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PMC11770199
Dox-induced mMSCs-tet-p14 treatment exhibited significant suppressive effect on tumor growth as early as 9 d after treatment and reached a 73.3% inhibition ratio by day 17.
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PMC3730428
However, dimerization of procaspase 8 (a prerequisite for its activation) at these complexes can be inhibited by FLIP.
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PMC11459296
Historically, humanization efforts have used two main approaches: (1) engraftment of immunodeficient mice with CD34+ hematopoietic stem and progenitor cells (HSPCs) from cord blood (CB), bone marrow (BM) or fetal liver (FL) or (2) the use of peripheral blood mononuclear cells (PB-MNCs).
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PMC9429973
The outputs were then uploaded on the Vidjil plateform for IGHV clonal analysis.
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PMC7987994
Thereafter, 100 µl of the cell suspension was seeded into a 96-well plate, which means the seeding density of 1 × 10 cells per well.
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PMC11047729
In a study on mononuclear cells from normal peripheral blood (PBMC), HL-60, and CD34+ cell lines, the mechanism of the TSY-1 effect on telomerase was investigated.
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PMC9429973
Summary/Conclusion: In the treatment of acute myeloid leukemia in adults, overweight and obesity were associated with decreased complete response rates.
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PMC11756937
When ReLeSR was used, the colonies were detached by the addition of 1 mL of mTeSR1 and manual tapping on the sides of the plate.
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PMC11633763
It is still unknown whether β‐catenin can be stabilised by other deubiquitinases, which has sparked our interest in further exploration.
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PMC10530622
Oxalate dysmetabolism has been associated with several cardiometabolic diseases, which can be related to common pathogenesis/AOPs and/or to common risk factors.
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PMC9429973
What is more, the expression of TMEM244 in the blood can differentiate Sezary syndrome patients from those suffering from benign erythroderma or other types of CTCL.
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PMC9429973
Aims: To evaluate the ED rate and causes of EDs in newly diagnosed APL patients Methods: We retrospectively analyzed adult patients (≥18 years old) with newly diagnosed APL treated at MHH between January 2009 and December 2021.
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PMC9429973
A particularly interesting group with potential clinical utility consists of patients with underlying conditions that confer an increased risk of lymphoma and leukemia.
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PMC9429973
Median cycles in first line before transplant were 5 (IQR 4-6) and time from last cycle to transplant was 9 weeks (IQR 5-17).
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PMC9429973
High levels increase the risk of APS while deficiency, either congenital or acquired by the aPL, protects against thrombosis.
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PMC11321678
Clusters from the same subgroup shared similar specific chromatin accessibility.
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PMC11627060
This configuration readily binds with negatively charged drug molecules, resulting in significant alterations in the absorption spectra of the sample, effectively demonstrating that the drug binds to the protein base for the successful formation of drug-loaded nanoparticles (NPs) .
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PMC11543853
Rupture of endosome membrane, which depends on N-WASP-regulated actin polymerization, enables the diffusion of virions into the cytoplasm where additional particles release their genomes. (
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PMC9693627
We show that PTCD2 deletion selectively decreased translation of COIII mRNA and the activity of the respiratory chain complex IV (CIV).
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PMC11040965
Target and effector cells were incubated together in round-bottom 96-well plates in TexMACS medium at 37 °C in a humidified atmosphere containing 5% CO2.
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PMC6379402
That is, for a given cancer, our prioritized genes are the always-expressed genes that are the most rewired in the cancer iCell compared to the control iCell (most rewired first).
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PMC8041314
Concentration-effect curves of compound 21 (●) against ABCB1 (A and D), ABCC1 (B and E), and ABCG2 (C and F) as determined in calcein AM (A and B), pheophorbide A (C), Hoechst 33342 (D and F), and daunorubicin (E) assays using ABCB1-overexpressing A2780/ADR cells (A and D), ABCC1-overexpressing H69AR cells (B and E), or ABCG2-overexpressing MDCK II BCRP cells (C and F).
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PMC11509278
The cytotoxicity of nanopropolis to human breast cancer cells is greater than that of propolis .
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PMC11377827
Our approach of using a pooled DUB sgRNA library allowed us to unbiasedly screen for DUBs involved in the HIF response.
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PMC11569208
The covalent addition of a phosphate group by kinases triggers conformational changes to its respective substrate thereby changing its response, typically towards activation.
