OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11300085	Chemerin decreased the expression of E-cadherin and increased expression of N-cadherin and vimentin; however, their expressions were reversed by C3T or Y27632 pretreatment (Figures 5(a) and 5(b)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The prognostic is very poor, with a 2-year survival rate reported to be less than 20%.There is no standard of care in this situation given the variability in patient’s and disease’s characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	The other limitation of interpretation of the lead SNPs is lack of direct functional validation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "limitation", "of", "interpretation", "of", ...
PMC11772585	Following a 24-h transfection period, the cells were exposed to actinomycin D (Act D, 10 μg/mL, Cat# GC16866, GLPBIO) for 0, 3, or 6 min before being collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	Fig. 5Upregulated MGST1 expression was modulated by the β-catenin/Tcf4 complex in MRTX1133-resistant PDAC cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5Upregulated", "MGST1", "expression", "was", "modulated",...
PMC11469524	HBL-1 cells were kindly provided by D. Krappmann (Munich, Germany).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HBL-1", "cells", "were", "kindly", "provided", "by", "D.", "Krappm...
PMC11742047	The blue edge means fatty acids deleted, the orange edge means fatty acids modified, the green edge means head groups deleted, red edge means head groups modified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	This progression contributes to the aggressive nature of AML relapses (De Haan and Lazare, 2018; Verovskaya et al., 2019; Long et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	Only NASeLM was able to increase caspase-3 activity in MTC-SK cells: at 250 µg/mL NASeLM, caspase-3 activity increased significantly to 28% after 24 and 48 h compared to the control (14%) or the same NALM concentration (14%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10978090	These two cases suggest that TPE could be a safe and effective peri-operative strategy to remove platelet-activating anti-PF4/H antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "two", "cases", "suggest"...
PMC11794847	No obvious abnormalities were found in the appearance, body weight, and the size of various organs in the HVEM knockout mice compared with wild type mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977	Interleukin-1 (Il-1), a multifunctional monokine, plays a significant role in the destruction of articular cartilage in degenerative arthropathies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interleukin-1", ...
PMC9219615	Research to further elucidate Tpz-1’s mechanism of action is ongoing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "to", "further", "elucidate", "Tpz-1", "’s", "mechanism", "of", "action", ...
PMC10729469	In the current study, monoclonal TCRAβ-Treg were generated by incorporating the Aβ-specific TCR identified from a highly reactive monoclonal Aβ-Teff cell previously developed in our lab .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	L, Milano (MI), Italy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L", ",", "Milano", "(", "MI", ")", ",", "Italy", "." ] } ]
PMC9812014	Lycorine alkaloid, isolated from C. miniata (Lindl.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lycorine", "alkaloid", ",", "isolated", "from", "C.", "miniata", "(", "Lindl", ".", ")" ...
PMC9386809	A round-bottom flask fitted with a reflux condenser was charged with α-naphthol (1 mmol), ethyl acetoacetate (2 mmol), and 1 mol % catalyst [≈9 mg of Cl2Zr–BPC complex 2].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A total of 134 patients with liver cirrhosis and aggressive lymphoma were found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "134", "patients", "with", "liver", "cirrhosis", "...
PMC11718031	In contrast, CD-FortiCHO performed significantly better, as the highest VCC peaked at 14.5 × 10 cells/mL in CD-FortiCHO + Efficient B plus and around 14.0 × 10 cells/mL in CD-FortiCHO + Efficient (A plus and C plus).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	The nature of the aryl/alkyl substituents at position 3 of the quinazoline moiety appears to be critical for the 8a–t hybrids' antiproliferative activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6650823	This work highlights challenges in developing ligands for functional RNAs and in understanding the behavior of small synthetic compounds that bind to and modulate the function of complex RNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672142	This reaction yielded the sodium salt of Fe(DefNEtTrp)2 (7) even with an excess of Fe(III) (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reac...
PMC11055443	The purity of human abdominal fat-derived MSCs was evaluated by immunophenotyping of CD45, CD105, CD90, CD73, and Sca-1 cell surface markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10988555	For 4, only 4″ is represented for simplicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "4", ",", "only", "4″", "is", "represented", "for", "simplicity", "." ] } ]
PMC2196094	The unprocessed protein has an 18-aa signal peptide and a 2-aa activation peptide (Gly-Glu).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "unprocessed", "protein", "has", "an", "18-aa", ...
