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OTAR3088
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BioData-CellLine_annotated

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PMC10142392
The amphiphiles formed in this case are used as a basis for forming micelles in order to encapsulate hydrophobic drugs.
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PMC8382973
These data suggest that new drugs are needed for HIV prevention.
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PMC9429973
Immune phenotyping of his peripheral mononuclear cells (PBMCs) showed transient CD4+ T- and B-cell lymphopenia and reduced T-cell proliferation upon PHA and SEB stimulation.
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PMC10605143
These analyses confirmed that the control (WT and those expressing pLVX or shCTRL) MCF10A and MCF12A cells had different phenotypes: MCF10A were enriched in the luminal progenitor population positive for EPCAM and ITGA6 (EPCAM/ITGA6), while MCF12A cells exhibited the basal phenotype (EPCAM/ITGA6; Figure 4a).
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PMC5443223
Following phosphorylation, CEP164 is able to phosphorylate H2AX and CHEK2 (15).
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PMC10197932
In fact, in AML cell lines, high ROS can downregulate SOD and GSH content as well as Bcl- 2, while pro-apoptotic BAX protein is upregulated 55,56.
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PMC11366496
These multiple glioma cell lines U‐251, T98G, LN‐229, A‐172, and U‐87MG were cultivated according to relevant literature reports. , ,
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PMC11525028
Slides were then incubated with secondary antibody and visualized using3,3′-diaminobenzidine (DAB) detection.
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PMC11228511
Brightness and contrast were adjusted to enhance the visibility of the lamina meshwork using ImageJ. The meshwork was outlined using the “Overlay” tool with a paintbrush set to a width of 1 pixel.
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PMC9429973
Summary/Conclusion: Del(17q) was a recurrent marker in immature T-ALL of adults and characterized 19% of cases undetermined at molecular-cytogenetic level.
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PMC9693627
Almost all translational activators in baker’s yeast mitochondria interact with mitoribosome and/or mRNAs.
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PMC9545474
Diagram showing the four quadrants in the cell population plots; Q1‐UL=cells with elevated O2⋅; Q1‐UR=cells with elevated ROS+O2⋅; Q1‐LR=cells with elevated ROS; Q1‐LL=healthy cells.
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PMC9429973
Methods: Following ethical approval, patients attending the National Sickle Cell Disease and Thalassemia service at St James’s Hospital, Dublin, were invited to share an anonymous, online, 33-item survey within their local communities to achieve snowball-sampling.
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PMC11721295
Furthermore, apoptotic cell death increased in MRTX-treated lung sections compared with vehicle-treated sections.
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PMC3888431
It has also been shown that the k-mer value has a great influence on the results of the de novo assemblers.
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PMC10154097
circSOX4 was upregulated in HCC tissue and cell lines, and its level was correlated with reduced patient survival.
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PMC10362265
Overall, nine MD systems representing all known variants of IL18-IL18BP complexes were analyzed to address how the complex dynamics are affected by (i) different decoys, (ii) different hIL18 surface structures of the region between 68 and 81, and (iii) different oligomeric states.
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PMC9429973
When analysis was restricted to the patients in CML-CP (n=65), a median duration of FTF was calculated as 11.6 mo, while the 12 mo FTF rate was 46.8% (28.9-62.8%).
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PMC11806106
First, a pcSYFP2-C was cloned amplifying the sYFP2 (mVenus (L68V)) ORF from pmVenus(L68V)-C1, which was a kind gift by Joachim Goedhart.
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PMC7519871
3D and (B) 2D poses of BA with Nuclear factor kappa-light-chain-enhancer Protein of activated B cells (NF-kB) PDB ID: 2RAM.
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PMC8662250
Although CBD's well‐known anti‐inflammatory and immunoregulatory activities have candidate it as a potential drug in the treatment of acute respiratory distress syndrome (ARDS) following COVID‐19 infection (Bifulco et al., 2021; Nagarkatti et al., 2020), it is a possible protective effect, as well as the role of SARS‐C...
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PMC11015054
HCC METTL5 expression analysis: Based on immunohistomicroarray analysis of METTL5 expression in 80 patients with HCC, different clinical stages (TNM staging, grading, and staging) were analyzed using the Kruskal–Wallis test.
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PMC11574271
Mice without BMS-777607 treatment served as the control.
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PMC6600592
All solvents and reagents were analytical grade.
