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OTAR3088
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BioData-CellLine_annotated

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PMC3931643
Active-site mTOR inhibitors (asTORi) are a novel class of anti-cancer drugs that suppress both rapamycin-sensitive and rapamycin-resistant functions of TORC1 and TORC2 , –. In preclinical models of cancer, asTORi produce a stronger cytostatic response than rapamycin and can induce apoptosis especially when combined wit...
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PMC11507371
Furthermore, basal ROS and antioxidant levels were compared in both cell lines.
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PMC11228511
All animal studies were approved by UCLA’s Animal Research Committee.
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PMC10174970
The gene expression profiles of PAAD cell lines correlate weakly with those of primary pancreatic tumors.
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PMC9429973
22 (81.5%) were males.
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PMC11791478
A late-intervention study using the HPAF-II xenograft model was conducted to evaluate the effect of XB002 on established tumors as large as 500 mm.
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PMC11680982
P < 0.05 (versus the indicated group) was considered statistically significant and determined by one-way analysis of variance or the t-test (GraphPad Prism 8.0).
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PMC11063646
809.020.0300518.631518.
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PMC11799978
Cancer associated fibroblasts (CAFs) are a major type of stromal cell in the tumor microenvironment (TME).
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PMC11678448
CXC chemokines are chiefly involved in attracting neutrophils, whereas CC chemokines play a primary role in recruiting monocytes and different lymphocyte subsets .
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PMC11530949
The biosynthesized Ag-doped CuO NPs exhibited the highest compatibility with healthy cells, showing the least cytotoxic effects (Figure 4B).
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PMC11464609
Conventional metagenomics resulted in 1 JCPyV read per million and an incomplete genome coverage, whereas viral enrichment sequencing led to a 1000-fold enrichment: 1016 JCPyV reads per million and an average genome coverage depth of 1450X.
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PMC9429973
For that reason, the registration of clinical trials with commercial and non-commercial products included very strict inclusion and exclusion criteria, to minimize severe adverse events and maximize therapeutic effect.
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PMC11477621
In summary, molecular docking revealed that compound 20 interacts more closely with HDAC1, thus further validating the experimental findings.
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PMC8916024
OTUs: operational taxonomic units. ;
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PMC11707577
Targeting of the M13EGFR(TNP) and HSA‐TM bioconjugates on A431 cell line.
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PMC11742431
Also, the 14 amino acids sequence “KIGLGRQKPPKATK” (named 14aa) placed at the N‐terminal end of the protein of interest is capable of recruiting the UBR class of E3 ligases.
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PMC9454178
We focused on the relationships between the expression level of CDK7 and clinicopathological characteristics, including sex, age, tumour size, mitotic index and risk category (Table 1).
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PMC11748618
The heat map depicts LD (D’) between functional chromosome 1 variants, with darker shades representing stronger LD between variants.
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PMC10551595
Support for this information was site‐directed mutagenesis studies converting Cys124 to Ala in the mutant P53R175H, preventing its reactivation by PRIMA‐1.
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PMC10976516
NCT00625456Breitbach et al.Vesicular stomatitis virusVoyager-V1 (VV1) VSV strain expressing IFN-βand NISVV1 and pembroluzimabIIIntravenous injection with VV1 in refractory NSCLC or pulmonary neuroendocrine cancer (NEC, including SCLC) patients after initial treatment with pembroluzimab.
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PMC10607604
For carboplatin, the IC50 increased from 16.05 µM (95% CI: 12.4–20.8) in parental cells to 45.5 µM (95% CI: 38.2–54.1), 29.4 µM (95% CI: 25.3–34.1), and 31.2 µM (95% CI: 25.7–37.79) in the Kura-A2, Kura-A3, and Kura-B1 clones, respectively (Figure 6A–D).
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PMC11683130
Impaired epidermal function is a significant feature of atopic dermatitis (78).