PMC6461034	These analyses show superior performance of INKA over its components and substrate‐based single‐sample tool KARP, and underscore target potential of high‐ranking kinases, encouraging further exploration of INKA's functional and clinical value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	As depicted in Figure 2a, PED0 of pure PVB without PF-127 exhibits hydrophobicity due to the hydrophobicity of PVB and, therefore, does not absorb liquid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8750422	Despite the development of advanced anticancer drugs to treat lung cancer, the prognosis of patients with lung cancer still remains poor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "t...
PMC11488203	One of these factors is represented by SDF-1, which can contribute to enhanced tropism towards tumors e.g. by interacting with the CXCR4/CXCR7 axes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11391695	In conclusion, pcDNA/PEI/NPs@M demonstrated exceptional safety and targeting capability in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "pcDNA/PEI/NPs@M", "demonstrated", "exceptional", "safety", "a...
PMC7171147	Our work is further supported by the findings of others that chemoresistant ovarian cancers exhibit a high metabolically active phenotype with the ability to utilize fatty acids as fuel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	In presence of dasatinib, cell migration into the wounded area was greatly impaired (Figure 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "presence", "of", "dasatinib", ",...
PMC11033180	Phosphorylation at Ser603 represents a molecular signal for synapsin 1 dissociation from synaptic vesicles, resulting in dispersion of synapsin 1 from presynaptic terminals to axonal regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684821	The MAIT cell subset is characterized by a TCR-α chain that is made up of the TRAV1-2 gene in combination with a TRAJ33, TRAJ12, or TRAJ20-joining region (11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10882807	Western Blot analysis of EIF4A3 in adjacent tissues and paired HCC tissues. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "Blot", "analysis", "of", "EIF4A3", "in", "adjacent", "tissues", ...
PMC10874773	oligandrumZhu et al., 200939Veranisatin EI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "oligandrumZhu", "et", "al.", ",", "200939Veranisatin", "EI", "." ] } ]
PMC7305184	1 generation followed by every 5 generation of CTRL, CTRL + EP and EP group were analyzed for a development of adaptive resistance by preforming permeabilization and survival curve.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11423992	The binding activity to CD3 and T-cell activation can be modulated by adjusting the length of the linker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "binding", "activity", "to", "CD...
PMC11672142	ICP-OES data were collected by using an Optima 8000 (PerkinElmer) system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ICP-OES", "data", "were", "collected", "by", "using", "an", "Optima", ...
PMC9429973	Despite the usage of corticosteroids and later life-saving rescue with cladribine 0.12 mg/kg 5 days, she developed severe multiorgan dysfunction - pancytopenia (hemoglobin 6.9 g/dL, leukocyte 0.6x10^9/L, platelet 10x10^9/L), liver dysfunction (bilirubin 24.7 mg/dL, gamma-glutamyl transferase 1071 U/L, alkaline phosphat...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	A trend between cytotoxicity and dendrimer generation (number of transported metallic fragments) was not observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "trend", "between", "cytotoxicity", "and", ...
PMC10969097	The mice were injected subcutaneously with 0.1 mL of HepG2 and Bel-7404 cells at a concentration of 1.0 × 107/mL. When the tumour volume reached 90–100 mm, the mice were randomly divided into groups (n = 6/group) and treated for 21 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11739504	The mixture was harvested with the culture medium and centrifuged at 1500 rpm for 3 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "harvested", "with", "the", ...
PMC7351993	Second, we employed the RIACS to sort out rare Chlamydomonas sp. mutants with high-lipid productivity toward microbial breeding for cost-effective algal biofuel development (see “sorting of Chlamydomonas sp. cells” in the Methods section for details).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11248911	Found: C, 69.20; H, 5.87; N, 14.29; S, 10.93.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Found", ":", "C", ",", "69.20", ";", ...
PMC9985266	P < 0.05, P < 0.01, *P < 0.001; values are expressed as the mean ± standard deviation (n = 3) Due to the aberrant expression of MEG3 in PF , we sought to verify whether MEG3 in MRC-5 attenuates PF by inhibiting the ERK/p38 signaling pathway to induce autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	At present, the mechanisms of cold response regulation and control networks are not fully elaborated, and cannot be implemented in production practices.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10362265	The resulting systems were simulated by the GROMACS algorithm , , , with the CHARMM36 force field including the correction map Water molecules were treated explicitly by the TIP3P model .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Sn at each amino acid site in tumour tissues (n = 711). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sn", "at", "each", "amino", "acid", "site", "in", "tu...
PMC11759543	The effect of doxorubicin in combination with vorinostat was evaluated as originally described by Ting-Chao Chou .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "doxorubicin", "in", "combinatio...
