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OTAR3088
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BioData-CellLine_annotated

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PMC11367146
The network comprises of 162 nodes and 487 edges. (
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PMC11283030
Simultaneously, Kaplan–Meier plotter analysis also validated that high ACLY mRNA expression was negatively correlated with RFS rate of the ∼400 ccRCC patients (P = 0.013, Fig. 2e), which was in line with former report .
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PMC11683130
Serpins are abundant in expression and distribution in the skin.
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PMC7504302
Unfortunately, the clinical trials targeting these molecular processes have demonstrated limited, if not completely ineffective, efficacy against MPM .
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PMC9429973
We used the cutoff values of protein co-expression are 50% for BCL2 and 40% for MYC.
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PMC11782508
Moreover, Bifidobacterium and Lactobacillus spp.
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PMC11721277
The ratio of tumor-to-liver is critically low for all doses studied.
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PMC10094992
Digital images were taken with the Bio-Rad ChemiDocTM Touch Imaging System and quantified using Bio-Rad Image Lab 5.2.1.
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PMC11026382
The residues linked to catalysis form a structurally distributed network inside the enzyme and are highly evolutionarily conserved.
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PMC10033453
We next sought to explain differences in sarcoma cell viability after VMG infection and possible reasons for incomplete oncolysis with a replicating virus.
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PMC9429973
This indicates that, depending on the clinical scenario, some patients may be receiving unnecessary blood transfusions.
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PMC11770746
The order of stability of the compounds is oxali(OAc)2 > cisPt(OAc)2 > cisPt(Pac)(OH), reflecting the greater stability of Pt(IV) complexes where the axial ligands are conjugated to the Pt(IV) via carboxylates compared with ligands conjugated via carbonates.
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PMC11534377
Analysis of the expression changes for selected genes, with the log (2) FC from both microarray and qPCR results, along with the corresponding p-values listed in table IV.
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PMC9503541
Lung cancer is by far the most common cause of cancer deaths in both men and women worldwide, accounting for 1.80 million deaths in 2020, or approximately 18% of all cancer deaths .
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PMC5311252
To predict treatment response and select targeted therapies, it is therefore of great importance to fully understand the signaling networks that drive cancer cell proliferation.
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PMC11707832
Aberrant glycosylation, considered a hallmark of cancer, has been implicated in its initiation and progression across various malignancies [90-92].
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PMC2196094
MC (connective tissue type) of ∼95% purity (the majority of the contaminating cells were red blood cells), as judged by staining with toluidine blue, were prepared by density gradient centrifugation on metrizamide as described by Sterk and Ishizaka (26).
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PMC9429973
The follow-up was 36,8 months.
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PMC9429973
The median time to any aGVHD was 55 days.
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PMC9856122
Moreover, tetrandrine was also assessed in this research but showed slightly lower activity than CEP .
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PMC11409031
C–E) Mapping a trajectory of differentiation based on cell differentiation status, coloring cell development time, and identifying cell clusters. (
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PMC11495567
The PCAIs were thus designed with the rationale that they will alter the secondary modifications and therefore the interaction patterns of the RAS proteins to curtail their oncogenic activities.
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PMC11721064
Previous studies have confirmed the capacity of LNCs to effectively maintain LEPCs in an undifferentiated state in vitro , making them widely used as feeder cells for in vitro LEPC cultivation .
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PMC11560255
Detection of the cells’ apoptosis was performed using the FITC Annexin V apoptosis detection kit with PI.
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PMC11365983
D–F) In IMCD3 cells, Foxc1 knock-down and OE respectively reduce and increase cilia length; graphs depict fold change in cilia length and prevalence of short and long cilia (shRNA, OE: n = 1). (
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PMC11366496
Herein, when we explored the regulation of RNF122 on JAK2, we unexpectedly found that overexpression or silencing of RNF122 did not change the expression levels of JAK2 protein and mRNA (Figure S5A,B), and the actinomycin (CHX) experiment confirmed that overexpression of RNF122 could not promote JAK2 degradation (Figur...