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PMC11774747
To mitigate these risks, strategies such as targeting CD30, which is expressed on both tumor cells and activated immune cells, including alloreactive T cells, have been explored.
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PMC10728200
Cells were treated with 100 μg/mL CHX for various time intervals after overexpression of STUB1.
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PMC9429973
I. Tonev, S. Simeonov, M. Ilieva, M. Muhtarova, R. Vladimirova, N. Andreinski, T. Yancheva, M. Guenova, M. MIncheff National Specialized Hospital for active treatment of hematological diseases, Sofia, Bulgaria Background: Trypan blue exclusion and flow cytometry were compared for testing of cell viability of hemopoietic stem cells (HSCs) cryopreserved at -80ºC. Stem cells were frozen and stored with 5% final DMSO concentration with different degree of cell packing.
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PMC11562028
As illustrated by the volcano gram of the transcriptome results, differentially expressed genes (DEGs) between the two groups were determined through the DESeq2 algorithm, predicated on fold change ≥2 and adjusted P value <0.05 (Fig. 5A).
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PMC11708541
We attempt to provide valuable insights that will contribute to further progress in the synthesis and utilization of aminopyridines in various fields.
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PMC6160470
Several naturally occurring potassium ionophores (e.g. salinomycin) were shown to inhibit P-gp effectively.
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PMC9516447
Table S1, Supp.
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PMC9429973
154 Covid PCR positive patients were randomly selected and their data in relation to age, sex, FBC parameters, CRP, D dimers, blood picture findings and days of hospitalization were obtained from the hospital records and entered into a data extraction sheet and statistically analyzed using SPSS version 20 and Pearson’s Correlation with a P value of <0.05 considered statistically significant.
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PMC11727145
This aspect, observed in situ with the burn wound model developed with DEDs and burn wound exudates, could help to evaluate different therapeutic cell topical delivery protocols for burn patients.
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PMC11803918
Compared with other exosome types, γδ-T exosomes offer unique advantages.
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PMC9429973
Methods: We included in the study all patients with MRC-AML or t-AML who were referred at our center from September 2019 to January 2022 and could be treated with CPX-351.
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PMC8996378
Other studies have reached similar conclusions (Yu et al., 2015).
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PMC6102174
Primary SARs study suggested that a long carbon chain (n > 8) in the amide alkaloids is helpful for the anti-HBV ability [56–58] (Fig. 11).Fig.
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PMC11786767
Nevertheless, our analyses using CDK1 inhibitors in the current study support that the cell cycle controls nuclear lipid distributions (Fig. 10).
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PMC11640419
The MILLIPLEX 7-plex Early Apoptosis Magnetic Bead Kit (Cat.
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PMC11764090
Plants can enhance seed germination through cold stratification .
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PMC11225860
This provides evidence that lower concentrations of alisertib can be used with Aurkin A combination to kill a cell population.
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PMC11687167
B Description of the production of PCSK9.
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PMC9429973
Questions covered topics such as disease impact on QoL, symptoms, disease complications, treatment goals, and treatment strategies.
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PMC11543885
After blocking, incubate the cells with 100 μL diluted anti-NLRP3 or anti-flag antibody (1:1000 dilution) and IRDye 800CW Streptavidin (1: 10000 dilution) for 16 h at 4°C.
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PMC11629461
A brief pulse of photodynamic action (1.5 min) with photosensitizer sulfonated aluminum phthalocyanine (SALPC 2 μM, 675 nm, 85 mW/cm) in NOX5‐CHO‐K1 cells, or with genetically encoded protein photosensitizer miniSOG fused to N‐terminus of NOX5 (450 nm, 85 mW/cm) in miniSOG‐NOX5‐CHO‐K1 cells, induces persistent calcium oscillations, which are blocked by DPI.
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PMC11634027
Polarity angles were plotted into a Rose plot using MATLAB.
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PMC11741906
These previous studies provide a detailed miRNAs profiling and further validated the expression changes for selected group in cisplatin resistant variant compared to the parental cell line.
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PMC10538569
As previously shown, after a single round of transduction, cells are double positive for GPI-scFv and GFP ( Figures 4A, B ).
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PMC11321678
These genes were extracted as putative TF target genes.
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PMC11591794
Many studies emphasize that flavonoids can be an important source of cancer treatment.
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PMC11718817
Extending previous work on tumor spheroids , a triple cell spheroid model of pancreatic cancer was generated by seeding three different, ex vivo generated cell types: tumor cells, CTLs, and macrophages.