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PMC11738017
The black horizontal line represents the median.
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PMC10808409
On the other hand, TPGS mixed micelles formula induced cell cycle arrest at S phase (Tables 4, 5 and Figs. 5, 6).
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PMC7582629
Besides, the hyperspectral Raman imaging of cells can obtain the morphological information in combination with PCA/LDA analysis, which could improve the identification and classification of different cell phenotypes and lead to non-invasive and accurate monitoring of maturation stages of the disease.
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PMC9370419
Nonetheless, both treatments have certain drawbacks .
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PMC11633763
D, F) OCR results showing the basal respiration and maximum respiration in 143B/shUSP22 cells (D) or U2OS/p‐USP22 cells (F).
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PMC11672617
The synthesis of the ionic compounds was accomplished in four steps from the methyl ester of lithocholic acid (1), which was previously synthesized from lithocholic acid according to a known procedure .
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PMC11665584
We did not observe any changes in the organization or integrity of the extracellular matrix in PITX1 mice, suggesting that wound healing in these mice is not accompanied by increased fibrosis.
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PMC11792740
In depleted T cells, key cytokine signaling pathways are suppressed.
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PMC11795610
The expression of K5 and K14 in the high Ca group was significantly reduced compared to the normal control group, while differentiation markers TGase l, K10, FLG, and IVL were significantly increased (Figure 4(a–f)).
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PMC9429973
They are characterized by approximately 220 differentially expressed genes (p-value < 0.05, log-fold change > 0.69), including common megakaryocyte markers such as CD41 and CD42b.
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PMC11365427
Evidently, cell death under the stress of phenylalanine deprivation was observable through TEM (Fig. 6F).
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PMC11224020
e, Heat map of genes in the ‘regulation of helper T cell differentiation’ pathway marked in blue in d. f, Antigen presentation assays with T cells incubated with DCs activated with LPS or confined at a height of 3 µm.
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PMC11806818
The schematic diagram of the sensor is shown in Fig. 2C.
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PMC6487404
The intra-day and inter-day coefficients of the variation (CV) were all less than 5%.
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PMC11541241
CaMV, cauliflower mosaic virus; Pst, Pseudomonas syringae pv.
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PMC11772449
A-C: PFD enhances the killing effect of Sora on liver cancer cells.
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PMC10713411
According to the landscape map, we found that the TRIB3 got the highest score.
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PMC11269933
In vivo phosphorylation assay of CgERK1/2 on CgPK Ser11 site. (
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PMC9429973
ctDNA was dynamically detected baseline, after 3 and 6 cycles to evaluate tumor mutational burden.
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PMC9429973
Here we present preliminary results of anti-PD-1 antibody combined with chidamide, lenalidomide and etoposide for the treatment of r/r-lymphoma.
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PMC11745823
Among the sh‐RNAs, sh‐c‐Myc#1 demonstrated the highest knockdown efficiency and will be utilised in subsequent studies (Figure S5C).
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PMC11089031
Endothelial cells in renal tubules are labeled with a red arrow, and cells in the kidney mesenchyme are labeled with a red star The expression pattern and distribution of ZNF692 in normal human kidney tissue.
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PMC11413393
Representative images are shown to the right.
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PMC11787381
Then, fetuses were removed from the uterus and immediately placed in ice-cold L15 Leibovitz medium with a 2% penicillin (10,000 U/mL) and streptomycin (10 mg/mL) solution (PS) and 1% bovine serum albumin (BSA).
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PMC7709199
The structure was solved by maximum-likelihood molecular replacement with Phaser (McCoy et al., 2007 ▸) as implemented in the Phenix GUI (Liebschner et al., 2019 ▸) utilizing the human IL-12B chain extracted from PDB entry 5mj3 (Desmet et al., 2014 ▸) as a search model.
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PMC9516447
The superscript indicates the KRAS mutation for each cell line.