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PMC11119602
This difference in molecular weight is due to a TG2-L-associated GTP-binding domain, which is absent in TG2-S. Thus, TG2-L can legitimately be termed a ‘small’ calcium-dependent G-protein that acts as a molecular switch inside cells.
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PMC9844987
CAGE gene expression values across cell types were obtained from the FANTOM5 project (FANTOM Consortium and the RIKEN PMI and CLST (DGT) et al., 2014).
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PMC10507284
After 48 h of incubation, cells were cultured using 50 μm EdU reagent (diluted with DMEM containing 10% FBS at 1:1000) for 2 h at 37°C.
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PMC11486946
10 compounds (except auranofin) suppressed the EGF-dependent decrease in MSD (d), and 7 compounds reduced MSD regardless of the EGF concentration (e).
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PMC9429973
Results: Compared to baseline, patients had significantly fewer number of VOCs at 24, 48, and 72 weeks following L-gln therapy (median change from 3.0 to 0;p<0.00001).
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PMC10317042
Treatment began when all tumors became palpable.
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PMC11380329
Afterwards, we investigated the in vitro antiproliferative potential of the different types of P against human ovarian cancer cell line supplemented or not with vitamin D in order to mimic the internal environment within the body and maintain a relatively similar biological condition to evaluate the efficacy and the cy...
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PMC11700165
Cells were transfected with the plasmids, and after 24 h, a suspension of the transfected cells was placed in both wells of the silicon-insert, and incubated for additional 24 h at 37 °C and 5% CO2.
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PMC9429973
Results: The a-KO animals demonstrate a worsening phenotype, paradoxically showing elevated hematocrit, high reticulocyte count and a high number of red blood cells (RBC) which expressed only b-globin chains (HbH).
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PMC9429973
One hundred and five peripheral blood (PB) samples were collected in EDTA tubes at days +1, +7, +14, +30 (10, 31, 33, and 31 samples, respectively) after CAR-T administration.
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PMC11806818
In addition, the exosomes on the separation column require a large amount of buffer solution to elute, resulting in a relatively low concentration of collected exosomes.
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PMC10878518
After 1 week of culture, normal fibroblasts have grown.
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PMC10170482
Densitometric quantification of the bands’ intensity was done utilizing the GeneTools quantification software (Syngene, Synoptics Group, Cambridge, UK).
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PMC7053076
Neoplastic cells are able to develop many different mechanisms of MDR, such as DNA mutations, cell metabolic changes and very often, overexpression of ATP-binding cassette (ABC) transporters and activation of the nuclear factor κB (NF-κB) [2–4].
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PMC7192625
It should be noted that distance preserving randomizations return very high values of expected ChAs in the neutrophils (0.66), due to a strong linear correlation in RT values.
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PMC7685376
To further investigate the correlation of MCM levels with the survival of HCC patients, we searched the GEPIA database that contained 160 normal liver tissue samples and 369 HCC tissue samples.
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PMC8358006
As per previous study, AP1 can exert its oncogenic and antioncogenic effects by regulating genes involved in cell proliferation, differentiation, apoptosis, angiogenesis, and tumor invasion.
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PMC9919300
Palmitic acid and oleic acid were bought from Starlab S.r.l. (
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PMC11684269
Similarly, TEPP-46 can hinder the differentiation of both Th1 and Th17 cells, thus attenuating autoimmunity (30).
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PMC9429973
Results: Twenty patients, 11 (55%) female, with a median age of 61 years (range 44-77) were identified.
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PMC11126803
When we used ER-specific inhibitors, the key molecule ERβ could be effectively blocked, tumor growth and diffusion were partially reversed also (Fig. 6, A–E).
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PMC11585994
Future research should investigate its long-term effects and explore its utility in combination therapies to further enhance its therapeutic impact.
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PMC11509309
The yeast strains form white colonies when they contain [PSI+] or [URE3] prions, whereas they form red colonies when the [PSI+] or [URE3] prions have been eliminated.
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PMC11783017
In situ 143B OS tumor models were established using Balb/c nude mice (5–6 weeks).
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PMC10823017
Both the Caki-1 and 786-0 cells show a significant reduction of c-Myc (P<0.001).
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PMC9895440
Recently, ex vivo models have been developed using human tumor explants, which preserve many important features of the tumor microenvironment and mimic patient response.
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PMC11013014
C NMR (101 MHz, CD3OD); δ (ppm): 195.8, 168.8, 157.2, 155.5, 150.1, 136.7, 133.5, 131.7, 130.3, 128.8 (2C), 128.5, 127.0, 122.5, 119.2 (2C), 111.4, 68.0, 39.5, 38.8, 23.0, 19.3, 11.5.