PMC4395774	Perforin expression and function in RBL-1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Perforin", "expression", "and", "function", "in", "RBL-1", "cells", "." ] } ]
PMC11638288	This research also illustrates that the binding of NKp46 to heparan sulfate involves a contiguous region containing the basic amino acids K133, R136, H139, R142, and K146.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779876	Illustrations and final figure arrangements were done in Adobe Illustrator (v28.1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illustrations", "and", "final", "figure", "arrangements", "were", "done", "...
PMC11049548	On the contrary, the signals of UDP-Glu are well visible in HGSOC_T and HGSOC_A spectra and below the detection limit in both the A2780 and A2780cis cells (Figure 3C and Figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352746	Scan settings are set for phase contrast at a magnification of 20× with the acquisition of 9 micrographs per well at 6 h intervals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6450504	The results clearly laid out the challenges to PEGylation, which had the lowest cellular association at both temperature levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "clearly", ...
PMC8409415	The proliferation rates of CD70‐silenced A2780cisR, SKOV3, and SKOV3cisR cells were similar (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proliferation", ...
PMC9429973	Multiple “rescued” clones exist in parallel within the bone marrow of patients, and dominance of an UPD or somatically mutated clone can displace the monosomy 7 clone and result in hematological remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Human normal breast epithelial cells MCF10A and human colon epithelial cells CCD841CoN were kind gifts from Prof. Lin Li at the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10976516	Considering that cells are the viruses’ natural hosts, seeing them as stealth OV carriers is indeed very tempting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Considering", "that", "cells...
PMC7504302	However, the functional consequences of SETD2 inactivation in MPM are not known.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "functional", "consequences", "of", "SETD2", "inactiv...
PMC11655536	In this study, we firstly demonstrated that elevated expression level of NHE1 is associated with poor prognosis of MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ...
PMC11612626	Biomedical implications of immunoproteasome activators may be significant to overcome deficiencies in immunoproteasome activity as seen in proteasome-associated autoinflammatory syndromes, as well as modulate antitumor immune responses, autoimmune and neurodegenerative diseases, and aging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	Cell surface receptor levels were determined by ELISA using an antibody against the N-terminally exposed FLAG epitope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "surface", "receptor", "levels", "were", ...
PMC11568601	Scale bar = 50 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "50", "μm", "." ] } ]
PMC11711127	The suppressive action of Tregs appears integrated with their heterogeneity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "suppressive", "action", "of", "Tregs", "appears", "integrated", "with", "their", "heterog...
PMC11665555	Initially, we evaluated the expression of enzymes responsible for ketone body metabolism in a diverse panel of BCa cell lines and their effect on gemcitabine sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Our prototype of an iCell, which is illustrated in Fig. 1 and detailed in Methods section iCell’s methodology, fuses three tissue-specific molecular interaction networks, protein–protein interaction (PPI), gene co-expression (COEX), and genetic interaction (GI) networks, into a single, unified representation of tissue-...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Plasmids were subcloned to express various combinations of the top three performing tat-directed gRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasmids", "were", "subcloned", "to", "express", "various", "combinati...
PMC10545062	There is evidence in translational models that vasopressin is associated with reduced morbidity and mortality in the context of catecholamine-refractory hemorrhagic shock due to endogenous vasopressin store depletion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9454178	Therefore, targeting CDK7 may provide an alternative therapeutic option to block the reactivation of receptor tyrosine kinase pathways in RTK-driven neoplasms, especially for TKI-resistant cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352746	Agilent BioTek’s Cytation 10 and Lionheart FX (Agilent Technologies, Santa Clara, CA, USA), featuring widefield and spinning disk confocal fluorescence microscopy, along with brightfield and phase-contrast capabilities, are also high-cost due to their comprehensive imaging and live-cell incubation features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The derivative bearing nido-7,8-dicarbaundecaborate modification (25) was obtained as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "derivative", "bearing", "nido-7,8-dicarbaundecaborate", "modification", "(", ...
