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OTAR3088
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BioData-CellLine_annotated

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PMC11672142
This result compares favorably with the finding that the apoptosis-inducing cisplatin (20 μM) experiences less antiproliferative activity against Jurkat cells when pretreated with the inhibitor.
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PMC10547921
Based on these characteristics, we summarized the effectiveness of existing ADC payloads, including payloads targeting tubulin/DNA/RNA, immune ADC payloads, novel potential ADC payloads, and the payloads used in the design of ADC drugs under the guidance of various new strategies.
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PMC11411131
Cos-7 cells expressing these sensors were exposed to 6 µM tunicamycin (Tun), 100 µM diethyl maleate (DEM), or 20 µM MeHg for 24 h before being subjected to a luciferase assay.
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PMC11730320
Together with the reduced TREC levels, these findings indicated markedly reduced thymic production and output of T cells.
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PMC11352746
Out of the thirteen publications reporting the use of primary cell cultures, five used primary cortical neurons, and two used rat spinal cord neurons from various species to conduct their experiments .
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PMC11704834
Visualization of protein bands on the membranes was performed using the ECL detection system (cat.
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PMC9429973
K. Kamachi, H. Ureshino, K. Kawasoe, N. Yoshida-Sakai, Y. Yamamoto, Y. Fukuda-Kurahashi, Y. Kurahashi, T. Watanabe, S. Kimura Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine; Department of Drug Discovery and Biomedical Sciences, Saga university, Saga; OHAR...
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PMC10705095
These results suggest that HBQ1 is pivotal in identifying new antioxidants that can specifically target cancer cells to enhance the effectiveness of ROS-targeted therapy.
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PMC7709199
Further optimization by additive screening (Additive Screen, Hampton Research) and/or manual hanging-drop vapor-diffusion experiments containing a 1.2 µl volume of protein solution and a 1.8 µl volume of mother liquor yielded single and larger crystals that diffracted to resolutions in the range 1.85–3 Å. The best diff...
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PMC10387886
Similarly, in our study, DUSP1 expression increased after TGFβ1 administration.
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PMC10891340
The above results indicated that CCCP could suppress the DPV infection within 48 h.Figure 2CCCP is effective in inhibiting DPV infection within 48 h. (A and B) DEF cells were infected with DPV-GFP at dose 1 MOI for 1 h, DMSO was added as a control group and 20 μM CCCP was added as treatment group, the cells were placed...
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PMC11343332
Each bar represents the mean + SEM of three independent observations. ‘*’
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PMC8735881
To measure the infectivity of the progeny virions, the collected supernatants containing 0.25 ng of p24 antigen were added to TZM-bl cells (1 × 10/well) and incubated for 2 days at 37 °C in 5% CO2.
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PMC9429973
RVd-D combination is now being suggested as first-line treatment.
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PMC9429973
Upon chromosomal translocation, we observed the appearance of an H3K4me3-BD over CCND1 concomitant with its overexpression and an extensive increase in chromatin accessibility of this locus.
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PMC9429973
Interestingly (but not surprisingly) the most severe forms were associated with a more prominent abnormalities, including leukoerythorblastic features and secondary hemophagocytic lymphohistiocytosis, leading to an often fatal outcomes.
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PMC11697703
See also Figure S3.
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PMC11568601
Owing to its significant antitumor effects, TGT has shown considerable application prospects in clinical cancer treatment.
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PMC8567602
A, Quantitative LICOR WBs of BAF components in nuclear extracts of EXPI293 cells transfected with either SS18–SSX or SS18 (n = 5 each) presenting the log-transformed two-tailed Student t test P value of the difference between and the ratio of protein in the fusion-transfected versus SS18-transfected cells.
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PMC11752740
A fraction affected (Fa) of 0.5 represents the effective dose that kills 50% of the cells.
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PMC11453378
T.J. Cole: None.
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PMC11648299
On the other hand, individuals that are immunocompromised, either due to disease or medication, have an increased risk for malignant conversion .
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PMC11657695
As shown in Fig. 6A, an enrichment of the Hippo signalling pathway ontology is observed in the siRNA CT-transfected cells, compared to the siRNA KCNA2-transfected cells (Fig. 6A).
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PMC10706275
The work will facilitate the efficient construction of recombinant stable CHO cell lines for expressing exogenous proteins.