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PMC9429973
Improved BTKis may achieve better therapeutic outcomes.
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PMC11337594
Data in D and G are shown as mean + SEM.
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PMC11190538
As controls, wells with media containing 1 % ethanol with no C-phycocyanin were put on each plate .
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PMC11562028
During the experimental cycle, the body weight of mice in all groups showed an upward trend (Fig. 7B).
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PMC11413393
Included in this list was UNC1999, an inhibitor of the Polycomb group H3K27me3 lysine methyltransferase EZH2, which has been previously characterized as a target in ccRCC.
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PMC8992508
Cancer cells that are originally sensitive to a single anti-cancer drug later become resistant to multiple anti-cancer drugs.
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PMC11753435
h MLP layers were applied with rectified linear unit (ReLU) activation on the embedding vector to obtain the output embedding, which is a vector of length eo.
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PMC11594588
Due to the large range of these products and pleiotropic action, knowledge about the molecular mechanisms of their action is still limited in the professional scientific literature.
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PMC11400680
Unlike CellSAM (24), Na et al. applied an auxiliary neural network, specifically U-Net for auto prompting.
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PMC11628904
Dashed line indicates tailfin boundary. (
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PMC5716223
We previously demonstrated that the activation of NF-κB and the parallel modulation of αB-crystallin (αB-Cry) and Hsp27 play a major role in the antiapoptotic effect exerted by vascular endothelial growth factor (VEGF) in C2C12 myoblasts exposed to oxidative or hypoxic-like stress “in vitro” , as well as in the positiv...
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PMC11627133
Efficient labeling methods for protein visualization with minimal tag size and appropriate photophysical properties are required for single‐molecule localization microscopy (SMLM), providing insights into the organization and interactions of biomolecules in cells at the molecular level.
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PMC6034753
Using immunofluorescence microscopy, we found that apoptin and Meq co-localize to the nucleus, and biochemical analysis indicated that the two proteins do physically interact.
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PMC11098378
First, ubiquitin activated interaction trap (UBAIT) assays were conducted in LD652 whole cell extract (Fig 5C).
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PMC11537649
Incubate cells for 24 hours, 48 hours, 72 hours, and 96 hours with 10 µL of CCK8 reagent.
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PMC11321678
Furthermore, we noted a modulation of GLI2 expression correlated with changes in EOMES expression levels in Group 3/4 cells when overexpressing EOMES (Figure S8H, Supporting Information).
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PMC11265931
While garlic exosome therapy significantly reduced cancer cell viability, it had no cytotoxic effect on the normal cell line, HUVEC.
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PMC10577955
To determine the relative expression of the examined genes’ mRNA, real-time data were used.
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PMC9429973
PV subjects with HTN were non-dippers, suffered from systolic/diastolic dysfunction as assessed by cardiac ultrasound, displayed elevated cell-free hemoglobin and nitrite/nitrate ratio, and an increased risk of thrombosis (HR=1.77).
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PMC10197932
Finally, CD137 expression also induces DNA demethylation and reprogramming gene expression 23.
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PMC4277423
genomic DNA isolated from mock-transduced TZM.bl; “+”: genomic DNA isolated from sorted CCR5-/CR2 cells.
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PMC11453018
For immunofluorescence assays, cells grown in 96-well plates were fixed with 4% paraformaldehyde (PFA) for 10 min, washed twice with PBS, and then permeabilized with 0.3% Triton X-100 for 30 min.
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PMC10858941
For Fig. 4, n = 6–8, except for the bafilomycin positive control (n = 4–5).
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PMC11026382
The resulting DHF concentration measurements over time were entered into GraphPad Prism and background-subtracted to zero for the initial time point across all samples.
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PMC11011837
Additionally, specific pathways emerge that vary among them, such as tryptophan metabolism, glutathione metabolism, arginine biosynthesis, purine metabolism, and others.