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PMC11413393
Protein concentrations were determined using the PierceTM BCA Protein Assay Kit according to the manufacturer’s instructions.
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PMC11684297
In a recent study, inorganic hybrid nanoflowers, which included ZnO-NFs impregnated with collagenase, were explored for their antiamyloid activity .
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PMC9325715
These cell lines were cultured in 75 cm flasks at 37 °C and 5% CO.
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PMC11721295
Single-positive cells were related, and double-positive cells were classified.
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PMC9429973
Methods: Thirty-seven MM patients were studied, of whom 22 were at diagnosis and then all 37 at relapse before lenalidomide-dexamethasone treatment (RD).
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PMC11597167
BACE1 activity is regulated by factors such as subcellular localization, post-translational modifications, and interactions with other proteins.
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PMC11698348
In HF SCs, a significant increase in the total number colonies being formed was observed after loss and gain of Elf5 activities compared to control SCs.
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PMC10344560
Since there was a sign of fluconazole resistance, fluconazole IP was switched into oral voriconazole, without any antimicrobial treatment intraperitoneally.
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PMC11754291
Statistical differences between a condition (i.e., day and light treatment) and its respective sham are marked by asterisks (* for p < 0.05, ** for p < 0.01, *** for p < 0.001).
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PMC11576293
All test compounds were characterized by having 3 to 5 H-bond acceptor atoms, these centers helped in H-bond formation and therefore enhanced water solubility.
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PMC10565698
Fig. 5Effect of miR-211-5p on tumorigenic properties of liver cancer cells.
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PMC11754432
Inhibition of EGFR activation increased STAT1 phosphorylation and in turn increased transcription and secretion of CCL2, CCL5 but reduced CXCL8.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", ...
PMC9429973
The omission of RT in patients with Deauville 5-point scale score (D5PSS) 4 often causes anxiety to the treating physicians, while handling of patients with D5PSS5 is controversial (RT vs high dose chemotherapy and autologous stem cell transplantation).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
An 87% indicated that when the percentage of resistance of A. fumigatus against an azole is ≥10% (as per the IDSA and ECCMID guidelines), a change should be made in the choice of early treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784
f Reaction pathways of DNP1-based computation in target cell microenvironment.
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PMC11502327
By comparing the free curcumin with the NLCs loaded with curcumin, it was found that NLCs loaded with curcumin can induce the decrease of anti-apoptotic proteins such as Bcl-2, Mcl-1 and survivin, activate p38 MAPK to promote apoptosis and down-regulate the homeostasis of IL-6 in OC cells with superior efficacy.
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PMC10589262
Moreover, inhibition of trans-Golgi-to-PM trafficking did not affect MT-KIT downstream signaling in GIST.
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PMC10812665
In parallel, we observed a depletion of free CoA to <50% of control values, which indicates also a block of the TCA.
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PMC9341513
We find that in this case, the CCND1 promoter still shows interaction peaks across the CCND1 gene body, at regions downstream (in and around LTO1) and to a lesser extent, the H3K4me3 broad domain regions upstream.
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PMC11528603
If this is the case, AM compound in S. affinis could contribute to the apoptotic induction in SA-EA treated HL60 cells as we have demonstrated.
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PMC11678130
Representative images were obtained at T0 (before sample application on the CAM) and at T5 (5 min after sample application) on a stereomicroscope (Stereomicroscope Discovery 8; Zeiss, Oberkochen, Germany), containing a color Axio CAM 105-Zeiss, and were then processed using the ZEN core version 3.8 software.
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PMC7348793
The sequencing revealed that the three major amplification products contained the same 108 bp sequence tandemly repeated three, four or five times.
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PMC11705547
Cisplatin resistance can promote tumor cell proliferation and suppress CD8+ T cells by upregulating PD-1, rendering it less effective .
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PMC7887261
Germline DNA was sequenced utilizing NimbleGen VCRome 2.1 (Roche), and HumanOmniExpressExome (Illumina).
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PMC8839885
The FDA approved kinase inhibitors imatinib, ceritinib, gefitinib, ibrutinib, dasatinib and cobimetinib were obtained from CellChem Pharmaceuticals Inc. (Nepean, ON, Canada).
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PMC11092382
Natural products have played vital roles in pharmacotherapy.
