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PMC10854447
These findings indicated that the type, position, and number of halogen atoms had a significant effect on antiproliferative activity, with activity increasing in the order 2,4-di-Cl > 3-Br > 3-Cl > 4-Br > 4-Cl > 4-F, Figure 4.
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PMC7351993
Finally, fluorescent labeling can lead to immunogenicity and introduction of xenobiotic compounds, such that human cells including human induced pluripotent stem cells (hiPSCs) and chimeric antigen receptor T (CAR-T) cells cannot be fluorescently labeled before in vivo use as cell therapies.
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PMC11721295
Material or data that require a Material Transfer Agreement (MTA) can be provided by the University of Michigan pending scientific review and the execution of an MTA negotiated by the university’s Office of Technology Transfer.
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PMC11323699
A mean score was calculated from three TMA cores from each sample.
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PMC11566417
Numbers of migrated cells were counted and recorded in a blinded manner.
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PMC8567602
G, Coomassie stain of a denaturing gel of FLAG-purified recombinant CBAF complexes generated from expression of SS18 or SS18–SSX.
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PMC11725127
HEK293T cell-derived HA-Ub-conjugated KRAS and recombinant USP2 (0.2 μg) at 37 °C for 2 h. The HA-Ub and Flag-KRAS levels were then determined by Western blot.
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PMC9884169
However, the mechanism through which MCT4 affects bladder cancer cell growth and cell death remains unclear.
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PMC11743316
Earlier studies found that the rate of metabolism within ovarian carcinoma tissues differed greatly from normal tissues, with higher concentrations of amino acids in comparison to normal controls .
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PMC11786156
IPI: International prognostic index Corrected P-value of Ki-67, P-value × (number of pairs tested + 1 – rank of P-value tested); 95% CI, 95% confidence interval; GCB, germinal center B-cell; DEL, double expresser lymphoma.
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PMC9429973
As a biologically targeted agent for patients with RARA overexpression, tamibarotene has the potential to provide benefit irrespective of mutation or cytogenetic risk classification.
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PMC8345486
The findings indicate that adenine nucleoside modified with metallacarboranes may help sensitize ovarian cancer cells to chemotherapeutic agents in combination therapy.
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PMC11535726
Besides establishing three novel Kirschsteiniothelia species and a new host record, we provide a checklist of all Kirschsteiniothelia taxa (Table 2), which incorporate 41 asexual morph species, amongst which 21 exhibit the sporidesmium-like morph, while 20 display the dendryphiopsis-like features (Hawksworth 1985; Boon...
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PMC11806818
Nanozyme-based aptasensors exhibit considerable potential, and future advancements in transduction technologies, development of novel nanozymes and catalytic substrates, and the introduction of new bioreceptors will further propel tumor biomarker detection technologies.
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PMC11609529
The treatment of both inhibitors for 2 days blocked the proliferation of ES-2 cells in a dose-dependent manner, with CA3 showing more potency at lower doses (Figures 8A and 8B).
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PMC11604830
This non‐invasive approach has the capacity to advance imaging techniques and expand the scope of nanoparticle‐based biomedical research.
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PMC10820104
4.2) (205.6 mg) was purified using semi-preparative HPLC with a gradient of MeOH-H2O containing 0.1% formic acid (65:35 to 95:05 in 21 min) to afford 1 (4.43 mg), 2 (1.04 mg), 3 (11.02 mg), 4 (40.48 mg), 5 (4.60 mg), 6 (3.01 mg), and 7 (1.47 mg) eluting at retention times; 33.5, 29.8, 25.7, 31.4, 32.0, 35.2, and 36.9 m...
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PMC7215832
Finally, the resulting pellets were dissolved in 150 μL of distilled water and transferred to 5.5 mL scintillation vials filled with 5 mL of scintillation fluid (Optiphase III), and counted 5 min for radioactivity in a scintillation counter.
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PMC10761218
W. somnifera is a reliable source of herbal products.
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PMC10565698
For example, a decrease in the expression level of E-cadherin can lead to a reduction in cell adhesion, making cells more prone to invasion and metastasis .