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PMC8389560
Vertebrate connexins (Cx) are represented by 20 protein isoforms containing four transmembrane domains and differing from each other in the length of the cytoplasmic domain.
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PMC11733919
Indeed, CD26 has been implicated in the regulation of immune responses, glucose metabolism, signal transduction, cell death pathways, and cancer progression.
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PMC11509278
In this study, untargeted metabolomics revealed 1052 small-molecule metabolites, of which 160 metabolites were significantly upregulated and 143 metabolites were significantly downregulated.
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PMC11802855
Furthermore, we assessed the expression levels of MMP2, MMP9, and MMP13, which serve as markers for proteins associated with the activation of the osteoclast signaling pathway.
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PMC11655536
E Statistical analysis of apoptotic cells of ARH-77 R in (D).
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PMC11502443
Following this, the well contents were removed and replaced with 14 μL of IP-one Gq assay kit stimulation buffer to extract IP1.
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PMC8427838
Cells were lysed, and normalized whole-cell lysates were subjected to immunoprecipitation by incubation with appropriate antibodies as shown in the figure legends.
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PMC11655498
However, discovering the ultimate cure for EBV-induced diseases remains a significant challenge.
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PMC8170755
Valproic acid (VPA) was used as a histone deacetylase inhibitor.
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PMC11683240
Additionally, the enzyme activity was tested in vitro using recombinant Gαi also showing only minor effects (Fig. S4).Figure 4Effect of α1AT on enzyme activity of PTS1 in vitro.
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PMC8540611
In some cases, the complexes are slightly less toxic than pure AuNPs, which can be caused by size effects; however, the effect is slight and will be excluded from any further consideration.
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PMC4695073
However, multivariable analysis suggested XPA expression together with T and N classification were independent prognostic factors for OS and PFS (Table 3).
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PMC11320834
1Topotecan- (TLL) and olaparib-loaded (OLL) liposomes characteristics involving a size expressed by z-average, b size distribution presented as polydispersity index, PDI, c zeta potential, and d drug loading expressed as a percentage of encapsulation efficacy after preparation of overtime after preparation (day 0) and ...
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PMC4816271
Oligonucleotides were purchased from IDTDNA (Coralsville, Iowa).
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PMC11539788
P < 0.05, **P < 0.01, and ***P < 0.001 RNF19A was expressed at low levels in BCa tissues and cell lines and was positively correlated with the clinical outcomes of patients with BCa. (
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PMC11429241
Five genes—CDH1, CDH2 , COL1A1 , SMAD3 , and TWIST1 —related to cell adhesion, migration, and extracellular matrix (ECM) organization were analyzed (Figure 8).
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PMC9429973
Differences were considered statistically significant at p<0.05.
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PMC11643361
Zinc complexes also exhibit promising activity, especially against difficult-to-treat cancers like triple-negative breast cancer.
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PMC6650823
A recent publication by Lee et al. identified a new potential target whose inhibition could restore normal PTEN functions: a ubiquitin E3 ligase (WWP1), which is an upstream regulator of PTEN dimerization and membrane localization, may be transcriptionally activated by the MYC proto-oncogene, and has previously been fo...
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PMC10988808
C YAP phosphorylation was detected by Western blot analysis, using ACTIN as reference.
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PMC11552389
Meanwhile, weight, skin tone, and mobility measurements were taken to assess overall health.
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PMC11569208
As a positive control, siRNA against retinoic acid-inducible gene I (RIG-I), central to innate antiviral interferon (IFN) signaling, and cells treated with vanadate were used.
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PMC10812665
Twelve of the twenty proteinogenic amino acids were up-regulated by Ber, five were down-regulated and only Gly, Ile and Thr were not altered (Figure 9A,B).
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PMC7759933
Another important proliferation marker KI67 encodes a nuclear antigen during the G1, S, and G2–M phases of proliferating cells, meaning that it is present during all active phases of the cell cycle, except the G0 phase .
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PMC11354239
The experiments were initially performed as in the case of degranulation analysis.