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PMC11661040
In simple terms, after the cells are uniformly inoculated on a 6-well plate and cultured to a density of 90 to 100%, a 200 µL sterile pipette tip is applied directly across the cell layer.
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PMC11682172
The current data suggest that the immune system, T lymphocyte effects in particular, also play a role in this, possibly by enhancing cellular motility of breast cancer cells.
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PMC5716223
p < 0.05.
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PMC11011020
Figure 6b).
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PMC9599726
The pellet was resuspended in 500 µL of cold PBS/FBS 2%.
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PMC9429973
In the group with higher ECOG status an influence of age was notable but of lower significance.
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PMC10419319
In addition, isoalantolactone supports the action of anticancer drugs by increasing the sensitivity of OC cells to cisplatin and helping to overcome cisplatin resistance.
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PMC7553912
There were no differences in the amount of renal crystal deposits between WT and OSMRβ mice on day 3 (Fig. 2b).
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PMC11682525
Using propidium iodide (PI, red), fluorescein diacetate (FDA, green), and Hoechst 33342 (blue) to stain HFSCs cultured under either normoxic conditions (upper part) or hypoxic conditions (lower part).
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PMC8010066
For all the data collected, a two-way analysis of variance (ANOVA) was performed using GraphPad Prism 6.0 (Graph Pad Software, USA).
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PMC11377827
HeLa HRE-GFP reporter expression in mixed knockout populations (denoted as sgRNA) of HIF1β (light blue) or USP43 (green).
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PMC10878518
OBP-401 was obtained from Oncolys BioPharma, Inc. (Tokyo, Japan).
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PMC7642379
Despite extensive usage of CHO and HEK in both suspension and adherent mode and several empirical protocols for adaptation in either direction, molecular knowledge of the key genes involved in the transition between the two growth states are limited.
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PMC10421378
Treatment with sublethal temperatures can induce cross-protection mechanisms in probiotic bacteria.
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PMC10854447
The 1,2,4-oxadiazole nucleus is the basic core of a number of drugs on the market today, including Oxolamine, Butalamine, Prenoxdiazine, Fasiplon, and Proxazole.
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PMC11040965
Cells were stained for surface and intracellular proteins as described previously using fluorochrome-conjugated mAb from both commercial and non-commercial sources (Supplemental Table 1) or PE-conjugated NY-ESO-1157–165–specific HLA-A*0201 pentamer (Proimmune, Oxford, UK).
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PMC11407042
Statistical analysis was performed using one-way ANOVA.
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PMC9509578
1Mechanisms contributing to the development of MDR in cancer cells.
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PMC11679326
Here, we provide a prospective research plan fostering investigations into carbohydrate-binding proteins of marine organisms, some of which were tested on glioma cells without precise glycomics, and some others need to be probed due to their presumptive potential in recognizing diversified patterns of aberrant glycosyl...
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PMC9739791
Additional experiments were carried out to explain the enhanced cytotoxicity of BODI-Pt 15 compared to carboplatin.
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PMC11806106
In recent years, diverse studies on the molecular characterization of the receptor and the effect of different agonists have been published, like several crystal and cryo-EM structures, as well as other approaches like the expression of the receptor as water-soluble protein.
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PMC7762347
Previously, Lankoff et al. described that MCLR at high concentrations (>25 µM) in non-target Chinese hamster ovarian (CHO-K1) cells caused the accumulation of cells in mitosis and thereby increased mitotic index (MI) was reported after 18 h of exposure.
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PMC9429973
Twenty-four out of 34 (70.5%), 14/34 (41.7%) and 8/34 (23.5%) achieved or maintained respectively MR2, MMR, DMR response at the last follow up.
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PMC11560255
After being cleansed, the dried stem barks were chopped into tiny pieces.
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PMC9429973
R. Koldej, A. Prabahran, C. W. Tan, M. Davis, D. Ritchie ACRF Translational Research Laboratory, Royal Melbourne Hospital; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne; Clinical Haematology, Royal Melbourne Hospital; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Aust...
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PMC11095939
Accordingly, Cyclin D1, which mediates the phosphorylation of Rb, was also maintained at extremely low levels during the very early stage of liver regeneration.