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PMC11448304
f Molecular Function enrichment on upregulated proteins; TOP 30 processes are shown.
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PMC11718109
Several studies have directly linked abnormalities in synaptic vesicle (SV) recycling as critical contributors to the preferential vulnerability of DA neurons, particularly in the development of early-onset parkinsonism (EOP).
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PMC10329074
ccRCC or normal tissues were the source of the variable data used to generate box plots to assess the differential expression of YBX3 in pan-cancer tissues and ccRCC tissues.
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PMC11791478
In all three studies, animals were removed from the study and euthanized once the tumor size reached 1,000 mm (endpoint volume), weight loss >30% (or >25% for three consecutive measurements), or at the end of the study on day 45 (day 36 for late-intervention study).
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PMC11787355
d PTPRZ1 expression after TCR-T cell treatment.
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PMC10907726
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC11718817
Afterwards, T cells were adjusted to 1.2 × 10 per 300 µL RPMI 1640 medium with 10% FCS, 3% HEPES, 2% Pen/Strep, 2% NaPyr, and 0.1% 2-mercaptoethanol.
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PMC9429973
Methods: In ACTIVATE (double-blind, placebo [PBO]-controlled study), 80 adult pts with PK deficiency who were not regularly transfused (≤4 transfusion episodes in prior yr; none in prior 3 months) were randomized 1:1 to receive mitapivat or PBO.
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PMC11541409
Overall, therapeutic antibody therapy has limited efficacy in preclinical and clinical settings.
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PMC11678448
Following a successful quality inspection of the RNA, subsequent analyses were conducted.
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PMC9429973
Future studies will be addressed to exploit the use of cfDNA in disease monitoring.
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PMC11626627
Lee et al. reported that the upregulation of TWIST1 could promote tumor stem cell characteristics in prostate cancer cells .
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PMC9878562
VAL-wt ex vivo did not display changes at surface expression of BLT1R compared to VAL-wt cultured in vitro ( Figure 5B ).
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PMC6190245
This was followed by flow cytometry to determine the sub-G1 peak.
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PMC9024365
not significant; *p < 0.05; one-way ANOVA with post-hoc Tukey’s test.
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PMC9429973
Four monotherapy dose levels of emavusertib were tested (200 to 500 mg orally BID).
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PMC5311252
U1810 cells were individually transduced with approximately 450 miRNA vectors (miR-Vecs) from a miRNA expression library (miR-Lib; for details see Voorhoeve et al. and Huang et al.) using retroviral infection and drug selection (Blasticidin 5 ug/ml) to obtain resistant growing cells, each containing a unique integrated...
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PMC11055323
b Venn plots showing the intersection between upregulated genes and A485 treatment downregulated genes in BJ fibroblasts expressing SS18-SSX1.
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PMC10440586
Kaplan-Meier curves of all glioma patients in the TCGA dataset. (
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PMC10006224
A non-parametric Mann–Whitney two-sided test and Holm’s correction for multiple comparisons was used. ***
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PMC8567602
All WB experiments were repeated to confirm the relationships presented and discussed.
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PMC8270637
n = 3, *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group.
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PMC11453018
Given the classification of samples into two categories through NMF, a direct understanding of the relationship between DEGs and patient overall survival was not immediately clear.
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PMC11206502
Patterns of relative gene expressions, found in our study, support the hypothesis that the efficiency of HB was associated with the expression of autophagy-specific genes.
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PMC5673060
Our data suggests that the Insulin receptor/IGF-1R pathway is an actionable target for salvage therapy and further investigation to dissect the contribution of components of this pathway to acquired dasatinib resistance is planned.
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PMC10297204
A statistically significant difference was observed between the ethanol concentrations of 20% and 30% (p < 0.001).
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PMC10761218
HepG2 and L929 cells were treated with W. somnifera leaf, stem, and root methanolic extracts of 20, 50, 100, 200, 500, 1000, 1500, and 2000 μg/mL for 24 h. Figures 2 and 3 show the in vitro morphological profiles of HepG2 and L929 cells, respectively, under an inverted microscope.