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PMC6450504
This increased buffering ability could easily disrupt the endosomal membrane with its acidic environment following internalization of the bPEI-coated PEIPOS and provide an effective endosomal escape.
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PMC6442998
YAP localization was considered to be nuclear when the ratio was <1.
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PMC5311252
For gene set enrichment analysis, the C2:canonical pathways gene sets were used, and the analysis was performed using standard settings.
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PMC5417661
Permeability of NOV202 was determined with Caco-2 monolayer assay.
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PMC11792090
Statistical significance was determined using two-way ANOVA (C), Student’s t-test (D, G) and one-way ANOVA (E, F, H). ***
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PMC11700340
This finding is consistent with other studies that have shown that treatment with linagliptin significantly decreased the viability of Saos-2 cells (a human osteosarcoma cell line) and hFOB1.19 cells (a human fetal osteoblastic cell line) at a statistically significant level (p < 0.001) .
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PMC11572213
Furthermore, our immunoblotting results confirmed the qPCR results, showing that the GLUL protein level was increased in all cells in low glutamine-containing medium, and the increase in GLUL expression was higher in TET2-knockdown cells (Figure 5B).
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PMC6163708
Here, we present results showing that the main components of the HH pathway are invariably expressed across a large panel of tumor cells of various cancer types.
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PMC11607321
Instead, complex interactions among multi-omic data and genomic and physiological variables were accounted for, facilitating a more holistic understanding of the underlying biological processes and phenomena.
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PMC8358176
All the rats were kept in an animal center in Biochemistry and Biophysics, Tehran University, Iran under controlled temperature conditions (22 ± 2 °C) with constant light of 12 hours (08:00–20:00).
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PMC7823217
Cancer cells cultured in hydrogels, spheroid monoculture, spheroid co-culture, cancer/stromal cells cultured in porous 3D scaffolds, and advanced bioprinted constructs are amongst the available 3D cancer models.
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PMC7039683
Together these findings support our conclusion that elements with more ATAC-seq reads in GFP-positive versus GFP-negative cells sorted from Tg(krt4:gfp) embryos at 11 hpf, and marked with H3K27Ac at 8 hpf and or at 24 hpf, have periderm enhancer (or promoter) activity in embryos at these stages.
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PMC11740399
Standard curve of SRT3025 (H).
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PMC11258145
The cholesterol and phospholipid ratio for the model systems were 0.35 for HL-60 and 0.21 for SK-N-SH.
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PMC11365427
To further study the biological functions of these genes, we performed a GSEA enrichment analysis using the GSEA software.
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PMC11422150
In recent years, stem cell transplantation has shown a remarkable therapeutic efficacy on SCI.
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PMC9429973
Results: The target numbers of CD3+ cells (>0.55 x10) were successfully collected within a single collection day in all patients but one.
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PMC11476666
This analogue also exhibits specific characteristics that set it apart, contributing to its distinct effects.
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PMC11488203
For this approach, different amounts of a neutralizing SDF-1 antibody and MSC-derived taxol exosomes were incubated together with A549 lung carcinoma cells for 72 h to examine cytotoxic effects.
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PMC9429973
E. M. Stein, A. Patel, L. C. Michaelis, G. Schiller, R. Swords, L. A. Carvajal, G. Bray, J. DiMartino, M. Y. Levy Memorial Sloan Kettering Cancer Center, New York; The University of Chicago Medical Center, Chicago; Medical College of Wisconsin, Milwaukee; University of California Los Angeles (UCLA), Los Angeles; Oregon...
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PMC3931643
For most of the experiments in this study, we used the asTORi compound MLN0128 (formerly INK128) that is in clinical trials , , .
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PMC10142392
This offers the possibility to modify the thermal behavior by altering the length of the PCL chains relative to those of PtBA or PMMA.
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PMC11727062
While these monomers have exhibited antitumor efficacy in vitro, concerns regarding their potential toxic side effects have been raised.
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PMC5854676
The HeLa cell line was cultured and maintained at 37 °C in a 5% CO2 humidified environment.
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