PMC11679326	A huge repertoire of carbohydrate-binding proteins in marine organisms is the main system of innate immunity required for the recognition of pathogen-associated molecular patterns (PAMPs), which are a variety of carbohydrate components of the pathogen cell surface .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Recent studies show that in 2024, the United States alone registered over 2,000000 new cases, with 611,720 deaths .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "show", ...
PMC11411131	In Cos-7 cells, the C322U cDNAs expressed more of the truncated form than of the full-length form across each section. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Cos-7"...
PMC11476264	During tumorigenesis, progression, and metastasis, cancer cells invade the stroma, enter the bloodstream, and colonize distant organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "tu...
PMC11013014	IR (neat): ν = 3443 (NH), 1687 (C=O Ketone), 1659 (C=O Amide) cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The targeted dose was 3x10/kg CAR+ cells and was administered in a fractionated manner (10%/30%/60%), with at least 24h between infusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11765243	Ten days after immunization, the proportion of germinal center B cells and CXCR5 CD4 T cells was significantly increased in p110αKD-T mice, but CXCR5ICOS or CXCR5PD-1 Tfh cells were not significantly enhanced in mutant mice (Figure 8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11011837	The statistical analysis, for both metabolic and lipid profiles, shows significant differences and similarities among the four cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", ...
PMC11536589	Treatment with 1 µM LF3 or 0.2 µM PKF-118-310, both AsPC1-MR cells and KPC210-MR cells showed a significant reduction in MGST1 expression (Fig. 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10490530	Image acquisition and analysis were made on Chemi-Doc imaging systems (Bio-rad).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "acquisition", "and", "analysis", "were", "made", "on", "Chemi-Doc"...
PMC11781181	After cluster generation, transcriptome sequencing was carried out on an Illumina Novaseq™ 6000 platform that generated raw reads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "cluster", "generati...
PMC8922418	Moreover, owing to the longer PAM sequence recognized by SaCas9, the target recognition rate is improved, and the off-target effects are reduced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11200978	Further, the in vitro nature of this study provides ideal conditions for cell survival and recovery following freezing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "the", "in", ...
PMC11098378	PSMC1 has been reported to be an essential component of the 19S cap of the 26S proteasome .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PSMC1", "has", "been", "reported", "to", "b...
PMC8009078	This enables the leveraging of considerable investments in research and development to compress the timeline required for drug discovery and development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "enables", ...
PMC11723210	In existing works, the coded ptychographic imaging method , using coded image sensors and laser sources, has also been applied to the reconstruction of large phase objects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587866	The Swiss-model database built the 3D-structure of the EYA3 protein, which was then refined and minimized with GalaxyRefine database (Heo et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median (range) treatment duration was 10.6 months (1.6–48.5) vs 28.3 months (0.2–48.6) and median (range) dose intensity was 447.1 mg/d (131.3–520.4) vs 288.8 mg/d (79.7–500.0) for resistant vs intolerant patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11617590	Therefore, the induction of Ser9 phosphorylation of GSK‐3β can be a therapeutic target for identifying the chemotherapy agent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "inductio...
PMC9429973	Of the 9/30 (30%) patients Day 1 WBC count ≥10x10/L, 89% (8/9) had a WBC count <10x10/L; all maintained a stable hemoglobin (see figures).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	Interestingly, a similar elevation of body weight was observed in Ntsr2 AKO mice when they were kept in the thermoneutral condition (a 12-h light/12-h dark cycle at constant 30 °C with free access to food and water) (Supplementary information, Fig. S2d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	The efficacy of PRESTO as a surgical guidance tool was evaluated in a realistic resection scenario, employing a murine model with an OvCar5 xenograft tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC9429973	In conclusion, this work may help to identify new therapeutic approaches that could eventually improve AML patients’ outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", ...
PMC11394386	Effective outcomes are typically observed only with combined treatment strategies involving PI3K/AKT inhibitors (such as API2 and BKM120) alongside Wnt/tankyrase inhibitors (like NVP-TNKS656 and XAV-939) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Furthermore, we built tibial orthotopic osteosarcoma models with those treatments and observed the volumes and metastasis of tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "built",...
PMC10047551	Details concerning the applied NSCLC cell lines, including the place of purchase, are described in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Details", "concerning", "the", "a...
PMC10976516	injection with MYXV-TNF-loaded PBMCs.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "injection", "with", "MYXV-TNF-loaded", "PBMCs", "." ] } ]