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PMC11522251
Haura et al. demonstrated that sustained STAT3 phosphorylation in NSCLC patients may lead to primary tumor resistance to EGFR inhibitors.
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PMC11756514
Langerin and Macrophage galactose-type lectin (MGL) are transmembrane proteins that form alpha-helical coil mediated trimers on the surface of antigen-presenting cells.
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PMC11344246
Plates were excluded if the Z′ factor was negative (a measure of the differentiation between positive death control siTOX and non-targeting control siOTP) or if the coefficient of variation (CV) of the non-targeting control wells was >20%.
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PMC9429973
In vivo treatments targeted signalling pathways at least partially responsible for the haematopoietic abnormalities in Sucnr1-KO.
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PMC11406030
FFPE specimens were collected from pathology labs in Western Sweden.
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PMC10507284
p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, not significant.
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PMC9000591
In general, the constituents isolated from C. speciosa showed high potential in their antioxidant and cytotoxic properties under in vitro approaches.
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PMC11795610
In particular, the epidermis, composed of keratinocytes and intercellular lipids, is the outermost protective barrier of the skin and protects the body against external environment factors, such as chemicals, microorganisms, antigens, and UV radiation, as well as preventing excessive water loss.
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PMC9596868
Analysis of the data from supplementary Fig. 4B–C in compusyn software suggested strong synergism for the combination (Supplementary Table 1B).
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PMC9817179
We previously Halo-tagged endogenous EWS::FLI1 in an Ewing sarcoma cell line A673 using CRISPR/Cas9-mediated genome editing (Chong et al., 2018).
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PMC11617590
Cells were cultured for 24 h at 37°C in an incubator supplied with 5% CO2.
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PMC10212663
AUC values were calculated for the 1‐, 2‐, and 3‐year OS rates of risk‐score, respectively (e).
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PMC10547921
Given these promising initial results, antibody‒PROTAC conjugates appear well-positioned for future growth and application.
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PMC9964635
The anti-hepatocellular therapeutic potential of triazole-based scaffolds was evaluated by dissolving its different concentrations in 0.05% DMSO.
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PMC7823217
B. 3D bioprinted breast cancer model with breast cancer cells (21PT cells) in the middle and surrounding Adipose-Derived Mesenchymal Stem Cells (ADMSCs). (
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PMC11723947
Horizontal bars represent the median, and the top and bottom of the box the upper and lower quartile, respectively.
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PMC11345828
The title compound (11 mg, 9% yield) was prepared following General Procedure B using compound 33 (90 mg, 0.17 mmol, 1.0 equiv) and methyl 7-bromo-1,5-dimethyl-1H-indole-2-carboxylate (96 mg, 0.34 mmol, 2.0 equiv) followed by saponification using General Procedure G. LCMS Method 1: RT = 2.412, 2.450 min, MS (ESI): mass...
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PMC11721587
Furthermore, both 2KR and AVAAV abolished Hh-induced Fu maturation and Ci activation (Fig. 3, D and E).
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PMC11532793
In panel (B), average log2 CPM values were computed from scaled counts obtained with Gibbs RTA-dispersion estimates.
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PMC11033180
Sema3A and its receptor Plexin A1 and Plexin A2 are expressed in enteric neurons in the rat distal colon (A, A′, B, and B′) Triple immunolabeling for Sema5A (green), Hu (marker of neuronal soma, red), and β3-tubulin (marker of neuronal soma and axonal processes, blue) in the myenteric plexus of rat distal colon. (
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PMC9429973
Image: Summary/Conclusion: Our real-world results show a high response rate (CR/VGPR) to D-RVd as first-line treatment in transplantation eligible patients with MM.
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PMC11224020
Data were analyzed by ordinary one-way ANOVA; ****P < 0.0001; *P = 0.0465; NS, P > 0.999.
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PMC11286266
Forty-eight hours after transfection, cells were lysed, ATF6α was immunoprecipitated (IP) using GFP-Trap Agarose and then subjected to FURIN cleavage by incubating with 1 U of commercial FURIN (#P8077S, NEB) for 6 hr at 25°C in the presence or absence of calcium (Ca).
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PMC8348645
Observation of yellow solution that turn colourless later would indicate the presence of flavonoids.
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PMC9429973
HLA genotyping of donors and recipients was performed by PCR-SBT.