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PMC11347429
Four genes showed different expression between these two ethnic groups and also exhibited genetic variations in cis (within or close to the transcribed region of the genes), suggesting that differences in expression level are caused by genetic differences ( Supplementary Figure S3 and Data file 14 ).
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PMC7553912
The expression of Col1a2, one of the ECM proteins related to fibrosis, was enhanced by OSM in the renal fibroblasts.
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PMC10976516
Thus intracellular aberrations that arise in gene expression or signaling pathways (such as RB/E2F/p16, p53, IFN, PKR, EGFR, Ras, Wnt, anti-apoptosis, or hypoxia) in cancer cells or tumor microenvironment have been studied and dissected with a variety of OVs such as adenovirus, HSV, poxvirus, VSV, measles virus, Newcastle disease virus (NDV), influenza virus, and reovirus.
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PMC6114978
All cells were cultured at 37°C and 5% CO2.
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PMC11806106
6H-F-Colenterazine was a kind gift of Dr. Wibke Diederich (University of Marburg, Germany) and was used as published previously.
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PMC11519077
1.5 mg/mL Collagenase Type I was used to digest adipose tissue pieces and was kept at 37°C for 45 min in a humidified environment with 97% humidity and 5% CO2.
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PMC9429973
The most common reasons for combination therapy were severe iron overload despite previous chelation therapy, followed by compliance or toxicity concerns.
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PMC8956657
Additionally, investigating functional variation within NLS regions among MERS-CoV and related merbecoviruses (including the bat merbecovirus HKU5) has the potential to identify altered interactions with nuclear import receptors with important consequences for host range, virulence and pathogenesis.
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PMC11360263
IE1/Nanog, IE1/Myc, and IE1/Nestin were concomitantly expressed in CTH, CTO, and CTP cells, respectively (Figure 3C).
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PMC11711127
Legoux et.
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PMC10055960
The dirhodium compounds 2–6 show a cytotoxicity that was greater than or comparable to carboplatin in the A2780 cell line; none of which, however, exceeded the cytotoxicity of cisplatin in this cell line.
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PMC11638255
Differential gene expression analysis used Seurat’s FindMarkers function and assumed negative binomial distribution of the data, with three conditions evaluated within groups of ROIs: treatment versus control; low-infiltration vs. high-infiltration (treated ROIs); treatment vs. control (infiltrated ROIs).
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PMC11638255
3 × 10 SK-N-BE(2)-C cells were seeded in a 24-well plate (Corning, USA; #3524) in 10% FBS/DMEM and counted daily over 48 h with matching media sampled for copper concentration using the QuantiChrom Copper Assay Kit (Universal Biologicals, UK; #DICU-250) according to the manufacturer’s instructions.
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PMC4112127
Re-expression of BMP3 in a biliary cancer cell line should therefore decrease cell proliferation and enhance apoptosis.
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PMC11672617
In order to gain a deeper comprehension of the impact of ionic compounds and hybrid molecules based on lithocholic acid, we conducted an in-depth analysis of the dissociation of the mitochondrial potential and the accumulation of ROS ions in mitochondria.
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PMC11438317
The data presented in this study support LYP regulation of T cell activation through dephosphorylation of TCR signaling proteins such as SKAP1, SKAP2, SLP76, FYB, Vav, and HS1.
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PMC8735881
The infected cells were extensively washed with Hanks’ balanced salt solution (HBSS) and then cultured in complete DMEM.
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PMC11423992
The tumor volume was measured with calipers and calculated according to the formula: 1/2 × maximum length of major axis (L) and maximum length of minor axis (W).
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PMC11411131
In summary, the second and subsequent Sec residues were processively inserted despite the inefficient insertion of the first Sec. These findings suggest a mechanism that controls the sorting of selenoproteins or non-selenoprotein synthesis at an early stage (Fig. 4G).
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PMC11525293
Fig. 2ΔNp63α and ACE2 parallel modulation at both protein and mRNA levels.
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PMC11576293
This study proposes that adding an aryl ring to the 2-TP ring at positions 4 and 6, which can form hydrogen bonds with proteins and nucleic acids, will modify the ring and result in antiproliferative properties.
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PMC9878278
Our previous studies collectively show that ZIKV titers in SC infected with both MOI 1 and 5 reach their peak at 48 h post-infection (hpi) and remain high till day 5 after infection (Siemann et al., 2017; Strange et al., 2019).