PMC11300085

Chemerin decreased the expression of E-cadherin and increased expression of N-cadherin and vimentin; however, their expressions were reversed by C3T or Y27632 pretreatment (Figures 5(a) and 5(b)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The prognostic is very poor, with a 2-year survival rate reported to be less than 20%.There is no standard of care in this situation given the variability in patient’s and disease’s characteristics.

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PMC11247842

The other limitation of interpretation of the lead SNPs is lack of direct functional validation.

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PMC11772585

Following a 24-h transfection period, the cells were exposed to actinomycin D (Act D, 10 μg/mL, Cat# GC16866, GLPBIO) for 0, 3, or 6 min before being collected.

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PMC11536589

Fig. 5Upregulated MGST1 expression was modulated by the β-catenin/Tcf4 complex in MRTX1133-resistant PDAC cells. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5Upregulated", "MGST1", "expression", "was", "modulated",...

PMC11469524

HBL-1 cells were kindly provided by D. Krappmann (Munich, Germany).

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PMC11742047

The blue edge means fatty acids deleted, the orange edge means fatty acids modified, the green edge means head groups deleted, red edge means head groups modified.

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PMC11740207

This progression contributes to the aggressive nature of AML relapses (De Haan and Lazare, 2018; Verovskaya et al., 2019; Long et al., 2022).

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PMC11172027

Only NASeLM was able to increase caspase-3 activity in MTC-SK cells: at 250 µg/mL NASeLM, caspase-3 activity increased significantly to 28% after 24 and 48 h compared to the control (14%) or the same NALM concentration (14%).

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PMC10978090

These two cases suggest that TPE could be a safe and effective peri-operative strategy to remove platelet-activating anti-PF4/H antibodies.

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PMC11794847

No obvious abnormalities were found in the appearance, body weight, and the size of various organs in the HVEM knockout mice compared with wild type mice.

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PMC11106977

Interleukin-1 (Il-1), a multifunctional monokine, plays a significant role in the destruction of articular cartilage in degenerative arthropathies .

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PMC9219615

Research to further elucidate Tpz-1’s mechanism of action is ongoing.

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PMC10729469

In the current study, monoclonal TCRAβ-Treg were generated by incorporating the Aβ-specific TCR identified from a highly reactive monoclonal Aβ-Teff cell previously developed in our lab .

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PMC11656657

L, Milano (MI), Italy.

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PMC9812014

Lycorine alkaloid, isolated from C. miniata (Lindl.)

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PMC9386809

A round-bottom flask fitted with a reflux condenser was charged with α-naphthol (1 mmol), ethyl acetoacetate (2 mmol), and 1 mol % catalyst [≈9 mg of Cl2Zr–BPC complex 2].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A total of 134 patients with liver cirrhosis and aggressive lymphoma were found.

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PMC11718031

In contrast, CD-FortiCHO performed significantly better, as the highest VCC peaked at 14.5 × 10 cells/mL in CD-FortiCHO + Efficient B plus and around 14.0 × 10 cells/mL in CD-FortiCHO + Efficient (A plus and C plus).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11618052

The nature of the aryl/alkyl substituents at position 3 of the quinazoline moiety appears to be critical for the 8a–t hybrids' antiproliferative activity.

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PMC6650823

This work highlights challenges in developing ligands for functional RNAs and in understanding the behavior of small synthetic compounds that bind to and modulate the function of complex RNAs.

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PMC11672142

This reaction yielded the sodium salt of Fe(DefNEtTrp)2 (7) even with an excess of Fe(III) (Figure 1A).

