC7338939
According to our results, we suggest that CSNK2A3 may play an important role in providing balances between Notch and Wnt pathways.
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PMC9429973
Median age was 71 years (range, 65–87), 65.6% of pts had low/intermediate simplified MIPI, and 8.6% had blastoid/pleiomorphic histology.
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PMC10808409
The reduction in the particle size due to the increase in the total Pluronics mixture (X1) together with the increase in the Pluronic P123% (X2) may be due to the increase in the total Pluronics which could lead to a higher micellar layer due to the larger surface active agent layer leading to a reduction in the micellar aggregation, and thus and a decrease in the particle size.
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PMC9429973
Aims: Determine MAGE-C1 gene expression by real-time polymerase chain reaction (RT-PCR).
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PMC9429973
However, at phylum level, an increase in Proteobacteria, a common feature of gut dysbiosis, was observed in stool samples from patients with stage Binet C compared to stage Binet A (p=0.042), and in oral samples with del11q compared to samples with no del11q (p=0.021).
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PMC11543885
For further information and requests for resources and reagents, please contact the lead contact, Professor Benedikt Kessler (benedikt.kessler@ndm.ox.ac.uk).
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PMC11775197
Furthermore, alterations in this pathway, such as APC /β-catenin mutations, can increase PPARβ/δ activity.
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PMC10900886
Gating strategy to determine percentages of α2,3- and α2,6-linked sialic acid (SAs) BLCL.
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PMC5673060
If necessary, 5 additional STRING interactors were imputed to the networks to propose possible intact, but not measured, systems.
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PMC11682172
We have demonstrated that direct cellular contact between activated T lymphocytes and breast cancer cells is crucial for enhanced BBB transmigration, which corresponds to the increased development of brain metastasis observed in breast carcinoma.
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PMC11185260
The SMARCB1 expression plasmid, pSCMV-SMARCB1 contains a 1.4-kb human wild-type (wt) SMARCB1 cDNA under the control of the cytomegalovirus (CMV) promoter, followed by the simian virus 40 (SV40) polyadenylation signal.
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PMC11763111
D Bioluminescence imaging (BLI) results of tumor burden.
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PMC10551595
The IC50 for each cell line is presented in Table 1.
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PMC11597291
In the case of nCGO-4armPEG(10 kDa) particles, a burst effect occurred at pH 6.0, with a 50% release in the first hour.
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PMC11687663
The drug membrane permeability (P) is calculated as the ratio of the drug flow (J) through the membrane to the difference in drug concentrations between the donor (outside) and acceptor (inside) compartments, expressed as P = J/ΔC .
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PMC9509578
These nanomicelles upon irradiation with NIR light generate higher levels of ROS, thus decreasing P-gp activity, leading to improved, higher concentrations of intracellular drugs and further cell apoptosis.
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PMC11525028
ac4C modification is catalyzed by the NAT10 enzyme.
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PMC11764090
GmbZIP44, GmbZIP62, and GmbZIP78 play a negative role in ABA signaling by up-regulating ABI1 and ABI2 proteins, inducing genes like ERF5KIN1, COR15, and COR78 for salt and cold tolerance in transgenic plants .
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PMC9429973
Furthermore, in vivo differentiation of CD34 positive cells into B-cells was almost completely abrogated upon LPIN1 KD.
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PMC9429973
No anaphylactic reactions have ever been reported due to transfusion of AP stored in PAS.
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PMC11727306
This behavior, except at high concentration, is contrary to the effect on other cell types.
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PMC7057940
On the other hand, when performing two rounds of amplification using two sets of EWS-FLI1 primers, the detection of the EWS-FLI1 fusion gene was possible in the A673 cells and the two patients (Fig. 3C).
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PMC10758402
Several preclinical studies have used oral DMF as a monotherapy for cancer with favorable findings (28, 29).
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PMC8140214
The data arepresented as mean±SD and analyzed usingone-way analysis of variance (one-way ANOVA) followed by Tukey’s multiple comparison test.
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PMC9429973
Summary/Conclusion: Our single center study results can give a ground to assume the potential role of the chronic inflammation and the pathogenetic impact of the circulating inflammatory cytokines on the MPNs clinical features and course.
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PMC10955424
The RAS-mitogen activated protein kinase (MAPK), which assists in cell survival, can also be induced by PGE2 .
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PMC11615101
The GO enrichment of the biological process indicated a major histocompatibility complex (MHC) class II protein binding complex, while cellular component enrichment indicated extracellular exosome and secretory granule by the associated proteins (Figure 4B).