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PMC11785489
To annotate T cell states in a consistent manner across datasets, we conducted reference mapping with Symphony (v1.0).
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PMC10048572
Therefore, we decided to carry out the two-step analysis.
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PMC11422497
P < 0.05, **P < 0.01, na: no statistical significance.
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PMC11401350
From aged plck-GAPDH mice, which developed AITL lymphoma, we isolated the enlarged spleens and lymph nodes.
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PMC11354239
Notably, rituximab (RTX), a chimeric monoclonal antibody targeting the CD20 antigen on B cells, has dramatically improved the prognosis and the outcomes in various B cell malignancies such as non-Hodgkin lymphoma (B-NHL) and chronic lymphocytic leukemia (CLL) by depleting CD20-positive B cells .
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PMC11657744
Data are presented as means ± SD from three independent experiments.
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PMC11612794
Combined, we propose that the Dsn1 basic motif masks the binding surface of Mis12C for binding region 1 of CENP-T, and the mask is released upon phosphorylation, leading to the interaction between binding region 1 of CENP-T and Mis12C during mitosis.
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PMC4355729
The resulting lentiviral vectors containing the CTNNB1 and AKT shRNA were named shCTNNB1 and shAKT lentivirus.
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PMC11707577
On the opposite, the absorption peak at 383nm was blue shifted and increased in intensity in the M13EGFR(TNP), due to the formation of the amidic bond between the TM derivative and the amine groups of the M13EGFR phage (See Figures S6 and S7, Supporting Information).
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PMC9429973
Decreased expression of NKG2D (P<0.01) and a tendency of decreasing DNAM-1 (P=0.38) was found in CD56 NK in AML, recovering to values closer to normal in AML-CR.
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PMC6889484
Since the first 19 amino acids of Vif overlap with the C-terminal region of IN, substitution of DRMR with SEMQ changed the 5 terminal amino acids of IN from RQDAD to KRDAD.
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PMC10595704
They cannot be degraded; thus they can be continuously accumulated and able to worsen pre-existing disease states or increase sensitivity to them. •
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PMC7582629
Therefore, the PCA-SVM model was used to estimate the percentage of cell viabilities in the mixed population of all other test conditions.
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PMC11087766
The second mutated gene encodes a protein of unknown function, gp69.
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PMC11216402
have a higher expression (lower ranking) in GTEx normal stomach, whereas TWIST2 has a higher expression in ENCODE fibroblast and a higher expression (lower ranking) in GTEx fibroblast. (
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PMC10094992
Triplicate reactions were performed for each marker and the melting curves were constructed using Dissociation Curves Software (Applied Biosystems, Foster City, CA, USA), to ensure that only a single product was amplified.
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PMC11411131
Akiyama and colleagues chose reactive sulfur species as standards and revealed the cooperative effects of Cu and Cd on MeHg toxicity.
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PMC11790971
We investigated label-free multimodal nonlinear optical microscopy for non-perturbative profiling of biopharmaceutical cell lines based on their intrinsic molecular contrast.
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PMC11216402
Our sequence-based machine learning analysis revealed that most of the variation among the GC cell lines is driven by a fibrotic versus epithelial regulatory program differentially activated by a small set of TFs, most of which have not previously been directly associated with EMT in GC.
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PMC11098378
Thus, we sought to recapitulate a similar restricted arbovirus replication system as found in LD652 cells but in a human cell background.
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PMC11676674
Three separate and independent pools, each containing almost the same number of leaves (>10), in healthy condition, were prepared, containing at least 5 g of fresh weight material.
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PMC11638255
Non-relevant or less informative pathways were excluded from visualization to emphasize the most relevant findings.
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PMC11696576
The mean % inhibition of arachidonic acid (AA) release ± stdev at 1 µM is shown for each inhibitor as well as the calculated EC50 values with 95% confidence intervals (CI).
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PMC11704135
Through various mechanisms, these compounds affect tumor development and progression processes.
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PMC9841531
Compound 7, for example, has been assessed in two different assay systems (fluorescence-based vs radioactivity-based) revealing IC50 values between 1 and 85 nM—with almost 2 orders of magnitude difference.
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PMC11297139
Targeting both ARID1A and its PrLDs could be a promising strategy to restrict EWS/FLI1 from attaching to regulatory enhancers and prevent chromatin contact in the vicinity of oncogenes, making ARID1A PrLDs a potential therapeutic target for Ewing’s sarcoma.
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