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PMC11544771
5-bromo-2-deoxyuridine (BrdU) and 4′,6-diamidino-2-phenylindole (DAPI) were from Life Technologies (Grand Island, NY, USA).
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PMC10631132
In terms of transitioning from murine cells to human cells, a robust source for human OCs is necessary not only for the creation of human iRANK cells but also for other applications that require human OCs .
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PMC7553912
The ratio of areas with renal crystal deposits.
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PMC11711066
Furthermore, the molecular mechanisms underlying the sex hormone‐like effects of AS‐IV and Rb1 are believed to involve anti‐apoptotic responses.
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PMC10850553
We could not answer about the potential impact of these factors on the observed difference in the C5a–C5ar1 axis between the two models.
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PMC9429973
Aims: To assess the effect of race on the progression from SMM to MM.
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PMC11697703
The ENCODE ATAC-seq uniform processing pipeline v1.4.2 was used for replicated and unreplicated data (https://www.encodeproject.org/atac-seq/).
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PMC11537649
The detailed characteristics of melanoma patients were shown in Table 1.
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PMC9874064
Unfortunately, the DNA repair machinery is powerful in cancer cells, resulting in drug resistance.
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PMC9275501
This effect may depend on super-deformable liposomes, which may accumulate in deeper skin layers, thereby creating a skin reservoir from which RES and 5-FU can be gradually released.
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PMC9429973
These low TET2 levels occur in patients from different T-ALL subtypes and were confirmed in a subset of T-ALL cell lines.
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PMC10850553
The prognosis of aneurysmal subarachnoid hemorrhage (SAH) remains poor despite modern technical advancements in medical care, with a mortality rate of 25–50%.
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PMC11739484
Hsa-miR-22-3p dysregulation has been associated with aberrant cell proliferation, migration, invasion, and metastasis, highlighting its involvement in key oncogenic processes.
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PMC11543885
Due to the wealth of MS data being generated, a SAINT (Significance Analysis of INTeractome) score analysis can be used to determine the proteins in close proximity to your bait protein under different conditions.
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PMC11783017
Particle size distribution of Lipo-IL11, Mn@Lipo-IL11, and Cis/Mn@Lipo-IL11. (
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PMC8973085
Found: C, 66.52; H, 4.62; N, 9.72.
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PMC11783017
Representative fluorescence images of L929 and 143B cells co-incubated with Lipo and Lipo-IL11 for 8 h. The cell skeleton is labeled with FITC-labeled phalloidin (green); the cell nuclei are stained with 4′,6-Diamidino-2′-phenylindole (DAPI blue), and the red spots indicate the Cy5.5-labeled nanoparticles. (
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PMC5173112
Cancer stem-like cells (CSCs) are defined by their ability of tumor initiation, self-renewal and differentiation .
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PMC10823017
N=3) (*** indicate P≤0.001).
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PMC11201989
In this study, we investigated the role of PD-L1 in the regulation of ciliogenesis.
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PMC10976516
Intratumoral injection of human SCLC PDX models in NSG mice background showed severe impairment of tumor growthKellish et al.Recombinant MYXV expressing IL-15IntravenousBone marrow-derived MSCsi.v.
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PMC11476004
After 72 h, a hypotonic solution (0.56% KCl, temperature 37 °C) was added to the suspension, and then it was fixed with Carnoy’s solution (3:1 methanol-acetic acid).
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PMC11082662
Intriguingly, our data showed significantly higher translation levels of SMPDL3B in the ovarian cancer tissues compared to the normal tissues (Figure 3A,3B; P<0.0001).
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PMC10440586
The UMAP plot of CD99 expression level in HF3016 GSCs from the Johnson et al. dataset. (
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PMC9813422
However, HBx does not bind DNA directly; rather, it seems to interact with the host transcriptional machinery proteins that do (38).
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PMC9429973
It causes both acute and chronic reactions, such as alopecia, erythema, peeling, hyperpigmentation and, in cases of repeated doses, even ulceration.