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PMC9080589
The following antibodies were used: anti-PCDH8, anti-E-cadherin, anti-N-cadherin, anti-vimentin, anti-Bcl-2, anti-Bax, anti-LC3BI, anti-LC3BII, anti-p62, anti-β-catenin, anti-cyclin D1, anti-c-Myc and anti-GAPDH.
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PMC10006224
To generate STAG1 and STAG2 KO cell lines, viruses were produced through transfection of 3 × 10 293T cells with 9 µg of lentiGuide-Puro (Addgene, #52963) containing guides for STAG1 or STAG2 (Supplementary Table 6), 5 µg of psPAX2 and 2.5 µg of pMD2G in Gibco Opti-MEM I Reduced Serum Media with Lipofectamine 2000 Transfection Reagent.
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PMC11055323
We found the occupancy of H2AK119ub modification and SUZ12/PRC2 decreased and BMI1/PRC1 increased at the sites with dynamic changes of H3K27ac/me3, except for just a few genes, like NKX3-2 (Supplementary Fig. 11e-g).
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PMC9429973
All patients underwent high doses of corticosteroids.
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PMC11700340
Linagliptin Linagliptin, obtained from Samarra Pharmaceutical Factory, was utilized as raw material.
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PMC11703896
While the in-silico analysis in the current study supports rapamycin’s stable binding.
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PMC11590870
Due to their high antioxidant activity, plant-derived peptides are among the most recently studied molecules as an alternative for the treatment or prevention of cancer.
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PMC11078693
All materials used in this protocol are commercially available in the United States and their information is provided in the key resources table.
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PMC8992508
The MDR phenotype is often linked to the overexpression of transmembrane efflux transporters.
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PMC9429973
Aims: The main objective of this study was to explore the impact of mutations in myeloid-related genes in TKI resistance and progression to AP/BC by targeted deep-sequencing (TDS).
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PMC10759659
ARID1A mutations occur in approximately 7% ~ 17% of HCC [8, 12–14].
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PMC11714165
The in vivo imaging system (IVIS) imaging and quantitative analysis were performed after incubating the artificial bone slices with NBD, NBD‐F, and DN‐F, respectively.
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PMC11791203
Albaayit et al. investigated the growth inhibition (IC50 = 47.1 ± 6.1 µg/ml) of the NCI-H460 cell line induced by an ethyl acetate extract of Clausena excavata through apoptosis.
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PMC11566417
a (i) Relative chemotaxis as a percentage of the control of neutrophils cultured in primary and immortalized p10 and p20 MDEC CM.
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PMC11172027
An increased concentration with 200, 250, and 375 µg/mL NASeLM showed no further inhibition.
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PMC11588085
In addition, XIST KD may increase CSCs in ovarian cancer cells based on our finding of a higher stemness index in ovarian tumors with low XIST expression (Fig. 1C).
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PMC10154881
In the B16/N4 model, although statistically not significant, there was a trend toward increasing IFN‐γCD8 T cells in rMV‐SLAMblind‐treated mice (Figures 3F,G, and S1E,F).
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PMC11188874
Fluorescence was measured using a Molecular Devices Spectramax plate reader.
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PMC11544771
In 72 h or 5 days, cell viability or cell proliferation was evaluated by the MTS assay (Promega, Madison, WI, USA) or cell counting, as described previously .
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PMC10873328
The relationship between classifiers and chemotherapy response and underlying pathways were detected by GSEA, CellMiner and CIBERSORT algorithm, respectively.
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PMC10523483
Overall survival curves of 176 lung cancer patients underwent chemotherapy as analyzed by KMplot.
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PMC11045125
D. Tumors were paraffin-fixed and H&E staining performed to examine tumor morphology and IHC staining performed to examine expression of the germinal center B cell marker, CD10.
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PMC11322866
In most cases, ERK1/2 is a regulator of cell proliferation; however, it can also promote senescence [ 40‒ 42] .
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PMC11696576
Among them, cytosolic Group IVA PLA2 (cPLA2α) plays a critical role in the release of AA and is the most well-studied PLA2 in inflammation.
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PMC9812014
Mosquitoes, especially Culex pipiens, are the major carriers of the virus .
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PMC7090062
P < 0.05 vs. NC; P < 0.05 vs. miR-30a inhibitor.
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PMC11706776
The “R2: Genomics Analysis and Visualization Platform” website provides free access datasets from patient biopsies.
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PMC11705862
The staining revealed a widespread expression of both IRIS-1 and IRIS-2 in cortex and hippocampal subregions including the hilus and the CA1/subiculum (Fig. 1A, B), CA2 and CA3.