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PMC11055443

The purity of human abdominal fat-derived MSCs was evaluated by immunophenotyping of CD45, CD105, CD90, CD73, and Sca-1 cell surface markers.

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PMC10988555

For 4, only 4″ is represented for simplicity.

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PMC2196094

The unprocessed protein has an 18-aa signal peptide and a 2-aa activation peptide (Gly-Glu).

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PMC6461034

These analyses show superior performance of INKA over its components and substrate‐based single‐sample tool KARP, and underscore target potential of high‐ranking kinases, encouraging further exploration of INKA's functional and clinical value.

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PMC11786600

As depicted in Figure 2a, PED0 of pure PVB without PF-127 exhibits hydrophobicity due to the hydrophobicity of PVB and, therefore, does not absorb liquid.

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PMC8750422

Despite the development of advanced anticancer drugs to treat lung cancer, the prognosis of patients with lung cancer still remains poor .

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PMC11488203

One of these factors is represented by SDF-1, which can contribute to enhanced tropism towards tumors e.g. by interacting with the CXCR4/CXCR7 axes.

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PMC11391695

In conclusion, pcDNA/PEI/NPs@M demonstrated exceptional safety and targeting capability in vivo.

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PMC7171147

Our work is further supported by the findings of others that chemoresistant ovarian cancers exhibit a high metabolically active phenotype with the ability to utilize fatty acids as fuel.

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PMC5363531

In presence of dasatinib, cell migration into the wounded area was greatly impaired (Figure 2D).

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PMC11033180

Phosphorylation at Ser603 represents a molecular signal for synapsin 1 dissociation from synaptic vesicles, resulting in dispersion of synapsin 1 from presynaptic terminals to axonal regions.

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PMC11684821

The MAIT cell subset is characterized by a TCR-α chain that is made up of the TRAV1-2 gene in combination with a TRAJ33, TRAJ12, or TRAJ20-joining region (11).

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PMC10882807

Western Blot analysis of EIF4A3 in adjacent tissues and paired HCC tissues. (

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PMC10874773

oligandrumZhu et al., 200939Veranisatin EI.

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PMC7305184

1 generation followed by every 5 generation of CTRL, CTRL + EP and EP group were analyzed for a development of adaptive resistance by preforming permeabilization and survival curve.

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PMC11423992

The binding activity to CD3 and T-cell activation can be modulated by adjusting the length of the linker.

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PMC11672142

ICP-OES data were collected by using an Optima 8000 (PerkinElmer) system.

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PMC9429973

Despite the usage of corticosteroids and later life-saving rescue with cladribine 0.12 mg/kg 5 days, she developed severe multiorgan dysfunction - pancytopenia (hemoglobin 6.9 g/dL, leukocyte 0.6x10^9/L, platelet 10x10^9/L), liver dysfunction (bilirubin 24.7 mg/dL, gamma-glutamyl transferase 1071 U/L, alkaline phosphat...

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PMC9960565

A trend between cytotoxicity and dendrimer generation (number of transported metallic fragments) was not observed.

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PMC10969097

The mice were injected subcutaneously with 0.1 mL of HepG2 and Bel-7404 cells at a concentration of 1.0 × 107/mL. When the tumour volume reached 90–100 mm, the mice were randomly divided into groups (n = 6/group) and treated for 21 days.

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PMC11739504

The mixture was harvested with the culture medium and centrifuged at 1500 rpm for 3 min.

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PMC7351993

Second, we employed the RIACS to sort out rare Chlamydomonas sp. mutants with high-lipid productivity toward microbial breeding for cost-effective algal biofuel development (see “sorting of Chlamydomonas sp. cells” in the Methods section for details).

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PMC11248911

Found: C, 69.20; H, 5.87; N, 14.29; S, 10.93.

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PMC9985266

P < 0.05, **P < 0.01, ***P < 0.001; values are expressed as the mean ± standard deviation (n = 3) Due to the aberrant expression of MEG3 in PF , we sought to verify whether MEG3 in MRC-5 attenuates PF by inhibiting the ERK/p38 signaling pathway to induce autophagy.

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PMC11764090

At present, the mechanisms of cold response regulation and control networks are not fully elaborated, and cannot be implemented in production practices.