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PMC9964635
Its path becomes irregular during cancer .
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PMC6684588
Data are means ± SEM (n = 10). ***
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PMC11632064
OCR and ECAR were normalized with cell counts.
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PMC7294030
Induction of apoptosis in the tumor is a desired result of treatment with chemotherapeutic agents and radiation.
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PMC11266100
The wide applicability of GET involves treatment of cancer and other diseases (Li and Huang, 2000; Fewell et al., 2005) and DNA vaccination (Chattergoon et al., 1997).
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PMC11269792
Subsequently, the location of circAPP in GIST-882 cells was examined by subcellular isolation assay, confirming circAPP mainly expressed in the cytoplasm (Fig. 1F).Fig.
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PMC11761919
Therefore, the survival rate of chickens in the Micro-E/Fiber2-PINs group was 100%.
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PMC2196094
20 μg of genomic DNA was digested to completion with the appropriate restriction enzymes and was fractionated through 0.6% agarose gels.
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PMC11743316
As an illustration, Etomoxir, the most commonly used CPT1 inhibitor, stops tumor growth in a model of HGSOC .
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PMC10502403
However, it was difficult to identify differences in SRC between TCR-stimulated NGMCs and NE1-GMCs.
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PMC11673128
Thermo Fisher), and TaqMan qPCR for CD47 (primer: Hs00179953_m1) was performed using Brilliant-II QPCR Master Mix (Agilent, Santa Clara, CA, USA) and probe mixes from Thermo Fisher.
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PMC9874064
What is more, the drug carriers can be degraded triggered by intracellular overexpressed glutatione (GSH), resulting in the dissociation of NP-Pt-USP1i.
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PMC9429973
Using the 2019 World Health Organisation (WHO) Global Health Expenditure Database, LC calculated the average percentage of health spending by these European countries’ governments - 8.2%.
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PMC11787355
Cells score over 0.15 GSC module score are defined as GSCs.
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PMC2614415
Cells were treated for 96 hours with differing doses of VE-465 in the presence of 15 ng/mL paclitaxel. (
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PMC5854676
One can see that there is a linear relationship, which implies a linear model.
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PMC10994876
Error bars represent the standard deviation (S.D)Fig.
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PMC11012012
According to our results, SLAMF4/CD244 was negative by flow cytometry in peripheral blood B cells from healthy control subjects, normal polyclonal B cells found in peripheral blood samples from CLL patients, and pathological CLL B cells from patients with CLL .
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PMC11332076
Immunoblot analysis revealed the presence of phosphorylated forms of these receptors in cells transfected with F-iIR and F-iIGF1R, but not iIR and iIGF1R (Fig. 3), indicating that membrane localization is a key step for phosphorylation.
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PMC9436459
The challenging formation of the dehydroprenyl-2-arylbenzofuran diene S15 was achieved in excellent yield via the Suzuki–Miyaura coupling of iodide S11 and pinacolboronate S14 (preparation by simple hydroboration of enyne S13 with pinacolborane S12) after extensive experimentation.
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PMC11750161
cAMP responsiveness increased in a dose-dependent manner.
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PMC11755624
The molecule is an anti-sense lncRNA of the TRAF3IP2 gene, which encodes the IL-17 adaptor, Act1.
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PMC11098378
D. Fold-change in normalized viral GFP signal relative to scrambled (control) treatments as in C. Cells were stained with CellTracker dye 16 hpi and imaged to calculate fold-change in normalized GFP signal over control treatments.
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PMC11518702
As considered below (Section 6.2), this extends to C1ORF150’s possible effects on signaling among KIT, FcϵR1, and/or type-1 JAK kinase-coupled receptors.
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PMC6468656
The selected stable clones were further cultured in the presence of 2 μg/mL puromycin.
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PMC10568263
The structures, morphologies, and elemental analysis of MoO3 and Au@MnO2 were characterized using XRD, TEM, and XPS.
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PMC11286266
As a control for transfection, cells were transfected with a mock plasmid.