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PMC10976516
Intriguingly, the first clinical observations of occasional viral infections that lead to partial and sometimes complete tumor regression in cancer patients date back more than a hundred years.
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PMC2944824
Neither staurosporine nor tunicamycin increased the percentage of fragmented nuclei in wild type MEF expressing Hr.
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PMC11190062
Myeloma patients suffer from frequent infections, and their cancer cells may express a broad range of TLRs.
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PMC11476004
Differences were observed in the frequency of DNA fragmentation (%T DNA) between individual dogs in both breed B1 and B2 within the groups of healthy and sick dogs (Supplementary Material Table S1).
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PMC11658074
c, d Quantification of PKH26 and CD151 fluorescence in the AT-EV group and ADSC-EV group.
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PMC11679033
Our study, which is rather descriptive, cannot provide definite answers to questions about specific mechanisms that could be considered responsible for the observed antiproliferative effects on lymphocytes, primarily due to limitations of the experimental model applied and the methods used.
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PMC11551844
After derivatization, the vial was dried under nitrogen at 60 °C and then reconstituted in n-heptane before GC-MS analysis.
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PMC11337594
A375-Control/GSDME-KO cells were treated with different doses of TER (0, 1.0, 2.0, and 3.0 µg/ml) for 24 h, after which LDH release was determined (n = 4). (
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PMC9688728
Increased enrichment values for amino acids, monosaccharides, and dicarboxylic acids are in good agreement with the features of the method used.
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PMC11680578
This combination treatment also results in an enhanced population of cells in the sub G0 phase and a decrease in the G0/G1 phase compared to the control group.
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PMC11740573
After 24 h, 48 h, and 72 h of further incubation at 37 °C and under 5% CO2, cell supernatants were collected and used for estimation of secreted cytokines.
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PMC10607604
We previously reported the first evidence that PTPN13 negatively regulates tumor growth in human breast cancer cell lines .
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PMC11638288
Activated ILC1 cells via the NKp46 signaling pathway promote the proliferation of pathologically relevant macrophages.
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PMC11585565
Briefly, total RNA was isolated from a HEK293 cell line using RiboEx (GeneAll).
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PMC11509224
These two amphilectane-type diterpenes, 8-isocyanato-15-formamidoamphilect-11(20)-ene and 8-isothiocyanato-15-formamidoamphilect-11(20)-ene (215–216, Figure 17), were isolated from the sponge Stylissa cf.
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PMC10932641
It is typically inhibited during adulthood but can be reactivated during organ injury and regeneration (36).
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PMC7612475
Intriguingly, unlike the other Rad51 paralogs, XRCC3 has been recently shown to be important for the restart of stalled replication forks (36).
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PMC11531735
The data presented here indicates that ER121 is a promising therapeutic candidate for HER2-positive breast cancer, particularly in cases where conventional treatments like Herceptin or antibody-drug conjugates exhibited limitations or adverse effects.
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PMC8316344
We found that knockout of TRIB2 upregulated while overexpression of TRIB2 downregulated TFRC protein expression in Bel-7404 and SK-Hep1 cells (Fig. 5A, B).
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PMC11721064
Antibody information is provided in Additional file 2: Table S2.2.
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PMC11752740
Recognized as a rich source of antioxidants, pistachio hulls offer easier accessibility and fewer side effects than traditional chemical drugs [27–29].
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PMC11672881
The cell viability was assessed using the Alamar Blue assay, which evaluated cytotoxicity induced by various agents.
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PMC11472639
One-way repeated measures analysis of variance (ANOVA) were performed to determine main effects of time (pre-, post-, 30-min post-exercise) for immune cell populations – including NK-cells, monocytes, B-cells, and T-cells.
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PMC11714165
Fluorescence spectra of NBD‐F and DN‐F in deionized water.
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PMC11753949
COS-7 cells expressing this construct did not stain with phalloidin and lacked SALs.
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PMC11543853
k, l Virions and empty particles in the cell cytoplasm.
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PMC9429973
The primary objective for phase 1 was to determine the recommended phase 2 dose (RP2D) and the primary objective of phase 2 was overall response rate (ORR); secondary objectives included duration of response (DoR), progression-free survival (PFS), overall survival (OS), safety and tolerability, and pharmacokinetics.
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PMC11703992
The co-expressed proteins, including CXCR3, CDK4, BCL2 and STAT3, mainly regulate the proliferation, differentiation and apoptosis of T cells, promoting the immune response in GCA.
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