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PMC7154001
Out of 830 published articles, 78 articles were included in the analysis based on pre-defined inclusion and exclusion criteria.
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PMC8864075
Then, Cytoscape 3.6.1 was used to build the “Ingredient-Target-Signal Pathway” network.
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PMC11794847
GO and KEGG analysis showed that mostly enrichments were correlated with immune cells migration,differentiation, and proliferation (Figure S10A–D).
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PMC11321678
Moreover, we compared the CNV profiles of tumor cells between different patients (Figure 2A; and Figure S3, Supporting Information).
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PMC11721064
Destruction of LEPCs due to ocular burns or severe ocular diseases results in limbal stem cell deficiency (LSCD), a primary cause of most blinding keratopathies .
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PMC7757104
By contrast, the levels of claudin-3 and cytokeratin-18 were non-significantly downregulated in the same experimental conditions (Fig. 3C).
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PMC10040136
The obtained single cell suspensions were stained using the MSC Characterization Antibody Panel (Cat No. 1000354, STEMCELL Technologies, Canada), counted by flow cytometry, and the proportion of MSC cells in the total cell count was calculated.
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PMC8633974
For gRNA co-transfection screening, 1.5 μg px333 plus 1.5 μg pHIV-1 were diluted in 150 μL OptiMEM, which was then further diluted with 150 μL OptiMEM / PEI.
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PMC9429973
Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases，suggesting that HIF1α may be involved in immune dysregulation in patients with immune thrombocytopenia (ITP).
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PMC11683240
Values are given as mean ± SD.
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PMC10968586
These effects were connected to (I) an increase in the phosphorylated form of apoptosis regulator JNK, which in turn ruled an increase in the phosphorylated forms of cell cycle controller activator protein 1 (AP-1) components c-Jun and ATF-2, and (II) an increase in the levels of tumor suppressors p53 and p21 .
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PMC4816271
Linking the iCasp9 to the receptor using a viral 2A sequence ensures equal expression with the CAR and overcomes the reduction in downstream gene expression frequently seen with an IRES sequence.
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PMC9856122
In vitro lipopolysaccharide assay suggested the potential of tetrandrine to inhibit TNF-α, IL-6, and NO release in lipopolysaccharide (LPS)-induced microglial activation .
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PMC11574029
Furthermore, our experiments showed that depletion of NOTCH3 inhibited tumor cell proliferation, migration, and invasion, and suppressed BLCA growth and metastasis in vivo.
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PMC11185260
Kaplan–Meier survival curves of mice.
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PMC9429973
Next, bioinformatic tool DREIMT was utilized to predict drugs for intratumor immunomodulation.
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PMC11772585
E, F The protein levels of PCNA in tumor tissues were detected by IHC and western blot.
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PMC11750696
ER stress plays a significant role in Treg cells which are pivotal in immunosuppression (55).
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PMC8973725
Additionally, ZNF677 overexpression suppressed the invasion and epithelial-mesenchymal transition of 786–0 cells by inactivating the PI3K/AKT signaling pathway.
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PMC11742231
Firstly, MGATAF constructs multimodal molecular graphs that incorporate both SMILES and drug fingerprints, providing a comprehensive representation of drug molecules.
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PMC11269792
With written informed consent, tissue sampling was done with the approval of the Ethics Committee of the Affiliated Hospital of Inner Mongolia Minzu University (n° 201211Y62).
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PMC11461833
The orange arrowheads indicate the Lamin A and Lamin C bands.
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PMC11267830
The primer information is provided in Supplementary Table 1.
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PMC11777207
We provide evidence that the amino acid residues necessary for CD80:PD-L1 interactions to promote DC migration include tyrosine-56 on PD-L1, and leucine-107 on CD80, as well as the intracellular tail of PD-L1.
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PMC11461874
The cell lysates were immunoblotted using antibodies indicated.
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