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PMC10362265

The resulting systems were simulated by the GROMACS algorithm , , , with the CHARMM36 force field including the correction map Water molecules were treated explicitly by the TIP3P model .

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PMC9621239

Sn at each amino acid site in tumour tissues (n = 711). (

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PMC11759543

The effect of doxorubicin in combination with vorinostat was evaluated as originally described by Ting-Chao Chou .

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PMC4395774

Perforin expression and function in RBL-1 cells.

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PMC11638288

This research also illustrates that the binding of NKp46 to heparan sulfate involves a contiguous region containing the basic amino acids K133, R136, H139, R142, and K146.

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PMC11779876

Illustrations and final figure arrangements were done in Adobe Illustrator (v28.1).

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PMC11049548

On the contrary, the signals of UDP-Glu are well visible in HGSOC_T and HGSOC_A spectra and below the detection limit in both the A2780 and A2780cis cells (Figure 3C and Figure 5).

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PMC11352746

Scan settings are set for phase contrast at a magnification of 20× with the acquisition of 9 micrographs per well at 6 h intervals.

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PMC6450504

The results clearly laid out the challenges to PEGylation, which had the lowest cellular association at both temperature levels.

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PMC8409415

The proliferation rates of CD70‐silenced A2780cisR, SKOV3, and SKOV3cisR cells were similar (Figure 2C).

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PMC9429973

Multiple “rescued” clones exist in parallel within the bone marrow of patients, and dominance of an UPD or somatically mutated clone can displace the monosomy 7 clone and result in hematological remission.

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PMC11790599

Human normal breast epithelial cells MCF10A and human colon epithelial cells CCD841CoN were kind gifts from Prof. Lin Li at the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.

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PMC10976516

Considering that cells are the viruses’ natural hosts, seeing them as stealth OV carriers is indeed very tempting.

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PMC7504302

However, the functional consequences of SETD2 inactivation in MPM are not known.

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PMC11655536

In this study, we firstly demonstrated that elevated expression level of NHE1 is associated with poor prognosis of MM.

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PMC11612626

Biomedical implications of immunoproteasome activators may be significant to overcome deficiencies in immunoproteasome activity as seen in proteasome-associated autoinflammatory syndromes, as well as modulate antitumor immune responses, autoimmune and neurodegenerative diseases, and aging.

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PMC11585254

Cell surface receptor levels were determined by ELISA using an antibody against the N-terminally exposed FLAG epitope.

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PMC11568601

Scale bar = 50 μm.

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PMC11711127

The suppressive action of Tregs appears integrated with their heterogeneity.

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PMC11665555

Initially, we evaluated the expression of enzymes responsible for ketone body metabolism in a diverse panel of BCa cell lines and their effect on gemcitabine sensitivity.

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PMC6379402

Our prototype of an iCell, which is illustrated in Fig. 1 and detailed in Methods section iCell’s methodology, fuses three tissue-specific molecular interaction networks, protein–protein interaction (PPI), gene co-expression (COEX), and genetic interaction (GI) networks, into a single, unified representation of tissue-...

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PMC8633974

Plasmids were subcloned to express various combinations of the top three performing tat-directed gRNAs.

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PMC10545062

There is evidence in translational models that vasopressin is associated with reduced morbidity and mortality in the context of catecholamine-refractory hemorrhagic shock due to endogenous vasopressin store depletion.

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PMC9454178

Therefore, targeting CDK7 may provide an alternative therapeutic option to block the reactivation of receptor tyrosine kinase pathways in RTK-driven neoplasms, especially for TKI-resistant cancer.

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PMC11352746

Agilent BioTek’s Cytation 10 and Lionheart FX (Agilent Technologies, Santa Clara, CA, USA), featuring widefield and spinning disk confocal fluorescence microscopy, along with brightfield and phase-contrast capabilities, are also high-cost due to their comprehensive imaging and live-cell incubation features.

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PMC8345486

The derivative bearing nido-7,8-dicarbaundecaborate modification (25) was obtained as previously described .

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PMC11679326

A huge repertoire of carbohydrate-binding proteins in marine organisms is the main system of innate immunity required for the recognition of pathogen-associated molecular patterns (PAMPs), which are a variety of carbohydrate components of the pathogen cell surface .