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PMC11711347
Characterization of Ni(II)ProDtc Molecular Docking Ligand and Protein Structure Modelling The web application MolView (https://molview.org/) was used to model Ni(II)ProDtc complex molecules.
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PMC8873393
Remarkably, the chromatin has the highest proportion of transcribed novel lncRNAs (~42.84% vs. ~14.59% for annotated lncRNAs), and TUCPs (~35.12%).
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PMC10530622
MitoTEMPO also increased ATP levels and selectively modulated NADPH oxidase subunits, particularly increased the expression of Nox4 and p22 without affecting Nox2.
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PMC11802929
Phenotype assignment based on transcriptomics was further validated by surface protein expression measured by scCITE-seq (see Methods) (Supplementary Fig. 6c).
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PMC11769516
Changes in the brain were visible after 3 days of exposure to T-2, and in the pituitary gland after 7 days.
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PMC8348645
At 80 µg/mL and 160 µg/mL concentrations, the BAX gene expression has shown upregulation to 1.05 and 1.21, respectively, in the HepG2 cell line (Figure 13 and Figure 14).
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PMC8557138
A heterogeneous mixture of isolated cells is proportionately mixed with desired biomaterials to produce bioink.
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PMC2944824
The percent control is computed by dividing the value from cultures treated with inducer by the value in cultures without (control) multiplied by 100.
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PMC2614416
Annotations are validated and expanded using an annotation expander.
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PMC8358006
The input-subtracted peak signal within a region was measured as a RPKM value using bigWigAverageOverBed.
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PMC9429973
Ex vivo mbIL21/4-1BBL expanded NK cells exhibited high cytotoxicity against leukemia cells.
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PMC5839394
Thereafter the two biogenerated silver nanoparticles were designed as AgNPs-EPS and of AgNPs-EPS.
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PMC11727000
Consistent with this, BRCA2 expression was highly correlated with higher clinical stage, histology, and MYCN amplification in the SEQC dataset. (
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PMC11204465
Two new halogenated sterigmatocystins, N-0532B (62) and N-0532A (63), were isolated from the fermentation products.
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PMC11534035
Our findings showed a reduction of malignant characteristics when the tumor cells expressed lower levels of PAI1.
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PMC11695546
Helicobacter pylori has a significant effect on communities as well as the global economy.
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PMC11604015
rheumatoid arthritis, and kidney transplantation, the percentage of CD7-negative T cells increases significantly, which implies that the loss of the CD7 antigen may contribute to the terminal differentiation of repeatedly stimulated CD7-positive T cells .
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PMC9429973
Methods: Data were extracted from patients with PNH aged ≥12 years between 2010-2021 from the TriNetX Dataworks USA Network, a federated electronic medical record (EMR) data network of >68 million de-identified patients.
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PMC11754291
These findings demonstrate that tyrosinase and DCT are reliable markers of melanogenesis, as their expression directly correlates with melanin synthesis in melanocytes.
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PMC9429973
SAT response evaluation showed CR in 28.3%, VGPR in 32.1% and PR in 37.7%.
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PMC9429973
M. Mancini, S. De Santis, C. Monaldi, S. Bruno, F. Castagnetti, G. Gugliotta, A. Iurlo, M. Cerrano, S. Galimberti, S. Balducci, F. Stagno, G. Rosti, M. Cavo, S. Soverini IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”; Dipartimento di Medicina Specialistica, Diagnostica e Sperimen...
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PMC11367146
The level of MMPs (MMP1, MMP2, and MMP9) are higher in individuals with OA as compared to those without, leading to matrix degradation .
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PMC11742231
This phenomenon is known as the “vanishing gradient problem.”
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PMC9429973
No correlation was observed between miRNA serum levels and age and sex at diagnosis and at RD initiation.
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PMC6034753
Detection of precipitated complexes in Western blotting assay with monoclonal FLAG antibody demonstrated that both these mutations did not affect the interaction of apoptin with Meq (Figure 3A).
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PMC7723249
Oblique bands: Basolateral infection.
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