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PMC11366496
Moreover, Cignal Finder Cancer 10‐Pathway Reporter Kits were used to screen the potential signaling pathways participating in this process.
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PMC11588085
Invasion and migration assays were performed using the Boyden chamber technique.
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PMC9429973
M. Vieri, B. Rolles, M. Crocioni, S. Isfort, J. Panse, T. H. Brümmendorf, F. Beier Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Uniklinik RWTH Aachen, Aachen, Germany Background: Immunosuppressive therapy (IS...
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PMC6742971
Patients were enrolled upon written informed consent.
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PMC8922418
To simplify the pegRNA design, Xu et al. introduced a database to improve the practicality of PE (Hsu et al., 2021; Kim et al., 2021).
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PMC10443665
So, it could be concluded that bassorin might escalate the cell toxicity induced by MTX through other mechanisms like facilitated cell apoptosis which could be further evaluated using some experimental methods such as flow cytometry.
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PMC11708541
When compared to the saline group, the 4-AP-induced muscular effects were also linked to a much higher quantity of proliferating cells (Ki67+) and regenerating stem cells (Pax7+).
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PMC11726848
In the case of HDR irradiation, it was 75–85%.
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PMC9143157
The 50% inhibitory concentration (IC50) values of THP and P-THP against the different cell lines are indicated in Table 1.
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PMC9429973
Aims: We describe and characterize BTM-3566, a first-in-class compound that activates the OMA1-dependent mitochondrial stress pathway.
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PMC9587298
To confirm the formation of mono- and di-MGO adducts of the studied phenolic compounds when elderberry extracts are incubated with MGO, elderberries samples (1 mg/mL) were analysed by ESI-MS in negative and positive ion mode (Fig. S2) before and after incubation with MGO.
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PMC11453018
This effect was further confirmed at the protein level by immunofluorescence (Fig. 5C and D; Supplementary Fig. 5D).
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PMC11407042
Add 10 μL 10× Lysis Solution (provided by The Kit) to positive control wells 45 min before adding CytoTox 96 Reagent (provided by The Kit).
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PMC11701801
G and H, IC50 values for CP-C27 in SMARCA4/SMARCA2-deficient DMS114 (G) and SS18–SSX fusion Fuji (H) cell lines transfected with the indicated siRNAs and treated with CBP/p300 inhibitor CP-C27.
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PMC9429973
Diseases were myeloid malignancies in 84 pts (79%).
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PMC9429973
27 pts (52%) remain on tx.
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PMC11481779
We have applied Gaussian blur to this example - in the case of blur with σ = 1, the FID score increases to 18.3; in the case of the blur with σ = 3, it’s 61.5, and in the last case, when Gaussian blur is performed with σ = 7, we are getting FID equal to 70.6.
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PMC8973725
The negative controls were processed using normal rabbit serum (Dako, Carpinteria, CA, USA) as the primary antibody.
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PMC11802855
It was formerly hypothesized that it was primarily activated via IL6 .
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PMC9341513
Broader comparison measures also showed significant correlations between the simulation and experimental Hi-C, though the agreement was reduced compared to the GM12878 case (likely due to the lower resolution of the data) (Supplemental Fig. S4; Supplemental Methods Section 4).
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PMC11347429
Comparing non-ICU infected patients with health controls revealed 659 upregulated and 317 downregulated DEGs ( Figure 3A ) while ICU patients showed 1071 upregulated and 818 down-regulated DEGs when compared to healthy controls ( Figure 3B ).
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PMC11675244
Efforts to increase APC concentration through APC-expressing liposomes have shown success in reducing colorectal cancer occurrence in APC-min mice .
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PMC11337594
It indicates that the expression trend change of cyclin E1 may not be directly regulated by p53, which is also consistent with the study of Zeng et al. Previously, they found similar levels of cyclin E1 expression in p53-positive and p53-knockout RPE1 cells induced by doxycycline .
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PMC11770746
The greater accumulation in the DRG is attributed to the higher expression levels of the Pt(II) related transporters (OCTs and Ctr1/2) in the DRG.
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PMC9268620
Then, 26 g of the crude extract was dissolved in CHCl3 and absorbed as a packed 10–50 cm column onto an acid-washed silica gel that was previously shaken for 30 min with 4% oxalic acid, filtered, and dried.
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