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PMC11680562

Recent studies show that in 2024, the United States alone registered over 2,000000 new cases, with 611,720 deaths .

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PMC11411131

In Cos-7 cells, the C322U cDNAs expressed more of the truncated form than of the full-length form across each section. (

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PMC11476264

During tumorigenesis, progression, and metastasis, cancer cells invade the stroma, enter the bloodstream, and colonize distant organs.

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PMC11013014

IR (neat): ν = 3443 (NH), 1687 (C=O Ketone), 1659 (C=O Amide) cm.

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PMC9429973

The targeted dose was 3x10/kg CAR+ cells and was administered in a fractionated manner (10%/30%/60%), with at least 24h between infusions.

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PMC11765243

Ten days after immunization, the proportion of germinal center B cells and CXCR5 CD4 T cells was significantly increased in p110αKD-T mice, but CXCR5ICOS or CXCR5PD-1 Tfh cells were not significantly enhanced in mutant mice (Figure 8B).

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PMC11011837

The statistical analysis, for both metabolic and lipid profiles, shows significant differences and similarities among the four cell lines.

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PMC11536589

Treatment with 1 µM LF3 or 0.2 µM PKF-118-310, both AsPC1-MR cells and KPC210-MR cells showed a significant reduction in MGST1 expression (Fig. 6A).

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PMC10490530

Image acquisition and analysis were made on Chemi-Doc imaging systems (Bio-rad).

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PMC11781181

After cluster generation, transcriptome sequencing was carried out on an Illumina Novaseq™ 6000 platform that generated raw reads.

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PMC8922418

Moreover, owing to the longer PAM sequence recognized by SaCas9, the target recognition rate is improved, and the off-target effects are reduced.

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PMC11200978

Further, the in vitro nature of this study provides ideal conditions for cell survival and recovery following freezing.

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PMC11098378

PSMC1 has been reported to be an essential component of the 19S cap of the 26S proteasome .

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PMC8009078

This enables the leveraging of considerable investments in research and development to compress the timeline required for drug discovery and development.

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PMC11723210

In existing works, the coded ptychographic imaging method , using coded image sensors and laser sources, has also been applied to the reconstruction of large phase objects.

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PMC9587866

The Swiss-model database built the 3D-structure of the EYA3 protein, which was then refined and minimized with GalaxyRefine database (Heo et al., 2013).

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PMC9429973

Median (range) treatment duration was 10.6 months (1.6–48.5) vs 28.3 months (0.2–48.6) and median (range) dose intensity was 447.1 mg/d (131.3–520.4) vs 288.8 mg/d (79.7–500.0) for resistant vs intolerant patients.

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PMC11617590

Therefore, the induction of Ser9 phosphorylation of GSK‐3β can be a therapeutic target for identifying the chemotherapy agent.

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PMC9429973

Of the 9/30 (30%) patients Day 1 WBC count ≥10x10/L, 89% (8/9) had a WBC count <10x10/L; all maintained a stable hemoglobin (see figures).

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PMC11770130

Interestingly, a similar elevation of body weight was observed in Ntsr2 AKO mice when they were kept in the thermoneutral condition (a 12-h light/12-h dark cycle at constant 30 °C with free access to food and water) (Supplementary information, Fig. S2d).

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PMC11348300

The efficacy of PRESTO as a surgical guidance tool was evaluated in a realistic resection scenario, employing a murine model with an OvCar5 xenograft tumor.

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PMC9429973

In conclusion, this work may help to identify new therapeutic approaches that could eventually improve AML patients’ outcomes.

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PMC11394386

Effective outcomes are typically observed only with combined treatment strategies involving PI3K/AKT inhibitors (such as API2 and BKM120) alongside Wnt/tankyrase inhibitors (like NVP-TNKS656 and XAV-939) .

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PMC11525028

Furthermore, we built tibial orthotopic osteosarcoma models with those treatments and observed the volumes and metastasis of tumors.

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PMC10047551

Details concerning the applied NSCLC cell lines, including the place of purchase, are described in Table S1.

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PMC10976516

injection with MYXV-TNF-loaded PBMCs.

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