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PMC9100622
Whole cell lysates were resolved by SDS-PAGE and transferred onto a nitrocellulose membrane (Bio-Rad, Hercules, CA, USA).
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PMC10926885
Finally, the colony formation experiment provided further evidence that the capacity of cells to proliferate was considerably decreased by NDE1 knockdown (Figure 10M,N).
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PMC9429973
Summary/Conclusion: Thus, for the first time, we revealed the involvement of Hh signaling pathway in the pathophysiology of mastocytosis and demonstrated the cooperative effects of the KIT and Hh oncogenic pathways in ASM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4816271
In summary, by modifying various elements of CAR design, incorporating an inducible suicide gene and DNA sequences which enhance, normalize and maintain transgene expression we have described here an optimized retroviral CAR vector to take forward to phase I clinical trial for neuroblastoma.
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PMC10734950
Consistently, all cells were cultured in a 5% CO2 humidified 37°C incubator.
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PMC11201989
The expression levels of target genes were normalized to the expression level of actin or GAPDH.
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PMC11172027
Colorectal cancer, bladder cancer, and skin cancer showed no cancer prevention with increased selenium levels .
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PMC10936243
Sometimes, they just tend to forget…” [D121].SOP are designed to provide a structure so that everyone in a specific practice knows what they are supposed to be doing for any given task.
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PMC11365427
Then, a real-time PCR reaction mixture was prepared, which included cDNA, gene primers, and SYBR Green, using a TAQ Pro Universal SYBR qPCR Kit (Vazyme Biotech, Nanjing, China).
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PMC10745221
For SDS-PAGE, the volume of sample applied was normalized to the protein concentration of histones measured using 3 μL of the histone fraction on a NanoDrop 2000c spectrophotometer.
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PMC11612794
Immunoprecipitation using anti-FLAG antibody in AID-based CENP-T conditional knockdown CENP-C/GFP-Dsn1 cells expressing 3xFLAG-CENP-T, 3xFLAG-CENP-T, or 3xFLAG-CENP-T. Cells were cultured with IAA for 12 h and nocodazole was added for last 10 h before immunoprecipitation experiments.
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PMC11756937
Gene expression was evaluated with a commercially available (Applied Biosystems) TaqMan Assay using on demand primers (OCT4: hs00742896_s1; SOX2: hs00602736_s1; NANOG: hs02387400_g1; GDF3: hs0020998_m1; REXO1: hs00381890_m1; PAX6: hs00240871_m1; NES: hs00707120_s1; TP63: hs00978340_m1; KRT14: hs00265033_m1; NOG: hs0027...
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PMC9429973
Decompensated liver cirrhosis (Child-Pugh B and C, ascites, jaundice, bleeding varices) was diagnosed in 35/76 patients (46.1%).
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PMC11787381
For each condition, 40 pictures per well were taken using ImageXpress (Molecular Devices) with 40x magnification.
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PMC8010066
Hence, in respiratory infections, resistance to carbapenem antibiotics in P. aeruginosa can provide a basis for the development and spread of co-infection with S. aureus.
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PMC11180402
Protein quantification was conducted using the NanoDrop (2000) spectrophotometer (Thermo Scientific, Waltham, MA, USA), followed by separation via SDS-PAGE and transfer onto polyvinylidene fluoride membranes (Bio-Rad, Hercules, CA, USA), ensuring precise protein analysis.
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PMC9429973
However, there is no evidence of the direct effect of IO on HSCs in BT.
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PMC11756514
Subsequently, the cells were washed twice before flow cytometry on a NovoCyte 3000 flow cytometer equipped with three lasers (405 nm, 488 nm, and 640 nm) and 13 fluorescence detectors (Agilent, CA).
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PMC2196094
One putative N-glycosylation site (Asn-X-Ser/Thr) is located in the COOH-terminal end of the protein.
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PMC11291490
n = 3).
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PMC11451940
The identified maxima/shoulders of the anodic and cathodic waves are summarised in Table S5 in the ESI.‡ Chemicals and solvents were purchased from commercial sources (Sigma-Aldrich Co., Acros Organics Co., Fluka Co. and Lachema Co.) and used without further purification.
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PMC10506676
According to studies conducted in Burkitt lymphoma cases, it is clear that EBV is involved in 90% of c-MYC gene translocations, which can cause the activation of this proto-oncogene, and subsequently, be involved in the development and/or progression of cancers (40).
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PMC11746948
Data are presented as mean ± SD.
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